Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment

Pharmaceutical Research

Volumn 26, Issue 7, 2009, Pages 1635-1643

  Ding, Z ^a,c   Van Riet, E ^a   Romeijn, S ^a   Kersten, G F A ^b   Jiskoot, W ^a   Bouwstra, J A ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NETHERLANDS VACCINE INSTITUTE   (Netherlands)

^c NANJING UNIVERSITY   (China)

Author keywords

Cholera toxin; Cp G; Diphtheria toxoid; Microneedle array; Transcutaneous immunization

Indexed keywords

ADJU PHOS; ALUMINUM POTASSIUM SULFATE; CHOLERA TOXIN; CPG OLIGODEOXYNUCLEOTIDE; DIPHTHERIA TOXOID; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; QUIL A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOMODULATION; MOUSE; NEEDLE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIBODY FORMATION; CHOLERA TOXIN; DIPHTHERIA TOXOID; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; SAPONINS;

EID: 67349089494     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9874-6     Document Type: Article

References (48)

1. EL Giudice JD Campbell 2006 Needle-free vaccine delivery Adv Drug Deliv Rev 58 68 89
2. GM Glenn M Rao GR Matyas CR Alving 1998 Skin immunization made possible by cholera toxin Nature 391 851
3. TS Kupper RC Fuhlbrigge 2004 Immune surveillance in the skin: mechanisms and clinical consequences Nat Rev Immunol 4 211 22
4. JB Alarcon AW Hartley NG Harvey JA Mikszta 2007 Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines Clin Vaccine Immunol 14 375 81
5. JA Mikszta JP Dekker 3rd NG Harvey CH Dean JM Brittingham J Huang VJ Sullivan B Dyas CJ Roy RG Ulrich 2006 Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine Infect Immun 74 6806 10
6. S Garg M Hoelscher JA Belser C Wang L Jayashankar Z Guo RH Durland JM Katz S Sambhara 2007 Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in mice Clin Vaccine Immunol 14 926 8
7. GM Glenn DC Flyer LR Ellingsworth SA Frech DM Frerichs RC Seid J Yu 2007 Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch Expert Rev Vaccines 6 809 19
8. YL Zhao SN Murthy MH Manjili LJ Guan A Sen SW Hui 2006 Induction of cytotoxic T-lymphocytes by electroporation-enhanced needle-free skin immunization Vaccine 24 1282 90
9. M Ogura S Paliwal S Mitragotri 2008 Low-frequency sonophoresis: current status and future prospects Adv Drug Deliv Rev 60 1218 23
10. CD Partidos S Muller 2005 Decision-making at the surface of the intact or barrier disrupted skin: potential applications for vaccination or therapy Cell Mol Life Sci 62 1418 24
11. Gerstel MS, Place VA. Drug delivery device, US, 1976.
12. S Henry DV McAllister MG Allen MR Prausnitz 1999 Microfabricated microneedles: a novel approach to transdermal drug delivery J Pharm Sci 88 948
13. FJ Verbaan SM Bal DJ van den Berg WH Groenink H Verpoorten R Luttge JA Bouwstra 2007 Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin J Control Release 117 238 45
14. JA Matriano M Cormier J Johnson WA Young M Buttery K Nyam PE Daddona 2002 Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization Pharm Res 19 63 70
15. G Widera J Johnson L Kim L Libiran K Nyam PE Daddona M Cormier 2006 Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system Vaccine 24 1653 64
16. JW Hooper JW Golden AM Ferro AD King 2007 Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge Vaccine 25 1814 23
17. P Van Damme F Oosterhuis-Kafeja M Van der Wielen Y Almagor O Sharon Y Levin 2009 Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults Vaccine 27 454 9
18. RK Sivamani D Liepmann HI Maibach 2007 Microneedles and transdermal applications Expert Opin Drug Deliv 4 19 25
19. SP Davis BJ Landis ZH Adams MG Allen MR Prausnitz 2004 Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force J Biomech 37 1155 63
20. FJ Verbaan SM Bal DJ van den Berg JA Dijksman M van Hecke H Verpoorten A van den Berg R Luttge JA Bouwstra 2008 Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method J Control Release 128 80 8
21. Ding Z, Verbaan FJ, Bivas-Benita M, Bungener L, Huckriede A, van den Berg DJ, Kersten G, Bouwstra JA. Microneedle Arrays for the Transcutaneous Immunization of Diptheria and Influenza in BALB/c Mice. J Control Release (2009) doi: 10.1016/j.jconrel.2009.01.025.
22. EA McNeela KH Mills 2001 Manipulating the immune system: humoral versus cell-mediated immunity Adv Drug Deliv Rev 51 43 54
