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Volumn 28, Issue 1, 2011, Pages 124-134

Vehicle composition influence on the microneedle-enhanced transdermal flux of naltrexone hydrochloride

Author keywords

microneedles; naltrexone hydrochloride; propylene glycol; transdermal drug delivery; viscosity

Indexed keywords

NALTREXONE; PROPYLENE GLYCOL; WATER;

EID: 78651254362     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0191-x     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 0001813673 scopus 로고    scopus 로고
    • Cutaneous and transdermal delivery-processes and systems of delivery
    • 1:CAS:528:DC%2BD38XnvVSmsbg%3D
    • GL Flynn 2002 Cutaneous and transdermal delivery-processes and systems of delivery Drugs Pharm Sci 121 187 235 1:CAS:528:DC%2BD38XnvVSmsbg%3D
    • (2002) Drugs Pharm Sci , vol.121 , pp. 187-235
    • Flynn, G.L.1
  • 2
    • 1242308254 scopus 로고    scopus 로고
    • Current status and future potential of transdermal drug delivery
    • MR Prausnitz S Mitragotri R Langer 2004 Current status and future potential of transdermal drug delivery Nat Rev Drug Discov 3 115 124 1:CAS:528:DC%2BD2cXhtlartbg%3D 10.1038/nrd1304 15040576 (Pubitemid 38239773)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.2 , pp. 115-124
    • Prausnitz, M.R.1    Mitragotri, S.2    Langer, R.3
  • 3
    • 55749108348 scopus 로고    scopus 로고
    • Transdermal drug delivery
    • 1:CAS:528:DC%2BD1cXhtlCktrrF 10.1038/nbt.1504 18997767
    • MR Prausnitz R Langer 2008 Transdermal drug delivery Nat Biotechnol 26 1261 1268 1:CAS:528:DC%2BD1cXhtlCktrrF 10.1038/nbt.1504 18997767
    • (2008) Nat Biotechnol , vol.26 , pp. 1261-1268
    • Prausnitz, M.R.1    Langer, R.2
  • 4
    • 0031852494 scopus 로고    scopus 로고
    • Microfabricated microneedles: A novel approach to transdermal drug delivery
    • DOI 10.1021/js980042+
    • S Henry DV McAllister MG Allen MR Prausnitz 1998 Microfabricated microneedles: a novel approach to transdermal drug delivery J Pharm Sci 87 922 925 1:CAS:528:DyaK1cXkvVGktrw%3D 10.1021/js980042+ 9687334 (Pubitemid 28381247)
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , Issue.8 , pp. 922-925
    • Henry, S.1    McAllister, D.V.2    Allen, M.G.3    Prausnitz, M.R.4
  • 6
    • 33644990451 scopus 로고    scopus 로고
    • Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles
    • 1:CAS:528:DC%2BD28XktlCisA%3D%3D 10.2174/156720106775197510 16472095
    • SA Coulman D Barrow A Anstey C Gateley A Morrissey N Wilke C Allender K Brain JC Birchall 2006 Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles Curr Drug Deliv 3 65 75 1:CAS:528: DC%2BD28XktlCisA%3D%3D 10.2174/156720106775197510 16472095
    • (2006) Curr Drug Deliv , vol.3 , pp. 65-75
    • Coulman, S.A.1    Barrow, D.2    Anstey, A.3    Gateley, C.4    Morrissey, A.5    Wilke, N.6    Allender, C.7    Brain, K.8    Birchall, J.C.9
  • 7
    • 44649083690 scopus 로고    scopus 로고
    • Flux across microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro
    • 1:CAS:528:DC%2BD1cXmslWmsrs%3D 10.1007/s11095-008-9578-3 18449628
    • SL Banks RR Pinninti HS Gill PA Crooks MR Prausnitz AL Stinchcomb 2008 Flux across microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro Pharm Res 25 1677 1685 1:CAS:528: DC%2BD1cXmslWmsrs%3D 10.1007/s11095-008-9578-3 18449628
    • (2008) Pharm Res , vol.25 , pp. 1677-1685
    • Banks, S.L.1    Pinninti, R.R.2    Gill, H.S.3    Crooks, P.A.4    Prausnitz, M.R.5    Stinchcomb, A.L.6
  • 9
    • 0021219060 scopus 로고
    • Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration
