메뉴 건너뛰기




Volumn 132, Issue 1, 2011, Pages 15-29

Pharmacological interventions for spinal cord injury: Where do we stand? How might we step forward?

Author keywords

Clinical trials; Erythropoietin; Fampridine; Minocycline; Mitochondria; Riluzole

Indexed keywords

4 AMINOPYRIDINE; BACLOFEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BOTULINUM TOXIN A; CANNABIS; CEFTRIAXONE; CIPROFLOXACIN; CRANBERRY EXTRACT; CYCLOSPORIN A; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; DARIFENACIN; ERYTHROPOIETIN; GLYCOPYRRONIUM BROMIDE; LEVACECARNINE; METHYLPREDNISOLONE SODIUM SUCCINATE; MINOCYCLINE; MORPHINE SULFATE; N(G) NITROARGININE METHYL ESTER; NEOSTIGMINE; OXYBUTYNIN; PRAZOSIN; PREGABALIN; RILUZOLE; SALSALATE; SOLIFENACIN; TROSPIUM CHLORIDE; UNINDEXED DRUG; VARDENAFIL; VENLAFAXINE; ZOLEDRONIC ACID;

EID: 79960570561     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.05.001     Document Type: Review
Times cited : (81)

References (315)
  • 1
    • 3142512865 scopus 로고    scopus 로고
    • International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP): Another step forward for spinal cord injury research
    • DOI 10.1038/sj.sc.3101597
    • M. Adams, and J.F. Cavanagh International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP): another step forward for spinal cord injury research Spinal Cord 42 5 2004 273 280 (Pubitemid 38903489)
    • (2004) Spinal Cord , vol.42 , Issue.5 , pp. 273-280
    • Adams, M.1    Cavanagh, J.F.R.2
  • 2
    • 37249048319 scopus 로고    scopus 로고
    • TGF-beta in neural stem cells and in tumors of the central nervous system
    • DOI 10.1007/s00441-007-0466-7
    • L. Aigner, and U. Bogdahn TGF-beta in neural stem cells and in tumors of the central nervous system Cell Tissue Res 331 1 2008 225 241 (Pubitemid 350265484)
    • (2008) Cell and Tissue Research , vol.331 , Issue.1 , pp. 225-241
    • Aigner, L.1    Bogdahn, U.2
  • 3
    • 68049098298 scopus 로고    scopus 로고
    • Neuroinflammation in spinal cord injury: Therapeutic targets for neuroprotection and regeneration
    • J.K. Alexander, and P.G. Popovich Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration Prog Brain Res 175 2009 125 137
    • (2009) Prog Brain Res , vol.175 , pp. 125-137
    • Alexander, J.K.1    Popovich, P.G.2
  • 5
    • 58149463913 scopus 로고    scopus 로고
    • Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain
    • E. Alves, Z. Binienda, F. Carvalho, C.J. Alves, E. Fernandes, and M. de Lourdes Bastos Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain Neuroscience 158 2 2009 514 523
    • (2009) Neuroscience , vol.158 , Issue.2 , pp. 514-523
    • Alves, E.1    Binienda, Z.2    Carvalho, F.3    Alves, C.J.4    Fernandes, E.5    De Lourdes Bastos, M.6
  • 6
    • 0032905498 scopus 로고    scopus 로고
    • Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury
    • DOI 10.1097/00006123-199905000-00052
    • A.P. Amar, and M.L. Levy Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury Neurosurgery 44 5 1999 1027 1040 (Pubitemid 29202863)
    • (1999) Neurosurgery , vol.44 , Issue.5 , pp. 1027-1040
    • Amar, A.P.1    Levy, M.L.2
  • 8
    • 7244242234 scopus 로고    scopus 로고
    • Targeting recovery: Priorities of the spinal cord-injured population
    • DOI 10.1089/neu.2004.21.1371
    • K.D. Anderson Targeting recovery: priorities of the spinal cord-injured population J Neurotrauma 21 10 2004 1371 1383 (Pubitemid 39435314)
    • (2004) Journal of Neurotrauma , vol.21 , Issue.10 , pp. 1371-1383
    • Anderson, K.D.1
  • 9
    • 0032831667 scopus 로고    scopus 로고
    • Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver
    • A. Andreyev, and G. Fiskum Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver Cell Death Differ 6 9 1999 825 832 (Pubitemid 29488080)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.9 , pp. 825-832
    • Andreyev, A.1    Fiskum, G.2
  • 10
    • 59349115909 scopus 로고    scopus 로고
    • Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury
    • D.P. Ankeny, and P.G. Popovich Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury Neuroscience 158 3 2009 1112 1121
    • (2009) Neuroscience , vol.158 , Issue.3 , pp. 1112-1121
    • Ankeny, D.P.1    Popovich, P.G.2
  • 11
    • 0033387588 scopus 로고    scopus 로고
    • Acetyl-l-carnitine
    • Anonymous Acetyl-l-carnitine Altern Med Rev 4 6 1999 438 441
    • (1999) Altern Med Rev , vol.4 , Issue.6 , pp. 438-441
  • 12
    • 33749523715 scopus 로고    scopus 로고
    • Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats
    • DOI 10.1097/01.brs.0000239124.41410.7a, PII 0000763220061001000007
    • Y. Arishima, T. Setoguchi, I. Yamaura, K. Yone, and S. Komiya Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats Spine 31 21 2006 2432 2438 (Phila Pa 1976) (Pubitemid 44527025)
    • (2006) Spine , vol.31 , Issue.21 , pp. 2432-2438
    • Arishima, Y.1    Setoguchi, T.2    Yamaura, I.3    Yone, K.4    Komiya, S.5
  • 13
    • 0031023404 scopus 로고    scopus 로고
    • +-channel function as an in vitro model of the ischemic penumbra: Action of lubeluzole and other neuroprotective drugs
    • DOI 10.1016/S0006-8993(96)01094-3, PII S0006899396010943
    • D. Ashton, R. Willems, J. Wynants, J. Van Reempts, R. Marrannes, and G. Clincke Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs Brain Res 745 1-2 1997 210 221 (Pubitemid 27055764)
    • (1997) Brain Research , vol.745 , Issue.1-2 , pp. 210-221
    • Ashton, D.1    Willems, R.2    Wynants, J.3    Van Reempts, J.4    Marrannes, R.5    Clincke, G.6
  • 14
    • 34249069211 scopus 로고    scopus 로고
    • Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury
    • DOI 10.1016/j.jocn.2006.03.023, PII S096758680600289X
    • O. Ates, S.R. Cayli, I. Gurses, Y. Turkoz, O. Tarim, and C.O. Cakir Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury J Clin Neurosci 14 7 2007 658 665 (Pubitemid 46783492)
    • (2007) Journal of Clinical Neuroscience , vol.14 , Issue.7 , pp. 658-665
    • Ates, O.1    Cayli, S.R.2    Gurses, I.3    Turkoz, Y.4    Tarim, O.5    Cakir, C.O.6    Kocak, A.7
  • 16
    • 0034698248 scopus 로고    scopus 로고
    • Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes
    • DOI 10.1016/S0006-8993(00)02430-6, PII S0006899300024306
    • R.D. Azbill, X. Mu, and J.E. Springer Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes Brain Res 871 2 2000 175 180 (Pubitemid 30433869)
    • (2000) Brain Research , vol.871 , Issue.2 , pp. 175-180
    • Azbill, R.D.1    Mu, X.2    Springer, J.E.3
  • 18
    • 0018621819 scopus 로고
    • Human botulism caused by Clostridium botulinum type E: The Birmingham outbreak
    • A.P. Ball, R.B. Hopkinson, I.D. Farrell, J.G. Hutchison, R. Paul, and R.D. Watson Human botulism caused by Clostridium botulinum type E: the Birmingham outbreak Q J Med 48 191 1979 473 491 (Pubitemid 10200363)
    • (1979) Quarterly Journal of Medicine , vol.48 , Issue.191 , pp. 473-491
    • Ball, A.P.1    Hopkinson, R.B.2    Farrell, I.D.3
  • 19
    • 9444291812 scopus 로고    scopus 로고
    • Recombinant human erythropoietin: Possible role as an antioxidant in premature rabbits
    • F.M. Bany-Mohammed, S. Slivka, and M. Hallman Recombinant human erythropoietin: possible role as an antioxidant in premature rabbits Pediatr Res 40 3 1996 381 387 (Pubitemid 26282569)
    • (1996) Pediatric Research , vol.40 , Issue.3 , pp. 381-387
    • Bany-Mohammed, P.M.1    Slivka, S.2    Hallman, M.3
  • 20
    • 33646571167 scopus 로고    scopus 로고
    • Pharmacological approaches to repair the injured spinal cord
    • DOI 10.1089/neu.2006.23.318
    • D.C. Baptiste, and M.G. Fehlings Pharmacological approaches to repair the injured spinal cord J Neurotrauma 23 3-4 2006 318 334 (Pubitemid 43726313)
    • (2006) Journal of Neurotrauma , vol.23 , Issue.3-4 , pp. 318-334
    • Baptiste, D.C.1    Fehlings, M.G.2
  • 21
    • 0025213383 scopus 로고
    • Glutamate receptors of a quisqualate-kainate subtype are involved in the presynaptic regulation of dopamine release in the cat caudate nucleus in vivo
    • L. Barbeito, A. Cheramy, G. Godeheu, J.M. Desce, and J. Glowinski Glutamate receptors of a quisqualate-kainate subtype are involved in the presynaptic regulation of dopamine release in the cat caudate nucleus in vivo Eur J Neurosci 2 4 1990 304 311 (Pubitemid 20147069)
    • (1990) European Journal of Neuroscience , vol.2 , Issue.4 , pp. 304-311
    • Barbeito, L.1    Cheramy, A.2    Godeheu, G.3    Desce, J.M.4    Glowinski, J.5
  • 22
    • 0030271253 scopus 로고    scopus 로고
    • Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat
    • DOI 10.1016/S0306-4522(96)00249-7
    • P. Barneoud, M. Mazadier, J.M. Miquet, S. Parmentier, P. Dubedat, and A. Doble Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat Neuroscience 74 4 1996 971 983 (Pubitemid 26313341)
    • (1996) Neuroscience , vol.74 , Issue.4 , pp. 971-983
    • Barneoud, P.1    Mazadier, M.2    Miquet, J.-M.3    Parmentier, S.4    Dubedat, P.5    Doble, A.6    Boireau, A.7
  • 23
    • 0025194861 scopus 로고
    • Acetyl-l-carnitine 2: effects on learning and memory performance of aged rats in simple and complex mazes
    • DOI 10.1016/0197-4580(90)90110-L
    • C.A. Barnes, A.L. Markowska, D.K. Ingram, H. Kametani, E.L. Spangler, and V.J. Lemken Acetyl-l-carnitine. 2: effects on learning and memory performance of aged rats in simple and complex mazes Neurobiol Aging 11 5 1990 499 506 (Pubitemid 20297142)
    • (1990) Neurobiology of Aging , vol.11 , Issue.5 , pp. 499-506
    • Barnes, C.A.1    Markowska, A.L.2    Ingram, D.K.3    Kametani, H.4    Spangler, E.L.5    Lemken, V.J.6    Olton, D.S.7
  • 24
    • 0028795058 scopus 로고
    • Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat
    • D. Bartholdi, and M.E. Schwab Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat Brain Res 672 1-2 1995 177 186
    • (1995) Brain Res , vol.672 , Issue.12 , pp. 177-186
    • Bartholdi, D.1    Schwab, M.E.2
  • 25
    • 21244446551 scopus 로고    scopus 로고
    • Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
    • DOI 10.1074/jbc.C500089200
    • E. Basso, L. Fante, J. Fowlkes, V. Petronilli, M.A. Forte, and P. Bernardi Properties of the permeability transition pore in mitochondria devoid of cyclophilin D J Biol Chem 280 19 2005 18558 18561 (Pubitemid 41379552)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 18558-18561
    • Basso, E.1    Fante, L.2    Fowlkes, J.3    Petronilli, V.4    Forte, M.A.5    Bernardi, P.6
  • 26
    • 0028293108 scopus 로고
    • Modeling of acute spinal cord injury in the rat: Neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673
    • DOI 10.1006/exnr.1994.1042
    • D.L. Behrmann, J.C. Bresnahan, and M.S. Beattie Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673 Exp Neurol 126 1 1994 61 75 (Pubitemid 24131103)
    • (1994) Experimental Neurology , vol.126 , Issue.1 , pp. 61-75
    • Behrmann, D.L.1    Bresnahan, J.C.2    Beattie, M.S.3
  • 27
    • 0022384359 scopus 로고
    • 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neutrotransmission - II. Biochemical properties
    • DOI 10.1016/0028-3908(85)90196-0
    • J. Benavides, J.C. Camelin, N. Mitrani, F. Flamand, A. Uzan, and J.J. Legrand 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission-II. Biochemical properties Neuropharmacology 24 11 1985 1085 1092 (Pubitemid 16176969)
    • (1985) Neuropharmacology , vol.24 , Issue.11 , pp. 1085-1092
    • Benavides, J.1    Camelin, J.C.2    Mitrani, N.3
  • 28
    • 0026334826 scopus 로고
    • Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre
    • E. Benoit, and D. Escande Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre Pflugers Arch 419 6 1991 603 609
    • (1991) Pflugers Arch , vol.419 , Issue.6 , pp. 603-609
    • Benoit, E.1    Escande, D.2
  • 29
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • DOI 10.1056/NEJM199403033300901
    • G. Bensimon, L. Lacomblez, and V. Meininger A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group N Engl J Med 330 9 1994 585 591 (Pubitemid 24065791)
    • (1994) New England Journal of Medicine , vol.330 , Issue.9 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 30
    • 0030592172 scopus 로고    scopus 로고
    • The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
    • DOI 10.1016/0005-2728(96)00041-2
    • P. Bernardi The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death Biochim Biophys Acta 1275 1-2 1996 5 9 (Pubitemid 26233155)
    • (1996) Biochimica et Biophysica Acta - Bioenergetics , vol.1275 , Issue.1-2 , pp. 5-9
    • Bernardi, P.1
  • 31
    • 0029998621 scopus 로고    scopus 로고
    • The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
    • DOI 10.1007/BF02110643
    • P. Bernardi, and V. Petronilli The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal J Bioenerg Biomembr 28 2 1996 131 138 (Pubitemid 26131526)
    • (1996) Journal of Bioenergetics and Biomembranes , vol.28 , Issue.2 , pp. 131-138
    • Bernardi, P.1    Petronilli, V.2
  • 34
    • 67650465866 scopus 로고    scopus 로고
    • Sustained-release fampridine for multiple sclerosis
    • C.T. Bever, and S.I. Judge Sustained-release fampridine for multiple sclerosis Expert Opin Investig Drugs 18 7 2009 1013 1024
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.7 , pp. 1013-1024
    • Bever, C.T.1    Judge, S.I.2
  • 36
    • 0024418456 scopus 로고
    • Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
    • A.R. Blight Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury Brain Res Bull 22 1 1989 47 52
    • (1989) Brain Res Bull , vol.22 , Issue.1 , pp. 47-52
    • Blight, A.R.1
  • 37
    • 0036829598 scopus 로고    scopus 로고
    • Miracles and molecules - Progress in spinal cord repair
    • DOI 10.1038/nn939
    • A.R. Blight Miracles and molecules-progress in spinal cord repair Nat Neurosci 5 2002 1051 1054 Suppl (Pubitemid 35247197)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1051-1054
    • Blight, A.R.1
  • 38
    • 0034009227 scopus 로고    scopus 로고
    • Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation
    • DOI 10.1006/exnr.1999.7250
    • Y.E. Bogaert, K.F. Sheu, P.R. Hof, A.M. Brown, J.P. Blass, and R.E. Rosenthal Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation Exp Neurol 161 1 2000 115 126 (Pubitemid 30136534)
    • (2000) Experimental Neurology , vol.161 , Issue.1 , pp. 115-126
    • Bogaert, Y.E.1    Sheu, K.-F.R.2    Hof, P.R.3    Brown, A.M.4    Blass, J.P.5    Rosenthal, R.E.6    Fiskum, G.7
  • 40
    • 28544446056 scopus 로고    scopus 로고
    • Erythropoietin enhances neurological recovery after experimental spinal cord injury
    • B.O. Boran, A. Colak, and M. Kutlay Erythropoietin enhances neurological recovery after experimental spinal cord injury Restor Neurol Neurosci 23 5-6 2005 341 345 (Pubitemid 41746167)
    • (2005) Restorative Neurology and Neuroscience , vol.23 , Issue.5-6 , pp. 341-345
    • Boran, B.O.1    Colak, A.2    Kutlay, M.3
  • 41
    • 0023214855 scopus 로고
    • Physiological effects of 4-aminopyridine on demyelinated mammalian motor and sensory fibers
    • C.M. Bowe, J.D. Kocsis, E.F. Targ, and S.G. Waxman Physiological effects of 4-aminopyridine on demyelinated mammalian motor and sensory fibers Ann Neurol 22 2 1987 264 268 (Pubitemid 17122589)
    • (1987) Annals of Neurology , vol.22 , Issue.2 , pp. 264-268
    • Bowe, C.M.1    Kocsis, J.D.2    Targ, E.F.3    Waxman, S.G.4
  • 42
    • 0024992390 scopus 로고
    • Methylprednisolone in the management of acute spinal cord injuries
    • M.B. Bracken Methylprednisolone in the management of acute spinal cord injuries Med J Aust 153 6 1990 368 (Pubitemid 20297099)
    • (1990) Medical Journal of Australia , vol.153 , Issue.6 , pp. 368
    • Bracken, M.B.1
  • 44
    • 0026601887 scopus 로고
    • Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study
    • M.B. Bracken, M.J. Shepard, W.F. Collins Jr., T.R. Holford, D.S. Baskin, and H.M. Eisenberg Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study J Neurosurg 76 1 1992 23 31
    • (1992) J Neurosurg , vol.76 , Issue.1 , pp. 23-31
    • Bracken, M.B.1    Shepard, M.J.2    Collins Jr., W.F.3    Holford, T.R.4    Baskin, D.S.5    Eisenberg, H.M.6
  • 46
    • 33746282112 scopus 로고    scopus 로고
    • Spinal cord repair strategies: Why do they work?
