Microneedles and their applications

Recent Patents on Drug Delivery and Formulation

Volumn 5, Issue 2, 2011, Pages 95-132

  Sachdeva, Vishal ^a   Banga, Ajay K ^a  

^a MERCER UNIVERSITY   (United States)

Author keywords

Delivery devices; Microchannels; Microneedle; Microporation; Sampling devices; Transdermal; Vaccine

Indexed keywords

ALPHA2B INTERFERON; ANTIINFLAMMATORY AGENT; ANTISENSE OLIGONUCLEOTIDE; BETA GALACTOSIDASE; BOTULINUM TOXIN A; CHOLERA VACCINE; DESMOPRESSIN; DICLOFENAC; DIPHTHERIA VACCINE; DNA VACCINE; ERYTHROPOIETIN; FLUORESCEIN SODIUM; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C VACCINE; HUMAN GROWTH HORMONE; INFLUENZA VACCINE; INSULIN; LIPOSOME; LOW MOLECULAR WEIGHT HEPARIN; METHOTREXATE; NALTREXONE; NANOPARTICLE; NICARDIPINE; PARATHYROID HORMONE[1-34]; PILOCARPINE; PLASMID DNA; SMALL INTERFERING RNA; SMALLPOX VACCINE; TETANUS TOXOID; UNINDEXED DRUG;

ADVERSE OUTCOME; ANIMAL IDENTIFICATION; ARTICLE; CHOLERA; DEEP VEIN THROMBOSIS; DENTAL SURGERY; DIPHTHERIA; DRUG BIOAVAILABILITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSE INCREASE; DRUG PENETRATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG TOLERABILITY; EQUIPMENT DESIGN; FEEDBACK SYSTEM; HEPATITIS B; HEPATITIS C; HUMAN; HYDROPHILICITY; INFLUENZA; INJECTION PAIN; INTRACUTANEOUS TEST; IONTOPHORESIS; LIPOSOMAL DELIVERY; MEMBRANE PERMEABILITY; MICRONEEDLE; MICROPORATION; MICROTECHNOLOGY; NEEDLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PAIN ASSESSMENT; PATIENT MONITORING; PHOBIA; POROSITY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PSORIASIS; SKIN ALLERGY; SKIN PERMEABILITY; SMALLPOX; TETANUS; TRANSDERMAL PATCH;

ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MICROINJECTIONS; NEEDLES; PATENTS AS TOPIC;

EID: 79955649994     PISSN: 18722113     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221111795471445     Document Type: Article

References (298)

1. Sachdeva V, Banga AK. Skin Deep. Pharm Manufac PackingSourcer 2009; 17-24.
2. Prausnitz MR, Mitragotri S, Langer R. Current status and futurepotential of transdermal drug delivery. Nat Rev Drug Discov 2004;3: 115-24.
3. Sachdeva V, Banga AK. Iontophoresis: Promises and Challenges.Transdermal 2010; 17-21.
4. Banga AK. Electrically assisted transdermal and topical drugdelivery. Bristol, PA: Taylor & Francis 1998,
5. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol 2008; 26: 1261-8.
6. Rizwan M, Aqil M, Talegaonkar S, Azeem A, Sultana Y, Ali A. Enhanced transdermal drug delivery techniques: An extensivereview of patents. Recent Pat Drug Deliv Formul 2009; 3: 105-24.
7. Subedi RK, Oh SY, Chun MK, Choi HK. Recent advances intransdermal drug delivery. Arch Pharm Res 2010; 33: 339-51.
8. Kasha PC, Banga AK. A review of patent literature foriontophoretic delivery and devices. Recent Pat Drug Deliv Formul2008; 2: 41-50.
9. Sieg A, Wascotte V. Diagnostic and therapeutic applications ofiontophoresis. J Drug Target 2009; 17: 690-700.
10. Rao R, Nanda S. Sonophoresis: Recent advancements and futuretrends. J Pharm Pharmacol 2009; 61: 689-705.
11. Karande P, Mitragotri S. Enhancement of transdermal drugdelivery via synergistic action of chemicals. Biochim Biophys Acta2009; 1788: 2362-73.
12. Banga AK. Microporation applications for enhancing drugdelivery. Expert Opin Drug Deliv 2009; 6: 343-54.
13. Singh TR, Garland MJ, Cassidy CM, Migalska K, Demir YK, Abdelghany S, et al. Microporation techniques for enhanceddelivery of therapeutic agents. Recent Pat Drug Deliv Formul 2010;4: 1-17.
14. Donnelly RF, Raj Singh TR, Woolfson AD. Microneedle-baseddrug delivery systems: Microfabrication, drug delivery, and safety.Drug Deliv 2010; 17: 187-207.
15. Prausnitz MR. Microneedles for transdermal drug delivery. AdvDrug Deliv Rev 2004; 56: 581-7.
16. Charoo NA, Rahman Z, Repka MA, Murthy SN. Electroporation:An avenue for transdermal drug delivery. Curr Drug Deliv 2010; 7:125-36.
17. Escobar-Chavez JJ, Bonilla-Martinez D, Villegas-Gonzalez MA, Revilla-Vazquez AL. Electroporation as an efficient physicalenhancer for skin drug delivery. J Clin Pharmacol 2009; 49: 1262-83.
18. Gerstel, M.S., Place, V.A. Drug delivery device. US3964482(1976).
19. Henry S, McAllister DV, Allen MG, Prausnitz MR.Microfabricated microneedles: A novel approach to transdermaldrug delivery. J Pharm Sci 1998; 87: 922-5.
20. Giudice EL, Campbell JD. Needle-free vaccine delivery. Adv DrugDeliv Rev 2006; 58: 68-89.
21. Kendall MA. Needle-free vaccine injection. Handb Exp Pharmacol2010; 193-219.
22. Prow TW, Chen X, Prow NA, Fernando GJ, Tan CS, Raphael AP, et al. Nanopatch-targeted skin vaccination against West Nile Virusand Chikungunya Virus in mice. Small 2010; 6: 1776-84.
23. Xu, B. high-aspect-ratio microdevices and methods for transdermaldelivery and sampling of active substances. US7591806 (2009).
24. Daddona, P.E., Fieldson, G.T., Nat, A.S., Lin, W.-Q. Minimallyinvasive detecting device. US6091975 (2000).
25. Godshall, N.A., Anderson, R.R. Method and apparatus fordisruption of the epidermis. US5879326 (1999).
26. Lastovich, A.G., Evans, J.D., Pettis, R.J. Microdevice and methodof manufacturing a microdevice. US006440096 (2002).
27. Andrianov AK, DeCollibus DP, Gillis HA, Kha HH, Marin A,Prausnitz MR, et al. Poly[di(carboxylatophenoxy)phosphazene]is a potent adjuvant for intradermal immunization. Proc NatlAcad Sci USA 2009; 106: 18936-41.
28. Mikszta JA, Alarcon JB, Brittingham JM, Sutter DE, Pettis RJ, Harvey NG. Improved genetic immunization via micromechanicaldisruption of skin-barrier function and targeted epidermal delivery.Nat Med 2002; 8: 415-9.
