A PZT insulin pump integrated with a silicon microneedle array for transdermal drug delivery

Microfluidics and Nanofluidics

Volumn 2, Issue 5, 2006, Pages 417-423

  Ma, Bin ^a   Liu, Sheng ^a,d   Gan, Zhiyn ^a   Liu, Guojun ^b   Cai, Xinxia ^c   Zhang, Honghai ^a   Yang, Zhigang ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JILIN UNIVERSITY   (China)

^c INSTITUTE OF ELECTRONICS   (China)

^d Wayne State University   (United States)

Author keywords

Bio MEMS; Microneedle array; Piezoelectric pump; Transdermal delivery

Indexed keywords

ANISOTROPY; BIOMEDICAL EQUIPMENT; ETCHING; INDUCTIVELY COUPLED PLASMA; INSULIN; NEEDLES; PIEZOELECTRIC DEVICES; PUMPS; SKIN;

DIABETES MELLITUS; INSULIN PUMP; MICRO-ELECTRO-MECHANICAL-SYSTEM (MEMS) TECHNOLOGY; MICRONEEDLE ARRAY; PIEZOELECTRIC PUMP; TRANSDERMAL DRUG DELIVERY;

DRUG PRODUCTS;

EID: 33747847766     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-006-0083-x     Document Type: Article

References (15)

1. Barry BW (2001) Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharma Sci 14:111-114
2. Bronaugh RL, Maibach HI (1999) Percutaneous Absorption: Drugs Cosmetics Mechanisms Methodology. Marcel Dekker, New York
3. Elias PM (1989) The stratum corneum as an organ of protection old and new concepts. In: Fritsch P, Schuler G, Hintner H (eds) Current problems in dermatology. New York Switzerland, pp 10-21
4. Emst T, Emst O (2000) Microactuators and their technologies. J Mech 10:431-445
5. Gong Q, Zhou Z, Yang Y, Wang X (2000) Design, optimization and simulation microelectro magnetic pump. Sens Actuators A 83:200-207
6. Junwu K, Zhigang Y, Kehong T, Guangmin C (2004) Pumping performance of a new piezoelectric pump for drug delivery. J Biomed Eng 21(2):297-301
7. Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, Prausnitz M (2001) Lack of pain associated with microfabricated microneedle. Anesth Analg 92:502-504
8. Van Lintel HTV, van de Pol FCM, Bouwstra A (1988) A Piezoelectric micropump based on micromachining of silicon. Sens Actuators A 15:153-168
9. Petersen K (1996) From microsensors to microinstruments. Sens Actuators 56:143-149
10. Van de Pol FCM, Van Lintel HTG, Elvenspoek M, Fluitman JHJ (1990) A thermopneumatic micropump based on microengineering techniques. Sens Actuators A 21:198-202
11. Spence WJ, Corbett WT, Dominguez LR (1978) An electronically controlled piezoelectric insulin pump and valves. IEEE Trans Son Ultra Son 25(3):153-159
12. Stemme E, Stemme G (1993) A valve less diffuser/nozzle-based fluid pumps. Sens Actuators A 39:159-167
13. Touitou E (2002) Drug delivery across the skin. Expert opin Biol Ther 2:723-733
14. Williams AC, Barry BW (1992) Skin Absorption enhancers. Crit Rev Ther Drug Carrier Syst 9:305-353
15. Woias P (2001) Micropumps:sUmmarizing the first two decades. Microfluid BioMEMS 4560:39-52