    • 1:CAS:528:DyaL2cXmt1ajsb4%3D 6469932
    • MC Meyer AB Straughn MW Lo WL Schary CC Whitney 1984 Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration J Clin Psychiatry 45 15 19 1:CAS:528:DyaL2cXmt1ajsb4%3D 6469932
    • (1984) J Clin Psychiatry , vol.45 , pp. 15-19
    • Meyer, M.C.1    Straughn, A.B.2    Lo, M.W.3    Schary, W.L.4    Whitney, C.C.5
  • 10
    • 0019509579 scopus 로고
    • Metabolism and disposition of naltrexone in man after oral and intravenous administration
    • 1:CAS:528:DyaL3MXlt1Grs78%3D 6114837
    • ME Wall DR Brine M Perez-Reyes 1981 Metabolism and disposition of naltrexone in man after oral and intravenous administration Drug Metab Dispos 9 369 375 1:CAS:528:DyaL3MXlt1Grs78%3D 6114837
    • (1981) Drug Metab Dispos , vol.9 , pp. 369-375
    • Wall, M.E.1    Brine, D.R.2    Perez-Reyes, M.3
  • 11
    • 78651261085 scopus 로고    scopus 로고
    • Vivitrol website. http://www.vivitrol.com/hcp/Vivitrol-Info/adherence. aspx.
  • 14
    • 20044383036 scopus 로고    scopus 로고
    • Human skin permeation of branched-chain 3-O-alkyl ester and carbonate prodrugs of naltrexone
    • DOI 10.1007/s11095-005-2592-9
    • HK Vaddi MO Hamad J Chen SL Banks PA Crooks AL Stinchcomb 2005 Human skin permeation of branched-chain 3-O-alkyl ester and carbonate prodrugs of naltrexone Pharm Res 22 758 765 1:CAS:528:DC%2BD2MXkt1Omsrg%3D 10.1007/s11095-005-2592-9 15906171 (Pubitemid 40768588)
    • (2005) Pharmaceutical Research , vol.22 , Issue.5 , pp. 758-765
    • Vaddi, H.K.1    Hamad, M.O.2    Chen, J.3    Banks, S.L.4    Crooks, P.A.5    Stinchcomb, A.L.6
  • 15
    • 68249115720 scopus 로고    scopus 로고
    • Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone
    • 1:CAS:528:DC%2BD1MXns1eqsbw%3D 10.1002/jps.21594 18972573
    • HK Vaddi SL Banks J Chen DC Hammell PA Crooks AL Stinchcomb 2009 Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone J Pharm Sci 98 2611 2625 1:CAS:528:DC%2BD1MXns1eqsbw%3D 10.1002/jps.21594 18972573
    • (2009) J Pharm Sci , vol.98 , pp. 2611-2625
    • Vaddi, H.K.1    Banks, S.L.2    Chen, J.3    Hammell, D.C.4    Crooks, P.A.5    Stinchcomb, A.L.6
  • 17
    • 46549083407 scopus 로고    scopus 로고
    • Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes
    • 1:CAS:528:DC%2BD1cXnsFaltbc%3D 10.1016/j.jconrel.2008.04.019 18538885
    • Y Qiu Y Gao K Hu F Li 2008 Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes J Control Release 129 144 150 1:CAS:528:DC%2BD1cXnsFaltbc%3D 10.1016/j.jconrel.2008.04.019 18538885
    • (2008) J Control Release , vol.129 , pp. 144-150
    • Qiu, Y.1    Gao, Y.2    Hu, K.3    Li, F.4
  • 18
    • 59349105168 scopus 로고    scopus 로고
    • Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: Dependency on needle size and applied formulation
    • 1:CAS:528:DC%2BD1MXhs1aqur4%3D 10.1016/j.ejps.2008.12.008 19146954
    • MM Badran J Kuntsche A Fahr 2009 Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation Eur J Pharm Sci 36 511 523 1:CAS:528:DC%2BD1MXhs1aqur4%3D 10.1016/j.ejps.2008.12.008 19146954
    • (2009) Eur J Pharm Sci , vol.36 , pp. 511-523
    • Badran, M.M.1    Kuntsche, J.2    Fahr, A.3
  • 19
    • 0030703655 scopus 로고    scopus 로고
    • Skin penetration enhancers cited in the technical literature
    • DW Osborne JJ Heneke 1997 Skin penetration enhancers cited in the technical literature Pharm Technol 21 58 66
    • (1997) Pharm Technol , vol.21 , pp. 58-66
    • Osborne, D.W.1    Heneke, J.J.2
  • 20
    • 0002086622 scopus 로고