29. Raphael AP, Prow TW, Crichton ML, Chen X, Fernando GJ, Kendall MA. Targeted, needle-free vaccinations in skin usingmultilayered, densely-packed dissolving microprojection arrays.Small 2010; 6: 1785-93.
30. Banks SL, Pinninti RR, Gill HS, Crooks PA, Prausnitz MR,Stinchcomb AL. Flux across [corrected] microneedle-treatedskin is increased by increasing charge of naltrexone and naltrexolin vitro. Pharm Res 2008; 25: 1677-85.
31. Banga AK, Microneedle-mediated transdermal delivery: How tocontribute to meaningful research to advance this growing field.TransDermal 2009; 8-13.
32. Armstrong JK, Wenby RB, Meiselman HJ, Fisher TC. Thehydrodynamic radii of macromolecules and their effect on redblood cell aggregation. Biophys J 2004; 87: 4259-70.
33. Kolli CS, Banga AK. Characterization of solid maltosemicroneedles and their use for transdermal delivery. Pharm Res2008; 25: 104-113.
34. Yuzhakov, V.V. Microneedle array, patch, and applicator fortransdermal drug delivery. US20070161964 (2007).
35. Gill HS, Prausnitz MR. Coated microneedles for transdermaldelivery. J Control Release 2007; 117: 227-37.
36. Gill HS, Prausnitz MR. Coating formulations for microneedles.Pharm Res 2007; 24: 1369-80.
37. Prausnitz, M.R., Allen, M.G., Henry, S., Mcallister, D.V., Ackley, D.E., Jackson, T. Devices and methods for enhanced microneedlepenetration of biological barriers. US006743211 (2004).
38. Sullivan SP, Koutsonanos DG, Del Pilar MM, Lee JW, Zarnitsyn V, Choi SO, et al. Dissolving polymer microneedle patches forinfluenza vaccination. Nat Med 2010; 16: 915-20.
39. Miyano T, Tobinaga Y, Kanno T, Matsuzaki Y, Takeda H, Wakui M, et al. Sugar micro needles as transdermic drug delivery system.Biomed Microdevices 2005; 7: 185-8.
40. Park JH, Allen MG, Prausnitz MR. Polymer microneedles forcontrolled-release drug delivery. Pharm Res 2006; 23: 1008-19.
41. Bodhale D, Nisar A, Afzulpurkar N. Structural and microfluidicanalysis of hollow side-open polymeric microneedles fortransdermal drug delivery applications. Microfluid Nanofluid 2010;373-92.
42. Roxhed N, Samel B, Nordquist L, Griss P, Stemme G. Painlessdrug delivery through microneedle-based transdermal patchesfeaturing active infusion. IEEE Trans Biomed Eng 2008; 55: 1063-71.
43. Martanto W, Moore JS, Couse T, Prausnitz MR. Mechanism offluid infusion during microneedle insertion and retraction. JControl Release 2006; 112: 357-61.
44. Martanto W, Moore JS, Kashlan O, Kamath R, Wang PM, O'NealJM, et al. Microinfusion using hollow microneedles. Pharm Res2006; 23: 104-113.
45. Wang PM, Cornwell M, Hill J, Prausnitz MR. Precisemicroinjection into skin using hollow microneedles. J InvestDermatol 2006; 126: 1080-7.
46. Coulman S, Allender C, Birchall J. Microneedles and otherphysical methods for overcoming the stratum corneum barrier forcutaneous gene therapy. Crit Rev Ther Drug Carrier Syst 2006; 23:205-58.
47. Zhou CP, Liu YL, Wang HL, Zhang PX, Zhang JL. Transdermaldelivery of insulin using microneedle rollersin vivo. Int J Pharm 2010; 392: 127-33.
48. ® transdermal technology development forthe delivery of therapeutic peptides and proteins. Drug DelivTechnol 2002; 54-7.
49. Pearton M, Kang SM, Song JM, Kim YC, Quan FS, Anstey A, et al. Influenza virus-like particles coated onto microneedles canelicit stimulatory effects on Langerhans cells in human skin.Vaccine 2010; 28: 6104-13.
50. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR.Formulation and coating of microneedles with inactivated influenzavirus to improve vaccine stability and immunogenicity. J ControlRelease 2010; 142: 187-95.
51. Kim YC, Quan FS, Yoo DG, Compans RW, Kang SM, Prausnitz MR. Enhanced memory responses to seasonal H1N1 influenzavaccination of the skin with the use of vaccine-coatedmicroneedles. J Infect Dis 2010; 201: 190-8.
52. Widera G, Johnson J, Kim L, Libiran L, Nyam K, Daddona PE, et al. Effect of delivery parameters on immunization to ovalbuminfollowing intracutaneous administration by a coated microneedlearray patch system. Vaccine 2006; 24: 1653-64.
53. Choi, H.-O., Knutson, G.P., David, M.M. Method of using a film tocoat a microneedle array. US20080051699 (2008).
54. Ameri M, Peters E, Wang X, Daddona P, Maa Y-F. Erythropoietin(EPO) coated microprojection transdermal system: Pre-clinicalformulation, stability and delivery. AAPS J 2009; 11(S2): T2245.
55. Chen X, Prow TW, Crichton ML, Jenkins DW, Roberts MS, FrazerIH, et al. Dry-coated microprojection array patches for targeteddelivery of immunotherapeutics to the skin. J Control Release2009; 139: 212-220.
56. Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, et al. Lack of pain associated with microfabricatedmicroneedles. Anesth Analg 2001; 92: 502-4.
57. Haq MI, Smith E, John DN, Kalavala M, Edwards C, Anstey A, et al. Clinical administration of microneedles: Skin puncture, painand sensation. Biomed Microdevices 2009; 11: 35-47.
58. Van Damme P, Oosterhuis-Kafeja F, Van der Wielen M, Almagor Y, Sharon O, Levin Y. Safety and efficacy of a novel microneedledevice for dose sparing intradermal influenza vaccination inhealthy adults. Vaccine 2009; 27: 454-9.
59. Gill HS, Denson DD, Burris BA, Prausnitz MR. Effect ofmicroneedle design on pain in human volunteers. Clin J Pain 2008;24: 585-94.
60. Li G, Badkar A, Nema S, Kolli CS, Banga AK. In vitro transdermaldelivery of therapeutic antibodies using maltose microneedles. Int JPharm 2009; 368: 109-15.
61. Li G, Badkar A, Kalluri H, Banga AK. Microchannels created bysugar and metal microneedles: Characterization by microscopy,macromolecular flux and other techniques. J Pharm Sci 2009; 99:1931-41.
62. Sivamani RK, Stoeber B, Wu GC, Zhai H, Liepmann D, MaibachH. Clinical microneedle injection of methyl nicotinate: Stratumcorneum penetration. Skin Res Technol 2005; 11: 152-6.
63. Vemulapalli V, Yang Y, Friden PM, Banga AK. Synergistic effectof iontophoresis and soluble microneedles for transdermal deliveryof methotrexate. J Pharm Pharmacol 2008; 60: 27-33.
64. Lanke SS, Kolli CS, Strom JG, Banga AK. Enhanced transdermaldelivery of low molecular weight heparin by barrier perturbation.Int J Pharm 2009; 365: 26-33.
