Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Nature

Volumn 434, Issue 7033, 2005, Pages 652-658

  Nakagawa, Takashi ^a,b   Shimizu, Shigeomi ^a,b   Watanabe, Tetsuya ^a   Yamaguchi, Osamu ^a   Otsu, Kinya ^a   Yamagata, Hirotaka ^a   Inohara, Hidenori ^a   Kubo, Takeshi ^a   Tsujimoto, Yoshihide ^a,b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; OXYGEN; POSITIVE IONS;

ENERGY PRODUCTION; HEMEOSTASIS; MITOCHONDRIAL PERMEABILITY TRANSITION (MPT); NECROTIC CELL DEATH;

CELLS;

CALCIUM ION; CYCLOPHILIN; CYCLOPHILIN D; CYCLOSPORIN; UNCLASSIFIED DRUG; CALCIUM; CASPASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE;

BIOLOGY;

ANIMAL CELL; ARTICLE; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; GENOTYPE; LIVER MITOCHONDRION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; FIBROBLAST; GENETICS; HEART MUSCLE ISCHEMIA; LIVER CELL; METABOLISM; MITOCHONDRION SWELLING; MOUSE MUTANT; NECROSIS; PATHOLOGY; PHYSIOLOGY; REPERFUSION INJURY; THYMUS;

ANIMALS; APOPTOSIS; CALCIUM; CASPASES; CELLS, CULTURED; CYCLOPHILINS; ENZYME ACTIVATION; FIBROBLASTS; HEPATOCYTES; HYDROGEN PEROXIDE; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; NECROSIS; REACTIVE OXYGEN SPECIES; THYMUS GLAND;

EID: 15844407874     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03317     Document Type: Article

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