    • DOI 10.1038/nrn1964, PII NRN1964
    • E.J. Bradbury, and S.B. McMahon Spinal cord repair strategies: why do they work? Nat Rev Neurosci 7 8 2006 644 653 (Pubitemid 44106746)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.8 , pp. 644-653
    • Bradbury, E.J.1    McMahon, S.B.2
  • 47
    • 0026544582 scopus 로고
    • Involvement of lipid peroxidation in CNS injury
    • J.M. Braughler, and E.D. Hall Involvement of lipid peroxidation in CNS injury J Neurotrauma 9 Suppl 1 1992 S1 S7
    • (1992) J Neurotrauma , vol.9 , Issue.SUPPL. 1
    • Braughler, J.M.1    Hall, E.D.2
  • 48
  • 49
    • 0029561991 scopus 로고
    • Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: Relationship between pore opening and the activity of mitochondrial phospholipases
    • DOI 10.1021/bi00050a027
    • K.M. Broekemeier, and D.R. Pfeiffer Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases Biochemistry 34 50 1995 16440 16449 (Pubitemid 26006490)
    • (1995) Biochemistry , vol.34 , Issue.50 , pp. 16440-16449
    • Broekemeier, K.M.1    Pfeiffer, D.R.2
  • 50
    • 0036313059 scopus 로고    scopus 로고
    • Calcium-induced Cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane
    • DOI 10.1046/j.0022-3042.2001.00671.x
    • N. Brustovetsky, T. Brustovetsky, R. Jemmerson, and J.M. Dubinsky Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane J Neurochem 80 2 2002 207 218 (Pubitemid 34809366)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.2 , pp. 207-218
    • Brustovetsky, N.1    Brustovetsky, T.2    Jemmerson, R.3    Dubinsky, J.M.4
  • 51
    • 0030255620 scopus 로고    scopus 로고
    • A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis
    • H.M. Bryson, B. Fulton, and P. Benfield Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis Drugs 52 4 1996 549 563 (Pubitemid 26340539)
    • (1996) Drugs , vol.52 , Issue.4 , pp. 549-563
    • Bryson, H.M.1    Benfield, P.2
  • 54
    • 0036479012 scopus 로고    scopus 로고
    • Apoptosis-inducing factor (AIF): A novel caspase-independent death effector released from mitochondria
    • C. Cande, I. Cohen, E. Daugas, L. Ravagnan, N. Larochette, and N. Zamzami Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria Biochimie 84 2-3 2002 215 222
    • (2002) Biochimie , vol.84 , Issue.23 , pp. 215-222
    • Cande, C.1    Cohen, I.2    Daugas, E.3    Ravagnan, L.4    Larochette, N.5    Zamzami, N.6
  • 56
    • 0026403940 scopus 로고
    • Acetyl-l-carnitine: A drug able to slow the progress of Alzheimer's disease?
    • A. Carta, and M. Calvani Acetyl-l-carnitine: a drug able to slow the progress of Alzheimer's disease? Ann N Y Acad Sci 640 1991 228 232
    • (1991) Ann N y Acad Sci , vol.640 , pp. 228-232
    • Carta, A.1    Calvani, M.2
  • 57
    • 33750071388 scopus 로고    scopus 로고
    • The effects of systemically administered methylprednisolone and recombinant human erythropoietin after acute spinal cord compressive injury in rats
    • DOI 10.1007/s00586-006-0091-2
    • A. Cetin, K. Nas, H. Buyukbayram, A. Ceviz, and G. Olmez The effects of systemically administered methylprednisolone and recombinant human erythropoietin after acute spinal cord compressive injury in rats Eur Spine J 15 10 2006 1539 1544 (Pubitemid 44583667)
    • (2006) European Spine Journal , vol.15 , Issue.10 , pp. 1539-1544
    • Cetin, A.1    Nas, K.2    Buyukbayram, H.3    Ceviz, A.4    Olmez, G.5
  • 58
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • DOI 10.1038/35022514
    • J. Chai, C. Du, J.W. Wu, S. Kyin, X. Wang, and Y. Shi Structural and biochemical basis of apoptotic activation by Smac/DIABLO Nature 406 6798 2000 855 862 (Pubitemid 30664254)
    • (2000) Nature , vol.406 , Issue.6798 , pp. 855-862
    • Chai, J.1    Du, C.2    Wu, J.-W.3    Kyin, S.4    Wang, X.5    Shi, Y.6
  • 60
    • 0026490217 scopus 로고
    • Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo
    • A. Cheramy, L. Barbeito, G. Godeheu, and J. Glowinski Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo Neurosci Lett 147 2 1992 209 212
    • (1992) Neurosci Lett , vol.147 , Issue.2 , pp. 209-212
    • Cheramy, A.1    Barbeito, L.2    Godeheu, G.3    Glowinski, J.4
  • 62
    • 0035181558 scopus 로고    scopus 로고
    • Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: Transcriptional regulation of inflammatory and neurotrophic genes
    • T. Chikawa, T. Ikata, S. Katoh, Y. Hamada, K. Kogure, and K. Fukuzawa Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes J Neurotrauma 18 1 2001 93 103 (Pubitemid 32055459)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.1 , pp. 93-103
    • Chikawa, T.1    Ikata, T.2    Katoh, S.3    Hamada, Y.4    Kogure, K.5    Fukuzawa, K.6
  • 63
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 8 1988 623 634
    • (1988) Neuron , vol.1 , Issue.8 , pp. 623-634
    • Choi, D.W.1
  • 64
    • 67349272341 scopus 로고    scopus 로고
    • Modeling spinal cord contusion, dislocation, and distraction: Characterization of vertebral clamps, injury severities, and node of Ranvier deformations
    • A.M. Choo, J. Liu, Z. Liu, M. Dvorak, W. Tetzlaff, and T.R. Oxland Modeling spinal cord contusion, dislocation, and distraction: characterization of vertebral clamps, injury severities, and node of Ranvier deformations J Neurosci Methods 181 1 2009 6 17
    • (2009) J Neurosci Methods , vol.181 , Issue.1 , pp. 6-17
    • Choo, A.M.1    Liu, J.2    Liu, Z.3    Dvorak, M.4    Tetzlaff, W.5    Oxland, T.R.6
  • 65
    • 33846951494 scopus 로고    scopus 로고
    • A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain
    • T.J. Coderre, N. Kumar, C.D. Lefebvre, and J.S. Yu A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain J Neurochem 100 5 2007 1289 1299
    • (2007) J Neurochem , vol.100 , Issue.5 , pp. 1289-1299
    • Coderre, T.J.1    Kumar, N.2    Lefebvre, C.D.3    Yu, J.S.4
  • 66
    • 0028226708 scopus 로고
    • Neuroprotective effects of riluzole in ALS CSF toxicity
    • P. Couratier, P. Sindou, F. Esclaire, E. Louvel, and J. Hugon Neuroprotective effects of riluzole in ALS CSF toxicity Neuroreport 5 8 1994 1012 1014 (Pubitemid 24138122)
    • (1994) NeuroReport , vol.5 , Issue.8 , pp. 1012-1014
    • Couratier, P.1    Sindou, P.2    Esclaire, F.3    Louvel, E.4    Hugon, J.5
  • 67
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeabitity transition pore and its role in cell death
    • DOI 10.1042/0264-6021:3410233
    • M. Crompton The mitochondrial permeability transition pore and its role in cell death Biochem J 341 Pt 2 1999 233 249 (Pubitemid 29373645)
    • (1999) Biochemical Journal , vol.341 , Issue.2 , pp. 233-249
    • Crompton, M.1
  • 68
    • 0035079692 scopus 로고    scopus 로고
    • The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential
    • DOI 10.1159/000047097
    • C. Dame, S.E. Juul, and R.D. Christensen The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential Biol Neonate 79 3-4 2001 228 235 (Pubitemid 32247092)
    • (2001) Biology of the Neonate , vol.79 , Issue.3-4 , pp. 228-235
    • Dame, C.1    Juul, S.E.2    Christensen, R.D.3
  • 69
    • 0025253455 scopus 로고
    • Orally administered 4-aminopyridine improves clinical signs in multiple sclerosis
    • F.A. Davis, D. Stefoski, and J. Rush Orally administered 4-aminopyridine improves clinical signs in multiple sclerosis Ann Neurol 27 2 1990 186 192 (Pubitemid 20086640)
    • (1990) Annals of Neurology , vol.27 , Issue.2 , pp. 186-192
    • Davis, F.A.1    Stefoski, D.2    Rush, J.3
  • 70
    • 0036591533 scopus 로고    scopus 로고
    • Acetyl-l-carnitine protects against amyloid-beta neurotoxicity: Roles of oxidative buffering and ATP levels
    • S. Dhitavat, D. Ortiz, T.B. Shea, and E.R. Rivera Acetyl-l-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels Neurochem Res 27 6 2002 501 505
    • (2002) Neurochem Res , vol.27 , Issue.6 , pp. 501-505
    • Dhitavat, S.1    Ortiz, D.2    Shea, T.B.3    Rivera, E.R.4
  • 75
    • 38749086493 scopus 로고    scopus 로고
    • Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
    • DOI 10.1016/j.expneurol.2007.06.009, PII S0014488607002518
    • D.J. Donnelly, and P.G. Popovich Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury Exp Neurol 209 2 2008 378 388 (Pubitemid 351181428)
    • (2008) Experimental Neurology , vol.209 , Issue.2 , pp. 378-388
    • Donnelly, D.J.1    Popovich, P.G.2
  • 77
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • C. Du, M. Fang, Y. Li, L. Li, and X. Wang Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Cell 102 1 2000 33 42
    • (2000) Cell , vol.102 , Issue.1 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 79
  • 80
    • 7944231471 scopus 로고    scopus 로고
    • Erythropoietin is a multifunctional tissue-protective cytokine
    • S. Erbayraktar, O. Yilmaz, N. Gokmen, and M. Brines Erythropoietin is a multifunctional tissue-protective cytokine Curr Hematol Rep 2 6 2003 465 470
    • (2003) Curr Hematol Rep , vol.2 , Issue.6 , pp. 465-470
    • Erbayraktar, S.1    Yilmaz, O.2    Gokmen, N.3    Brines, M.4
  • 81
    • 0029021812 scopus 로고
    • Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures
    • A.G. Estevez, J.M. Stutzmann, and L. Barbeito Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures Eur J Pharmacol 280 1 1995 47 53
    • (1995) Eur J Pharmacol , vol.280 , Issue.1 , pp. 47-53
    • Estevez, A.G.1    Stutzmann, J.M.2    Barbeito, L.3
  • 83
    • 0019402518 scopus 로고
    • Pharmacokinetics of 4-aminopyridine in human volunteers. A preliminary study using a new GLC method for its estimation
    • J. Evenhuis, S. Agoston, P.J. Salt, A.R. de Lange, W. Wouthuyzen, and W. Erdmann Pharmacokinetics of 4-aminopyridine in human volunteers. A preliminary study using a new GLC method for its estimation Br J Anaesth 53 6 1981 567 570 (Pubitemid 11075345)
    • (1981) British Journal of Anaesthesia , vol.53 , Issue.6 , pp. 567-570
    • Evenhuis, J.1    Agoston, S.2    Salt, P.J.3
  • 84
    • 0023946078 scopus 로고
    • A potential role for excitotoxins in the pathophysiology of spinal cord injury
    • A.I. Faden, and R.P. Simon A potential role for excitotoxins in the pathophysiology of spinal cord injury Ann Neurol 23 6 1988 623 626
    • (1988) Ann Neurol , vol.23 , Issue.6 , pp. 623-626
    • Faden, A.I.1    Simon, R.P.2
  • 85
    • 0024379203 scopus 로고
    • TRH analog YM-14673 improves outcome following traumatic brain and spinal cord injury in rats: Dose-response studies
    • DOI 10.1016/0006-8993(89)90509-X
    • A.I. Faden TRH analog YM-14673 improves outcome following traumatic brain and spinal cord injury in rats: dose-response studies Brain Res 486 2 1989 228 235 (Pubitemid 19135134)
    • (1989) Brain Research , vol.486 , Issue.2 , pp. 228-235
    • Faden, A.I.1
  • 86
    • 0025165274 scopus 로고
    • Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury
    • DOI 10.1016/0014-2999(90)90227-W
    • A.I. Faden, J.A. Ellison, and L.J. Noble Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury Eur J Pharmacol 175 2 1990 165 174 (Pubitemid 20030154)
    • (1990) European Journal of Pharmacology , vol.175 , Issue.2 , pp. 165-174
    • Faden, A.I.1    Ellison, J.A.2    Noble, L.J.3
  • 87
    • 70349554348 scopus 로고    scopus 로고
    • Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta
    • X.Q. Fang, M. Fang, S.W. Fan, and C.L. Gu Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta Chin Med J (Engl) 122 14 2009 1631 1635
    • (2009) Chin Med J (Engl) , vol.122 , Issue.14 , pp. 1631-1635
    • Fang, X.Q.1    Fang, M.2    Fan, S.W.3    Gu, C.L.4
  • 88
    • 0028326586 scopus 로고
    • Effect of the 21-aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats
    • M. Farooque, Y. Olsson, and A. Holtz Effect of the 21-aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats Acta Neurol Scand 89 1994 36 41 (Pubitemid 24084106)
    • (1994) Acta Neurologica Scandinavica , vol.89 , Issue.1 , pp. 36-41
    • Farooque, M.1    Olsson, Y.2    Holtz, A.3
  • 90
    • 0029900695 scopus 로고    scopus 로고
    • Initial stabilization and medical management of acute spinal cord injury
    • M.G. Fehlings, and D. Louw Initial stabilization and medical management of acute spinal cord injury Am Fam Physician 54 1 1996 155 162 (Pubitemid 26242141)