65. Badran MM, Kuntsche J, Fahr A. Skin penetration enhancement bya microneedle device (Dermaroller) in vitro: Dependency on needlesize and applied formulation. Eur J Pharm Sci 2009; 36: 511-23.
66. Park JH, Choi SO, Seo S, Choy YB, Prausnitz MR. A microneedleroller for transdermal drug delivery. Eur J Pharm Biopharm 2010;76: 282-9.
67. Banks SL, Pinninti RR, Gill HS, Paudel KS, Crooks PA, Brogden NK, et al. Transdermal delivery of naltrexol and skin permeabilitylifetime after microneedle treatment in hairless guinea pigs. JPharm Sci 2010; 99: 3072-80.
68. Kalluri H, Banga AK. Formation and closure of microchannels inskin following microporation. Pharm Res 2010.
69. Ding Z, Verbaan FJ, Bivas-Benita M, Bungener L, Huckriede A, van den Berg DJ, et al. Microneedle arrays for the transcutaneousimmunization of diphtheria and influenza in BALB/c mice. JControl Release 2009; 136: 71-8.
70. Sathyan, G., Weyers, R., Daddona, P., Staehr, P., Gupta, S., Ameri,M., Cormier, M.J.N. Apparatus and method for transdermaldelivery of desmopressin. US20060093658 (2006).
71. Andrianov AK, Marin A, Decollibus DP. Microneedles withintrinsic immunoadjuvant properties: Microfabrication, Proteinstability, and modulated release. Pharm Res 2011; 28(1):58-65(Epub 2010).
72. Kim YC, Quan FS, Yoo DG, Compans RW, Kang SM, Prausnitz MR. Improved influenza vaccination in the skin using vaccinecoated microneedles. Vaccine 2009; 27: 6932-8.
73. Patel SR, Lin AS, Edelhauser HF, Prausnitz MR. Suprachoroidaldrug delivery to the back of the eye using hollow microneedles.Pharm Res 2010.
74. Matriano JA, Cormier M, Johnson J, Young WA, Buttery M, Nyam K, et al. Macroflux microprojection array patch technology: a newand efficient approach for intracutaneous immunization. Pharm Res2002; 19: 63-70.
75. Jiang J, Gill HS, Ghate D, McCarey BE, Patel SR, Edelhauser HF, et al. Coated microneedles for drug delivery to the eye. InvestOphthalmol Vis Sci 2007; 48: 4038-43.
76. Katikaneni S, Li G, Badkar A, Banga A. Transdermal delivery of aapproximately 13kDa protein-an in vivo comparison of physicalenhancement methods. J Drug Target 2010; 18: 141-7.
77. Wu Y, Qiu Y, Zhang S, Qin G, Gao Y. Microneedle-based drugdelivery: Studies on delivery parameters and biocompatibility.Biomed Microdevices 2008; 10: 601-10.
78. Bal SM, Ding Z, Kersten GF, Jiskoot W, Bouwstra JA.Microneedle-based transcutaneous immunisation in mice with Ntrimethylchitosan adjuvanted diphtheria toxoid formulations.Pharm Res 2010; 27: 1837-47.
79. Bal S, Kruithof AC, Liebl H, Tomerius M, Bouwstra J, Lademann J, et al. In vivo visualization of microneedle conduits in human skinusing laser scanning microscopy. Laser Physics Letters 2010; 7:242-6.
80. Chen H, Zhu H, Zheng J, Mou D, Wan J, Zhang J, et al.Iontophoresis-driven penetration of nanovesicles throughmicroneedle-induced skin microchannels for enhancingtransdermal delivery of insulin. J Control Release 2009; 139: 63-72.
81. Coulman SA, Birchall JC, Alex A, Pearton M, Hofer B, O'Mahony C, et al. In Vivo, in situ imaging of microneedle insertion into theskin of human volunteers using optical coherence tomography.Pharm Res 2010.
82. Donnelly RF, Majithiya R, Singh TR, Morrow DI, Garland MJ, Demir YK, et al. Design, optimization and characterisation ofpolymeric microneedle arrays prepared by a novel laser-basedmicromoulding technique. Pharm Res 2010.
83. Enfield J, O'Connell ML, Lawlor K, Jonathan E, O'Mahony C, Leahy M. In vivo dynamic characterization of microneedle skinpenetration using optical coherence tomography. J Biomed Opt2010; 15: 046001.
84. Donnelly RF, Garland MJ, Morrow DI, Migalska K, Singh TR, Majithiya R, et al. Optical coherence tomography is a valuable toolin the study of the effects of microneedle geometry on skinpenetration characteristics and in-skin dissolution. J ControlRelease 2010;
85. Simons, J.K., Frederickson, F.L. Device for applying a microneedlearray. US20090198189 (2009).
86. Gupta J. Microneedles for transdermal drug delivery in humansubjects. Georgia Institute of Technology: Atlanta, School ChemBiomolecular Engin 2009; 1-198.
87. Laurent PE, Bonnet S, Alchas P, Regolini P, Mikszta JA, Pettis R, et al. Evaluation of the clinical performance of a new intradermalvaccine administration technique and associated delivery system.Vaccine 2007; 25: 8833-42.
88. Ashraf MW, Tayyaba S, Nisar A, Afzulpurkar N, Bodhale DW, Lomas T, et al. Design, fabrication and analysis of silicon hollowmicroneedles for transdermal drug delivery system for treatment ofhemodynamic dysfunctions. Cardiovasc Eng 2010; 10: 91-108.
89. Gardeniers JGE, Luttge R, Berenschot EJW, Boer MJd, Yeshurun SY, Hefetz M, et al. Silicon micromachined hollow microneedlesfor transdermal liquid transport. J Microelectrochemical Syst 2003;12: 855-62.
90. Teo MA, Shearwood C, Ng KC, Lu J, Moochhala S. In vitro andin vivo characterization of MEMS microneedles. BiomedMicrodevices 2005; 7: 47-52.
91. Shawgo RS, Grayson ACR, Li Y, Cima MJ. BioMEMS for drugdelivery. Current Opin Solid State Mat Sci 2002; 6: 329-34.
92. Hilt JZ, Peppas NA. Microfabricated drug delivery devices. Int JPharm 2005; 306: 15-23.
93. Tao SL, Desai TA. Microfabricated drug delivery systems: Fromparticles to pores. Adv Drug Deliv Rev 2003; 55: 315-28.
94. McAllister DV, Wang PM, Davis SP, Park JH, Canatella PJ, Allen MG, et al. Microfabricated needles for transdermal delivery ofmacromolecules and nanoparticles: Fabrication methods andtransport studies. Proc Natl Acad Sci USA 2003; 100: 13755-60.
95. Wood, R.L., Wynands, H.A., Markus, K.W. Methods of fabricatingmicroneedle arrays using sacrificial molds, and microneedle arraysfabricated thereby. US20030111759 (2003).
96. Arias, F., Sherman, F.F., Owens, G.D. Method of manufacturingmicroneedle structures using soft lithography andphotolithography. US20040146611 (2004).
97. Roy, S., Fleischman, A.J. Microneedle array module and method offabricating the same. US20040243063 (2004).
98. Prausnitz, M.R., Allen, M.G., Gujral, I.J. Microneedle device forextraction and sensing of bodily fluids. US007344499 (2008).
