Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: Transcriptional regulation of inflammatory and neurotrophic genes

Journal of Neurotrauma

Volumn 18, Issue 1, 2001, Pages 93-103

  Chikawa, T ^a   Ikata, T ^a   Katoh, S ^a   Hamada, Y ^a   Kogure, K ^b   Fukuzawa, K ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Lecithinized superoxide dismutase; Methylprednisolone; Neurotrophin 3; Oxidative stress; Proinflammatory substances; Spinal cord injury

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPID PEROXIDE; MESSENGER RNA; METHYLPREDNISOLONE; NEUROTROPHIN 3; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLCHOLINE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE REPRESSION; MALE; MOTOR PERFORMANCE; NONHUMAN; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; TRANSCRIPTION REGULATION;

EID: 0035181558     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771501750055802     Document Type: Article

References (52)

1. Double-immunolabeling studies of glucocorticoid receptors in enkephalinergic neurons of the rat spinal cord
2. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
3. Function and activation of NF-κB in the immune system
4. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
5. A sensitive and reliable locomotor rating scale for open field testing in rats
6. MASCIS evaluation of open field locomotor scores: Effects of experience and teamwork on reliability
7. Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells
8. Traumatic spinal cord injury induces nuclear factor-κB activation
9. Transition from interleukin 1β (IL-1β) to IL-1α production during maturation of inflammatory macrophages in vivo
10. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study
11. Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat
12. Increased nerve growth factor receptor mRNA in contused rat spinal cord
13. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
14. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats
15. Thiol modulation of TNFα and IL-1 induced MnSOD gene expression and activation of NF-κB
16. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain
17. The free radical pathology and the microcirculation in the major central nervous disorders
18. Opiate antagonist improves neurologic recovery after spinal injury
19. Recovery of motor function after spinal-cord injury - A randomized, placebo-controlled trial with GM-1 ganglioside
20. Regulation of HIV-1 gene expression
21. Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats
22. The neuroprotective pharmacology of methylprednisolone
23. Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury
24. Free radical in CNS injury
25. Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury
26. Lack of effect of postinjury treatment with methylprednisolone or tirilazad mesylate on the increase in eicosanoid levels in the acutely injured cat spinal cord
27. Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury
28. Roles of nitric oxide in compression injury of rat spinal cord
29. 1 on spinal cord injury in rats
30. Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury
31. Lecithinized superoxide dismutase potentiates its protective effect against forssman antiserum-induced elevation in guinea pig airway resistance
32. Lecithinized superoxide dismutase enhances its pharmacologic potency by increasing its cell membrane affinity
33. Protective effect of vitamin E on spinal cord injury by compression and concurrent lipid peroxidation
34. Effects of pro-inflammatory cytokines in experimental spinal cord injury
35. Spinal cord transplants enhance the recovery of locomotor function after spinal cord injury at birth
36. Methods to assess the development and recovery of locomotor function after spinal cord injury in rats
37. 2 and tumor necrosis factor-alpha in endothelial and epithelial cells
38. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
39. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase m-RNA
40. Neurotrophin-3: A neurotrophic factor related to NGF and BDNF
41. Induction of mitochondrial manganese superoxide dismutase by interleukin 1
42. Effects of lecithinized superoxide dismutase on rat spinal cord injury
43. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
44. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
45. Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization
46. Objective clinical assessment of motor function after experimental spinal cord injury in the rat
47. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
48. Spinal cord injury in the rat
49. Spinal cord compression studies
50. Rel/NF-κB/IκB family: Intimate tales of association and dissociation
51. Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat
52. Methylprednisolone inhibition of TNF-alpha expression and NF-κB activation after spinal cord injury in rats