Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Nature

Volumn 417, Issue 6884, 2002, Pages 74-78

  Zhu, Shan ^a   Stavrovskaya, Irina G ^b   Drozda, Martin ^a   Kim, Betty Y S ^a   Ona, Victor ^a   Li, Mingwel ^a   Sarang, Satinder ^a   Liu, Allen S ^a   Hartley, Dean M ^a   Wu, Du Chu ^c   Guilans, Steven ^a   Ferrante, Robert J ^d,e   Przedborski, Serge ^a,c   Kristal, Bruce S ^b,f   Friedlander, Robert M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BRAIN; CELLS; DISEASES; ENZYMES; NITROGEN OXIDES;

MINOCYCLINES;

CYTOLOGY;

CASPASE 3; CYTOCHROME C; INTERLEUKIN 1BETA CONVERTING ENZYME; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE;

PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; DRUG SAFETY; ENZYME INHIBITION; ENZYME RELEASE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

AGE OF ONSET; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CASPASES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROME C GROUP; DISEASE PROGRESSION; ENZYME ACTIVATION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIA; MICE; MICE, INBRED C57BL; MINOCYCLINE; MITOCHONDRIA; MITOCHONDRIAL SWELLING; N-METHYLASPARTATE; PERMEABILITY; RATS; SURVIVAL RATE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037007645     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/417074a     Document Type: Article

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