    • Physical chemical analysis of percutaneous absorption process from creams and ointments
    • T Higuchi 1960 Physical chemical analysis of percutaneous absorption process from creams and ointments J Soc Cosmet Chem 11 85 97
    • (1960) J Soc Cosmet Chem , vol.11 , pp. 85-97
    • Higuchi, T.1
  • 21
    • 0023597397 scopus 로고
    • Mode of action of penetration enhancers in human skin
    • DOI 10.1016/0168-3659(87)90066-6
    • BW Barry 1987 Mode of action of penetration enhancers in human skin J Control Release 6 85 97 1:CAS:528:DyaL1cXotF2rsw%3D%3D 10.1016/0168-3659(87) 90066-6 (Pubitemid 18017724)
    • (1987) Journal of Controlled Release , vol.6 , Issue.SPEC. NO. , pp. 85-97
    • Barry, B.W.1
  • 22
    • 0023680522 scopus 로고
    • Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique
    • 1:CAS:528:DyaL1cXmtFGrurg%3D 10.1111/1523-1747.ep12475655 3171212
    • M Goodman BW Barry 1988 Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique J Invest Dermatol 91 323 327 1:CAS:528: DyaL1cXmtFGrurg%3D 10.1111/1523-1747.ep12475655 3171212
    • (1988) J Invest Dermatol , vol.91 , pp. 323-327
    • Goodman, M.1    Barry, B.W.2
  • 23
    • 0028884828 scopus 로고
    • Estradiol permeation through human skin and silastic membrane: Effects of propylene glycol and supersaturation
    • 1:CAS:528:DyaK2MXosVOgtLc%3D 10.1016/0168-3659(95)00062-D
    • NA Megrab AC Williams BW Barry 1995 Estradiol permeation through human skin and silastic membrane: effects of propylene glycol and supersaturation J Control Release 36 277 294 1:CAS:528:DyaK2MXosVOgtLc%3D 10.1016/0168-3659(95) 00062-D
    • (1995) J Control Release , vol.36 , pp. 277-294
    • Megrab, N.A.1    Williams, A.C.2    Barry, B.W.3
  • 24
    • 1842505256 scopus 로고    scopus 로고
    • Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride
    • DOI 10.1016/j.ijpharm.2004.01.013, PII S0378517304000286
    • L Trottet C Merly M Mirza J Hadgraft AF Davis 2004 Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride Int J Pharm 274 213 219 1:CAS:528:DC%2BD2cXivFGksLg%3D 10.1016/j.ijpharm.2004.01.013 15072797 (Pubitemid 38457020)
    • (2004) International Journal of Pharmaceutics , vol.274 , Issue.1-2 , pp. 213-219
    • Trottet, L.1    Merly, C.2    Mirza, M.3    Hadgraft, J.4    Davis, A.F.5
  • 25
    • 38349093694 scopus 로고    scopus 로고
    • Effect of propylene glycol on ibuprofen absorption into human skin in vivo
    • 10.1002/jps.20829
    • C Herkenne A Naik YN Kalia J Hadgraft RH Guy 2007 Effect of propylene glycol on ibuprofen absorption into human skin in vivo J Pharm Sci 97 185 197 10.1002/jps.20829
    • (2007) J Pharm Sci , vol.97 , pp. 185-197
    • Herkenne, C.1    Naik, A.2    Kalia, Y.N.3    Hadgraft, J.4    Guy, R.H.5
  • 26
    • 67749102207 scopus 로고    scopus 로고
    • Optimisation of cosolvent concentration for topical drug delivery-II: Influence of propylene glycol on ibuprofen permeation
    • 1:CAS:528:DC%2BD1MXhtFOhsbfK 10.1159/000231528 19648784
    • RM Watkinson RH Guy J Hadgraft ME Lane 2009 Optimisation of cosolvent concentration for topical drug delivery-II: influence of propylene glycol on ibuprofen permeation Skin Pharmacol Physiol 22 225 230 1:CAS:528: DC%2BD1MXhtFOhsbfK 10.1159/000231528 19648784
    • (2009) Skin Pharmacol Physiol , vol.22 , pp. 225-230
    • Watkinson, R.M.1    Guy, R.H.2    Hadgraft, J.3    Lane, M.E.4
  • 27
    • 33846492454 scopus 로고    scopus 로고
    • Coated microneedles for transdermal delivery
    • Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Controlled Release. 2007;117(2):227-37.