99. Sparks, D.R. Process of forming a microneedle and microneedleformed thereby. US20020193818 (2002).
100. Liu, M.Y., Huang, H.C., Yang, J.J., Pan, K.C. Method formanufacturing 3-D high aspect-ratio microneedle array device.US20040126707 (2004).
101. Yeshurun, Y. Systems and methods for the transport of fluidsthrough a biological barrier and production techniques for suchsystems. US20040019331 (2004).
102. Cho, S.T. Microneedles for minimally invasive drug delivery.US20040186419 (2004).
103. Raju, R.S.O.G. Method of fabricating microneedles.US20060086689 (2006).
104. Wood, R.L., Wynands, H.A., Markus, K.W. Methods of fabricatingmicroneedle arrays using sacrificial molds. US006511463 (2003).
105. Yuzhakov, V.V., Gartstein, V., Owens, G.D. Microneedleapparatus used for marking skin and for dispensing semi-permanentsubcutaneous makeup. US006565532 (2003).
106. Frazier, A.B., Brazzle, J.D. Surface micromachined microneedles.US007048723 (2006).
107. Chiou, J.C., Hung, C.C., Chang, C.W. Method for fabricatingmicroneedle array and method for fabricating embossing mold ofmicroneedle array. US007429333 (2008).
108. Prausnitz, M.R., Allen, M.G., McAllister, D.V., Henry, S.Microneedle device for transport of molecules across tissue.US006503231 (2003).
109. Yeshurun, Y., Hefetz, M., Berenschot, E., Boer, M.D., Altpeter, D.M., Boom, G. Polymer microneedles. US6924087 (2005).
110. Xu, Y., Chen, M.M., Li, Z., Lim, C.Y., Tan, P.Y.J. Microneedlesand microneedle fabrication. US7497980 (2009).
111. Lim, C.Y. Microneedles and methods for fabricating microneedles.US20090326415 (2009).
112. Yeung, K.L., Wong, L.W., Sun, W., Leung, W.K., Lai, W.Y., Chan, N.W. Molecular sieve and zeolite microneedles andpreparation thereof. US20070280878 (2007).
113. Gartstein, V., Nebrigic, D.D., Owens, G.D., Sherman, F.F., Yuzhakov, V.V., Arias, F. Intracutaneous edged microneedleapparatus. US006652478 (2003).
114. Xu, Y., Chen, M.M., Li, Z., Lim, C.Y., Ying, J.TP. Microneedlesand microneedle fabrication. WO2005044364 (2005).
115. Cachemaille, A.,Cannehanx, F. Out-of-plane microneedlemanufacturing process. EP2072076 (2009).
116. Griss, P., Stemme, G. Molded micro-needles. US20070255205(2007).
117. Pisano, A.P., Lebouitz, K.S. Microneedle with isotropically etchedtip, and method of fabricating such a device. US005928207(1999).
118. Lin, L., Pisano, A.P. IC-processed microneedles. US005591139(1997).
119. Kravitz, S.H., Ingersoll, D., Schmidt, C., Flemming, J. Hollowmicroneedle array. US20070023386 (2007).
120. Sherman, F.F., Yuzhakov, V.V., Gartstein, V., Owens, G.D.Apparatus and method for manufacturing an intracutaneousmicroneedle array. US6471903 (2002).
121. Ferguson, D.E., Nayar, S.K., Pochardt, D.L. Method of molding amicroneedle. US20080088066 (2008).
122. Golubovic-liakopoulos, N., Fricano, G., Danielson, M. System andmethod for drug delivery and microfluidic applications usingmicroneedles. US20060030812 (2006).
123. Boone, M.R., Carter, C.J., Frederickson, F.L. Method of moldingfor microneedle arrays. US20070191761 (2007).
124. Allen, M.G., Prausnitz, M.R., Mcallister, D.V., Cros, F.P.M.Microneedle devices and methods of manufacture and use thereof.US6334856 (2002).
125. Johnson, P.R., Emery, M.R., Wolter, J.T., Raeder-devens, J.E., Duan, D.C., David, M.M., Choi, H.-O. Masking method for coatinga microneedle array. US20080102192 (2008).
126. Park, J.-H., Prausnitz, M.R. Microneedle devices and productionthereof. US20020082543 (2002).
127. Trautman, J.C., Worsham, R.W., Bayramov, D.F., Bowers, D.L., Klemm, S.R., Singh, P. Applicators for microneedlesUS20080183144 (2008).
128. Yang M, Zahn JD. Microneedle insertion force reduction usingvibratory actuation. Biomed Microdevices 2004; 6: 177-82.
129. Wang, P.M., Prausnitz, M.R. Drilling microneedle device.US20080027384 (2008).
130. Verbaan FJ, Bal SM, van den Berg DJ, Dijksman JA, van Hecke M, Verpoorten H, et al. Improved piercing of microneedle arrays indermatomed human skin by an impact insertion method. J ControlRelease 2008; 128: 80-8.
131. Davidson A, Al-Qallfaf B, Das DB. Transdermal drug delivery bycoated microneedles: Geometry effects on effective skin thicknessand drug permeability. Chem Engg Res Design 2008; 86: 1196-206
132. Oh JH, Park HH, Do KY, Han M, Hyun DH, Kim CG, et al.Influence of the delivery systems using a microneedle array on thepermeation of a hydrophilic molecule, calcein. Eur J PharmBiopharm 2008; 69: 1040-1045.
133. Al-Qallaf B, Das DB. Optimizing microneedle arrays to increaseskin permeability for transdermal drug delivery. Ann NY Acad Sci2009; 1161: 83-94.
134. Fredrikson M, Annas P, Fischer H, Wik G. Gender and agedifferences in the prevalence of specific fears and phobias. BehavRes Ther 1996; 34: 33-9.
135. Kleinknecht RA. Acquisition of blood, injury, and needle fears andphobias. Behav Res Ther 1994; 32: 817-23.
136. Marks I. Blood-injury phobia: A review. Am J Psychiatry 1988;145: 1207-13.
137. Nir Y, Paz A, Sabo E, Potasman I. Fear of injections in youngadults: Prevalence and associations. Am J Trop Med Hyg 2003; 68:341-4.
138. Deacon B, Abramowitz J. Fear of needles and vasovagal reactionsamong phlebotomy patients. J Anxiety Disord 2006; 20: 946-60.
139. Hamilton JG. Needle phobia: A neglected diagnosis. J Fam Pract1995; 41: 169-175.
140. Birchall JC. Microneedle array technology: The time is right but isthe science ready? Expert Rev Med Devices 2006; 3: 1-4.
141. Pharmacy based immunization delivery. American PharmacistAssociation 2009; 95-96: 11 ed.
142. Shirkhanzadeh M. Microneedles coated with porous calciumphosphate ceramics: Effective vehicles for transdermal delivery ofsolid trehalose. J Mater Sci Mater Med 2005; 16: 37-45.
143. Collins SL, Moore RA, McQuay HJ. The visual analogue painintensity scale: What is moderate pain in millimetres? Pain 1997;72: 95-7.