    • (1996) American Family Physician , vol.54 , Issue.1 , pp. 155-162
    • Fehlings, M.G.1    Louw, D.2
  • 91
    • 21344461953 scopus 로고    scopus 로고
    • Current status of clinical trials for acute spinal cord injury
    • M.G. Fehlings, and D.C. Baptiste Current status of clinical trials for acute spinal cord injury Injury 36 Suppl 2 2005 B113 B122
    • (2005) Injury , vol.36 , Issue.SUPPL. 2
    • Fehlings, M.G.1    Baptiste, D.C.2
  • 92
    • 0026002180 scopus 로고
    • Experimental studies on spinal cord injuries in the last fifteen years
    • E. Fernandez, R. Pallini, E. Marchese, and G. Talamonti Experimental studies on spinal cord injuries in the last fifteen years Neurol Res 13 3 1991 138 159
    • (1991) Neurol Res , vol.13 , Issue.3 , pp. 138-159
    • Fernandez, E.1    Pallini, R.2    Marchese, E.3    Talamonti, G.4
  • 93
    • 33646598662 scopus 로고    scopus 로고
    • Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury
    • DOI 10.1111/j.1471-4159.2006.03799.x
    • B.W. Festoff, S. Ameenuddin, P.M. Arnold, A. Wong, K.S. Santacruz, and B.A. Citron Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury J Neurochem 97 5 2006 1314 1326 (Pubitemid 43725571)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.5 , pp. 1314-1326
    • Festoff, B.W.1    Ameenuddin, S.2    Arnold, P.M.3    Wong, A.4    Santacruz, K.S.5    Citron, B.A.6
  • 94
    • 0033782296 scopus 로고    scopus 로고
    • Mitochondrial participation in ischemic and traumatic neural cell death
    • G. Fiskum Mitochondrial participation in ischemic and traumatic neural cell death J Neurotrauma 17 10 2000 843 855
    • (2000) J Neurotrauma , vol.17 , Issue.10 , pp. 843-855
    • Fiskum, G.1
  • 97
    • 0038305638 scopus 로고    scopus 로고
    • Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: A mechanistic target-site approach to neuroprotection
    • D.A. Fox, A.T. Poblenz, L. He, J.B. Harris, and C.J. Medrano Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection Eur J Ophthalmol 13 Suppl 3 2003 S44 S56
    • (2003) Eur J Ophthalmol , vol.13 , Issue.SUPPL. 3
    • Fox, D.A.1    Poblenz, A.T.2    He, L.3    Harris, J.B.4    Medrano, C.J.5
  • 98
    • 0032528154 scopus 로고    scopus 로고
    • Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
    • H. Friberg, M. Ferrand-Drake, F. Bengtsson, A.P. Halestrap, and T. Wieloch Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death J Neurosci 18 14 1998 5151 5159 (Pubitemid 28311932)
    • (1998) Journal of Neuroscience , vol.18 , Issue.14 , pp. 5151-5159
    • Friberg, H.1    Ferrand-Drake, M.2    Bengtsson, F.3    Halestrap, A.P.4    Wieloch, T.5
  • 99
    • 0036479054 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in acute neurodegeneration
    • H. Friberg, and T. Wieloch Mitochondrial permeability transition in acute neurodegeneration Biochimie 84 2-3 2002 241 250
    • (2002) Biochimie , vol.84 , Issue.23 , pp. 241-250
    • Friberg, H.1    Wieloch, T.2
  • 100
    • 32644434547 scopus 로고    scopus 로고
    • Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease
    • DOI 10.1016/j.expneurol.2005.11.010, PII S0014488605004206
    • E. Fumagalli, P. Bigini, S. Barbera, M. De Paola, and T. Mennini Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease Exp Neurol 198 1 2006 114 128 (Pubitemid 43243750)
    • (2006) Experimental Neurology , vol.198 , Issue.1 , pp. 114-128
    • Fumagalli, E.1    Bigini, P.2    Barbera, S.3    De Paola, M.4    Mennini, T.5
  • 101
    • 36549069212 scopus 로고    scopus 로고
    • Single exposure to erythropoietin modulates Nerve Growth Factor expression in the spinal cord following traumatic injury: Comparison with methylprednisolone
    • DOI 10.1016/j.ejphar.2007.09.021, PII S0014299907010485
    • F. Fumagalli, L. Madaschi, P. Brenna, L. Caffino, G. Marfia, and A.M. Di Giulio Single exposure to erythropoietin modulates nerve growth factor expression in the spinal cord following traumatic injury: comparison with methylprednisolone Eur J Pharmacol 578 1 2008 19 27 (Pubitemid 350179757)
    • (2008) European Journal of Pharmacology , vol.578 , Issue.1 , pp. 19-27
    • Fumagalli, F.1    Madaschi, L.2    Brenna, P.3    Caffino, L.4    Marfia, G.5    Di Giulio, A.M.6    Racagni, G.7    Gorio, A.8
  • 102
    • 0027525882 scopus 로고
    • GM-1 ganglioside and motor recovery following human spinal cord injury
    • F.H. Geisler GM-1 ganglioside and motor recovery following human spinal cord injury J Emerg Med 11 1993 49 55 (Pubitemid 23054999)
    • (1993) Journal of Emergency Medicine , vol.11 , Issue.SUPPL. 1 , pp. 49-55
    • Geisler, F.H.1
  • 103
    • 0027164322 scopus 로고
    • Antagonists of excitatory amino acids and endogenous opioid peptides in the treatment of experimental central nervous system injury
    • DOI 10.1016/S0196-0644(05)82746-5
    • N.T. Gentile, and T.K. McIntosh Antagonists of excitatory amino acids and endogenous opioid peptides in the treatment of experimental central nervous system injury Ann Emerg Med 22 6 1993 1028 1034 (Pubitemid 23163046)
    • (1993) Annals of Emergency Medicine , vol.22 , Issue.6 , pp. 1028-1034
    • Gentile, N.T.1    McIntosh, T.K.2
  • 108
    • 77956408004 scopus 로고    scopus 로고
    • Review of the use of the glutamate antagonist riluzole in psychiatric disorders and a description of recent use in childhood obsessive-compulsive disorder
    • P. Grant, J.Y. Song, and S.E. Swedo Review of the use of the glutamate antagonist riluzole in psychiatric disorders and a description of recent use in childhood obsessive-compulsive disorder J Child Adolesc Psychopharmacol 20 4 2010 309 315
    • (2010) J Child Adolesc Psychopharmacol , vol.20 , Issue.4 , pp. 309-315
    • Grant, P.1    Song, J.Y.2    Swedo, S.E.3
  • 109
    • 36048956106 scopus 로고    scopus 로고
    • Neuroprotection by erythropoietin administration after experimental traumatic brain injury
    • DOI 10.1016/j.brainres.2007.08.078, PII S0006899307021397
    • G. Grasso, A. Sfacteria, F. Meli, V. Fodale, M. Buemi, and D.G. Iacopino Neuroprotection by erythropoietin administration after experimental traumatic brain injury Brain Res 1182 2007 99 105 (Pubitemid 350086993)
    • (2007) Brain Research , vol.1182 , Issue.1 , pp. 99-105
    • Grasso, G.1    Sfacteria, A.2    Meli, F.3    Fodale, V.4    Buemi, M.5    Iacopino, D.G.6
  • 110
    • 26244434881 scopus 로고    scopus 로고
    • User-defined variables that affect outcome in spinal cord contusion/compression models
    • DOI 10.1016/j.expneurol.2005.08.005, PII S0014488605002785
    • R.J. Grill User-defined variables that affect outcome in spinal cord contusion/compression models Exp Neurol 196 1 2005 1 5 (Pubitemid 41416643)
    • (2005) Experimental Neurology , vol.196 , Issue.1 , pp. 1-5
    • Grill, R.J.1
  • 111
    • 43049137966 scopus 로고    scopus 로고
    • The systemic inflammatory response after spinal cord injury damages lungs and kidneys
    • D. Gris, E.F. Hamilton, and L.C. Weaver The systemic inflammatory response after spinal cord injury damages lungs and kidneys Exp Neurol 211 1 2008 259 270
    • (2008) Exp Neurol , vol.211 , Issue.1 , pp. 259-270
    • Gris, D.1    Hamilton, E.F.2    Weaver, L.C.3
  • 112
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • DOI 10.1002/ana.410390203
    • M.E. Gurney, F.B. Cutting, P. Zhai, A. Doble, C.P. Taylor, and P.K. Andrus Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis [see comments] Ann Neurol 39 2 1996 147 157 (Pubitemid 26071564)
    • (1996) Annals of Neurology , vol.39 , Issue.2 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 113
    • 0030826778 scopus 로고    scopus 로고
    • Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
    • DOI 10.1023/A:1006879618176
    • A.P. Halestrap, C.P. Connern, E.J. Griffiths, and P.M. Kerr Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury Mol Cell Biochem 174 1-2 1997 167 172 (Pubitemid 27404185)
    • (1997) Molecular and Cellular Biochemistry , vol.174 , Issue.1-2 , pp. 167-172
    • Halestrap, A.R.1    Connern, C.R.2    Griffiths, E.J.3    Kerr, P.M.4
  • 114
    • 0031013623 scopus 로고    scopus 로고
    • Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
    • A.P. Halestrap, K.Y. Woodfield, and C.P. Connern Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase J Biol Chem 272 6 1997 3346 3354
    • (1997) J Biol Chem , vol.272 , Issue.6 , pp. 3346-3354
    • Halestrap, A.P.1    Woodfield, K.Y.2    Connern, C.P.3
  • 115
    • 0036478989 scopus 로고    scopus 로고
    • The permeability transition pore complex: Another view
    • A.P. Halestrap, G.P. McStay, and S.J. Clarke The permeability transition pore complex: another view Biochimie 84 2-3 2002 153 166
    • (2002) Biochimie , vol.84 , Issue.23 , pp. 153-166
    • Halestrap, A.P.1    McStay, G.P.2    Clarke, S.J.3
  • 116
    • 0041810128 scopus 로고    scopus 로고
    • The adenine nucleotide translocase: A central component of the mitochondrial permeability transition pore and key player in cell death
    • A.P. Halestrap, and C. Brennerb The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death Curr Med Chem 10 16 2003 1507 1525 (Pubitemid 36896553)
    • (2003) Current Medicinal Chemistry , vol.10 , Issue.16 , pp. 1507-1525
    • Halestrap, A.P.1    Brenner, C.2
  • 117
    • 0020048289 scopus 로고
    • +)-ATPase activity. Dose-response analysis during 1st hour after contusion injury in the cat
    • E.D. Hall, and J.M. Braughler Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and Na+ + K+)-ATPase activity. Dose-response analysis during 1st hour after contusion injury in the cat J Neurosurg 57 2 1982 247 253 (Pubitemid 12099610)
    • (1982) Journal of Neurosurgery , vol.57 , Issue.2 , pp. 247-253
    • Hall, E.D.1    Braughler, J.M.2
  • 118
    • 0026500593 scopus 로고
    • The neuroprotective pharmacology of methylprednisolone
    • E.D. Hall The neuroprotective pharmacology of methylprednisolone J Neurosurg 76 1 1992 13 22
    • (1992) J Neurosurg , vol.76 , Issue.1 , pp. 13-22
    • Hall, E.D.1
  • 119
    • 0027301060 scopus 로고
    • Lipid antioxidants in acute central nervous system injury
    • DOI 10.1016/S0196-0644(05)82745-3
    • E.D. Hall Lipid antioxidants in acute central nervous system injury Ann Emerg Med 22 6 1993 1022 1027 (Pubitemid 23163045)
    • (1993) Annals of Emergency Medicine , vol.22 , Issue.6 , pp. 1022-1027
    • Hall, E.D.1
  • 120
    • 17444392322 scopus 로고    scopus 로고
    • Neuroprotection and Acute Spinal Cord Injury: A Reappraisal
    • DOI 10.1602/neurorx.1.1.80, PII S1545534306700098
    • E.D. Hall, and J.E. Springer Neuroprotection and acute spinal cord injury: a reappraisal NeuroRx 1 1 2004 80 100 (Pubitemid 46589342)
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 80-100
    • Hall, E.D.1    Springer, J.E.2
  • 121
    • 0027243935 scopus 로고
    • 4-Aminopyridine in chronic spinal cord injury: A controlled, double- blind, crossover study in eight patients
    • R.R. Hansebout, A.R. Blight, S. Fawcett, and K. Reddy 4-Aminopyridine in chronic spinal cord injury: a controlled, double-blind, crossover study in eight patients J Neurotrauma 10 1 1993 1 18 (Pubitemid 23153141)
    • (1993) Journal of Neurotrauma , vol.10 , Issue.1 , pp. 1-18
    • Hansebout, R.R.1    Blight, A.R.2    Fawcett, S.3    Reddy, K.4
  • 122
    • 0037449449 scopus 로고    scopus 로고
    • Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria
    • DOI 10.1016/S0006-8993(02)03798-8, PII S0006899302037988
    • M.J. Hansson, T. Persson, H. Friberg, M.F. Keep, A. Rees, and T. Wieloch Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria Brain Res 960 1-2 2003 99 111 (Pubitemid 36044567)
    • (2003) Brain Research , vol.960 , Issue.1-2 , pp. 99-111
    • Hansson, M.J.1    Persson, T.2    Friberg, H.3    Keep, M.F.4    Rees, A.5    Wieloch, T.6    Elmer, E.7
  • 124
    • 55949111684 scopus 로고    scopus 로고
    • Dosing and safety of cyclosporine in patients with severe brain injury
    • J. Hatton, B. Rosbolt, P. Empey, R. Kryscio, and B. Young Dosing and safety of cyclosporine in patients with severe brain injury J Neurosurg 109 4 2008 699 707
    • (2008) J Neurosurg , vol.109 , Issue.4 , pp. 699-707
    • Hatton, J.1    Rosbolt, B.2    Empey, P.3    Kryscio, R.4    Young, B.5
