Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Nature

Volumn 434, Issue 7033, 2005, Pages 658-662

  Baines, Christopher P ^a   Kaiser, Robert A ^a   Purcell, Nicole H ^a   Blair, N Scott ^a   Osinska, Hanna ^a   Hambleton, Michael A ^a   Brunskill, Eric W ^b   Sayen, M Richard ^c   Gottlieb, Roberta A ^c   Dorn II, Gerald W ^b   Bobbins, Jeffrey ^a   Molkentin, Jeffery D ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; ELECTRIC POTENTIAL; NEGATIVE IONS; SWELLING; TUMORS;

ANION CHANNELS; CELL DEATH; MITOCHONDRIAL PERMEABILITY TRANSITION (MPT); MITOCHONDRIAL SWELLING;

CELLS;

BETA GALACTOSIDASE; CALCIUM ION; COMPLEMENTARY DNA; CYCLOPHILIN; CYCLOPHILIN D; CYCLOSPORIN A; GENE PRODUCT; HYDROGEN PEROXIDE; PROTEIN BCL 2; UNCLASSIFIED DRUG; ATRACTYLOSIDE; BID PROTEIN, MOUSE; CALCIUM; CARRIER PROTEIN; CASPASE; CYTOCHROME C; PROTEIN BAX; PROTEIN BID;

BIOLOGY;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; EMBRYO; FIBROBLAST CULTURE; HEART MITOCHONDRION; HEART MUSCLE CELL; LIVER MITOCHONDRION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TISSUE CULTURE; TRANSGENIC MOUSE; ANIMAL; BRAIN; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENE DELETION; GENETICS; LIVER; METABOLISM; MITOCHONDRION; MITOCHONDRION SWELLING; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ADENOVIRIDAE; ANIMALS; ATRACTYLOSIDE; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BRAIN; CALCIUM; CARRIER PROTEINS; CASPASES; CELL DEATH; CELLS, CULTURED; CYCLOPHILINS; CYTOCHROMES C; FIBROBLASTS; GENE DELETION; HYDROGEN PEROXIDE; LIVER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL SWELLING; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 15844375853     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03434     Document Type: Article

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