Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol

Journal of Micromechanics and Microengineering

Volumn 16, Issue 3, 2006, Pages 473-479

  Perennes F ^a,d   Marmiroli, B ^b   Matteucci, M ^a   Tormen, M ^b   Vaccari, L ^a   Di Fabrizio, E ^b,c  

^a SINCROTRONE TRIESTE   (Italy)

^b LABORATORIO TASC   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d EUROPEAN PATENT OFFICE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; LITHOGRAPHY; MASKS; POLYMERIZATION; POLYMETHYL METHACRYLATES; POLYVINYL ALCOHOLS; X RAYS;

3D SOFT LITHOGRAPHY; MASS-FABRICATION; MICRONEEDLE ARRAYS; X-RAY MASKS;

MICROELECTRONICS;

EID: 33344467371     PISSN: 09601317     EISSN: None     Source Type: Journal    
DOI: 10.1088/0960-1317/16/3/001     Document Type: Article

References (17)

1. Tao S L and Desai T A 2003 Microfabricated drug delivery systems: from particles to pores Adv. Drug Deliv. Rev. 55 315-28
2. Thomas B J and Finnin B C 2004 The transdermal revolution Drug Discov. Today 9 697-703
3. Barry B W 2001 Novel mechanisms and devices to enable successful transdermal drug delivery Eur. J. Pharm. Sci. 14 101-14
4. Tiwari S W and Udupa N 2003 Investigation into the potential of ionthophoresis facilited delivery of kerotolac Int. J. Pharm. 260 93-103
5. Sung K C, Fang J Y, Wang J J and Hu O Y P 2003 Transdermal delivery of nalbuphine and its prodrugs by electroporation Eur. J. Pharm. Sci. 18 63-70
6. Lavon I and Kost J 2004 Ultrasound and transdermal drug delivery Drug Discov. Today 9 670-6
7. Wang P M, Cornwell M G and Prausnitz M R 2002 Effects of microneedle tip geometry on injection and extraction in the skin Proc. 2nd Joint EMBS/BMES Conf. (Houston, TX, USA, Oct.) pp 506-7
8. Henry S, McAllister D V, Allen M G and Prausnitz M R 1998 Microfabricated microneedles: A novel approach to transdermal drug delivery J. Pharm. Sci. 87 922-5
9. Stoeber B and Liepmann D 2002 Design, fabrication and testing of a MEMS syringe Proc. of S-S Sensors and Actuators Workshop (Hilton Head.)
10. McAllister D V, Wang PM P M, Davis S P, Park J H, Canatella P J, Allen M G and Prausnitz M R 2003 Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies Proc. the National Academy of Sciences of the USA 100 pp 13755-60
11. Moon S J and Lee S S 2005 A novel fabrication method of a microneedle array using inclined deep x-ray exposure J. Micromech. Microeng. 15 903-11
12. Sugiyama S, Khumpuang S and Kawaguchi G 2004 Plain-pattern to cross-section transfer (PCT) technique for deep x-ray lithography and applications J. Micromech. Microeng. 14 1399-404
13. Pérennès F, De Bona F and Pantenburg F J 2001 Deep x-ray lithography beamline at ELETTRA Nucl. Instrum. Methods A 467-468 1274-8
14. http://www.jo-mikrotechnik.com/
15. Meyer P, El-Kholi A and Schulz J 2002 Investigations of the development rate of irradiated PMMA microstructures in deep x-ray lithography Microelectron. Eng. 63 319-28
16. Pérennès F, Marmirolli B, Tormen M, Matteucci M and Di Fabrizio E 2006 Replication of deep x-ray lithography fabricated microstructures through casting of soft material J. Microlithogr. Microfabric. Microsyst. 5 at press
17. http://www.rexco-usa.com/part.htm