  • 125
    • 63849186608 scopus 로고    scopus 로고
    • Protection and repair of the injured spinal cord: A review of completed, ongoing, and planned clinical trials for acute spinal cord injury
    • G.W. Hawryluk, J. Rowland, B.K. Kwon, and M.G. Fehlings Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury Neurosurg Focus 25 5 2008 E14
    • (2008) Neurosurg Focus , vol.25 , Issue.5 , pp. 14
    • Hawryluk, G.W.1    Rowland, J.2    Kwon, B.K.3    Fehlings, M.G.4
  • 128
    • 0037380712 scopus 로고    scopus 로고
    • Pharmacokinetics of an immediate-release oral formulation of fampridine (4-aminopyridine) in normal subjects and patients with spinal cord injury
    • DOI 10.1177/0091270003251388
    • K.C. Hayes, M.A. Katz, J.G. Devane, J.T. Hsieh, D.L. Wolfe, and P.J. Potter Pharmacokinetics of an immediate-release oral formulation of fampridine (4-aminopyridine) in normal subjects and patients with spinal cord injury J Clin Pharmacol 43 4 2003 379 385 (Pubitemid 36368779)
    • (2003) Journal of Clinical Pharmacology , vol.43 , Issue.4 , pp. 379-385
    • Hayes, K.C.1    Katz, M.A.2    Devane, J.G.3    Hsieh, J.T.C.4    Wolfe, D.L.5    Potter, P.J.6    Blight, A.R.7
  • 129
    • 0042134783 scopus 로고    scopus 로고
    • Pharmacokinetic studies of single and multiple oral doses of fampridine-SR (sustained-release 4-aminopyridine) in patients with chronic spinal cord injury
    • DOI 10.1097/00002826-200307000-00007
    • K.C. Hayes, P.J. Potter, R.R. Hansebout, J.M. Bugaresti, J.T. Hsieh, and S. Nicosia Pharmacokinetic studies of single and multiple oral doses of fampridine-SR (sustained-release 4-aminopyridine) in patients with chronic spinal cord injury Clin Neuropharmacol 26 4 2003 185 192 (Pubitemid 36951063)
    • (2003) Clinical Neuropharmacology , vol.26 , Issue.4 , pp. 185-192
    • Hayes, K.C.1    Potter, P.J.2    Hansebout, R.R.3    Bugaresti, J.M.4    Hsieh, J.T.C.5    Nicosia, S.6    Katz, M.A.7    Blight, A.R.8    Cohen, R.9
  • 130
    • 12344297545 scopus 로고    scopus 로고
    • The use of 4-aminopyridine (Fampridine) in demyelinating disorders
    • K.C. Hayes The use of 4-aminopyridine (fampridine) in demyelinating disorders CNS Drug Rev 10 4 2004 295 316 (Pubitemid 40128914)
    • (2004) CNS Drug Reviews , vol.10 , Issue.4 , pp. 295-316
    • Hayes, K.C.1
  • 131
    • 0347989568 scopus 로고    scopus 로고
    • Pharmacokinetics and Safety of Multiple Oral Doses of Sustained-Release 4-Aminopyridine (Fampridine-SR) in Subjects with Chronic, Incomplete Spinal Cord Injury
    • DOI 10.1016/S0003-9993(03)00651-8
    • K.C. Hayes, P.J. Potter, J.T. Hsieh, M.A. Katz, A.R. Blight, and R. Cohen Pharmacokinetics and safety of multiple oral doses of sustained-release 4-aminopyridine (Fampridine-SR) in subjects with chronic, incomplete spinal cord injury Arch Phys Med Rehabil 85 1 2004 29 34 (Pubitemid 38049587)
    • (2004) Archives of Physical Medicine and Rehabilitation , vol.85 , Issue.1 , pp. 29-34
    • Hayes, K.C.1    Potter, P.J.2    Hsieh, J.T.3    Katz, M.A.4    Blight, A.R.5    Cohen, R.6
  • 132
    • 46649120495 scopus 로고    scopus 로고
    • Minocycline protects motor but not autonomic neurons after cauda equina injury
    • T.X. Hoang, M. Akhavan, J. Wu, and L.A. Havton Minocycline protects motor but not autonomic neurons after cauda equina injury Exp Brain Res 189 1 2008 71 77
    • (2008) Exp Brain Res , vol.189 , Issue.1 , pp. 71-77
    • Hoang, T.X.1    Akhavan, M.2    Wu, J.3    Havton, L.A.4
  • 133
    • 0032697485 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappa B and JNK activation and apoptosis through distinct pathways
    • W.-H. Hu, H. Johnson, and H.-B. Shu Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappa B and JNK activation and apoptosis through distinct pathways J Biol Chem 274 43 1999 30603 30610
    • (1999) J Biol Chem , vol.274 , Issue.43 , pp. 30603-30610
    • Hu, W.-H.1    Johnson, H.2    Shu, H.-B.3
  • 134
    • 0344348821 scopus 로고    scopus 로고
    • Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
    • DOI 10.1093/emboj/18.13.3586
    • Y. Hu, M.A. Benedict, L. Ding, and G. Nunez Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase- 9 activation and apoptosis EMBO J 18 13 1999 3586 3595 (Pubitemid 29308839)
    • (1999) EMBO Journal , vol.18 , Issue.13 , pp. 3586-3595
    • Yuanming, H.1    Benedict, M.A.2    Ding, L.3    Nunez, G.4
  • 135
    • 66649087222 scopus 로고    scopus 로고
    • Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK
    • H. Huang, S. Fan, X. Ji, Y. Zhang, F. Bao, and G. Zhang Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK J Int Med Res 37 2 2009 511 519
    • (2009) J Int Med Res , vol.37 , Issue.2 , pp. 511-519
    • Huang, H.1    Fan, S.2    Ji, X.3    Zhang, Y.4    Bao, F.5    Zhang, G.6
  • 136
    • 0024500877 scopus 로고
    • 3H]aspartate release from cultured cerebellar granule cells
    • DOI 10.1016/0304-3940(89)90403-5
    • J.P. Hubert, and A. Doble Ibotenic acid stimulates D-[3H]aspartate release from cultured cerebellar granule cells Neurosci Lett 96 3 1989 345 350 (Pubitemid 19026705)
    • (1989) Neuroscience Letters , vol.96 , Issue.3 , pp. 345-350
    • Hubert, J.P.1    Doble, A.2
  • 137
    • 0028058808 scopus 로고
    • Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: Evidence for a dual mechanism of action
    • J.P. Hubert, J.C. Delumeau, J. Glowinski, J. Premont, and A. Doble Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action Br J Pharmacol 113 1 1994 261 267 (Pubitemid 24271747)
    • (1994) British Journal of Pharmacology , vol.113 , Issue.1 , pp. 261-267
    • Hubert, J.P.1    Delumeau, J.C.2    Glowinski, J.3    Premont, J.4    Doble, A.5
  • 138
    • 0342647473 scopus 로고    scopus 로고
    • Methylprednisolone for acute spinal cord injury: An inappropriate standard of care
    • R.J. Hurlbert Methylprednisolone for acute spinal cord injury: an inappropriate standard of care J Neurosur 93 1 Suppl 2000 1 7
    • (2000) J Neurosur , vol.93 , Issue.1 SUPPL. , pp. 1-7
    • Hurlbert, R.J.1
  • 141
    • 0038722051 scopus 로고    scopus 로고
    • Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury
    • DOI 10.1016/S0006-8993(03)02898-1
    • A. Ibarra, D. Correa, K. Willms, M.T. Merchant, G. Guizar-Sahagun, and I. Grijalva Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury Brain Res 979 1-2 2003 165 178 (Pubitemid 36792167)
    • (2003) Brain Research , vol.979 , Issue.1-2 , pp. 165-178
    • Ibarra, A.1    Correa, D.2    Willms, K.3    Merchant, M.T.4    Guizar-Sahagun, G.5    Grijalva, I.6    Madrazo, I.7
  • 142
    • 0026526168 scopus 로고
    • Erythropoietin: Structure, control of production, and function
    • W. Jelkmann Erythropoietin: structure, control of production, and function Physiol Rev 72 2 1992 449 489
    • (1992) Physiol Rev , vol.72 , Issue.2 , pp. 449-489
    • Jelkmann, W.1
  • 143
    • 0020508919 scopus 로고
    • Effects of 4-aminopyridine in patients with multiple sclerosis
    • DOI 10.1016/0022-510X(83)90145-4
    • R.E. Jones, J.R. Heron, D.H. Foster, R.S. Snelgar, and R.J. Mason Effects of 4-aminopyridine in patients with multiple sclerosis J Neurol Sci 60 3 1983 353 362 (Pubitemid 13051185)
    • (1983) Journal of the Neurological Sciences , vol.60 , Issue.3 , pp. 353-362
    • Jones, R.E.1    Heron, J.R.2    Foster, D.H.3
  • 144
    • 68149172596 scopus 로고    scopus 로고
    • Sustained release oral fampridine in the treatment of multiple sclerosis
    • N.J. Kachuck Sustained release oral fampridine in the treatment of multiple sclerosis Expert Opin Pharmacother 10 12 2009 2025 2035
    • (2009) Expert Opin Pharmacother , vol.10 , Issue.12 , pp. 2025-2035
    • Kachuck, N.J.1
  • 145
    • 1642269715 scopus 로고    scopus 로고
    • Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: Effect on lipid peroxidation and early ultrastructural findings
    • DOI 10.1007/s10143-003-0300-y
    • E. Kaptanoglu, I. Solaroglu, O. Okutan, H.S. Surucu, F. Akbiyik, and E. Beskonakli Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings Neurosurg Rev 27 2 2004 113 120 (Pubitemid 38374415)
    • (2004) Neurosurgical Review , vol.27 , Issue.2 , pp. 113-120
    • Kaptanoglu, E.1    Solaroglu, I.2    Okutan, O.3    Surucu, H.S.4    Akbiyik, F.5    Beskonakli, E.6
  • 146
    • 0035914398 scopus 로고    scopus 로고
    • Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia
    • M. Kawakami, M. Sekiguchi, K. Sato, S. Kozaki, and M. Takahashi Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia J Biol Chem 276 42 2001 39469 39475
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 39469-39475
    • Kawakami, M.1    Sekiguchi, M.2    Sato, K.3    Kozaki, S.4    Takahashi, M.5
  • 147
    • 63449138429 scopus 로고    scopus 로고
    • Effectiveness of riluzole in suppressing spasticity in the spinal cord injured rat
    • P.H. Kitzman Effectiveness of riluzole in suppressing spasticity in the spinal cord injured rat Neurosci Lett 455 2 2009 150 153
    • (2009) Neurosci Lett , vol.455 , Issue.2 , pp. 150-153
    • Kitzman, P.H.1
  • 148
    • 0032926745 scopus 로고    scopus 로고
    • Antioxidative and proapoptotic effects of riluzole on cultured cortical neurons
    • DOI 10.1046/j.1471-4159.1999.0720716.x
    • J.Y. Koh, D.K. Kim, J.Y. Hwang, Y.H. Kim, and J.H. Seo Antioxidative and proapoptotic effects of riluzole on cultured cortical neurons J Neurochem 72 2 1999 716 723 (Pubitemid 29055235)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.2 , pp. 716-723
    • Koh, J.-Y.1    Kim, D.-K.2    Hwang, J.Y.3    Kim, Y.H.4    Seo, J.H.5
  • 149
    • 0027232014 scopus 로고
    • Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo
    • Y. Konishi, D.H. Chui, H. Hirose, T. Kunishita, and T. Tabira Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo Brain Res 609 1-2 1993 29 35 (Pubitemid 23136796)
    • (1993) Brain Research , vol.609 , Issue.1-2 , pp. 29-35
    • Konishi, Y.1    Chui, D.-H.2    Hirose, H.3    Kunishita, T.4    Tabira, T.5
  • 150
    • 0027049472 scopus 로고
    • The molecular mechanism of erythropoietin action
    • DOI 10.1111/j.1432-1033.1992.tb17466.x
    • M.J. Koury, and M.C. Bondurant The molecular mechanism of erythropoietin action Eur J Biochem 210 3 1992 649 663 (Pubitemid 23015763)
    • (1992) European Journal of Biochemistry , vol.210 , Issue.3 , pp. 649-663
    • Koury, M.J.1    Bondurant, M.C.2
  • 151
    • 0031918742 scopus 로고    scopus 로고
    • The mitochondrial death/life regulator in apoptosis and necrosis
    • DOI 10.1146/annurev.physiol.60.1.619
    • G. Kroemer, B. Dallaporta, and M. Resche-Rigon The mitochondrial death/life regulator in apoptosis and necrosis Annu Rev Physiol 60 1998 619 642 (Pubitemid 28157889)
    • (1998) Annual Review of Physiology , vol.60 , pp. 619-642
    • Kroemer, G.1    Dallaporta, B.2    Resche-Rigon, M.3
  • 152
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • DOI 10.1038/74994
    • G. Kroemer, and J. Reed Mitochondrial control of cell death Nat Med 6 5 2000 513 519 (Pubitemid 30305900)
    • (2000) Nature Medicine , vol.6 , Issue.5 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 157
    • 0342978014 scopus 로고    scopus 로고
    • Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-x(L) has activity independent of cytochrome c release
    • DOI 10.1074/jbc.272.48.30299
    • F. Li, A. Srinivasan, Y. Wang, R.C. Armstrong, K.J. Tomaselli, and L.C. Fritz Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release J Biol Chem 272 48 1997 30299 30305 (Pubitemid 27512235)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.48 , pp. 30299-30305
    • Li, F.1    Srinivasan, A.2    Wang, Y.3    Armstrong, R.C.4    Tomaselli, K.J.5    Fritz, L.C.6
  • 159
    • 0031576527 scopus 로고    scopus 로고
    • Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation
    • DOI 10.1006/bbrc.1997.7672
    • J. Li, T.R. Billiar, R.V. Talanian, and Y.M. Kim Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation Biochem Biophys Res Commun 240 2 1997 419 424 (Pubitemid 27523676)
    • (1997) Biochemical and Biophysical Research Communications , vol.240 , Issue.2 , pp. 419-424
    • Li, J.1    Billiar, T.R.2    Talanian, R.V.3    Kim, Y.M.4
  • 160
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • DOI 10.1038/35083620
