Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays

Journal of Controlled Release

Volumn 148, Issue 3, 2010, Pages 327-333

  Chen, Xianfeng ^a   Kask, Angela Shaulov ^b   Crichton, Michael L ^a   McNeilly, Celia ^a   Yukiko, Sally ^a   Dong, Lichun ^b   Marshak, Joshua O ^b   Jarrahian, Courtney ^c   Fernando, Germain J P ^a   Chen, Dexiang ^c   Koelle, David M ^b,d   Kendall, Mark A F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF WASHINGTON   (United States)

^c PATH   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

DNA vaccine; Microprojection; Skin vaccine delivery

Indexed keywords

ANTIBODY RESPONSE; ANTIGEN PRESENTING CELLS; DNA VACCINATION; DNA VACCINE; EPIDERMAL LAYERS; INTRAMUSCULAR INJECTIONS; MICRO-PROJECTION ARRAYS; MICROPROJECTION; MOUSE SKIN; TARGETED DELIVERY;

ANTIGENS; DNA; VIRUSES;

VACCINES;

DNA VACCINE; HERPES SIMPLEX VACCINE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG DOSAGE FORM COMPARISON; EPIDERMIS; FEMALE; GENE DELIVERY SYSTEM; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; MOUSE; NANODEVICE; NONHUMAN; PRIORITY JOURNAL; SKIN;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIBODY FORMATION; DRUG DELIVERY SYSTEMS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; MICE; MICE, INBRED BALB C; SKIN; SKIN ABSORPTION; VACCINATION; VACCINES, DNA;

EID: 78649802326     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.09.001     Document Type: Article

References (49)

