Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress

Journal of Neuroscience Research

Volumn 79, Issue 1-2, 2005, Pages 240-247

  Martin, Erica ^a   Rosenthal, Robert E ^a   Fiskum, Gary ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Acetyl L carnitine; Acidosis; Lactate; Mitochondria; Peroxynitrite

Indexed keywords

ACETYL COENZYME A; CARBON DIOXIDE; LACTIC ACID; LEVACECARNINE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ALZHEIMER DISEASE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN OXYGEN CONSUMPTION; CATALYSIS; CONFERENCE PAPER; DECARBOXYLATION; ENERGY METABOLISM; ENZYME ACTIVITY; GLUCOSE BRAIN LEVEL; GLUCOSE INTAKE; HUMAN; IMMUNOREACTIVITY; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MODIFICATION; REPERFUSION INJURY; RESPIRATORY CHAIN; WERNICKE KORSAKOFF SYNDROME;

ANIMALS; BRAIN ISCHEMIA; ENERGY METABOLISM; ENZYME ACTIVATION; FRONTAL LOBE; HEART ARREST; HUMANS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; PYRUVATE DEHYDROGENASE COMPLEX; TIME FACTORS;

EID: 12244289642     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20293     Document Type: Conference Paper

References (72)

1. Baker JC, Yan X, Peng T, Kasten S, Roche TE. 2000. Marked differences between two isoforms of human pyruvate dehydrogenase kinase. J Biol Chem 275:15773-15781.
2. Beckman JS. 1996. Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836-844.
3. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624.
4. Biros MH, Dimlich RV, Barsan WG. 1986. Postinsult treatment of ischemia-induced cerebral lactic acidosis in the rat. Ann Emerg Med 15:397-404.
5. Bogaert YE, Rosenthal RE, Fiskum G. 1994. Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Radic Biol Med 16:811-820.
6. Bogaert YE, Sheu KF, Hof PR, Brown AM, Blass JP, Rosenthal RE, Fiskum G. 2000. Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation. Exp Neurol 161:115-126.
7. Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM. 1998. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 329:191-196.
8. Bresolin N, Freddo L, Vergani L, Angelini C. 1982. Carnitine, carnitine acyltransferases, and rat brain function. Exp Neurol 78:285-292.
9. Butterworth RF, Heroux M. 1989. Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes. J Neurochem 52:1079-1084.
10. Butterworth RF, Kril JJ, Harper CG. 1993. Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wemicke-Korsakoff syndrome. Alcohol Clin Exp Res 17:1084-1088.
11. Calabrese V, Scapagnini G, Latteri S, Colombrita C, Ravagna A, Catalano C, Pennisi G, Calvani M, Butterfield DA. 2002. Long-term ethanol administration enhances age-dependent modulation of redox state in different brain regions in the rat: protection by acetyl carnitine. Inc J Tissue React 24:97-104.
12. Calabrese V, Scapagnini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. 2003. Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Neurochem Res 28:1321-1328.
13. Cardell M, Koide T, Wieloch T. 1989. Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia. J Cereb Blood Flow Metab 9:350-357.
14. Chan PH. 2001. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21:2-14.
15. Chandy MJ, Ravindra J. 2000. Effect of dichloracetate on infarct size in a primate model of focal cerebral ischaemia. Neurol India 48:227-230.
16. Chang LH, Shimizu H, Abiko H, Swanson RA, Faden AI, James TL, Weinstein PR. 1992. Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. J Cereb Blood Flow Metab 12:1030-1038.
17. Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. 2001. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke 32: 1000-1004.
18. Corbett R, Laptook A, Gee J, Garcia D, Silmon S, Tollefsbol G. 1998. Age-related differences in the effect of dichloroacetate on postischemic lactate and acid clearance measured in vivo using magnetic resonance spectroscopy and microdialysis. J Neurochem 71:1205-1214.
19. Feelisch M, Ostrowski J, Noack E. 1989. On the mechanism of NO release from sydnonimines. J Cardiovasc Pharmacol 14(Suppl):13-22.
20. Floyd RA, Hensley K. 2002. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23:795-807.