144. Melzack R. The McGill Pain Questionnaire: Major properties andscoring methods. Pain 1975; 1: 277-99.
145. Melzack R. The short-form McGill Pain Questionnaire. Pain 1987;30: 191-7.
146. Bal SM, Caussin J, Pavel S, Bouwstra JA. In vivo assessment ofsafety of microneedle arrays in human skin. Eur J Pharm Sci 2008;35: 193-202.
147. Wermeling DP, Banks SL, Hudson DA, Gill HS, Gupta J, Prausnitz MR, et al. Microneedles permit transdermal delivery of a skinimpermeantmedication to humans. Proc Natl Acad Sci USA 2008;105: 2058-63.
148. ® desmopressin transdermal delivery system: Pharmacokineticsand pharmacodynamic evaluation in healthy volunteers.AAPS J 2004; 6(S1): 665
149. Smart WH, Subramanian K. The use of silicon microfabricationtechnology in painless blood glucose monitoring. Diabetes TechnolTher 2000; 2: 549-59.
150. Wang PM, Cornwell M, Prausnitz MR. Minimally invasiveextraction of dermal interstitial fluid for glucose monitoring usingmicroneedles. Diabetes Technol Ther 2005; 7: 131-41.
151. Prausnitz MR, Mikszta JA, Cormier M, Andrianov AK.Microneedle-based vaccines. Curr Top Microbiol Immunol 2009;333: 369-93.
152. Alarcon JB, Hartley AW, Harvey NG, Mikszta JA. Preclinicalevaluation of microneedle technology for intradermal delivery ofinfluenza vaccines. Clin Vaccine Immunol 2007; 14: 375-81.
153. Dean CH, Alarcon JB, Waterston AM, Draper K, Early R, Guirakhoo F, et al. Cutaneous delivery of a live, attenuatedchimeric flavivirus vaccine against Japanese encephalitis(ChimeriVax)-JE) in non-human primates. Hum Vaccin 2005; 1:106-11.
154. Mikszta JA, Dekker JP, Harvey NG, Dean CH, Brittingham JM,Huang J, et al. Microneedle-based intradermal delivery of theanthrax recombinant protective antigen vaccine. Infect Immun2006; 74: 6806-68010.
155. Mikszta JA, Sullivan VJ, Dean C, Waterston AM, Alarcon JB, Dekker JP, et al. Protective immunization against inhalationalanthrax: a comparison of minimally invasive delivery platforms. JInfect Dis 2005; 191: 278-88.
156. Davis SP, Martanto W, Allen MG, Prausnitz MR. Hollow metalmicroneedles for insulin delivery to diabetic rats. IEEE TransBiomed Eng 2005; 52: 909-15.
157. Martanto W, Davis SP, Holiday NR, Wang J, Gill HS, Prausnitz MR. Transdermal delivery of insulin using microneedles in vivo.Pharm Res 2004; 21: 947-52.
158. Daddona P, Matriano J, Mandema J, Maa Y. Parathyroid Hormone(1-34)-coated microneedle patch system: Clinical pharmacokineticsand pharmacodynamics for treatment of osteoporosis. Pharm Res2010.
159. Lin W, Cormier M, Samiee A, Griffin A, Johnson B, Teng CL, et al. Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux) technology. Pharm Res 2001;18: 1789-93.
160. Matriano J, Cormier M, Johnson J, Young W, Buttery M, Nyam K,et al. Macroflux microprojection array patch technology: A newand efficient approach for intracutaneous immunization. Pharm Res2002; 19: 63-70.
161. Widera G, Johnson J, Kim L, Libiran L, Nyam K, Daddona P, Cormier M. Effect of delivery parameters on immunization toovalbumin following intracutaneous administration by a coatedmicroneedle array patch system. Vaccine 2006; 24: 1653-64.
162. Roth RR, James WD. Microbiology of the skin: Resident flora,ecology, infection. J Am Acad Dermatol 1989; 20: 367-90.
163. Cormier M, Johnson B, Ameri M, Nyam K, Libiran L, Zhang D, et al. Transdermal delivery of desmopressin using a coatedmicroneedle array patch system. J Control Release 2004; 97: 503-11.
164. Donnelly RF, Singh TR, Tunney MM, Morrow DI, McCarron PA, O'Mahony C, et al. Microneedle arrays allow lower microbialpenetration than hypodermic needles in vitro. Pharm Res 2009; 26:2513-22.
165. Kennish L, Reidenberg B. A review of the effect of occlusivedressings on lamellar bodies in the stratum corneum and relevanceto transdermal absorption. Dermatol Online J 2005; 11: 7.
166. Zhai H, Maibach HI. Occlusion vs. skin barrier function. Skin ResTechnol 2002; 8: 1-6.
167. Cormier, M., Johnson, J., Lin, W.Q., Matriano, J., Daddona, P.Methods for inhibiting decrease in transdermal drug flux byinhibition of pathway closure. US20020102292 (2002).
168. Lee SH, Elias PM, Proksch E, Menon GK, Mao-Quiang M, Feingold KR. Calcium and potassium are important regulators ofbarrier homeostasis in murine epidermis. J Clin Invest 1992; 89:530-8.
169. Milewski M, Brogden NK, Stinchcomb AL. Current aspects offormulation efforts and pore lifetime related to microneedletreatment of skin. Expert Opin Drug Deliv 2010; 7: 617-29.
170. Li WZ, Huo MR, Zhou JP, Zhou YQ, Hao BH, Liu T, et al. Supershortsolid silicon microneedles for transdermal drug deliveryapplications. Int J Pharm 2010; 389: 122-9.
171. Popp W, Rasslan O, Unahalekhaka A, Brenner P, Fischnaller E, Fathy M, et al. What is the use? An international look at reuse ofsingle-use medical devices. Int J Hyg Environ Health 2010; 213:302-7.
172. ®. http://www.dermaroller.de/Home [Accessed on 30thDecember 2010].
173. Prausnitz, M.R., Allen, M.G., Gujral, I.-J. Microneedle drugdelivery device. US20030208167 (2003).
174. Iliescu, C., Chen, B. Ultrasonic enhanced microneedles.US20090326441 (2009).
175. Katikaneni S, Badkar A, Nema S, Banga AK. Molecular chargemediated transport of a 13 kD protein across microporated skin. IntJ Pharm 2009; 378: 93-100.
176. Fukushima K, Ise A, Morita H, Hasegawa R, Ito Y, Sugioka N, et al. Two-layered dissolving microneedles for percutaneousdelivery of peptide/protein drugs in rats. Pharm Res 2010.
177. Wu XM, Todo H, Sugibayashi K. Enhancement of skin permeationof high molecular compounds by a combination of microneedlepretreatment and iontophoresis. J Control Release 2007; 118: 189-95.
178. Burton SA, Ng CY, Simmers R, Moeckly C, Brandwein D, Gilbert T, et al. Rapid intradermal delivery of liquid formulations using ahollow microstructured array. Pharm Res 2011; 28: 31-40.
179. Ito Y, Yoshimitsu J, Shiroyama K, Sugioka N, Takada K. Selfdissolvingmicroneedles for the percutaneous absorption of EPO inmice. J Drug Target 2006; 14: 255-61.