    • (2007) J Controlled Release. , vol.117 , Issue.2 , pp. 227-237
    • Gill, H.S.1    Prausnitz, M.R.2
  • 28
    • 0023264053 scopus 로고
    • Improvement of the oral bioavailability of naltrexone in dogs: A prodrug approach
    • 1:CAS:528:DyaL2sXlt1SqtLw%3D 10.1002/jps.2600760503 3656096
    • MA Hussain CA Koval MJ Myers EG Shami E Shefter 1987 Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach J Pharm Sci 76 356 358 1:CAS:528:DyaL2sXlt1SqtLw%3D 10.1002/jps.2600760503 3656096
    • (1987) J Pharm Sci , vol.76 , pp. 356-358
    • Hussain, M.A.1    Koval, C.A.2    Myers, M.J.3    Shami, E.G.4    Shefter, E.5
  • 29
    • 0014683583 scopus 로고
    • Biological membranes behave as nonporous polymeric sheets with respect to the diffusion of nonelectrolytes
    • 10.1038/224240a0
    • WR Lieband WD Stein 1969 Biological membranes behave as nonporous polymeric sheets with respect to the diffusion of nonelectrolytes Nature (London, United Kingdom) 224 240 243 10.1038/224240a0
    • (1969) Nature (London, United Kingdom) , vol.224 , pp. 240-243
    • Lieband, W.R.1    Stein, W.D.2
  • 30
    • 0016168286 scopus 로고
    • Interpretation of nonelectrolyte partition coefficients between dimyristoyl lecithin and water
    • 1:CAS:528:DyaE2cXkvVKqu7c%3D 10.1007/BF01870176 4407798
    • JM Diamond Y Katz 1974 Interpretation of nonelectrolyte partition coefficients between dimyristoyl lecithin and water J Membr Biol 17 121 154 1:CAS:528:DyaE2cXkvVKqu7c%3D 10.1007/BF01870176 4407798
    • (1974) J Membr Biol , vol.17 , pp. 121-154
    • Diamond, J.M.1    Katz, Y.2
  • 31
    • 0001818318 scopus 로고
    • Prodrugs for dermal delivery: Solubility, molecular size, and functional group effects
    • Sloan KB, editor. New York, USA: Marcel Dekker
    • Kasting GB, Smith RL, Anderson BD. Prodrugs for dermal delivery: solubility, molecular size, and functional group effects. In: Sloan KB, editor. Prodrugs: topical and ocular drug delivery. New York, USA: Marcel Dekker; 1992. p. 117-61.
    • (1992) Prodrugs: Topical and Ocular Drug Delivery , pp. 117-161
    • Kasting, G.B.1    Smith, R.L.2    Anderson, B.D.3
  • 32
    • 0026606514 scopus 로고
    • Predicting skin permeability
    • Potts RO, Guy RH. Predicting skin permeability. Pharm Res. 1992;9:663-9.