21. Fouque F, Brivet M, Boutron A, Vequaud C, Marsac C, Zabot MT, Benelli C. 2003. Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. Pediatr Res 53:793-799.
22. Fukuchi T, Katayama Y, Kamiya T, McKee A, Kashiwagi F, Terashi A. 1998. The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain. Brain Res 792:59-65.
23. Garcia-Estrada J, Gonzalez-Perez O, Gonzalez-Castaneda RE, Martinez-Contreras A, Luquin S, de la Mora PG, Navarro-Ruiz A. 2003. An alpha-lipoic acid-vitamin E mixture reduces post-embolism lipid peroxidation, cerebral infarction, and neurological deficit in rats. Neurosci Res 47:219-224.
24. Goldstein S, Czapski G. 1995. The reaction of NO. with O2.- and HO2.: a pulse radiolysis study. Free Radic Biol Med 19:505-510.
25. Graham GD, Barker PB, Brooks WM, Morris DC, Ahmed W, Bryniarski E, Hearshen DO, Sanders JA, Holshouser BA, Turkel CC. 2000. MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Neurology 55:1376-1378.
26. Hinman LM, Blass JP. 1981. An NADH-linked spectrophotometric assay for pyruvate dehydrogenase complex in crude tissue homogenates. J Biol Chem 256:6583-6586.
27. Huang B, Gudi R, Wu P, Harris RA, Hamilton J, Popov KM. 1998. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. J Biol Chem 273:17680-17688.
28. Karpova T, Danchuk S, Kolobova E, Popov KM. 2003. Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity. Biochim Biophys Acta 1652:126-135.
29. Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL. 2000. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci USA 97:5440-5444.
30. Katayama Y, Welsh FA. 1989. Effect of dichloroacetate on regional energy metabolites and pyruvate dehydrogenase activity during ischemia and reperfusion in gerbil brain. J Neurochem 52:1817-1822.
31. Lipinski CA, Hicks SD, Callaway CW. 1999. Normoxic ventilation during resuscitation and outcome from asphyxial cardiac arrest in rats. Resuscitation 42:221-229.
32. Liu Y, Rosenthal RE, Haywood Y, Miljkovic-Lolic M, Vanderhoek JY, Fiskum G. 1998. Normoxic ventilation after cardiac arrest reduces oxidation of brain lipids and improves neurological outcome. Stroke 29: 1679-1686.
33. Liu Y, Rosenthal RE, Starke-Reed P, Fiskum G. 1993. Inhibition of postcardiac arrest brain protein oxidation by acetyl-L-camitine. Free Radic Biol Med 15:667-670.
34. Lundy EF, Klima LD, Huber TS, Zelenock GB, D'Alecy LG. 1987. Elevated blood ketone and glucagon levels cannot account for 1,3-butanediol induced cerebral protection in the Levine rat. Stroke 18:217-222.
35. Lundy EF, Luyckx BA, Combs DJ, Zelenock GB, D'Alecy LG. 1984. Butanediol induced cerebral protection from ischemic-hypoxia in the instrumented Levine rat. Stroke 15:547-552.
36. Marie C, Bralet AM, Bralet J. 1987. Protective action of 1,3-butanediol in cerebral ischemia. A neurologic, histologic, and metabolic study. J Cereb Blood Flow Metab 7:794-800.
37. Metodiewa D, Koska C. 2000. Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro) toxic events and neurologic disorders. An overview. Neurotox Res 1:197-233.
38. Mickel HS, Vaishnav YN, Kempski O, von Lubitz D, Weiss JF, Feuerstein G. 1987. Breathing 100% oxygen after global brain ischemia in Mongolian gerbils results in increased lipid peroxidation and increased mortality. Stroke 18:426-430.
39. Munujos P, Coll-Canti J, Beleta J, Gonzalez-Sastre F, Gella FJ. 1996. Brain pyruvate oxidation in experimental thiamin-deficiency encephalopathy. Clin Chim Acta 255:13-25.
40. Murphy MP, Packer MA, Scarlett JL, Martin SW. 1998. Peroxynitrite: a biologically significant oxidant. Gen Pharmacol 31:179-186.
41. Ottani A, Saltini S, Bartiromo M, Zaffe D, Renzo BA, Ferrari A, Bertolini A, Genedani S. 2003. Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage. Brain Res 986:181-190.
42. Packer L. 1998. alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Drug Metab Rev 30:245-275.
43. Parker WD, Haas R, Stumpf DA, Parks J, Eguren LA, Jackson C. 1984. Brain mitochondrial metabolism in experimental thiamine deficiency. Neurology 34:1477-1481.
44. Pascual JM, Carceller F, Roda JM, Cerdan S. 1998. Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. Stroke 29:1048-1056.
45. Patel MS, Harris RA. 1995. Mammalian alpha-keto acid dehydrogenase complexes: gene regulation and genetic defects. FASEB J 9:1164-1172.
