Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin

Journal of Controlled Release

Volumn 139, Issue 1, 2009, Pages 63-72

  Chen, Huabing ^a   Zhu, Hongda ^a   Zheng, Jingnan ^a   Mou, Dongsheng ^a   Wan, Jiangling ^a   Zhang, Junyong ^a   Shi, Tielin ^a   Zhao, Yingjun ^a   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Insulin; Iontophoresis; Microneedles; Nanovesicles; Transdermal delivery

Indexed keywords

BLOOD GLUCOSE LEVEL; DIABETIC RATS; ENTRAPMENT EFFICIENCY; FLUORESCENCE IMAGING; IN-VIVO; IONTOPHORESIS; LOW PERMEATION; MEMBRANE THICKNESS; MICRONEEDLES; NANOVESICLES; NEW STRATEGY; NON-INVASIVE; PASSIVE DIFFUSIONS; PERMEATION RATE; PHYSICAL DEVICES; TRANSDERMAL DELIVERY; UNILAMELLAR;

AMINES; ELECTROTHERAPEUTICS; GLUCOSE; INSULIN; MICROCHANNELS; NEEDLES; SKIN; SUGAR (SUCROSE);

ELECTROPHORESIS;

DRUG CARRIER; GLUCOSE; INSULIN; NANOVESICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; FLUORESCENCE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; MALE; NEEDLE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; ELECTROCHEMISTRY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GUINEA PIGS; HYPOGLYCEMIC AGENTS; INSULIN; IONTOPHORESIS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR WEIGHT; NANOPARTICLES; NANOTECHNOLOGY; NEEDLES; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION;

EID: 68949218781     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.05.031     Document Type: Article

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