Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin

Biomaterials

Volumn 33, Issue 2, 2012, Pages 668-678

  Kim, MinYoung ^a   Jung, Bokyung ^b   Park, Jung Hwan ^a  

^a Gachon University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Biodegradable polymer; Microneedle; Swelling of hydrogel; Transdermal drug delivery

Indexed keywords

ABSORBED WATER; FRANZ CELL; HYDROGEL SWELLING; IN-VITRO; IN-VIVO; MATRIX POLYMERS; MICRO-PARTICLES; MICROMOLDING; MICRONEEDLES; MODEL DRUGS; MOUSE SKIN; PNIPAAM; POLY LACTIC-CO-GLYCOLIC ACID; POLYN-ISOPROPYLACRYLAMIDE; STRESS-STRAIN BEHAVIORS; SUSTAINED RELEASE; TRANSDERMAL DRUG DELIVERY; TRANSDERMAL DRUGS; VOLUME EXPANSION;

ACRYLIC MONOMERS; AMIDES; BIODEGRADABLE POLYMERS; DRUG DELIVERY; DRUG PRODUCTS; EMULSIFICATION; HYDROGELS; MAMMALS; SWELLING;

NEEDLES;

BIOPOLYMER; POLY(N ISOPROPYLACRYLAMIDE); POLYGLACTIN; WATER;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FLUID; DRUG DELIVERY SYSTEM; EMULSION; HUMIDITY; HYDROGEL; MICRONEEDLE; MOLECULAR STABILITY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SKIN; STRESS STRAIN RELATIONSHIP; SUSTAINED DRUG RELEASE; SWINE; SYNTHESIS; WETTABILITY;

ABSORBABLE IMPLANTS; ACRYLIC RESINS; ADMINISTRATION, CUTANEOUS; ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HYDROGELS; LACTIC ACID; MICE; MICROINJECTIONS; NEEDLES; PHYSICOCHEMICAL PHENOMENA; POLYGLYCOLIC ACID; POLYMERS; SKIN; SWINE;

SUS;

EID: 80055120196     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.09.074     Document Type: Article

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