Pharmacological Strategies to Block Rod Photoreceptor Apoptosis Caused by Calcium Overload: A Mechanistic Target-Site Approach to Neuroprotection

European Journal of Ophthalmology

Volumn 13, Issue 3_suppl, 2003, Pages 44-56

  Fox, D A ^a,b,c   Poblenz, A T ^b   He, L ^b   Harris, J B ^a   Medrano, C J ^a  

^a The Ocular Surface Institute   (United States)

^b Department of Biology and Biochemistry ^*  (United States)

^c UNIVERSITY OF HOUSTON   (United States)

Author keywords

Apoptosis; Ca2+ overload; Mitochondria; Neuroprotection; Retinal degeneration; Rod photoreceptors

Indexed keywords

CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CASP3 PROTEIN, MOUSE; CASP3 PROTEIN, RAT; CASPASE; CASPASE 3; CYCLIC GMP PHOSPHODIESTERASE; CYCLOSPORIN; CYTOCHROME C; DILTIAZEM; LEAD ACETATE; ORGANOMETALLIC COMPOUND; SODIUM CALCIUM EXCHANGE PROTEIN; VERAPAMIL;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL PROTECTION; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; LONG EVANS RAT; METABOLISM; MOUSE; OXYGEN CONSUMPTION; PATHOLOGY; RAT; RETINA DEGENERATION; RETINA ROD;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CASPASE 3; CASPASES; CYCLOSPORINE; CYTOCHROME C GROUP; CYTOPROTECTION; DILTIAZEM; FEMALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; ORGANOMETALLIC COMPOUNDS; OXYGEN CONSUMPTION; RATS; RATS, LONG-EVANS; RETINAL DEGENERATION; RODS (RETINA); SODIUM-CALCIUM EXCHANGER; VERAPAMIL;

MLCS; MLOWN;

EID: 0038305638     PISSN: 11206721     EISSN: 17246016     Source Type: Journal    
DOI: 10.1177/112067210301303S08     Document Type: Article

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