180. Ito Y, Hagiwara E, Saeki A, Sugioka N, Takada K. Feasibility ofmicroneedles for percutaneous absorption of insulin. Eur J PharmSci 2006; 29: 82-8.
181. Wilson JR, Kehl LJ, Beiraghi S. Enhanced topical anesthesia of 4%lidocaine with microneedle pretreatment and iontophoresis.Northwest Dent 2008; 87: 40-1.
182. Ito Y, Murakami A, Maeda T, Sugioka N, Takada K. Evaluation ofself-dissolving needles containing low molecular weight heparin(LMWH) in rats. Int J Pharm 2008; 349: 124-9.
183. Park JH, Allen MG, Prausnitz MR. Biodegradable polymermicroneedles: Fabrication, mechanics and transdermal drugdelivery. J Control Release 2005; 104: 51-66.
184. Park JH, Choi SO, Kamath R, Yoon YK, Allen MG, Prausnitz MR.Polymer particle-based micromolding to fabricate novelmicrostructures. Biomed Microdevices 2007; 9: 223-34.
185. Yoon J, Son T, Choi E, Choi B, Nelson JS, Jung B. Enhancementof optical skin clearing efficacy using a microneedle roller. JBiomed Optics 2008; 13.
186. You SK, Noh YW, Park HH, Han M, Lee SS, Shin SC, et al. Effectof applying modes of the polymer microneedle-roller on thepermeation of L-ascorbic acid in rats. J Drug Target 2009; 18: 15-20.
187. Chowdhury, D.F.H. Microneedle transdermal delivery device.US20100042050 (2010).
188. Guidance for Industry, Residual drug in transdermal and relateddrug delivery systems. Food Drug Admin 2010; 1-3.
189. Zhu Q, Zarnitsyn VG, Ye L, Wen Z, Gao Y, Pan L, et al.Immunization by vaccine-coated microneedle arrays protectsagainst lethal influenza virus challenge. Proc Natl Acad Sci USA2009; 106: 7968-73.
190. Ameri M, Daddona P, Maa Y. Demonstrated solid-state stability ofparathyroid hormone PTH(1-34) coated on a novel transdermalmicroprojection delivery system. Pharm Res 2009; 26: 2454-63.
191. Ameri M, Fan S, Maa Y. Parathyroid hormone PTH(1-34)formulation that enables uniform coating on a novel transdermalmicroprojection delivery system. Pharm Res 2009; 27: 303-13.
192. Trautman, J., Wright, C., Cormier, M. Method and apparatus forcoating skin piercing microprojections. US6855372 (2005).
193. Lee JW, Park JH, Prausnitz MR. Dissolving microneedles fortransdermal drug delivery. Biomaterials 2008; 29: 2113-24.
194. Sullivan SP, Murthy N, Prausnitz MR. Minimally invasive proteindelivery with rapidly dissolving polymer. Microneedles Adv Mater2008; 20: 933-938.
195. Gonnelli, R.R., Mcallister, D.V. Microneedle array patch.US20090118672 (2009).
196. Gonnelli, R.R. Microneedles, microneedle arrays, and systems andmethods relating to same. US20030135167 (2003).
197. Gupta J, Felner EI, Prausnitz MR. Minimally invasive insulindelivery in subjects with type 1 diabetes using hollowmicroneedles. Diabetes Technol Ther 2009; 11: 329-37.
198. Hooper JW, Golden JW, Ferro AM, King AD. Smallpox DNAvaccine delivered by novel skin electroporation device protectsmice against intranasal poxvirus challenge. Vaccine 2007; 25:1814-23.
199. Yan G, Warner KS, Zhang J, Sharma S, Gale BK. Evaluationneedle length and density of microneedle arrays in the pretreatmentof skin for transdermal drug delivery. Int J Pharm 2010; 391: 7-12.
200. Cantor, A.S. Non-skin-contacting microneedle array applicator.US20080009811 (2008).
201. Ackley, D.E. Davis, S. Jackson, T. Microneedle adapter.US20030181863 (2003).
202. Clarke, G.M., Delmore, M.D., Domroese, M.K., Ferber, R.H., Jacobs, J.D., Keister, J.C., Frederickson, F.L. Microneedle devicesand microneedle delivery apparatus. US20050261631 (2005).
203. Ringsred, T.K., Frederickson, F.L. Microneedle array applicatorand retainer. US20080009825 (2008).
204. Yeshurun, Y., Levin, Y., Almagor, Y., Lavi, G., Hefetz, M., Sefi, Y. Microneedle device. US20080091226 (2008).
205. Trautman, J., Keenan, R., Samiee, A.W., Lin, W., Cormier, M., Matriano, J., Daddona, P. Apparatus and method for piercing skinwith microprotrusions. US7131960 (2006).
206. Cormier, M.J.N., Young, W.A., Nyam, K., Daddona, P.E., Lin, W.-Q. Transdermal drug delivery devices having coatedmicroprotrusions. US20060200069 (2006).
207. Trautman, J.C., Keenan, R.L. Microprotrusion member retainer forimpact applicator. US6855131 (2005).
208. Trautman, J.C., Olson, L. Self-actuating applicator formicroprojection array. US2005096586 (2005).
209. Yuzhakov V, The AdminPen microneedle device for painless andconvenient drug delivery. Drug Del Technol 2010; 32-6.
210. Crichton ML, Ansaldo A, Chen X, Prow TW, Fernando GJ, Kendall MA. The effect of strain rate on the precision ofpenetration of short densely-packed microprojection array patchescoated with vaccine. Biomaterials 2010; 31: 4562-72.
211. Adachi, H., Tokumoto, S., Higo, N. Transdermal drugadministration system with microneedles. US20070250018 (2007).
212. Gartstein, V., Nebrigic, D.D., Owens, G.D., Sherman, F.F., Yuzhakov, V.V. Intracutaneous microneedle array apparatus.US006379324 (2002).
213. Gross, J., Zucker, S. Transdermal or interdermal drug deliverydevices US005279544 (1994).
214. Gonnelli, R.R. Microneedle with membrane. US20090043250(2009).
215. Frazier, A.B., Andrade, J.D., Bartholomeusz, D.A., Brazzle, J.D.Active microneedles and microneedle arrays. US20090069697(2009).
216. Gertsek, M., Wilkinson, B.M., Pettis, R.J. Method and deliverydevice for the transdermal administration of a substance.US006656147 (2003).
217. Rosenberg, Z.B. Method and apparatus for the transdermaladministration of a substance. US006623457 (2003).
218. Cachemaille, A. Medical injection device with microneedles.WO2009053919 (2009).
219. Yuzhakov, V.V. Microneedle array, patch, and applicator fortransdermal drug delivery. US007658728 (2010).
220. Pekurovsky, M.L., Johnson, M.A.F. Microneedle devices.US20080319404 (2008).
221. Batheja P, Thakur, R. and Michniak, B. Transdermal iontophoresis.Exp Opin Drug Deliv 2006; 3: 127-38.
222. Guy RH, Kalia YN, Delgado-Charro MB, Merino V, Lopez A, Marro D. Iontophoresis: Electrorepulsion and electroosmosis. JControl Release 2000; 64: 129-32.