23. B Metz W Jiskoot WE Hennink DJ Crommelin GF Kersten 2003 Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines Vaccine 22 156 67
24. T Scharton-Kersten GM Glenn R Vassell J Yu D Walwender CR Alving 1999 Principles of transcutaneous immunization using cholera toxin as an adjuvant Vaccine 17 Suppl 2 S37 43
25. P van der Ley L Steeghs HJ Hamstra J ten Hove B Zomer L van Alphen 2001 Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity Infect Immun 69 5981 90
26. M Amidi HC Pellikaan H Hirschberg AH de Boer DJ Crommelin WE Hennink G Kersten W Jiskoot 2007 Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs Vaccine 25 6818 29
27. B Guy 2007 The perfect mix: recent progress in adjuvant research Nat Rev Microbiol 5 505 17
28. S Godefroy M Peyre N Garcia S Muller D Sesardic CD Partidos 2005 Effect of skin barrier disruption on immune responses to topically applied cross-reacting material, CRM(197), of diphtheria toxin Infect Immun 73 4803 9
29. LC Agren L Ekman B Lowenadler NY Lycke 1997 Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit J Immunol 158 3936 46
30. TD Connell 2007 Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins Expert Rev Vaccines 6 821 34
31. P Stickings M Peyre L Coombes R Rappuoli G Del Giudice CD Partidos D Sesardic 2008 Transcutaneous immunization with Cross-Reacting Material CRM197 of Diphtheria Toxin Boosts Functional Antibody Levels in Mice Primed Parenterally with Adsorbed Diphtheria Toxoid Vaccine Infect Immun 76 1766 1773
32. I Skountzou FS Quan J Jacob RW Compans SM Kang 2006 Transcutaneous immunization with inactivated influenza virus induces protective immune responses Vaccine 24 6110 19
33. F Anjuere A George-Chandy F Audant D Rousseau J Holmgren C Czerkinsky 2003 Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses J Immunol 170 1586 92
34. H Hemmi O Takeuchi T Kawai T Kaisho S Sato H Sanjo M Matsumoto K Hoshino H Wagner K Takeda S Akira 2000 A Toll-like receptor recognizes bacterial DNA Nature 408 740 5
35. LS Miller OE Sorensen PT Liu HR Jalian D Eshtiaghpour BE Behmanesh W Chung TD Starner J Kim PA Sieling T Ganz RL Modlin 2005 TGF-alpha regulates TLR expression and function on epidermal keratinocytes J Immunol 174 6137 43
36. M Ozel S Hoglund HR Gelderblom B Morein 1989 Quaternary structure of the immunostimulating complex (iscom) J Ultrastruct Mol Struct Res 102 240 8
37. A Ghochikyan M Mkrtichyan I Petrushina N Movsesyan A Karapetyan DH Cribbs MG Agadjanyan 2006 Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch Vaccine 24 2275 82
38. K Hoshino O Takeuchi T Kawai H Sanjo T Ogawa Y Takeda K Takeda S Akira 1999 Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J Immunol 162 3749 52
39. AM van der Aar RM Sylva-Steenland JD Bos ML Kapsenberg EC de Jong MB Teunissen 2007 Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition J Immunol 178 1986 90
40. MC Lebre AM van der Aar L van Baarsen TM van Capel JH Schuitemaker ML Kapsenberg EC de Jong 2007 Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9 J Invest Dermatol 127 331 41
41. G Kollisch BN Kalali V Voelcker R Wallich H Behrendt J Ring S Bauer T Jakob M Mempel M Ollert 2005 Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes Immunology 114 531 41
42. Male D, Brostoff J, Roth DB, Roitt I. Immunology. Oxford: Elsevier; 2006.
43. M Kool T Soullie M van Nimwegen MA Willart F Muskens S Jung HC Hoogsteden H Hammad BN Lambrecht 2008 Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells J Exp Med 205 869 82
44. T Lagergard B Trollfors BA Claesson J Karlberg J Taranger 1992 Determination of neutralizing antibodies and specific immunoglobulin isotype levels in infants after vaccination against diphtheria Eur J Clin Microbiol Infect Dis 11 341 5
45. L Bungener F Geeraedts W Ter Veer J Medema J Wilschut A Huckriede 2008 Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection Vaccine 26 2350 9
46. T Scharton-Kersten J Yu R Vassell D O'Hagan CR Alving GM Glenn 2000 Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants Infect Immun 68 5306 13
47. C Arigita T Luijkx W Jiskoot M Poelen WE Hennink DJ Crommelin P Ley C Els GF Kersten 2005 Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives Vaccine 23 5091 8
48. YH Lee DW Shin JH Lee HW Nam MH Ahn 2007 Vaccination against murine toxoplasmosis using recombinant Toxoplasma gondii SAG3 antigen alone or in combination with Quil A Yonsei Med J 48 396 404