Clinical administration of microneedles: Skin puncture, pain and sensation

Biomedical Microdevices

Volumn 11, Issue 1, 2009, Pages 35-47

  Haq, M I ^a   Smith, E ^a   John, D N ^a   Kalavala, M ^b   Edwards, C ^b   Anstey, A ^b   Morrissey, A ^c   Birchall, J C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b ROYAL GWENT HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Clinical trial; Microneedle; Pain; Sensation; Visual analogue scale

Indexed keywords

CLINICAL TRIAL; MICRONEEDLE; PAIN; SENSATION; VISUAL ANALOGUE SCALE;

APPLICATIONS; BLOOD; BLOOD VESSELS; DRUG DELIVERY; DRUG THERAPY; MICROCHANNELS; NEEDLES; NUCLEIC ACIDS; ORGANIC ACIDS; SENSORY PERCEPTION;

SKIN;

METHYLENE BLUE;

ADULT; AGED; APPLICATION SITE BLEEDING; APPLICATION SITE ERYTHEMA; ARTICLE; CONTROLLED STUDY; EPILUMINESCENCE MICROSCOPY; EQUIPMENT DESIGN; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTERMETHOD COMPARISON; MCGILL PAIN QUESTIONNAIRE; NEEDLE; NEEDLESTICK INJURY; NORMAL HUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; PUNCTURE; SKIN DISCOMFORT; SKIN PAIN; SKIN PENETRATION; SKIN SENSATION; SKIN WATER LOSS; STAINING; STRATUM CORNEUM; VISUAL ANALOG SCALE; WET ETCH SILICON MICRONEEDLE;

ENZYME INHIBITORS; FEMALE; HUMANS; INJECTIONS, INTRADERMAL; MALE; METHYLENE BLUE; MICROTECHNOLOGY; NEEDLES; PAIN; PILOT PROJECTS; SKIN;

EID: 59949083746     PISSN: 13872176     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10544-008-9208-1     Document Type: Article

References (37)