46. Pocernich CB, Butterfield DA. 2003. Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotox Res 5:515-520.
47. Powell CS, Jackson RM. 2003. Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD. Am J Physiol Lung Cell Mol Physiol 285:189-198.
48. Pulsinelli WA, Levy DE, Duffy TE. 1982. Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann Neurol 11:499-502.
49. Reed LJ. 1981. Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle. Curr Top Cell Regul 18:95-106.
50. Reed LJ. 2001. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. J Biol Chem 276:38329-38336.
51. Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J. 2003. Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1. Eur J Biochem 270:1050-1056.
52. Rosenthal M, Feng ZC, Raffin CN, Harrison M, Sick TJ. 1995. Mitochondrial hyperoxidation signals residual intracellular dysfunction after global ischemia in rat neocortex. J Cereb Blood Flow Metab 15:655-665.
53. Rosenthal RE, Silbergleit R, Hof PR, Haywood Y, Fiskum G. 2003. Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke 34:1311-1316.
54. Rosenthal RE, Williams R, Bogaert YE, Getson PR, Fiskum G. 1992. Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke 23:1312-1317.
55. Sadek HA, Humphries KM, Szweda PA, Szweda LI. 2002. Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Arch Biochem Biophys 406:222-228.
56. Schoder H, Knight RJ, Kofoed KF, Schelbert HR, Buxton DB. 1998. Regulation of pyruvate dehydrogenase activity and glucose metabolism in post-ischaemic myocardium. Biochim Biophys Acta 1406:62-72.
57. Sheu KF, Kim YT, Blass JP, Weksler ME. 1985. An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. Ann Neurol 17:444-449.
58. Sims NR. 1995. Calcium, energy metabolism and the development of selective neuronal loss following short-term cerebral ischemia. Metab Brain Dis 10:191-217.
59. Sims NR, Heward SL. 1994. Delayed treatment with 1,3-butanediol reduces loss of CA1 neurons in the hippocampus of rats following brief forebrain ischemia. Brain Res 662:216-222.
60. Stadtman ER. 1990. Covalent modification reactions are marking steps in protein turnover. Biochemistry 29:6323-6331.
61. Sugden MC, Holness MJ. 2003. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 284:855-862.
62. Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S. 2003. D-beta-Hydroxybucyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest 112:892-901.
63. van der Worp HB, Kappelle LJ, Algra A, Bar PR, Orgogozo JM, Ringelstein EB, Bath PM, van Gijn J. 2002. The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology 58:133-135.
64. Vereczki V, Martin E, Rosenthal RE, Hof PR, Sherwood CC, Chinopoulos C, Hu W, Hoffman GE, Fiskum G. 2003. Normoxic versus hyperoxic ventilation after cardiac arrest: hippocampal protein nitration, pyruvate dehydrogenase immunoreactivity, and cell death. Soc Neurosci Abstr 739.8.
65. Whitehouse S, Cooper RH, Randle PJ. 1974. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 141:761-774.
66. Wilson JS, Rushing G, Johnson BL, Kline JA, Back MR, Bandyk DF. 2003. Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia. Vasc Endovascular Surg 37:191-195.
67. Wolz P, Krieglstein J. 1996. Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. Neuropharmacology 35:369-375.
68. Yosunkaya A, Ak A, Bariskaner H, Ustun ME, Tuncer S, Gurbilek M. 2004. Effect of γ-hydroxybutyric acid on lipid peroxidation and tissue lactate level in experimental head trauma. J Trauma 56:585-590.
69. Zaidan E, Sims NR. 1993. Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats. J Cereb Blood Flow Metab 13:98-104.
70. Zaidan E, Sims NR. 1997. Reduced activity of the pyruvate dehydrogenase complex but not cytochrome c oxidase is associated with neuronal loss in the striatum following short-term forebrain ischemia. Brain Res 772:23-28.
71. Zwemer CF, Whitesall SE, D'Alecy LG. 1994. Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs. Resuscitation 27:159-170. Erratum in: Resuscitation 27:267.
72. Zwemer CF, Whitesall SE, D'Alecy LG. 1994. Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs. Resuscitation 27:159-170. Erratum in: Resuscitation 27:267.