    • L.Y. Li, X. Luo, and X. Wang Endonuclease G is an apoptotic DNase when released from mitochondria Nature 412 6842 2001 95 99 (Pubitemid 32851517)
    • (2001) Nature , vol.412 , Issue.6842 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 161
    • 0035879809 scopus 로고    scopus 로고
    • Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-Dependent pathway in esophageal cancer cells
    • DOI 10.1002/ijc.1322
    • M. Li, X. Wu, and X.C. Xu Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway in esophageal cancer cells Int J Cancer 93 2 2001 218 223 (Pubitemid 32574278)
    • (2001) International Journal of Cancer , vol.93 , Issue.2 , pp. 218-223
    • Li, M.1    Wu, X.2    Xu, X.-C.3
  • 162
    • 0034902004 scopus 로고    scopus 로고
    • Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway
    • M. Li, X. Wu, and X.C. Xu Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway Clin Cancer Res 7 4 2001 1010 1016 (Pubitemid 32708740)
    • (2001) Clinical Cancer Research , vol.7 , Issue.4 , pp. 1010-1016
    • Li, M.1    Wu, X.2    Xu, X.-C.3
  • 163
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, and E.S. Alnemri Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 4 1997 479 489 (Pubitemid 27508237)
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 164
    • 0030951890 scopus 로고    scopus 로고
    • Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia
    • DOI 10.1016/S0006-8993(97)00005-X, PII S000689939700005X
    • P.A. Li, H. Uchino, E. Elmer, and B.K. Siesjo Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia Brain Res 753 1 1997 133 140 (Pubitemid 27156143)
    • (1997) Brain Research , vol.753 , Issue.1 , pp. 133-140
    • Li, P.-A.1    Uchino, H.2    Elmer, E.3    Siesjo, B.K.4
  • 165
    • 0034143360 scopus 로고    scopus 로고
    • Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter
    • S. Li, and P.K. Stys Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter J Neurosci 20 3 2000 1190 1198 (Pubitemid 30220475)
    • (2000) Journal of Neuroscience , vol.20 , Issue.3 , pp. 1190-1198
    • Li, S.1    Stys, P.K.2
  • 166
    • 0342803565 scopus 로고    scopus 로고
    • Action of locally administered NMDA and AMPA/kainate receptor antagonists in spinal cord injury
    • S. Li, and C.H. Tator Action of locally administered NMDA and AMPA/kainate receptor antagonists in spinal cord injury Neurol Res 22 2 2000 171 180 (Pubitemid 30180796)
    • (2000) Neurological Research , vol.22 , Issue.2 , pp. 171-180
    • Shuxin, L.1    Tator, C.H.2
  • 167
    • 20244377653 scopus 로고    scopus 로고
    • Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion
    • DOI 10.1161/01.STR.0000047100.84604.BA
    • T.N. Lin, G.M. Kim, J.J. Chen, W.M. Cheung, Y.Y. He, and C.Y. Hsu Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion Stroke 34 1 2003 177 186 (Pubitemid 36070819)
    • (2003) Stroke , vol.34 , Issue.1 , pp. 177-186
    • Lin, T.-N.1    Kim, G.-M.2    Chen, J.-J.3    Cheung, W.-M.4    He, Y.Y.5    Hsu, C.Y.6
  • 168
    • 0027186008 scopus 로고
    • Molecular mechanisms of trauma-induced neuronal degeneration
    • S.A. Lipton Molecular mechanisms of trauma-induced neuronal degeneration Curr Opin Neurol Neurosurg 6 4 1993 588 596 (Pubitemid 23232826)
    • (1993) Current Opinion in Neurology and Neurosurgery , vol.6 , Issue.4 , pp. 588-596
    • Lipton, S.A.1
  • 169
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • S.A. Lipton, and P.A. Rosenberg Excitatory amino acids as a final common pathway for neurologic disorders N Engl J Med 330 9 1994 613 622
    • (1994) N Engl J Med , vol.330 , Issue.9 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 170
    • 0031942369 scopus 로고    scopus 로고
    • Calcium, free radicals and excitotoxins in neuronal apoptosis
    • DOI 10.1016/S0143-4160(98)90115-4
    • S.A. Lipton, and P. Nicotera Calcium, free radicals and excitotoxins in neuronal apoptosis Cell Calcium 23 2-3 1998 165 171 (Pubitemid 28190033)
    • (1998) Cell Calcium , vol.23 , Issue.2-3 , pp. 165-171
    • Lipton, S.A.1    Nicotera, P.2
  • 171
    • 0025907224 scopus 로고
    • Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
    • D. Liu, W. Thangnipon, and D.J. McAdoo Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord Brain Res 547 2 1991 344 348
    • (1991) Brain Res , vol.547 , Issue.2 , pp. 344-348
    • Liu, D.1    Thangnipon, W.2    McAdoo, D.J.3
  • 172
    • 0032791163 scopus 로고    scopus 로고
    • Neurotoxicity of glutamate at the concentration released upon spinal cord injury
    • DOI 10.1016/S0306-4522(99)00278-X, PII S030645229900278X
    • D. Liu, G.Y. Xu, E. Pan, and D.J. McAdoo Neurotoxicity of glutamate at the concentration released upon spinal cord injury Neuroscience 93 4 1999 1383 1389 (Pubitemid 29397567)
    • (1999) Neuroscience , vol.93 , Issue.4 , pp. 1383-1389
    • Liu, D.1    Xu, G.-Y.2    Pan, E.3    McAdoo, D.J.4
  • 173
    • 0031005895 scopus 로고    scopus 로고
    • NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord
    • DOI 10.1016/S0006-8993(97)00137-6, PII S0006899397001376
    • S. Liu, G.L. Ruenes, and R.P. Yezierski NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord Brain Res 756 1-2 1997 160 167 (Pubitemid 27241621)
    • (1997) Brain Research , vol.756 , Issue.1-2 , pp. 160-167
    • Liu, S.1    Ruenes, G.L.2    Yezierski, R.P.3
  • 174
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • DOI 10.1016/S0092-8674(00)80085-9
    • X. Liu, C.N. Kim, J. Yang, R. Jemmerson, and X. Wang Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 86 1 1996 147 157 (Pubitemid 26256586)
    • (1996) Cell , vol.86 , Issue.1 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 175
    • 62349129124 scopus 로고    scopus 로고
    • Neuronal mitochondrial toxicity of malondialdehyde: Inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria
    • J. Long, C. Liu, L. Sun, H. Gao, and J. Liu Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria Neurochem Res 34 4 2009 786 794
    • (2009) Neurochem Res , vol.34 , Issue.4 , pp. 786-794
    • Long, J.1    Liu, C.2    Sun, L.3    Gao, H.4    Liu, J.5
  • 176
    • 0029004336 scopus 로고
    • Acetyl-l-carnitine corrects the altered peripheral nerve function of experimental diabetes
    • S. Lowitt, J.I. Malone, A.F. Salem, J. Korthals, and S. Benford Acetyl-l-carnitine corrects the altered peripheral nerve function of experimental diabetes Metabolism 44 5 1995 677 680
    • (1995) Metabolism , vol.44 , Issue.5 , pp. 677-680
    • Lowitt, S.1    Malone, J.I.2    Salem, A.F.3    Korthals, J.4    Benford, S.5
  • 177
    • 0842267115 scopus 로고    scopus 로고
    • Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue
    • DOI 10.1016/j.neuint.2003.09.006
    • J. Luo, and R. Shi Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue Neurochem Int 44 7 2004 475 486 (Pubitemid 38183298)
    • (2004) Neurochemistry International , vol.44 , Issue.7 , pp. 475-486
    • Luo, J.1    Shi, R.2
  • 178
    • 0033756931 scopus 로고    scopus 로고
    • Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alpha D: A potential new anti- inflammatory treatment
    • P.J. Mabon, L.C. Weaver, and G.A. Dekaban Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alpha D: a potential new anti- inflammatory treatment Exp Neurol 166 1 2000 52 64
    • (2000) Exp Neurol , vol.166 , Issue.1 , pp. 52-64
    • Mabon, P.J.1    Weaver, L.C.2    Dekaban, G.A.3
  • 180
    • 0026580780 scopus 로고
    • Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission
    • J. Mantz, A. Cheramy, A.M. Thierry, J. Glowinski, and J.M. Desmonts Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission Anesthesiology 76 5 1992 844 848
    • (1992) Anesthesiology , vol.76 , Issue.5 , pp. 844-848
    • Mantz, J.1    Cheramy, A.2    Thierry, A.M.3    Glowinski, J.4    Desmonts, J.M.5
  • 182
    • 1842524064 scopus 로고    scopus 로고
    • Glutamate transporters: Animal models to neurologic disease
    • DOI 10.1016/j.nbd.2003.12.007, PII S0969996103002729
    • N.J. Maragakis, and J.D. Rothstein Glutamate transporters: animal models to neurologic disease Neurobiol Dis 15 3 2004 461 473 (Pubitemid 38429961)
    • (2004) Neurobiology of Disease , vol.15 , Issue.3 , pp. 461-473
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 183
  • 184
    • 0030010159 scopus 로고    scopus 로고
    • Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens
    • DOI 10.1016/0924-977X(95)00056-U
    • M.M. Marcus, G.G. Nomikos, and T.H. Svensson Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens Eur Neuropsychopharmacol 6 1 1996 29 38 (Pubitemid 26099130)
    • (1996) European Neuropsychopharmacology , vol.6 , Issue.1 , pp. 29-38
    • Marcus, M.M.1    Nomikos, G.G.2    Svensson, T.H.3
  • 186
    • 0027762836 scopus 로고
    • The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1
    • DOI 10.1016/0014-2999(93)90037-I
    • D. Martin, M.A. Thompson, and J.V. Nadler The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1 Eur J Pharmacol 250 3 1993 473 476 (Pubitemid 24010985)
    • (1993) European Journal of Pharmacology , vol.250 , Issue.3 , pp. 473-476
    • Martin, D.1    Thompson, M.A.2    Nadler, J.V.3
  • 187
    • 12244289642 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress
    • DOI 10.1002/jnr.20293, Brain Energy Metabolism: Transporters, Mitochondria and Neurodegeneration
    • E. Martin, R.E. Rosenthal, and G. Fiskum Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress J Neurosci Res 79 1-2 2005 240 247 (Pubitemid 40116441)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.1-2 , pp. 240-247
    • Martin, E.1    Rosenthal, R.E.2    Fiskum, G.3
  • 188
    • 0033495895 scopus 로고    scopus 로고
    • Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
    • S. Matsumoto, H. Friberg, M. Ferrand-Drake, and T. Wieloch Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion J Cereb Blood Flow Metab 19 7 1999 736 741 (Pubitemid 30159798)
    • (1999) Journal of Cerebral Blood Flow and Metabolism , vol.19 , Issue.7 , pp. 736-741
    • Matsumoto, S.1    Friberg, H.2    Ferrand-Drake, M.3    Wieloch, T.4
  • 189
    • 72949118213 scopus 로고    scopus 로고
    • Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: Results from a prospective randomized trial
    • A.T. Mazzeo, G.M. Brophy, C.B. Gilman, O.L. Alves, J.R. Robles, and R.L. Hayes Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial J Neurotrauma 26 12 2009 2195 2206
    • (2009) J Neurotrauma , vol.26 , Issue.12 , pp. 2195-2206
    • Mazzeo, A.T.1    Brophy, G.M.2    Gilman, C.B.3    Alves, O.L.4    Robles, J.R.5    Hayes, R.L.6
  • 190
    • 0032848944 scopus 로고    scopus 로고
    • Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
    • DOI 10.1006/exnr.1999.7166
    • D.J. McAdoo, G.Y. Xu, G. Robak, and M.G. Hughes Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord Exp Neurol 159 2 1999 538 544 (Pubitemid 29485240)
    • (1999) Experimental Neurology , vol.159 , Issue.2 , pp. 538-544
    • McAdoo, D.J.1    Xu, G.-Y.2    Robak, G.3    Hughes, M.G.4
  • 191
    • 0034717084 scopus 로고    scopus 로고
    • Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
    • DOI 10.1016/S0006-8993(00)02296-4, PII S0006899300022964
    • D.J. McAdoo, G. Xu, G. Robak, M.G. Hughes, and E.M. Price Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord Brain Res 865 2 2000 283 285 (Pubitemid 30256009)
    • (2000) Brain Research , vol.865 , Issue.2 , pp. 283-285
    • McAdoo, D.J.1    Xu, G.-Y.2    Robak, G.3    Hughes, M.G.4    Price, E.M.5
  • 192
    • 14844336917 scopus 로고    scopus 로고
    • The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage → glutamate release → damage → glutamate release → etc.
    • DOI 10.1016/j.brainres.2005.01.024
    • D.J. McAdoo, M.G. Hughes, L. Nie, B. Shah, C. Clifton, and S. Fullwood The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage -> glutamate release -> damage -> glutamate release -> etc Brain Res 1038 1 2005 92 99 (Pubitemid 40340965)
    • (2005) Brain Research , vol.1038 , Issue.1 , pp. 92-99
    • McAdoo, D.J.1    Hughes, M.G.2    Nie, L.3    Shah, B.4    Clifton, C.5    Fullwood, S.6    Hulsebosch, C.E.7
  • 193
    • 0242580631 scopus 로고    scopus 로고
    • "Brain-specific" nutrients: A memory cure?