223. Kalia YN, Naik A, Garrison J, Guy RH. Iontophoretic drugdelivery. Adv Drug Deliv Rev 2004; 56: 619-58.
224. Badkar AV, Smith AM, Eppstein JA, Banga AK. Transdermaldelivery of interferon alpha-2B using microporation andiontophoresis in hairless rats. Pharm Res 2007; 24: 1389-95.
225. Smith, G.A. Functionalized microneedles transdermal drugdelivery systems, devices, and methods. US20070078376 (2007).
226. Yoon J, Park D, Son T, Seo J, Nelson J, Jung B. A physical methodto enhance transdermal delivery of a tissue optical clearing agent:Combination of microneedling and sonophoresis. Lasers Surg Med2010; 42: 412-417.
227. Chen B, Wei J, Iliescu C. Sonophoretic enhanced microneedlesarray (SEMA) - improving the efficiency of transdermal drugdelivery. Sensors Actuators B: Chem 2010; 145: 54-60.
228. Choi SO, Kim YC, Park JH, Hutcheson J, Gill HS, Yoon YK, et al.An electrically active microneedle array for electroporation.Biomed Microdevices 12: 263-273.
229. Daugimont L, Baron N, Vandermeulen G, Pavselj N, Miklavcic D, Jullien MC, et al. Hollow microneedle arrays for intradermal drugdelivery and DNA electroporation. J Membr Biol 2010; 236: 117-25.
230. Yan K, Todo H, Sugibayashi K. Transdermal drug delivery by inskinelectroporation using a microneedle array. Int J Pharm 2010;397: 77-83.
231. Qiu Y, Gao Y, Hu K, Li F. Enhancement of skin permeation ofdocetaxel: A novel approach combining microneedle and elasticliposomes. J Control Release 2008; 129: 144-50.
232. Harper SA, Fukuda K, Uyeki TM, Cox NJ, Bridges CB. Preventionand control of influenza: Recommendations of the AdvisoryCommittee on Immunization Practices (ACIP). Morb Mortal WklyRep Recomm Rep 2004; 53: 1-40.
233. Harper SA, Fukuda K, Uyeki TM, Cox NJ, Bridges CB. Preventionand control of influenza. Recommendations of the AdvisoryCommittee on Immunization Practices (ACIP). Morb Mortal WklyRep Recomm Rep 2005; 54: 1-40.
234. Hinman AR, Orenstein WA, Santoli JM, Rodewald LE, Cochi SL.Vaccine shortages: History, impact, and prospects for the future.Annu Rev Public Health 2006; 27: 235-59.
235. Laurent PE, Bourhy H, Fantino M, Alchas P, Mikszta JA. Safetyand efficacy of novel dermal and epidermal microneedle deliverysystems for rabies vaccination in healthy adults. Vaccine 2010; 28:5850-6.
236. Holland D, Booy R, De Looze F, Eizenberg P, McDonald J, Karrasch J, et al. Intradermal influenza vaccine administered usinga new microinjection system produces superior immunogenicity inelderly adults: A randomized controlled trial. J Infect Dis 2008;198: 650-8.
237. Bos JD, Kapsenberg ML. The skin immune system: Progress incutaneous biology. Immunol Today 1993; 14: 75-8.
238. Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin:Mechanisms and clinical consequences. Nat Rev Immunol 2004; 4:211-22.
239. Koutsonanos DG, del Pilar Martin M, Zarnitsyn VG, Sullivan SP,Compans RW, Prausnitz MR, et al. Transdermal influenzaimmunization with vaccine-coated microneedle arrays. PLoS One2009; 4: e4773.
240. Flacher V, Bouschbacher M, Verronese E, Massacrier C, Sisirak V, Berthier-Vergnes O, et al. Human Langerhans cells express aspecific TLR profile and differentially respond to viruses andGram-positive bacteria. J Immunol 2006; 177: 7959-67.
241. Steinhoff M, Brzoska T, Luger TA. Keratinocytes in epidermalimmune responses. Curr Opin Allergy Clin Immunol 2001; 1: 469-76.
242. Stingl G, Steiner G. Immunological host defense of the skin. CurrProbl Dermatol 1989; 18: 22-30.
243. Nicolas JF, Guy B. Intradermal, epidermal and transcutaneousvaccination: From immunology to clinical practice. Expert RevVaccines 2008; 7: 1201-14.
244. Kendall M. Engineering of needle-free physical methods to targetepidermal cells for DNA vaccination. Vaccine 2006; 24: 4651-6.
245. Capua I, Alexander DJ. Ecology, epidemiology and human healthimplications of avian influenza viruses: Why do we need to sharegenetic data? Zoonoses Public Health 2008; 55: 2-15.
246. Greenbaum JA, Kotturi MF, Kim Y, Oseroff C, Vaughan K, Salimi N, et al. Pre-existing immunity against swine-origin H1N1influenza viruses in the general human population. Proc Natl AcadSci USA 2009; 106: 20365-70.
247. Jones JH, Salathe M. Early assessment of anxiety and behavioralresponse to novel swine-origin influenza A(H1N1). PLoS One2009; 4: e8032.
248. Webby RJ, Webster RG. Are we ready for pandemic influenza?Science 2003; 302: 1519-22.
249. Quan FS, Kim YC, Yoo DG, Compans RW, Prausnitz MR, Kang SM. Stabilization of influenza vaccine enhances protection bymicroneedle delivery in the mouse skin. PLoS One 2009; 4: e7152.
250. Song JM, Kim YC, Lipatov AS, Pearton M, Davis CT, Yoo DG, et al. Microneedle delivery of H5N1 influenza virus-like particlesto the skin induces long-lasting B- and T-cell responses in mice.Clin Vaccine Immunol 2010; 17: 1381-9.
251. Beran J, Ambrozaitis A, Laiskonis A, Mickuviene N, Bacart P, Calozet Y, et al. Intradermal influenza vaccination of healthyadults using a new microinjection system: A 3-year randomisedcontrolled safety and immunogenicity trial. BMC Med 2009; 7: 13.
252. Quan FS, Kim YC, Vunnava A, Yoo DG, Song JM, Prausnitz MR, et al. Intradermal vaccination with influenza virus-like particles byusing microneedles induces protection superior to that withintramuscular immunization. J Virol 2010; 84: 7760-9.
253. Quan FS, Kim YC, Compans RW, Prausnitz MR, Kang SM. Dosesparing enabled by skin immunization with influenza virus-likeparticle vaccine using microneedles. J Control Release 2010;
254. Lambert PH, Laurent PE. Intradermal vaccine delivery: Will newdelivery systems transform vaccine administration? Vaccine 2008;26: 3197-208.
255. Pape KA, Catron DM, Itano AA, Jenkins MK. The humoralimmune response is initiated in lymph nodes by B cells that acquiresoluble antigen directly in the follicles. Immunity 2007; 26: 491-502.
256. Gill HS, Soderholm J, Prausnitz MR, Sallberg M. Cutaneousvaccination using microneedles coated with hepatitis C DNAvaccine. Gene Ther 2010; 17: 811-4.
257. Morefield GL, Tammariello RF, Purcell BK, Worsham PL, Chapman J, Smith LA, et al. An alternative approach tocombination vaccines: intradermal administration of isolatedcomponents for control of anthrax, botulism, plague andstaphylococcal toxic shock. J Immune Based Ther Vaccines 2008;6: 5.