    • (1992) Pharm Res , vol.9 , pp. 663-669
    • Potts, R.O.1    Guy, R.H.2
  • 33
    • 0016545625 scopus 로고
    • Drug permeation through human skin. Theory and in vitro experimental measurement
    • 1:CAS:528:DyaE2MXlvVyitbg%3D 10.1002/aic.690210522
    • AS Michaels SK Chandrasekaran JE Shaw 1975 Drug permeation through human skin. Theory and in vitro experimental measurement AIChE J 21 985 996 1:CAS:528:DyaE2MXlvVyitbg%3D 10.1002/aic.690210522
    • (1975) AIChE J , vol.21 , pp. 985-996
    • Michaels, A.S.1    Chandrasekaran, S.K.2    Shaw, J.E.3
  • 34
    • 0018383835 scopus 로고
    • Percutaneous absorption: In vivo experiments
    • 1:CAS:528:DyaE1MXltFOqurs%3D 34686
    • WJ Albery J Hadgraft 1979 Percutaneous absorption: in vivo experiments J Pharm Pharmacol 31 140 147 1:CAS:528:DyaE1MXltFOqurs%3D 34686
    • (1979) J Pharm Pharmacol , vol.31 , pp. 140-147
    • Albery, W.J.1    Hadgraft, J.2
  • 35
    • 0023122664 scopus 로고
    • Drug permeation across the skin: Effect of penetrant hydrophilicity
    • DOI 10.1002/jps.2600760208
    • K Tojo 1987 Random brick model for drug transport across stratum corneum J Pharm Sci 76 889 891 1:CAS:528:DyaL1cXkvVKqtQ%3D%3D 10.1002/jps.2600760208 3440932 (Pubitemid 17043677)
    • (1987) Journal of Pharmaceutical Sciences , vol.76 , Issue.2 , pp. 123-126
    • Tojo, K.1    Chiang, C.C.2    Chien, Y.W.3
  • 36
    • 0028093040 scopus 로고
    • A linear theory of transdermal transport phenomena
    • 1:CAS:528:DyaK2cXlsVWls74%3D 10.1002/jps.2600830925 7830250
    • DA Edwards R Langer 1994 A linear theory of transdermal transport phenomena J Pharm Sci 83 1315 1334 1:CAS:528:DyaK2cXlsVWls74%3D 10.1002/jps.2600830925 7830250
    • (1994) J Pharm Sci , vol.83 , pp. 1315-1334
    • Edwards, D.A.1    Langer, R.2
  • 37
    • 0030886388 scopus 로고    scopus 로고
    • Evaluation of solute permeation through the stratum corneum: Lateral bilayer diffusion as the primary transport mechanism
    • DOI 10.1021/js960198e
    • ME Johnson D Blankschtein R Langer 1997 Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism J Pharm Sci 86 1162 1172 1:CAS:528:DyaK2sXlvVygsLs%3D 10.1021/js960198e 9344175 (Pubitemid 27430923)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.10 , pp. 1162-1172
    • Johnson, M.E.1    Blankschtein, D.2    Langer, R.3
  • 39
    • 0242290769 scopus 로고    scopus 로고
    • Steady-State Flux and Lag Time in the Stratum Corneum Lipid Pathway: Results from Finite Element Models
    • DOI 10.1002/jps.10466
    • HF Frasch AM Barbero 2003 Steady-state flux and lag time in the stratum corneum lipid pathway: results from finite element models J Pharm Sci 92 2196 2207 1:CAS:528:DC%2BD3sXovFCrs7o%3D 10.1002/jps.10466 14603505 (Pubitemid 37356693)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.11 , pp. 2196-2207
    • Frasch, H.F.1    Barbero, A.M.2
  • 40
    • 0001813673 scopus 로고    scopus 로고
    • Cutaneous and transdermal delivery: Processes and systems of delivery
    • C.T. Rhodes G.S. Banker (eds). Marcel Dekker New York
    • Flynn GL. Cutaneous and transdermal delivery: processes and systems of delivery. In: Rhodes CT, Banker GS, editors. Modern pharmaceutics. New York: Marcel Dekker; 1990. p. 239-98.