1. D. Fioretti, S. Iurescia, V.M. Fazio, and M. Rinaldi DNA vaccines: developing new strategies against cancer J. Biomed. Biotechnol. 2010 Article No.: 174378.
2. H.L. Robinson, and T.M. Pertmer DNA vaccines for viral infections: basic studies and applications Adv. Virus Res. 55 2000 1 74
3. A. Cattamanchi, C.M. Posavad, A. Wald, Y. Baine, J. Moses, T.J. Higgins, R. Ginsberg, R. Ciccarelli, L. Corey, and D.M. Koelle Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system Clin. Vaccine Immunol. 15 11 2008 1638 1643
4. J.R. Haynes Particle-mediated DNA vaccine delivery to the skin Expert Opin. Biol. Ther. 4 6 2004 889 900
5. R.B. MacGregor, R. Ginsberg, K.E. Ugen, Y. Baine, C.U. Kang, X.M. Tu, T. Higgins, D.B. Weiner, and J.D. Boyer T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev AIDS 16 16 2002 2137 2143
6. R.R. MacGregor, J.D. Boyer, R.B. Ciccarelli, R.S. Ginsberg, and D.B. Weiner Safety and immune responses to a DNA-based human immunodeficiency virus (HIV) type I env/rev vaccine in HIV-infected recipients: follow-up data J. Infect. Dis. 181 1 2000 406-406
7. R.R. MacGregor, J.D. Boyer, K.E. Ugen, K.E. Lacy, S.J. Gluckman, M.L. Bagarazzi, M.A. Chattergoon, Y. Baine, T.J. Higgins, R.B. Ciccarelli, L.R. Coney, R.S. Ginsberg, and D.B. Weiner First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response J. Infect. Dis. 178 1 1998 92 100
8. J.D. Boyer, M.A. Chattergoon, K.E. Ugen, A. Shah, M. Bennett, A. Cohen, S. Nyland, K.E. Lacy, M.L. Bagarazzi, T.J. Higgins, Y. Baine, R.B. Ciccarelli, R.S. Ginsberg, R.R. MacGregor, and D.B. Weiner Enhancement of cellular immune response in HIV-1 seropositive individuals: a DNA-based trial Clin. Immunol. 90 1 1999 100 107
9. J.D. Boyer, A.D. Cohen, S. Vogt, K. Schumann, B. Nath, L. Ahn, K. Lacy, M.L. Bagarazzi, T.J. Higgins, Y. Baine, R.B. Ciccarelli, R.S. Ginsberg, R.R. MacGregor, and D.B. Weiner Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines J. Infect. Dis. 181 2 2000 476 483
10. R.B. Wang, D.L. Doolan, T.P. Le, R.C. Hedstrom, K.M. Coonan, Y.P. Charoenvit, T.R. Jones, P. Hobart, M. Margalit, J. Ng, W.R. Weiss, M. Sedegah, C. de Taisne, J.A. Norman, and S.L. Hoffman Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine Science 282 5388 1998 476 480
11. R.B. Wang, J. Epstein, F.M. Baraceros, E.J. Gorak, Y. Charoenvit, D.J. Carucci, R.C. Hedstrom, N. Rahardjo, T. Gay, P. Hobart, R. Stout, T.R. Jones, T.L. Richie, S.E. Parker, D.L. Doolan, J. Norman, and S.L. Hoffman Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine PNAS 98 19 2001 10817 10822
12. T.P. Le, K.M. Coonan, R.C. Hedstrom, Y. Charoenvit, M. Sedegah, J.E. Epstein, S. Kumar, R.B. Wang, D.L. Doolan, J.D. Maguire, S.E. Parker, P. Hobart, J. Norman, and S.L. Hoffman Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers Vaccine 18 18 2000 1893 1901
13. T.S. Kupper, and R.C. Fuhlbrigge Immune surveillance in the skin: mechanisms and clinical consequences Nat. Rev. Immunol. 4 3 2004 211 222
14. K. Nagao, F. Ginhoux, W.W. Leitner, S. Motegi, C.L. Bennett, B.E. Clausen, M. Merad, and M.C. Udey Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions PNAS 106 9 2009 3312 3317
15. J.D. Bos, and M. Meinardi The 500 Dalton rule for the skin penetration of chemical compounds and drugs Exp. Dermatol. 9 3 2000 165 169
16. M. Kendall, T. Mitchell, and P. Wrighton-Smith Intradermal ballistic delivery of micro-particles into excised human skin for pharmaceutical applications J. Biomech. 37 11 2004 1733 1741 (Pubitemid 39237586)
17. M. Kendall, S. Rishworth, F. Carter, and T. Mitchell Effects of relative humidity and ambient temperature on the ballistic delivery of micro-particles to excised porcine skin J. Invest. Dermatol. 122 3 2004 739 746
18. S. Mitragotri Innovation - current status and future prospects of needle-free liquid jet injectors Nat. Rev. Drug Discov. 5 7 2006 543 548
19. M.R. Prausnitz, and R. Langer Transdermal drug delivery Nat. Biotechnol. 26 11 2008 1261 1268
20. P.A. Raju, N. McSloy, N.K. Truong, and M.A.F. Kendall Assessment of epidermal cell viability by near infrared multi-photon microscopy following ballistic delivery of gold micro-particles Vaccine 24 21 2006 4644 4647
21. Y.C. Kim, F.S. Quan, R.W. Compans, S.M. Kang, and M.R. Prausnitz Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity J. Control. Release 142 2 2010 187 195
22. T.W. Prow, X. Chen, N.A. Prow, G.J. Fernando, C.S. Tan, et al., Nanopatch-targeted skin vaccination against West Nile virus and Chikungunya virus in mice, Small, 6 (16) (2010) 1776-1784.
23. A. Yamaoka, X. Guan, S. Takemoto, M. Nishikawa, and Y. Takakura Development of a novel Hsp70-based DNA vaccine as a multifunctional antigen delivery system J. Control. Release 142 3 2010 411 415