258. Song JM, Kim YC, Barlow PG, Hossain MJ, Park KM, Donis RO, et al. Improved protection against avian influenza H5N1 virus by asingle vaccination with virus-like particles in skin usingmicroneedles. Antiviral Res 2010; 88(2): 244-247
259. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR.Stability Kinetics of influenza vaccine coated onto microneedlesduring drying and storage. Pharm Res 2010; 28(1):135-44.
260. Slutter B, Soema PC, Ding Z, Verheul R, Hennink W, Jiskoot W.Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen. J Control Release 2010; 143: 207-14.
261. Bal SM, Slutter B, van Riet E, Kruithof AC, Ding Z, Kersten GF, et al. Efficient induction of immune responses through intradermalvaccination with N-trimethyl chitosan containing antigenformulations. J Control Release 2010; 142: 374-83.
262. Kersten G, Hirschberg H. Antigen delivery systems. Expert RevVaccines 2004; 3: 453-62.
263. Ding Z, Van Riet E, Romeijn S, Kersten GF, Jiskoot W, Bouwstra JA. Immune modulation by adjuvants combined with diphtheriatoxoid administered topically in BALB/c mice after microneedlearray pretreatment. Pharm Res 2009; 26: 1635-43.
264. Vogelbruch M, Nuss B, Korner M, Kapp A, Kiehl P, Bohm W.Aluminium-induced granulomas after inaccurate intradermalhyposensitization injections of aluminium-adsorbed depotpreparations. Allergy 2000; 55: 883-7.
265. Fernando GJ, Chen X, Prow TW, Crichton ML, Fairmaid EJ, Roberts MS, et al. Potent immunity to low doses of influenzavaccine by probabilistic guided micro-targeted skin delivery in amouse model. PLoS One 2010; 5: e10266.
266. Alchas, P.G. Intradermal delivery device including a needleassembly. US6494865 (2002).
267. Alchas, P.G., Guillermo, C.E., Korisch, M.S. Prefillableintradermal injector. US6569123 (2003).
268. Alchas, P.G., Laurent, P.E.F. Method of intradermally injectingsubstances. US6569143 (2003).
269. Alchas, P.G., Laurent, P.E.F., Guillermo, C.E., Korisch, M.S.Intradermal needle. US6843781 (2005).
270. Bal SM, Ding Z, van Riet E, Jiskoot W, Bouwstra JA. Advances intranscutaneous vaccine delivery: Do all ways lead to Rome? JControl Release 2010; 148(3): 266-82.
271. Kersten G, Hirschberg H. Needle-free vaccine delivery. ExpertOpin Drug Deliv 2007; 4: 459-74.
272. Wendorf JR, Ghartey-Tagoe EB, Williams SC, Enioutina E, Singh P, et al. Transdermal delivery of macromolecules using solid-statebiodegradable microstructures. Pharm Res 2011; 28: 22-30.
273. Huang J, D'Souza AJ, Alarcon JB, Mikszta JA, Ford BM, Ferriter MS, et al. Protective immunity in mice achieved with dry powderformulation and alternative delivery of plague F1-V vaccine. ClinVaccine Immunol 2009; 16: 719-25.
274. Whitson, R.C. Hollow microneedle patch. US20020006355(2002).
275. Cormier, M.J.N., Theeuwes, F.T. Device and method forenchancing transdermal sampling. US006219574 (2001).
276. Zimmermann S, Fienbork D, Stoeber B, Flounders A, Liepmann D.A microneedle-based glucose monitor: Fabricated on a wafer-levelusing in-device enzyme immobilization in 12th Int. Conf. Solid-State Sensors and Actuators. 2003.
277. Ahn C, Choi J, Beaucage G, Nevin J, Lee J, Puntambekar A, et al.Disposable samrt lab-on-a-chip for point-of-c may be clinicaldiagnostics. Proc IEEE 2004; 92: 154-73.
278. Fleming PR, Delmore MD, Erickson LE, Ferber RH: Microneedledevices and methods of manufacture. US20050187521 (2005).
279. Jiang J, Moore JS, Edelhauser HF, Prausnitz MR. Intrascleral drugdelivery to the eye using hollow microneedles. Pharm Res 2009;26: 395-403.
280. Morrison JC, Moore CG: Microneedle for injection of ocular bloodvessels. US5364374 (1994).
281. Nanogen. http://nanogen.co.uk/scalproller-hair-loss-treatmentenhancer.html [Accessed on 30th December 2010].
282. Lee, J., Hong, S.I. Microneedle roller. US20080161735 (2008).
283. Lee, J., Hong, S.I. Electrically conductive microneedle roller.US20080161747 (2008).
284. Gonzalez-Gonzalez E, Speaker TJ, Hickerson RP, Spitler R, Flores MA, Leake D, et al. Silencing of reporter gene expression in skinusing siRNAs and expression of plasmid DNA delivered by asoluble protrusion array device (PAD). Mol Ther 2010; 18: 1667-74.
285. Pearton M, Allender C, Brain K, Anstey A, Gateley C, Wilke N, et al. Gene delivery to the epidermal cells of human skin explantsusing microfabricated microneedles and hydrogel formulations.Pharm Res 2008; 25: 407-16.
286. Coulman SA, Barrow D, Anstey A, Gateley C, Morrissey A, Wilke N, et al. Minimally invasive cutaneous delivery ofmacromolecules and plasmid DNA via microneedles. Curr DrugDeliv 2006; 3: 65-75.
287. Ginaven, R.O., Facciotti, D. Needle array and method ofintroducing biological substances into living cells using the needlearray. US005457041 (1995).
288. Tharian EB, Tandon S. Iontophoresis. A novel drug administrationfor extraction of deciduous teeth. A clinical evaluation. Indian J Dent Res 1994; 5: 97-100.
289. Tokumoto, S., Matsudo, T., Kuwahara, T. Microneedle device fordiagnosis of allergy. US20100030100 (2010).
290. American Veterinary Identification devices.http://www.avidid.com/index.html [Acessed on: December 31,2010].
291. Birchall JC, Clemo R, Anstey A, John DN. Microneedles in clinicalpractice-an exploratory study into the opinions of healthcareprofessionals and the public. Pharm Res 2010;
292. Free patents online. http://www.freepatentsonline.com/result.html?query_txt=microneedle&sort=relevance&srch=top&search=[Accessed on: October 11, 2010].
293. Zosano Pharma. http://www.zosanopharma.com/ [Accessed on:December 30, 2010].
294. 3M.http://solutions.3m.com/wps/portal/3M/en_WW/Worldwide/WW/[Accessed on: December 30, 2010].
295. Corium International Inc. http://www.coriumgroup.com/tech_microcor.html [Accessed on: December 30, 2010].
296. Singh TR, Dunne NJ, Cunningham E, Donnelly RF. Review ofpatents on microneedle applicators. Recent Pat Drug Deliv Formul2010; Epub ahead of print.
297. Nanopass Technologies Ltd. http://www.nanopass.com/contente.asp?cid=19# [Accessed on: December 30, 2010].
298. Prausnitz MR, Birchall JC. Atanta, GA. 1st Int Conf Microneedles2010.