    • M.A. McDaniel, S.F. Maier, and G.O. Einstein "Brain-specific" nutrients: a memory cure? Nutrition 19 11-12 2003 957 975
    • (2003) Nutrition , vol.19 , Issue.11-12 , pp. 957-975
    • McDaniel, M.A.1    Maier, S.F.2    Einstein, G.O.3
  • 194
    • 34249855626 scopus 로고    scopus 로고
    • Pretreatment with the cyclosporin derivative, NIM811, improves the function of synaptic mitochondria following spinal cord contusion in rats
    • DOI 10.1089/neu.2006.9969
    • M.L. McEwen, P.G. Sullivan, and J.E. Springer Pretreatment with the cyclopsorin derivative, NIM811, improves the function of synaptic mitochondria following spinal cord contusion in rats J Neurotrauma 24 4 2007 613 624 (Pubitemid 46996022)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.4 , pp. 613-624
    • McEwen, M.L.1    Sullivan, P.G.2    Springer, J.E.3
  • 195
    • 79955071811 scopus 로고    scopus 로고
    • Targeting mitochondrial function for the treatment of acute spinal cord injury
    • M.L. McEwen, P.G. Sullivan, A.G. Rabchevsky, and J.E. Springer Targeting mitochondrial function for the treatment of acute spinal cord injury Neurotherapeutics 8 2 2011 168 179
    • (2011) Neurotherapeutics , vol.8 , Issue.2 , pp. 168-179
    • McEwen, M.L.1    Sullivan, P.G.2    Rabchevsky, A.G.3    Springer, J.E.4
  • 196
    • 0030468988 scopus 로고    scopus 로고
    • Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat
    • T.K. McIntosh, D.H. Smith, M. Voddi, B.R. Perri, and J.M. Stutzmann Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat J Neurotrauma 13 12 1996 767 780 (Pubitemid 27043978)
    • (1996) Journal of Neurotrauma , vol.13 , Issue.12 , pp. 767-780
    • McIntosh, T.K.1    Smith, D.H.2    Voddi, M.3    Perri, B.R.4    Stutzmann, J.-M.5
  • 197
    • 0022362589 scopus 로고
    • 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. I. Anticonvulsant properties
    • DOI 10.1016/0028-3908(85)90011-5
    • J. Mizoule, B. Meldrum, M. Mazadier, M. Croucher, C. Ollat, and A. Uzan 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission-I. Anticonvulsant properties Neuropharmacology 24 8 1985 767 773 (Pubitemid 15239052)
    • (1985) Neuropharmacology , vol.24 , Issue.8 , pp. 767-773
    • Mizoule, J.1    Meldrum, B.2    Mazadier, M.3
  • 198
    • 0036456428 scopus 로고    scopus 로고
    • Chondroitin sulphate proteoglycans in the CNS injury response
    • DOI 10.1016/S0079-6123(02)37024-9
    • D.A. Morgenstern, R.A. Asher, and J.W. Fawcett Chondroitin sulphate proteoglycans in the CNS injury response Prog Brain Res 137 2002 313 332 (Pubitemid 35460952)
    • (2002) Progress in Brain Research , vol.137 , pp. 313-332
    • Morgenstern, D.A.1    Asher, R.A.2    Fawcett, J.W.3
  • 199
    • 0034617464 scopus 로고    scopus 로고
    • Riluzole improves measures of oxidative stress following traumatic spinal cord injury
    • DOI 10.1016/S0006-8993(00)02402-1, PII S0006899300024021
    • X. Mu, R.D. Azbill, and J.E. Springer Riluzole improves measures of oxidative stress following traumatic spinal cord injury Brain Res 870 1-2 2000 66 72 (Pubitemid 30408404)
    • (2000) Brain Research , vol.870 , Issue.1-2 , pp. 66-72
    • Mu, X.1    Azbill, R.D.2    Springer, J.E.3
  • 200
    • 0033802214 scopus 로고    scopus 로고
    • Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury
    • X. Mu, R.D. Azbill, and J.E. Springer Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury J Neurotrauma 17 9 2000 773 780
    • (2000) J Neurotrauma , vol.17 , Issue.9 , pp. 773-780
    • Mu, X.1    Azbill, R.D.2    Springer, J.E.3
  • 201
    • 0019476136 scopus 로고
    • Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission
    • N.M. Murray, and J. Newsom-Davis Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission Neurology 31 3 1981 265 271 (Pubitemid 11146987)
    • (1981) Neurology , vol.31 , Issue.3 , pp. 265-271
    • Murray, N.M.F.1    Newsom-Davis, J.2
  • 202
    • 37349030729 scopus 로고    scopus 로고
    • Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat-Effects on BBB breakdown and MMP expression in the acute and subacute phase
    • DOI 10.1016/j.brainres.2007.10.052, PII S0006899307024778
    • S. Nagel, Y. Su, S. Horstmann, S. Heiland, H. Gardner, and J. Koziol Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase Brain Res 1188 2008 198 206 (Pubitemid 350296055)
    • (2008) Brain Research , vol.1188 , Issue.1 , pp. 198-206
    • Nagel, S.1    Su, Y.2    Horstmann, S.3    Heiland, S.4    Gardner, H.5    Koziol, J.6    Martinez-Torres, F.J.7    Wagner, S.8
  • 203
    • 15844407874 scopus 로고    scopus 로고
    • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    • DOI 10.1038/nature03317
    • T. Nakagawa, S. Shimizu, T. Watanabe, O. Yamaguchi, K. Otsu, and H. Yamagata Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death Nature 434 7033 2005 652 658 (Pubitemid 40488558)
    • (2005) Nature , vol.434 , Issue.7033 , pp. 652-658
    • Nakagawa, T.1    Shimizu, S.2    Watanabe, T.3    Yamaguchi, O.4    Otsu, K.5    Yamagata, H.6    Inohara, H.7    Kubo, T.8    Tsujimoto, Y.9
  • 204
    • 0030051609 scopus 로고    scopus 로고
    • Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel
    • DOI 10.1074/jbc.271.4.2185
    • A. Nicolli, E. Basso, V. Petronilli, R.M. Wenger, and P. Bernardi Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel J Biol Chem 271 4 1996 2185 2192 (Pubitemid 26047809)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.4 , pp. 2185-2192
    • Nicolli, A.1    Basso, E.2    Petronilli, V.3    Wenger, R.M.4    Bernardi, P.5
  • 205
    • 33845288983 scopus 로고    scopus 로고
    • Delayed riluzole treatment is able to rescue injured rat spinal motoneurons
    • DOI 10.1016/j.neuroscience.2006.09.046, PII S0306452206012930
    • A. Nogradi, A. Szabo, S. Pinter, and G. Vrbova Delayed riluzole treatment is able to rescue injured rat spinal motoneurons Neuroscience 144 2 2007 431 438 (Pubitemid 44873042)
    • (2007) Neuroscience , vol.144 , Issue.2 , pp. 431-438
    • Nogradi, A.1    Szabo, A.2    Pinter, S.3    Vrbova, G.4
  • 206
    • 36049040405 scopus 로고    scopus 로고
    • Rat models of traumatic spinal cord injury to assess motor recovery
    • S.M. Onifer, A.G. Rabchevsky, and S.W. Scheff Rat models of traumatic spinal cord injury to assess motor recovery ILAR J 48 4 2007 385 395 (Pubitemid 350194370)
    • (2007) ILAR Journal , vol.48 , Issue.4 , pp. 385-395
    • Onifer, S.M.1    Rabchevsky, A.G.2    Scheff, S.W.3
  • 210
    • 0032971226 scopus 로고    scopus 로고
    • Long-term effects of methylprednisolone following transection of adult rat spinal cord
    • DOI 10.1046/j.1460-9568.1999.00666.x
    • M. Oudega, C.G. Vargas, A.B. Weber, N. Kleitman, and M.B. Bunge Long-term effects of methylprednisolone following transection of adult rat spinal cord Eur J Neurosci 11 7 1999 2453 2464 (Pubitemid 29292340)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.7 , pp. 2453-2464
    • Oudega, M.1    Vargas, C.G.2    Weber, A.B.3    Kleitman, N.4    Bunge, M.B.5
  • 211
    • 0025162091 scopus 로고
    • Alteration in extracellular amino acids after traumatic spinal cord injury
    • DOI 10.1002/ana.410270115
    • S.S. Panter, S.W. Yum, and A.I. Faden Alteration in extracellular amino acids after traumatic spinal cord injury Ann Neurol 27 1 1990 96 99 (Pubitemid 20031364)
    • (1990) Annals of Neurology , vol.27 , Issue.1 , pp. 96-99
    • Panter, S.S.1    Yum, S.W.2    Faden, A.I.3
  • 212
    • 0026516050 scopus 로고
    • Pharmacokinetics of IV and oral acetyl-l-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type
    • L. Parnetti, A. Gaiti, P. Mecocci, D. Cadini, and U. Senin Pharmacokinetics of IV and oral acetyl-l-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type Eur J Clin Pharmacol 42 1 1992 89 93
    • (1992) Eur J Clin Pharmacol , vol.42 , Issue.1 , pp. 89-93
    • Parnetti, L.1    Gaiti, A.2    Mecocci, P.3    Cadini, D.4    Senin, U.5
  • 213
    • 63249086847 scopus 로고    scopus 로고
    • Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury
    • S.P. Patel, P.G. Sullivan, J.D. Pandya, and A.G. Rabchevsky Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury J Neurosci Res 87 1 2009 130 140
    • (2009) J Neurosci Res , vol.87 , Issue.1 , pp. 130-140
    • Patel, S.P.1    Sullivan, P.G.2    Pandya, J.D.3    Rabchevsky, A.G.4
  • 214
    • 77953294755 scopus 로고    scopus 로고
    • Acetyl-l-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury
    • S.P. Patel, P.G. Sullivan, T.S. Lyttle, and A.G. Rabchevsky Acetyl-l-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury J Neurochem 114 1 2010 291 301
    • (2010) J Neurochem , vol.114 , Issue.1 , pp. 291-301
    • Patel, S.P.1    Sullivan, P.G.2    Lyttle, T.S.3    Rabchevsky, A.G.4
  • 215
    • 0035853721 scopus 로고    scopus 로고
    • The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ
    • V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, and F. Di Lisa The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ J Biol Chem 276 15 2001 12030 12034
    • (2001) J Biol Chem , vol.276 , Issue.15 , pp. 12030-12034
    • Petronilli, V.1    Penzo, D.2    Scorrano, L.3    Bernardi, P.4    Di Lisa, F.5
  • 216
    • 0033653231 scopus 로고    scopus 로고
    • Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: Relevance for its mode of action in Alzheimer's disease and geriatric depression
    • J.W. Pettegrew, J. Levine, and R.J. McClure Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression Mol Psychiatry 5 6 2000 616 632
    • (2000) Mol Psychiatry , vol.5 , Issue.6 , pp. 616-632
    • Pettegrew, J.W.1    Levine, J.2    McClure, R.J.3
  • 217
    • 49449094589 scopus 로고    scopus 로고
    • A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury
    • A. Pinzon, A. Marcillo, D. Pabon, H.M. Bramlett, M.B. Bunge, and W.D. Dietrich A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury Exp Neurol 213 1 2008 129 136
    • (2008) Exp Neurol , vol.213 , Issue.1 , pp. 129-136
    • Pinzon, A.1    Marcillo, A.2    Pabon, D.3    Bramlett, H.M.4    Bunge, M.B.5    Dietrich, W.D.6
  • 218
    • 55649088905 scopus 로고    scopus 로고
    • A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model
    • A. Pinzon, A. Marcillo, A. Quintana, S. Stamler, M.B. Bunge, and H.M. Bramlett A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model Brain Res 1243 2008 146 151
    • (2008) Brain Res , vol.1243 , pp. 146-151
    • Pinzon, A.1    Marcillo, A.2    Quintana, A.3    Stamler, S.4    Bunge, M.B.5    Bramlett, H.M.6
  • 220
    • 0028294639 scopus 로고
    • 4-Aminopyridine in the treatment of patients with multiple sclerosis: Long-term efficacy and safety
    • C.H. Polman, F.W. Bertelsmann, A.C. van Loenen, and J.C. Koetsier 4-aminopyridine in the treatment of patients with multiple sclerosis. Long-term efficacy and safety Arch Neurol 51 3 1994 292 296 (Pubitemid 24088417)
    • (1994) Archives of Neurology , vol.51 , Issue.3 , pp. 292-296
    • Polman, C.H.1    Bertelsmann, F.W.2    Van Loenen, A.C.3    Koetsier, J.C.4
  • 221
    • 4544298249 scopus 로고    scopus 로고
    • Mitochondrial mechanisms of neural cell apoptosis
    • DOI 10.1111/j.1471-4159.2004.02572.x
    • B.M. Polster, and G. Fiskum Mitochondrial mechanisms of neural cell apoptosis J Neurochem 90 6 2004 1281 1289 (Pubitemid 39223632)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.6 , pp. 1281-1289
    • Polster, B.M.1    Fiskum, G.2
  • 222
    • 43949114888 scopus 로고    scopus 로고
    • Can the immune system be harnessed to repair the CNS?
    • DOI 10.1038/nrn2398, PII NRN2398
    • P.G. Popovich, and E.E. Longbrake Can the immune system be harnessed to repair the CNS? Nat Rev Neurosci 9 6 2008 481 493 (Pubitemid 351704948)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.6 , pp. 481-493
    • Popovich, P.G.1    Longbrake, E.E.2
  • 223
    • 0031888625 scopus 로고    scopus 로고
    • Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: Three cases
    • P.J. Potter, K.C. Hayes, J.T. Hsieh, G.A. Delaney, and J.L. Segal Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: three cases Spinal Cord 36 3 1998 147 155 (Pubitemid 28120689)
    • (1998) Spinal Cord , vol.36 , Issue.3 , pp. 147-155
    • Potter, P.J.1    Hayes, K.C.2    Hsieh, J.T.C.3    Delaney, G.A.4    Segal, J.L.5
  • 224
  • 227
    • 0035008642 scopus 로고    scopus 로고
    • Cyclosporin a treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing
    • A.G. Rabchevsky, I. Fugaccia, P.G. Sullivan, and S.W. Scheff Cyclosporin A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing J Neurotrauma 18 5 2001 513 522 (Pubitemid 32472841)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.5 , pp. 513-522
    • Rabchevsky, A.G.1    Fugaccia, I.2    Sullivan, P.G.3    Scheff, S.W.4
  • 228
    • 0035023427 scopus 로고    scopus 로고
    • Therapeutic interventions following mammalian spinal cord injury
    • A.G. Rabchevsky, and G.M. Smith Therapeutic interventions following mammalian spinal cord injury Arch Neurol 58 5 2001 721 726 (Pubitemid 32423043)
    • (2001) Archives of Neurology , vol.58 , Issue.5 , pp. 721-726
    • Rabchevsky, A.G.1    Smith, G.M.2
  • 230
    • 0024786493 scopus 로고
    • Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia
    • G. Rai, G. Wright, L. Scott, B. Beston, J. Rest, and A.N. Exton-Smith Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia Curr Med Res Opin 11 10 1990 638 647
    • (1990) Curr Med Res Opin , vol.11 , Issue.10 , pp. 638-647
    • Rai, G.1    Wright, G.2    Scott, L.3    Beston, B.4    Rest, J.5    Exton-Smith, A.N.6
  • 232
    • 35648942661 scopus 로고    scopus 로고
    • Post-treatment with the cyclosporin derivative, NIM811, reduced indices of cell death and increased the volume of spared tissue in the acute period following spinal cord contusion
    • DOI 10.1089/neu.2007.0329