24. Y. Zhou, F. Fang, J.J. Chen, H.D. Wang, H.Y. Chang, Z.D. Yang, and Z. Chen Electroporation at low voltages enables DNA vaccine to provide protection against a lethal H5N1 avian influenza virus challenge in mice Intervirology 51 4 2008 241 246
25. A.R. Denet, R. Vanbever, and V. Preat Skin electroporation for transdermal and topical delivery Adv. Drug Deliv. Rev. 56 5 2004 659 674
26. M. Wallace, B. Evans, S. Woods, R. Mogg, L. Zhang, A.C. Finnefrock, D. Rabussay, M. Fons, J. Mallee, D. Mehrotra, F. Schodel, and L. Musey Tolerability of two sequential electroporation treatments using MedPulser DNA Delivery System (DDS) in healthy adults Mol. Ther. 17 5 2009 922 928
27. H.S. Gill, J. Soderholm, M.R. Prausnitz, and M. Sallberg Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine Gene Ther. 17 6 2010 811 814
28. M.L. Crichton, A. Ansaldo, X. Chen, T.W. Prow, G.J.P. Fernando, and M.A.F. Kendall The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine Biomaterials 31 2010 4562 4572
29. G.J.P. Fernando, X. Chen, T.W. Prow, M.L. Crichton, J.F. Emily, M.S. Roberts, I.H. Frazer, L.E. Brown, and M.A.F. Kendall Potent immunity to low doses of influenza vaccine by direct delivery to immune cells in skin PLoS ONE 5 4 2010 e10266
30. X. Chen, T.W. Prow, M.L. Crichton, D.W.K. Jenkins, M.S. Roberts, I.H. Frazer, G.J.P. Fernando, and M.A.F. Kendall Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin J. Control. Release 139 2009 212 220
31. S.W. Han, C. Nakamura, I. Obataya, N. Nakamura, and J. Miyake Gene expression using an ultrathin needle enabling accurate displacement and low invasiveness Biochem. Biophys. Res. Commun. 332 3 2005 633 639
32. D.W. Kimberlin Neonatal herpes simplex infection Clin. Microbiol. Rev. 17 1 2004 1 13
33. M. Jazayeri, H. Soleimanjahi, F. Fotouhi, and N. Pakravan Comparison of intramuscular and footpad subcutaneous immunization with DNA vaccine encoding HSV-gD2 in mice Comp. Immunol. Microbiol. Infect. Dis. 32 5 2009 453 461
34. V. Landolfi, C.D. Zarley, and A.S. Abramovitz Baculovirus-expressed herpes-simplex virus type-2 glycoprotein-D is immunogenic and protective against lethal HSV challenge Vaccine 11 4 1993 407 414
35. http://www.who.int/vaccine-research/diseases/soa-std/en/index3.html
36. D. Bernstein Glycoprotein D adjuvant herpes simplex virus vaccine Expert Rev. Vaccines 4 5 2005 615 627
37. L.R. Stanberry, S.L. Spruance, A.L. Cunningham, D.I. Bernstein, A. Mindel, S. Sacks, S. Tyring, F.Y. Aoki, M. Slaoui, M. Denis, P. Vandepapeliere, and G. Dubin E. GlaxoSmithKline herpes vaccine, glycoprotein-D-adjuvant vaccine to prevent genital herpes N Engl J. Med. 347 21 2002 1652 1661
38. M.B. Parr, L. Kepple, M.R. McDermott, M.D. Drew, J.J. Bozzola, and E.L. Parr A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2 Lab. Invest. 70 3 1994 369 380
39. M.M. Linehan, S. Richman, C. Krummenacher, R.J. Eisenberg, G.H. Cohen, and A. Iwasaki In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa J. Virol. 78 5 2004 2530 2536
40. H.S. Gill, and M.R. Prausnitz Coating formulations for microneedles Pharm. Res. 24 7 2007 1369 1380
41. J.A. Matriano, M. Cormier, J. Johnson, W.A. Young, M. Buttery, K. Nyam, and P.E. Daddona Macroflux (R) microprojection array patch technology: a new and efficient approach for intracutaneous immunization Pharm. Res. 19 1 2002 63 70
42. W.J. Mulholland, E.A.H. Arbuthnott, B.J. Bellhouse, J.F. Cornhill, J.M. Austyn, M.A.F. Kendall, Z.F. Cui, and U.K. Tirlapur Multiphoton high-resolution 3D imaging of Langerhans cells and keratinocytes in the mouse skin model adopted for epidermal powdered immunization J. Invest. Dermatol. 126 7 2006 1541 1548
43. L.G. Ng, A. Hsu, M.A. Mandell, B. Roediger, C. Hoeller, P. Mrass, A. Iparraguirre, L.L. Cavanagh, J.A. Triccas, S.M. Beverley, P. Scott, and W. Weninger Migratory dermal dendritic cells act as rapid sensors of protozoan parasites PLoS Pathog. 4 11 2008
44. S.V. Littel-van den Hurk, D. Hannaman, Electroporation for DNA immunization: clinical application. Expert Rev. Vaccines 9(5) (2010) 503-517.
45. S.P. Deshpande, U. Kumaraguru, and B.T. Rouse Why do we lack an effective vaccine against herpes simplex virus infections? Microbes Infect. 2 8 2000 973 978
46. J.H. McDoland Handbook of Biological Statistics second ed. 2009 Sparky House Publishing Baltimore, Maryland
47. S. Babiuk, M. Baca-Estrada, L.A. Babiuk, C. Ewen, and M. Foldvari Cutaneous vaccination: the skin as an immunologically active tissue and the challenge of antigen delivery J. Control. Release 66 2-3 2000 199 214
48. H.S. Gill, and M.R. Prausnitz Coated microneedles for transdermal delivery J. Control. Release 117 2 2007 227 237
49. D.P. Wermeling, S.L. Banks, D.A. Hudson, H.S. Gill, J. Gupta, M.R. Prausnitz, and A.L. Stinchcom Microneedles permit transdermal delivery of a skin-impermeant medication to humans PNAS 105 6 2008 2058 2063