Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux®) technology

Pharmaceutical Research

Volumn 18, Issue 12, 2001, Pages 1789-1793

  Lin, W ^a   Cormier, M ^a   Samiee, A ^a   Griffin, A ^a   Johnson, B ^a   Teng, C L ^b   Hardee, G E ^b   Daddona, P E ^b  

^a ALZA CORPORATION   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense oligonucleotides; Hairless guinea pigs; ISIS 2302; Microprojection array; Skin patch; Transdermal delivery

Indexed keywords

ALICAFORSEN; ANTISENSE OLIGONUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE THERAPY; NONHUMAN; PRIORITY JOURNAL; SKIN ABSORPTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; GUINEA PIGS; IONTOPHORESIS; LIVER; MICROINJECTIONS; OLIGONUCLEOTIDES, ANTISENSE; SKIN; TIME FACTORS;

EID: 0035659567     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013395102049     Document Type: Article

References (20)

1. Perspectives in antisense therapeutics
2. Iontophoretic delivery of oligonucleotides across full thickness hairless mouse skin
3. Effects of size and sequence on the iontophoretic delivery of oligonucleotides
4. Live confocal microscopy of oligonucleotlde uptake by keratinocytes in human skin grafts on nude mice
5. Localization of a FITC-labeled phosphorothioate oligodeoxynucleotide in the skin after topical delivery by iontophoresis and electroporation
6. Methods for in vitro percutaneous absorption studies V: Permeation through damaged skin
7. Effects of removal of stratum corneum, delipidization and addition of enhancers, ethanol and l-menthol, on skin permeation of benzoic acid and its 4-n-alkyl substituents in excised guinea pig dorsal skin
8. Transdermal delivery of antisense compounds
9. Passive enhancement strategies in topical and transdermal drug delivery
10. Delivery of oligonucleotides and polynucleotides
11. In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides
12. Iontophoretic delivery of a telomeric oligonucleotide
13. Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression
14. Hairless guinea pig skin: Anatomical basis for studies of cutaneous biology
15. Diseased skin models in the hairless guinea pig skin: In vivo percutaneous absorption
16. A new hairless strain of guinea pig: Characterization of the cutaneous morphology and pharmacology
17. A dose-related curve of wound tensile strength following ultraviolet irradiation in the hairless guinea pig
18. An analysis of solute structure-human epidermal transport relationships in epidermal iontophoresis using the ionic mobility: Pore model
19. Iontophoresis of bases, nucleosides, and nucleotides
20. Intercellular adhesion molecule-1 suppression in skin by topical delivery of antisense oligonucleotides