Microneedle array technology: The time is right but is the science ready?

Expert Review of Medical Devices

Volumn 3, Issue 1, 2006, Pages 1-4

  Birchall, James C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; DRUG; HEPATITIS B VACCINE; INFLUENZA VACCINE; MEASLES MUMPS RUBELLA VACCINE; NANOPARTICLE; PLASMID DNA; POLYMER; SILICON; VACCINE;

BIOENGINEERING; DRUG COST; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SAFETY; DRUG STORAGE; DRY POWDER; EDITORIAL; EMULSION; EPIDEMIC; HEPATITIS B; HUMAN; INFLUENZA VIRUS A; MACROMOLECULE; MATERIAL COATING; MEASLES; MEDICAL SPECIALIST; MEDICAL TECHNOLOGY; MUMPS; NEEDLE; NONHUMAN; RUBELLA; SKIN SURFACE; SUSPENSION; SUSTAINED DRUG RELEASE; TRANSDERMAL PATCH; ANIMAL; INSTRUMENTATION; INTRADERMAL DRUG ADMINISTRATION; METHODOLOGY; MICROINJECTION;

INFLUENZAVIRUS A;

ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; INJECTIONS, INTRADERMAL; MICROINJECTIONS;

EID: 33644844200     PISSN: 17434440     EISSN: 17452422     Source Type: Journal    
DOI: 10.1586/17434440.3.1.1     Document Type: Editorial

References (17)

1. Kaushik S, Hord AH, Denson DD et al. Lack of pain associated with microfabricated microneedles. Anesth. Analg. 92, 502-504 (2001).
2. Chiarello K. Breaking the barrier: advances in transdermal technology. Pharm. Tech. 28. 46-56 (2004).
3. Chabri F, Bouris K, Jones T et al. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br. J. Dermatol. 150, 869-877 (2004).
4. McAllister DV, Wang PM, Davis SP et al. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl Acad. Sci. USA 100, 13755-13760 (2003).
5. Kuo S-C, Chou Y. A novel polymer microneedle arrays and PDMS micromolding technique. Tamkang J. Sci. Eng. 7, 95-98 (2004).
6. McAllister DV, Cros F, Davis SP, Matta LM, Prausnitz MR, Allen MG. Three-dimensional hollow microneedle and microtube arrays. Abstract presented at Transducers' 99. Sendai, Japan (1999).
7. Kim K, Park DS, Lu HM et al. A tapered hollow metallic microneedle array using backside exposure of SU-8. J. Micromech. Microeng. 14, 597-603 (2004).
8. Teo MAL, Shearwood C, Ng KC, Lu J, Moochhala S. In vitro and in vivo characterization of MEMS microneedles. Biomed. Microdevices 7, 47-52 (2005).
9. Zahn JD, Deshmukh A, Pisano AP, Liepmann D. Continuous on-chip micropumping for microneedle enhanced drug delivery. Biomed. Microdevices 6. 183-190 (2004).
10. Hamilton JG. Needle phobia: a neglected diagnosis. J. Fam. Pract. 41, 169-175 (1995).
11. Widera G, Johnson J, Kim L et al. Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system. Vaccine (2005) (In Press).
12. Kenney RT, Frech SA, Muenz LR, Villar CP Glenn GM. Dose sparing with intradermal injection of Influenza vaccine, N. Engl, J. Med. 351, 2295-2301 (2004).
13. Wakefield AJ. MMR vaccination and autism. Lancet 354, 949-950 (1999).
14. Prausnitz M, Mikszta J, Raeder-Devens J. Microneedles. In: Percutaneous Penetration Enhancers. Smith EW, Maibach H (Eds). CRC Press, FL, USA (2005) (In Press).
15. Birchall J, Coulman S, Pearton M et al. Cutaneous DNA delivery and gene expression in e,x vivo human skin explants via wet-etch microfabricated microneedles. J. Drug Target. 13(7), 415-421 (2005).
16. Coulman SA, Barrow D, Anstey A et al. Minimally invasive delivery of macromolecules and plasmid DNA via microneedles. Curr. Drug Deliv (2005) (In Press).
17. Mikszta JA, Alarcon JB, Brittingham JM. Sutter DE. Pettis RJ, Harvey NG. Improvrd genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nature Med. 8, 415-419 (2002).