A Trail of Research from Lipoic Acid to α-Keto Acid Dehydrogenase Complexes

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 38329-38336

  Reed, Lester J ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID; OXIDOREDUCTASE; THIOCTIC ACID; 2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); MULTIENZYME COMPLEX;

CHEMICAL ANALYSIS; DEPHOSPHORYLATION; ENZYME PURIFICATION; ESCHERICHIA COLI; HUMAN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RESEARCH; REVIEW; ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HISTORY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); ANIMALS; ESCHERICHIA COLI; HISTORY, 20TH CENTURY; KETONE OXIDOREDUCTASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCTIC ACID;

EID: 0035914303     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.R100026200     Document Type: Review

References (10)

1. Reed, L. J., DeBusk, B. G., Gunsalus, I. C., and Hornberger, C. S., Jr. (1951) Crystalline α-lipoic acid: a catalytic agent associated with pyruvate dehydrogenase. Science 114, 93-94
2. Nawa, H., Brady, W. T., Koike, M., and Reed, L. J. (1960) Studies on the nature of protein-bound lipoic acid. J. Am. Chem. Soc. 82, 896-903
3. Koike, M., Reed, L. J., and Carroll, W. R. (1960) α-Keto acid dehydrogenation complexes. I. Purification and properties of pyruvate and α-ketoglutarate dehydrogenation complexes of Escherichia coli. J. Biol. Chem. 235, 1924-1930
4. Koike, M., Reed, L. J., and Carroll, W. R. (1963) α-Keto acid dehydrogenation complexes. IV. Resolution and reconstitution of the Escherichia coli pyruvate dehydrogenation complex. J. Biol. Chem. 238, 30-39
5. Bleile, D. M., Munk, P., Oliver, R. M., and Reed, L. J. (1979) Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 76, 4385-4389
6. Linn, T. C., Pettit, F. H., and Reed, L. J. (1969) α-Keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. Proc. Natl. Acad. Sci. U. S. A. 62, 234-241
7. Linn, T. C., Pelley, J. W., Pettit, F. H., Hucho, F., Randall, D. D., and Reed, L. J. (1972) α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart. Arch. Biochem. Biophys. 148, 327-342
8. Yan, J., Lawson, J. E., and Reed, L. J. (1996) Role of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase. Proc. Natl. Acad. Sci. U. S. A. 93, 4953-4956
9. Stoops, J. K., Cheng, R. H., Yazdi, M. A., Maeng, C-Y., Schroeter, J. P., Klueppelberg, U., Kolodziej, S. J., Baker, T. S., and Reed, L. J. (1997) On the unique structural organization of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. J. Biol. Chem. 272, 5757-5764
10. Zhou, Z. H., Liao, W., Cheng, R. H., Lawson, J. E., McCarthy, D. B., Reed, L. J., and Stoops, J. K. (2001) Direct evidence for the size and conformational variability of the pyruvate dehydrogenase complex revealed by three-dimensional electron microscopy. J. Biol. Chem. 276, 21704-21713