    • (1990) Modern Pharmaceutics , pp. 239-298
    • Flynn, G.L.1
  • 41
    • 0034098046 scopus 로고    scopus 로고
    • The 500 Dalton rule for the skin penetration of chemical compounds and drugs
    • DOI 10.1034/j.1600-0625.2000.009003165.x
    • JD Bos MMHM Meinardi 2000 The 500 Dalton rule for the skin penetration of chemical compounds and drugs Exp Dermatol 9 165 169 1:CAS:528: DC%2BD3cXjvVWitLw%3D 10.1034/j.1600-0625.2000.009003165.x 10839713 (Pubitemid 30255378)
    • (2000) Experimental Dermatology , vol.9 , Issue.3 , pp. 165-169
    • Bos, J.D.1    Meinardi, M.M.H.M.2
  • 42
    • 5444241167 scopus 로고    scopus 로고
    • Emerging technologies in transdermal therapeutics
    • 10.1097/01.mjt.0000101826.94820.6b 15266225
    • M Meidan 2004 Emerging technologies in transdermal therapeutics Am J Ther 11 312 316 10.1097/01.mjt.0000101826.94820.6b 15266225
    • (2004) Am J Ther , vol.11 , pp. 312-316
    • Meidan, M.1
  • 43
    • 0016053262 scopus 로고
    • Mass transport phenomena and models. Theoretical concepts
    • 1:CAS:528:DyaE2cXksVKnsLg%3D 10.1002/jps.2600630403 4828694
    • GL Flynn SH Yalkowsky TJ Roseman 1974 Mass transport phenomena and models. Theoretical concepts J Pharm Sci 63 479 510 1:CAS:528:DyaE2cXksVKnsLg%3D 10.1002/jps.2600630403 4828694
    • (1974) J Pharm Sci , vol.63 , pp. 479-510
    • Flynn, G.L.1    Yalkowsky, S.H.2    Roseman, T.J.3
  • 44
    • 34247171927 scopus 로고    scopus 로고
    • A geometrical model of dermal capillary clearance
    • DOI 10.1016/j.mbs.2006.10.012, PII S0025556406002203
    • K Kretsos B Kasting Gerald 2007 A geometrical model of dermal capillary clearance Math Biosci 208 430 453 10.1016/j.mbs.2006.10.012 17303187 (Pubitemid 47101854)
    • (2007) Mathematical Biosciences , vol.208 , Issue.2 , pp. 430-453
    • Kretsos, K.1    Kasting, G.B.2
  • 45
    • 0027301862 scopus 로고
    • In vitro permeation of human skin by multipolar ions
    • DOI 10.1016/0378-5173(93)90321-6
    • M Sznitowska B Berner HI Maibach 1993 In vitro permeation of human skin by multipolar ions Int J Pharm 99 43 49 1:CAS:528:DyaK3sXms1Wqt7k%3D 10.1016/0378-5173(93)90321-6 (Pubitemid 23276361)
    • (1993) International Journal of Pharmaceutics , vol.99 , Issue.1 , pp. 43-49
    • Sznitowska, M.1    Berner, B.2    Maibach, H.I.3
  • 46
    • 0030910348 scopus 로고    scopus 로고
    • A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs
    • DOI 10.1021/js950346l
    • JA Cordero L Alarcon E Escribano R Obach J Domenech 1997 A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs J Pharm Sci 86 503 508 1:CAS:528:DyaK2sXhslagurs%3D 10.1021/js950346l 9109056 (Pubitemid 27154769)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.4 , pp. 503-508
    • Cordero, J.A.1    Alarcon, L.2    Escribano, E.3    Obach, R.4    Domenech, J.5
  • 47
    • 0034630911 scopus 로고    scopus 로고
    • pH, pK(a) and dermal delivery
    • DOI 10.1016/S0378-5173(00)00402-6, PII S0378517300004026
    • J Hadgraft C Valenta 2000 pH, pKa and dermal delivery Int J Pharm 200 243 247 1:CAS:528:DC%2BD3cXktFemsrc%3D 10.1016/S0378-5173(00)00402-6 10867254 (Pubitemid 30364911)
    • (2000) International Journal of Pharmaceutics , vol.200 , Issue.2 , pp. 243-247
    • Hadgraft, J.1    Valenta, C.2
  • 48
    • 0016741904 scopus 로고
    • Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence
    • 1:CAS:528:DyaE2MXltVylsrY%3D 10.1021/jm00241a001 239235
    • JJ Kaufman NM Semo WS Koski 1975 Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence J Med Chem 18 647 655 1:CAS:528:DyaE2MXltVylsrY%3D 10.1021/jm00241a001 239235
    • (1975) J Med Chem , vol.18 , pp. 647-655
    • Kaufman, J.J.1    Semo, N.M.2    Koski, W.S.3
  • 49
    • 0037173513 scopus 로고    scopus 로고
    • Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model
    • DOI 10.1016/S0378-5173(02)00240-5, PII S0378517302002405
    • K Sugano N Takata M Machida K Saitoh K Terada 2002 Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model Int J Pharm 241 241 251 1:CAS:528: DC%2BD38XkvFelt74%3D 10.1016/S0378-5173(02)00240-5 12100852 (Pubitemid 34718026)
    • (2002) International Journal of Pharmaceutics , vol.241 , Issue.2 , pp. 241-251
    • Sugano, K.1    Takata, N.2    Machida, M.3    Saitoh, K.4    Terada, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.