1. J. Aramaki, S. Kawana, I. Effendy et al., Differences of skin irritation between Japanese and European women Br. J. Dermatol 146, 1052-1056 (2002)
2. C.S. Asbill, A.F. El-Kattan, B. Michniak, Enhancement of transdermal drug delivery: Chemical and physical approaches Crit. Rev. Ther. Drug Carrier Syst 17, 621-658 (2000)
3. B.W. Barry, Novel mechanisms and devices to enable successful transdermal drug delivery Eur. J. Pharm. Sci 14, 101-14 (2001)
4. J. Birchall, S. Coulman, M. Pearton et al., Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch micro-fabricated micro-needles J. Drug Target 13, 415-421 (2005)
5. J. Birchall, S. Coulman, A. Anstey et al., Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation Int. J. Pharm 312, 15-23 (2006)
6. S.L. Collins, R.A. Moore, H.J. McQuay, The visual analogue pain intensity scale: What is moderate pain in millimetres? Pain 72, 95-97 (1997)
7. S. Coulman, C. Allender, J. Birchall, Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy Crit. Rev. Ther. Drug Carrier Syst 23, 205-258 (2006a)
8. S.A. Coulman, D. Barrow, A. Anstey et al., Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles Curr. Drug Deliv 3, 65-75 (2006b)
9. A.R. Denet, R. Vanbever, V. Preat, Skin electroporation for transdermal and topical delivery Adv. Drug Deliv. Rev 56, 659-674 (2004)
10. F. Dreher, B.S. Modjtahedi, S.P. Modjtahedi et al., Quantification of stratum corneum removal by adhesive tape stripping by total protein assay in 96-well microplates Skin Res. Technol 11, 97-101
11. M. Fredrikson, P. Annas, H. Fischer et al., Gender and age differences in the prevalence of specific fears and phobias Behav. Res. Ther 34, 33-39 (1996)
12. S. Henry, D.V. McAllister, M.G. Allen et al., Microfabricated microneedles: A novel approach to transdermal drug delivery J. Pharm. Sci 87, 922-925 (1998)
13. Y.J. Hutin, A.M. Hauri, G.L. Armstrong, Use of injections in healthcare settings worldwide, 2000: Literature review and regional estimates BMJ 327, 1075 (2003)
14. C.C.J. Kahl, Visual analogue scale, numeric pain rating scale and the McGill pain Questionnaire: An overview of psychometric properties Phys. Ther. Rev. 10, 123-128 (2005)
15. S. Kaushik, A.H. Hord, D.D. Denson et al., Lack of pain associated with microfabricated microneedles Anesth. Analg 92, 502-504 (2001)
16. R.A. Kleinknecht, Acquisition of blood, injury, and needle fears and phobias Behav. Res. Ther. 32, 817-823 (1994)
17. I. Marks, Blood-injury phobia: A review Am. J. Psychiatry 145, 1207-1213 (1988)
18. D.V. McAllister, M.G. Allen, M.R. Prausnitz, Microfabricated microneedles for gene and drug delivery Annu Rev. Biomed. Eng 2, 289-313 (2000)
19. R. Melzack, The McGill Pain Questionnaire: Major properties and scoring methods Pain 1, 277-299 (1975)
20. R. Melzack, The short-form McGill Pain Questionnaire Pain 30, 191-197 (1987)
21. R.K.J. Melzack, Katz J, in Pain measurement in persons in pain, ed. By PDMR Wall. Textbook of pain, 3rd edn. (Churchill Livingstone, New York, 1994), pp. 337-351
22. P. Milgrom, S.E. Coldwell, T. Getz et al., Four dimensions of fear of dental injections J. Am. Dent. Assoc 128, 756-766 (1997)
23. T. Miyano, Y. Tobinaga, T. Kanno et al., Sugar micro needles as transdermic drug delivery system Biomed. Microdevices 7, 185-188 (2005)
24. Y. Nir, A. Paz, E. Sabo et al., Fear of injections in young adults: prevalence and associations Am. J. Trop Med. Hyg 68, 341-344 (2003)
25. L.G. Ost, Blood and injection phobia: Background and cognitive, physiological, and behavioral variables J. Abnorm. Psychol 101, 68-74 (1992)
26. M. Pearton, C. Allender, K. Brain et al., Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations Pharm Res 25, 407-416 (2008)
27. M.R. Prausnitz, Overcoming skin's barrier: The search for effective and user-friendly drug delivery Diabetes Technol. Ther 3, 233-236 (2001)
28. C. Rosado, P. Pinto, L.M. Rodrigues, Modeling TEWL-desorption curves: A new practical approach for the quantitative in vivo assessment of skin barrier Exp. Dermatol 14, 386-390 (2005)
29. D.A. Schwindt, K.P. Wilhelm, H.I. Maibach, Water diffusion characteristics of human stratum corneum at different anatomical sites in vivo J. Invest. Dermatol 111, 385-389 (1998)
30. M. Shirkhanzadeh, Microneedles coated with porous calcium phosphate ceramics: Effective vehicles for transdermal delivery of solid trehalose J. Mater Sci. Mater Med 16, 37-45 (2005)
31. R.K. Sivamani, B. Stoeber, G.C. Wu et al., Clinical microneedle injection of methyl nicotinate: Stratum corneum penetration Skin Res. Technol 11, 152-156 (2005)
32. W.H. Smart, K. Subramanian, The use of silicon microfabrication technology in painless blood glucose monitoring Diabetes Technol. Ther 2, 549-559 (2000)
33. P. Treffel, F. Panisset, B. Faivre et al., Hydration, transepidermal water loss, pH and skin surface parameters: Correlations and variations between dominant and non-dominant forearms Br. J. Dermatol. 130, 325-328 (1994)
34. P.M. Wang, M. Cornwell, M.R. Prausnitz, Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles Diabetes Technol. Ther 7, 131-141 (2005)
35. WHO. Safety of injections. In Secretariat of the Safe Injection Global Network, vol. 2007. Department of Essential Health Technologies, World Health Organization (2004)
36. WHO. Safety of injections: Questions and answers. In WHO fact sheet, no. 234, vol. 2007. World Health Organization, Geneva (1999)
37. N. Wilke, C. Hibert, J. O'Brien et al., Silicon microneedle electrode array with temperature monitoring for electroporation Sens Actuators A Phys 123-124, 319-325 (2005)