    • R. Ravikumar, M.L. McEwen, and J.E. Springer Post-treatment with the cyclosporin derivative, NIM811, reduced indices of cell death and increased the volume of spared tissue in the acute period following spinal cord contusion J Neurotrauma 24 10 2007 1618 1630 (Pubitemid 350035843)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.10 , pp. 1618-1630
    • Ravikumar, R.1    McEwen, M.L.2    Springer, J.E.3
  • 233
    • 17744376764 scopus 로고    scopus 로고
    • Mechanisms of mitochondrial membrane permeabilization
    • DOI 10.1038/sj.cdd.4400777
    • J.C. Reed, and G. Kroemer Mechanisms of mitochondrial membrane permeabilization Cell Death Differ 7 12 2000 1145 (Pubitemid 32042220)
    • (2000) Cell Death and Differentiation , vol.7 , Issue.12 , pp. 1145
    • Reed, J.C.1    Kroemer, G.2
  • 234
    • 0019348939 scopus 로고
    • Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle
    • L.J. Reed Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle Curr Top Cell Regul 18 1981 95 106
    • (1981) Curr Top Cell Regul , vol.18 , pp. 95-106
    • Reed, L.J.1
  • 235
    • 0035914303 scopus 로고    scopus 로고
    • A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes
    • L.J. Reed A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes J Biol Chem 276 42 2001 38329 38336
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38329-38336
    • Reed, L.J.1
  • 237
    • 77953320193 scopus 로고    scopus 로고
    • Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells
    • S.K. Roy Chowdhury, G.V. Sangle, X. Xie, G.L. Stelmack, A.J. Halayko, and G.X. Shen Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells Am J Physiol Endocrinol Metab 2009
    • (2009) Am J Physiol Endocrinol Metab
    • Roy Chowdhury, S.K.1    Sangle, G.V.2    Xie, X.3    Stelmack, G.L.4    Halayko, A.J.5    Shen, G.X.6
  • 238
    • 40849126421 scopus 로고    scopus 로고
    • Limited minocycline neuroprotection after balloon-compression spinal cord injury in the rat
    • K. Saganova, J. Orendacova, D. Cizkova, and I. Vanicky Limited minocycline neuroprotection after balloon-compression spinal cord injury in the rat Neurosci Lett 433 3 2008 246 249
    • (2008) Neurosci Lett , vol.433 , Issue.3 , pp. 246-249
    • Saganova, K.1    Orendacova, J.2    Cizkova, D.3    Vanicky, I.4
  • 240
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • discussion
    • R.O. Sanchez Mejia, V.O. Ona, M. Li, and R.M. Friedlander Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction Neurosurgery 48 6 2001 1399 1401 discussion
    • (2001) Neurosurgery , vol.48 , Issue.6 , pp. 1399-1401
    • Sanchez Mejia, R.O.1    Ona, V.O.2    Li, M.3    Friedlander, R.M.4
  • 241
    • 0019195180 scopus 로고
    • Eaton-Lambert syndrome: A clinical and electrophysiological study of a patient treated with 4-aminopyridine
    • D.B. Sanders, Y.I. Kim, J.F. Howard Jr., and C.A. Goetsch Eaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine J Neurol Neurosurg Psychiatry 43 11 1980 978 985 (Pubitemid 11217271)
    • (1980) Journal of Neurology Neurosurgery and Psychiatry , vol.43 , Issue.11 , pp. 978-985
    • Sanders, D.B.1    Kim, Y.I.2    Howard Jr., J.F.3    Goetsch, C.A.4
  • 242
    • 0026460074 scopus 로고
    • Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's disease
    • M. Sano, K. Bell, L. Cote, G. Dooneief, A. Lawton, and L. Legler Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's disease Arch Neurol 49 11 1992 1137 1141
    • (1992) Arch Neurol , vol.49 , Issue.11 , pp. 1137-1141
    • Sano, M.1    Bell, K.2    Cote, L.3    Dooneief, G.4    Lawton, A.5    Legler, L.6
  • 243
    • 0032878575 scopus 로고    scopus 로고
    • Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents
    • S.W. Scheff, and P.G. Sullivan Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents J Neurotrauma 16 9 1999 783 792
    • (1999) J Neurotrauma , vol.16 , Issue.9 , pp. 783-792
    • Scheff, S.W.1    Sullivan, P.G.2
  • 245
    • 0037039823 scopus 로고    scopus 로고
    • Repairing the injured spinal cord
    • DOI 10.1126/science.1067840
    • M.E. Schwab Repairing the injured spinal cord Science 295 5557 2002 1029 1031 (Pubitemid 34132224)
    • (2002) Science , vol.295 , Issue.5557 , pp. 1029-1031
    • Schwab, M.E.1
  • 246
    • 0034867539 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole
    • G. Schwartz, and M.G. Fehlings Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole J Neurosurg 94 2 Suppl 2001 245 256 (Pubitemid 32786052)
    • (2001) Journal of Neurosurgery , vol.94 , Issue.2 SUPPL. , pp. 245-256
    • Schwartz, G.1    Fehlings, M.G.2
  • 247
    • 0036454326 scopus 로고    scopus 로고
    • Secondary injury mechanisms of spinal cord trauma: A novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole
    • DOI 10.1016/S0079-6123(02)37016-X
    • G. Schwartz, and M.G. Fehlings Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole Prog Brain Res 137 2002 177 190 (Pubitemid 35460945)
    • (2002) Progress in Brain Research , vol.137 , pp. 177-190
    • Schwartz, G.1    Fehlings, M.G.2
  • 248
    • 0030989459 scopus 로고    scopus 로고
    • Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis
    • S.R. Schwid, M.D. Petrie, M.P. McDermott, D.S. Tierney, D.H. Mason, and A.D. Goodman Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis Neurology 48 4 1997 817 821
    • (1997) Neurology , vol.48 , Issue.4 , pp. 817-821
    • Schwid, S.R.1    Petrie, M.D.2    McDermott, M.P.3    Tierney, D.S.4    Mason, D.H.5    Goodman, A.D.6
  • 249
    • 0030766182 scopus 로고    scopus 로고
    • Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin
    • L. Scorrano, A. Nicolli, E. Basso, V. Petronilli, and P. Bernardi Two modes of activation of the permeability transition pore: the role of mitochondrial cyclophilin Mol Cell Biochem 174 1-2 1997 181 184
    • (1997) Mol Cell Biochem , vol.174 , Issue.12 , pp. 181-184
    • Scorrano, L.1    Nicolli, A.2    Basso, E.3    Petronilli, V.4    Bernardi, P.5
  • 250
    • 0030995428 scopus 로고    scopus 로고
    • On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal
    • DOI 10.1074/jbc.272.19.12295
    • L. Scorrano, V. Petronilli, and P. Bernardi On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal J Biol Chem 272 19 1997 12295 12299 (Pubitemid 27203313)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.19 , pp. 12295-12299
    • Scorrano, L.1    Petronilli, V.2    Bernardi, P.3
  • 251
    • 0032107910 scopus 로고    scopus 로고
    • 4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans
    • J.L. Segal, and S.R. Brunnemann 4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans J Spinal Cord Med 21 3 1998 200 204 (Pubitemid 128735588)
    • (1998) Journal of Spinal Cord Medicine , vol.21 , Issue.3 , pp. 200-204
    • Segal, J.L.1    Brunnemann, S.R.2
  • 252
    • 34848842158 scopus 로고    scopus 로고
    • The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
    • DOI 10.1016/j.neuint.2007.03.012, PII S0197018607000770
    • A.L. Sheldon, and M.B. Robinson The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention Neurochem Int 51 6-7 2007 333 355 (Pubitemid 47503456)
    • (2007) Neurochemistry International , vol.51 , Issue.6-7 , pp. 333-355
    • Sheldon, A.L.1    Robinson, M.B.2
  • 253
    • 0031056540 scopus 로고    scopus 로고
    • Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord
    • DOI 10.1016/S0306-4522(96)00477-0, PII S0306452296004770
    • R. Shi, and A.R. Blight Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord Neuroscience 77 2 1997 553 562 (Pubitemid 27079623)
    • (1997) Neuroscience , vol.77 , Issue.2 , pp. 553-562
    • Shi, R.1    Blight, A.R.2
  • 254
    • 0034024692 scopus 로고    scopus 로고
    • High dose methylprednisolone in the management of acute spinal cord injury - A systematic review from a clinical perspective
    • D.J. Short, W.S. El Masry, and P.W. Jones High dose methylprednisolone in the management of acute spinal cord injury - a systematic review from a clinical perspective Spinal Cord 38 5 2000 273 286 (Pubitemid 30307193)
    • (2000) Spinal Cord , vol.38 , Issue.5 , pp. 273-286
    • Short, D.J.1    El Masry, W.S.2    Jones, P.W.3
  • 255
    • 0029986949 scopus 로고    scopus 로고
    • Primary preventive and secondary interventionary effects of acetyl-l-carnitine on diabetic neuropathy in the bio-breeding Worcester rat
    • A.A. Sima, H. Ristic, A. Merry, M. Kamijo, S.A. Lattimer, and M.J. Stevens Primary preventive and secondary interventionary effects of acetyl-l-carnitine on diabetic neuropathy in the bio-breeding Worcester rat J Clin Invest 97 8 1996 1900 1907
    • (1996) J Clin Invest , vol.97 , Issue.8 , pp. 1900-1907
    • Sima, A.A.1    Ristic, H.2    Merry, A.3    Kamijo, M.4    Lattimer, S.A.5    Stevens, M.J.6
  • 256
    • 0032862658 scopus 로고    scopus 로고
    • Expression patterns and regulation of glutamate transporters in the developing and adult nervous system
    • K.D. Sims, and M.B. Robinson Expression patterns and regulation of glutamate transporters in the developing and adult nervous system Crit Rev Neurobiol 13 2 1999 169 197 (Pubitemid 29431429)
    • (1999) Critical Reviews in Neurobiology , vol.13 , Issue.2 , pp. 169-197
    • Sims, K.D.1    Robinson, M.B.2
  • 259
  • 260
    • 0018853878 scopus 로고
    • Poisoning with 4-aminopyridine: Report of three cases
    • D.A. Spyker, C. Lynch, J. Shabanowitz, and J.A. Sinn Poisoning with 4-aminopyridine: report of three cases Clin Toxicol 16 4 1980 487 497 (Pubitemid 10048631)
    • (1980) Clinical Toxicology , vol.16 , Issue.4 , pp. 487-497
    • Spyker, D.A.1    Lynch, C.2    Shabanowitz, J.3    Sinn, J.A.4
  • 262
    • 0031239776 scopus 로고    scopus 로고
    • Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: Implications for neuroprotective strategies
    • DOI 10.1006/exnr.1997.6554
    • A. Stefani, F. Spadoni, and G. Bernardi Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies Exp Neurol 147 1 1997 115 122 (Pubitemid 27402448)
    • (1997) Experimental Neurology , vol.147 , Issue.1 , pp. 115-122
    • Stefani, A.1    Spadoni, F.2    Bernardi, G.3
  • 264
    • 33645949401 scopus 로고    scopus 로고
    • A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats
    • O. Steward, K. Sharp, G. Selvan, A. Hadden, M. Hofstadter, and E. Au A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats Exp Neurol 198 2 2006 483 499
    • (2006) Exp Neurol , vol.198 , Issue.2 , pp. 483-499
    • Steward, O.1    Sharp, K.2    Selvan, G.3    Hadden, A.4    Hofstadter, M.5    Au, E.6
  • 265
    • 38649105790 scopus 로고    scopus 로고
    • A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice
    • O. Steward, K. Sharp, K.M. Yee, and M. Hofstadter A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice Exp Neurol 209 2 2008 446 468
    • (2008) Exp Neurol , vol.209 , Issue.2 , pp. 446-468
    • Steward, O.1    Sharp, K.2    Yee, K.M.3    Hofstadter, M.4
  • 266
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • DOI 10.1523/JNEUROSCI.5275-03.2004
    • D.P. Stirling, K. Khodarahmi, J. Liu, L.T. McPhail, C.B. McBride, and J.D. Steeves Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury J Neurosci 24 9 2004 2182 2190 (Pubitemid 38314550)
    • (2004) Journal of Neuroscience , vol.24 , Issue.9 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6    Ramer, M.S.7    Tetzlaff, W.8
  • 268
    • 0036186061 scopus 로고    scopus 로고
    • Experimental modelling of human spinal cord injury: A model that crosses the species barrier and mimics the spectrum of human cytopathology
    • DOI 10.1038/sj/sc/3101254
    • B.T. Stokes, and L.B. Jakeman Experimental modelling of human spinal cord injury: a model that crosses the species barrier and mimics the spectrum of human cytopathology Spinal Cord 40 3 2002 101 109 (Pubitemid 34188275)
    • (2002) Spinal Cord , vol.40 , Issue.3 , pp. 101-109
    • Stokes, B.T.1    Jakeman, L.B.2
  • 270
    • 0029976154 scopus 로고    scopus 로고
    • The effect of riluzole on post-traumatic spinal cord injury in the rat
    • J.M. Stutzmann, J. Pratt, T. Boraud, and C. Gross The effect of riluzole on post-traumatic spinal cord injury in the rat Neuroreport 7 2 1996 387 392 (Pubitemid 26105006)
    • (1996) NeuroReport , vol.7 , Issue.2 , pp. 387-392
    • Stutzmann, J.-M.1    Pratt, J.2    Boraud, T.3    Gross, C.4
  • 271
    • 0032736595 scopus 로고    scopus 로고
    • Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
    • P.G. Sullivan, M.B. Thompson, and S.W. Scheff Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury Exp Neurol 160 1 1999 226 234
    • (1999) Exp Neurol , vol.160 , Issue.1 , pp. 226-234
    • Sullivan, P.G.1    Thompson, M.B.2    Scheff, S.W.3
  • 272
    • 0033767740 scopus 로고    scopus 로고
    • Dietary supplement creatine protects against traumatic brain injury
    • P.G. Sullivan, J.D. Geiger, M.P. Mattson, and S.W. Scheff Dietary supplement creatine protects against traumatic brain injury Ann Neurol 48 5 2000 723 729
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 723-729
    • Sullivan, P.G.1    Geiger, J.D.2    Mattson, M.P.3    Scheff, S.W.4
  • 273
    • 0034619442 scopus 로고    scopus 로고
    • Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats
    • P.G. Sullivan, A.G. Rabchevsky, R.R. Hicks, T.R. Gibson, A. Fletcher-Turner, and S.W. Scheff Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats Neuroscience 101 2 2000 289 295
    • (2000) Neuroscience , vol.101 , Issue.2 , pp. 289-295
    • Sullivan, P.G.1    Rabchevsky, A.G.2    Hicks, R.R.3    Gibson, T.R.4    Fletcher-Turner, A.5    Scheff, S.W.6
  • 274
    • 0034057187 scopus 로고    scopus 로고
    • Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury
    • DOI 10.1006/exnr.1999.7282
    • P.G. Sullivan, M. Thompson, and S.W. Scheff Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury Exp Neurol 161 2 2000 631 637 (Pubitemid 30137020)
    • (2000) Experimental Neurology , vol.161 , Issue.2 , pp. 631-637
    • Sullivan, P.G.1    Thompson, M.2    Scheff, S.W.3
  • 276
    • 12244281831 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death?
    • DOI 10.1002/jnr.20292, Brain Energy Metabolism: Transporters, Mitochondria and Neurodegeneration
    • P.G. Sullivan, A.G. Rabchevsky, P.C. Waldmeier, and J.E. Springer Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death? J Neurosci Res 79 1-2 2005 231 239 (Pubitemid 40116440)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.1-2 , pp. 231-239
    • Sullivan, P.G.1    Rabchevsky, A.G.2    Waldmeier, P.C.3    Springer, J.E.4
  • 277
    • 34347329078 scopus 로고    scopus 로고
    • Temporal characterization of mitochondrial bioenergetics after spinal cord injury
    • DOI 10.1089/neu.2006.0242
    • P.G. Sullivan, S. Krishnamurthy, S.P. Patel, J.D. Pandya, and A.G. Rabchevsky Temporal characterization of mitochondrial bioenergetics after spinal cord injury J Neurotrauma 24 6 2007 991 999 (Pubitemid 47015433)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.6 , pp. 991-999
    • Sullivan, P.G.1    Krishnamurthy, S.2    Patel, S.P.3    Pandya, J.D.4    Rabchevsky, A.G.5
  • 278
    • 0032790256 scopus 로고    scopus 로고
    • Acetyl-L-carnitine decreases glycation of lens proteins: In vitro studies
    • DOI 10.1006/exer.1999.0680
    • S. Swamy-Mruthinti, and A.L. Carter Acetyl-l-carnitine decreases glycation of lens proteins: in vitro studies Exp Eye Res 69 1 1999 109 115 (Pubitemid 29335457)
    • (1999) Experimental Eye Research , vol.69 , Issue.1 , pp. 109-115
    • Swamy-Mruthinti, S.1    Carter, A.L.2
  • 279
    • 0026550587 scopus 로고
    • The mitochondrial megachannel is the permeability transition pore
    • I. Szabo, and M. Zoratti The mitochondrial megachannel is the permeability transition pore J Bioenerg Biomembr 24 1 1992 111 117
    • (1992) J Bioenerg Biomembr , vol.24 , Issue.1 , pp. 111-117
    • Szabo, I.1    Zoratti, M.2
  • 280
    • 0035008462 scopus 로고    scopus 로고
    • Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-α production
    • Y. Taoka, K. Okajima, M. Uchiba, and M. Johno Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-a production J Neurotrauma 18 5 2001 533 543 (Pubitemid 32472843)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.5 , pp. 533-543
    • Taoka, Y.1    Okajima, K.2    Uchiba, M.3    Johno, M.4
  • 281
    • 0023279113 scopus 로고
    • L-acetylcarnitine in depressed elderly subjects. A cross-over study vs placebo
    • E. Tempesta, L. Casella, C. Pirrongelli, L. Janiri, M. Calvani, and L. Ancona l-Acetylcarnitine in depressed elderly subjects. A cross-over study vs placebo Drugs Exp Clin Res 13 7 1987 417 423 (Pubitemid 17125265)
    • (1987) Drugs under Experimental and Clinical Research , vol.13 , Issue.7 , pp. 417-423
    • Tempesta, E.1    Casella, L.2    Pirrongelli, C.3
  • 283
    • 33746285448 scopus 로고    scopus 로고
    • Therapeutic interventions after spinal cord injury
    • DOI 10.1038/nrn1955, PII NRN1955
    • S. Thuret, L.D. Moon, and F.H. Gage Therapeutic interventions after spinal cord injury Nat Rev Neurosci 7 8 2006 628 643 (Pubitemid 44106745)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.8 , pp. 628-643
    • Thuret, S.1    Moon, L.D.F.2    Gage, F.H.3
  • 284
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • T. Tikka, B.L. Fiebich, G. Goldsteins, R. Keinanen, and J. Koistinaho Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia J Neurosci 21 8 2001 2580 2588 (Pubitemid 32298200)
    • (2001) Journal of Neuroscience , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 285
    • 0842305087 scopus 로고    scopus 로고
    • Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: Results of a pilot, randomised, double-blind, crossover trial
    • DOI 10.1016/j.jns.2003.11.005
    • V. Tomassini, C. Pozzilli, E. Onesti, P. Pasqualetti, F. Marinelli, and A. Pisani Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial J Neurol Sci 218 1-2 2004 103 108 (Pubitemid 38169402)
    • (2004) Journal of the Neurological Sciences , vol.218 , Issue.1-2 , pp. 103-108
    • Tomassini, V.1    Pozzilli, C.2    Onesti, E.3    Pasqualetti, P.4    Marinelli, F.5    Pisani, A.6    Fieschi, C.7
  • 286
    • 33746223208 scopus 로고    scopus 로고
    • Acetyl-l-carnitine up-regulates expression of voltage-dependent anion channel in the rat brain
    • DOI 10.1016/j.neuint.2005.11.005, PII S0197018605002603
    • G. Traina, R. Bernardi, M. Rizzo, M. Calvani, M. Durante, and M. Brunelli Acetyl-l-carnitine up-regulates expression of voltage-dependent anion channel in the rat brain Neurochem Int 48 8 2006 673 678 (Pubitemid 44389610)
    • (2006) Neurochemistry International , vol.48 , Issue.8 , pp. 673-678
    • Traina, G.1    Bernardi, R.2    Rizzo, M.3    Calvani, M.4    Durante, M.5    Brunelli, M.6
  • 288
    • 0036403825 scopus 로고    scopus 로고
    • Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition
    • DOI 10.1006/nbdi.2002.0514
    • H. Uchino, R. Minamikawa-Tachino, T. Kristian, G. Perkins, M. Narazaki, and B.K. Siesjo Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition Neurobiol Dis 10 3 2002 219 233 (Pubitemid 35217576)
    • (2002) Neurobiology of Disease , vol.10 , Issue.3 , pp. 219-233
    • Uchino, H.1    Minamikawa-Tachino, R.2    Kristian, T.3    Perkins, G.4    Narazaki, M.5    Siesjo, B.K.6    Shibasaki, F.7
  • 290
    • 36949015374 scopus 로고    scopus 로고
    • Analysis of age-associated changes in mitochondrial free radical generation by rat testis
    • DOI 10.1007/s11010-007-9580-9
    • M.E. Vazquez-Memije, R. Capin, A. Tolosa, and M. El-Hafidi Analysis of age-associated changes in mitochondrial free radical generation by rat testis Mol Cell Biochem 307 1-2 2008 23 30 (Pubitemid 350238643)
    • (2008) Molecular and Cellular Biochemistry , vol.307 , Issue.1-2 , pp. 23-30
    • Vazquez-Memije, M.E.1    Capin, R.2    Tolosa, A.3    El-Hafidi, M.4
  • 291
    • 4444289045 scopus 로고    scopus 로고
    • Role of carnitine esters in brain neuropathology
    • DOI 10.1016/j.mam.2004.06.003, PII S0098299704000482
    • A. Virmani, and Z. Binienda Role of carnitine esters in brain neuropathology Mol Aspects Med 25 5-6 2004 533 549 (Pubitemid 39195075)
    • (2004) Molecular Aspects of Medicine , vol.25 , Issue.5-6 , pp. 533-549
    • Virmani, A.1    Binienda, Z.2
  • 292
    • 33845778397 scopus 로고    scopus 로고
    • Erythropoietin-mediated preservation of the white matter in rat spinal cord injury
    • DOI 10.1016/j.neuroscience.2006.10.023, PII S0306452206013790
    • L. Vitellaro-Zuccarello, S. Mazzetti, L. Madaschi, P. Bosisio, A. Gorio, and S. De Biasi Erythropoietin-mediated preservation of the white matter in rat spinal cord injury Neuroscience 144 3 2007 865 877 (Pubitemid 46013988)
    • (2007) Neuroscience , vol.144 , Issue.3 , pp. 865-877
    • Vitellaro-Zuccarello, L.1    Mazzetti, S.2    Madaschi, L.3    Bosisio, P.4    Gorio, A.5    De Biasi, S.6
  • 293
    • 0030915422 scopus 로고    scopus 로고
    • Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury
    • DOI 10.1016/S0006-8993(97)00144-3, PII S0006899397001443
    • F. Wahl, E. Renou, V. Mary, and J.M. Stutzmann Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury Brain Res 756 1-2 1997 247 255 (Pubitemid 27241633)
    • (1997) Brain Research , vol.756 , Issue.1-2 , pp. 247-255
    • Wahl, F.1    Renou, E.2    Mary, V.3    Stutzmann, J.-M.4
  • 294
    • 0036088518 scopus 로고    scopus 로고
    • Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811
    • DOI 10.1124/mol.62.1.22
    • P.C. Waldmeier, J.J. Feldtrauer, T. Qian, and J.J. Lemasters Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811 Mol Pharmacol 62 1 2002 22 29 (Pubitemid 34680512)
    • (2002) Molecular Pharmacology , vol.62 , Issue.1 , pp. 22-29
    • Waldmeier, P.C.1    Feldtrauer, J.-J.2    Qian, T.3    Lemasters, J.J.4
  • 296
    • 84992641926 scopus 로고    scopus 로고
    • Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury
    • M. Watanabe, Y. Fujimura, M. Nakamura, Y. Yato, K. Ohta, and H. Okai Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury J Neurotrauma 15 4 1998 285 293 (Pubitemid 28166580)
    • (1998) Journal of Neurotrauma , vol.15 , Issue.4 , pp. 285-293
    • Watanabe, M.1    Fujimura, Y.2    Nakamura, M.3    Yato, Y.4    Ohta, K.5    Okai, H.6    Ogawa, Y.7
  • 297
    • 64949161526 scopus 로고    scopus 로고
    • Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging
    • Y.H. Wei, S.B. Wu, Y.S. Ma, and H.C. Lee Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging Chang Gung Med J 32 2 2009 113 132
    • (2009) Chang Gung Med J , vol.32 , Issue.2 , pp. 113-132
    • Wei, Y.H.1    Wu, S.B.2    Ma, Y.S.3    Lee, H.C.4
  • 298
    • 0037481943 scopus 로고    scopus 로고
    • Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice
    • J.E. Wells, R.J. Hurlbert, M.G. Fehlings, and V.W. Yong Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice Brain 126 Pt 7 2003 1628 1637 (Pubitemid 36834939)
    • (2003) Brain , vol.126 , Issue.7 , pp. 1628-1637
    • Wells, J.E.A.1    Hurlbert, R.J.2    Fehlings, M.G.3    Yong, V.W.4
  • 300
    • 34249781673 scopus 로고    scopus 로고
    • Erythropoietin is neuroprotective on GABAergic neurons against kainic acid-excitotoxicity in the rat spinal cell cultures
    • DOI 10.1016/j.brainres.2007.04.010, PII S0006899307008177
    • Y.J. Won, J.Y. Yoo, J.H. Lee, S.J. Hwang, D. Kim, and H.N. Hong Erythropoietin is neuroprotective on GABAergic neurons against kainic acid-excitotoxicity in the rat spinal cell cultures Brain Res 1154 2007 31 39 (Pubitemid 46856347)
    • (2007) Brain Research , vol.1154 , Issue.1 , pp. 31-39
    • Won, Y.J.1    Yoo, J.Y.2    Lee, J.H.3    Hwang, S.J.4    Kim, D.5    Hong, H.N.6
  • 301
    • 0027939233 scopus 로고
    • Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX
    • J.R. Wrathall, D. Choiniere, and Y.D. Teng Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX J Neurosci 14 11 Pt 1 1994 6598 6607 (Pubitemid 24333080)
    • (1994) Journal of Neuroscience , vol.14 , Issue.11 I , pp. 6598-6607
    • Wrathall, J.R.1    Choiniere, D.2    Teng, Y.D.3
  • 302
    • 0030054133 scopus 로고    scopus 로고
    • Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors
    • DOI 10.1006/exnr.1996.0012
    • J.R. Wrathall, Y.D. Teng, and D. Choiniere Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors Exp Neurol 137 1 1996 119 126 (Pubitemid 26041788)
    • (1996) Experimental Neurology , vol.137 , Issue.1 , pp. 119-126
    • Wrathall, J.R.1    Teng, Y.D.2    Choiniere, D.3
  • 303
    • 0342813092 scopus 로고    scopus 로고
    • Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma
    • DOI 10.1006/exnr.1997.6506
    • J.R. Wrathall, Y.D. Teng, and R. Marriott Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma Exp Neurol 145 2 Pt 1 1997 565 573 (Pubitemid 27314807)
    • (1997) Experimental Neurology , vol.145 , Issue.2 I , pp. 565-573
    • Wrathall, J.R.1    Teng, Y.D.2    Marriott, R.3
  • 304
    • 0032584936 scopus 로고    scopus 로고
    • Methylprednisolone inhibition of TNF-α expression and NF-κB activation after spinal cord injury in rats
    • DOI 10.1016/S0169-328X(98)00142-9, PII S0169328X98001429
    • J. Xu, G. Fan, S. Chen, Y. Wu, X.M. Xu, and C.Y. Hsu Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats Brain Res Mol Brain Res 59 2 1998 135 142 (Pubitemid 28434496)
    • (1998) Molecular Brain Research , vol.59 , Issue.2 , pp. 135-142
    • Xu, J.1    Fan, G.2    Chen, S.3    Wu, Y.4    Xu, X.M.5    Hsu, C.Y.6
  • 305
    • 0032031920 scopus 로고    scopus 로고
    • Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome C
    • DOI 10.1016/S0891-5849(97)00367-5, PII S0891584997003675
    • J.C. Yang, and G.A. Cortopassi Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c Free Radic Biol Med 24 4 1998 624 631 (Pubitemid 28150480)
    • (1998) Free Radical Biology and Medicine , vol.24 , Issue.4 , pp. 624-631
    • Yang, J.C.1    Cortopassi, G.A.2
  • 306
    • 56949085559 scopus 로고    scopus 로고
    • Erythropoietin improves oxidative stress following spinal cord trauma in rats
    • N. Yazihan, K. Uzuner, B. Salman, M. Vural, T. Koken, and A. Arslantas Erythropoietin improves oxidative stress following spinal cord trauma in rats Injury 39 12 2008 1408 1413
    • (2008) Injury , vol.39 , Issue.12 , pp. 1408-1413
    • Yazihan, N.1    Uzuner, K.2    Salman, B.3    Vural, M.4    Koken, T.5    Arslantas, A.6
  • 307
    • 0023782824 scopus 로고
    • Pharmacological therapy of acute spinal cord injury: Studies of high dose methylprednisolone and naloxone
    • W. Young, V. DeCrescito, E.S. Flamm, A.R. Blight, and J.A. Gruner Pharmacological therapy of acute spinal cord injury: studies of high dose methylprednisolone and naloxone Clin Neurosurgery 34 1988 675 697
    • (1988) Clin Neurosurgery , vol.34 , pp. 675-697
    • Young, W.1    Decrescito, V.2    Flamm, E.S.3    Blight, A.R.4    Gruner, J.A.5
  • 310
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • J. Yrjanheikki, T. Tikka, R. Keinanen, G. Goldsteins, P.H. Chan, and J. Koistinaho A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc Natl Acad Sci USA 96 23 1999 13496 13500
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 311
    • 34447643571 scopus 로고    scopus 로고
    • Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury
    • DOI 10.1523/JNEUROSCI.1661-07.2007
    • T.Y. Yune, J.Y. Lee, G.Y. Jung, S.J. Kim, M.H. Jiang, and Y.C. Kim Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury J Neurosci 27 29 2007 7751 7761 (Pubitemid 47093808)
    • (2007) Journal of Neuroscience , vol.27 , Issue.29 , pp. 7751-7761
    • Yune, T.Y.1    Lee, J.Y.2    Jung, G.Y.3    Kim, S.J.4    Jiang, M.H.5    Kim, Y.C.6    Oh, Y.J.7    Markelonis, G.J.8    Oh, T.H.9
  • 312
    • 2642692695 scopus 로고    scopus 로고
    • The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats
    • E. Zaidan, K.F. Sheu, and N.R. Sims The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats J Neurochem 70 1 1998 233 241 (Pubitemid 28020848)
    • (1998) Journal of Neurochemistry , vol.70 , Issue.1 , pp. 233-241
    • Zaidan, E.1    Sheu, K.-F.R.2    Sims, N.R.3
  • 313
    • 0032080444 scopus 로고    scopus 로고
    • Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat
    • DOI 10.1002/(SICI)1097-4547(19980 501)52:3<342::AID-JNR10>3.0.CO;2- 8
    • C. Zhang, R. Raghupathi, K.E. Saatman, D.H. Smith, J.M. Stutzmann, and F. Wahl Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat J Neurosci Res 52 3 1998 342 349 (Pubitemid 28196651)
    • (1998) Journal of Neuroscience Research , vol.52 , Issue.3 , pp. 342-349
    • Zhang, C.1    Raghupathi, R.2    Saatman, K.E.3    Smith, D.H.4    Stutzmann, J.-M.5    Wahl, F.6    McIntosh, T.K.7
  • 314
    • 67651216492 scopus 로고    scopus 로고
    • Combined R-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease
    • H. Zhang, H. Jia, J. Liu, N. Ao, B. Yan, and W. Shen Combined R-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease J Cell Mol Med 2008
    • (2008) J Cell Mol Med
    • Zhang, H.1    Jia, H.2    Liu, J.3    Ao, N.4    Yan, B.5    Shen, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.