Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats

Neuroscience Letters

Volumn 266, Issue 1, 1999, Pages 61-64

  Diaz Ruiz, Araceli ^a,b   Rios, Camilo ^b   Duarte, Ivonne ^a   Correa, Dolores ^c   Guizar Sahagun, Gabriel ^a   Grijalva, Israel ^a   Ibarra, Antonio ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^c HOSPITAL GENERAL DE MÉXICO   (Mexico)

Author keywords

Cyclosporin A; Free radicals; Inflammatory response; Lipid peroxidation; Neuroprotection; Spinal cord injury

Indexed keywords

CYCLOSPORIN A; FREE RADICAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; FEMALE; IMMUNOSUPPRESSIVE TREATMENT; INHIBITION KINETICS; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

EID: 0345711646     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00255-4     Document Type: Article

References (20)

1. Aspberg A., Tottmar O. Oxidative stress decreases antioxidant enzyme activities in reaggregation cultures of brain cells. Free Radical Biol. Med. 17:1994;511-516.
2. Balentine J.D., Paris D. Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury. Lab. Invest. 39:1978;236-253.
3. Bartram L., Kasiske M.D. Cyclosporine and lipid peroxidation. Am. J. Kidney Dis. 31:1998;149-154.
4. Borel J. Mechanism of action of cyclosporin-A and rationale for its use in nephrotic syndrome. Clin. Nephrol. 35:1991;23-30.
5. Dawson T.M., Snyder S.H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14:1995;5147-5159.
6. Grijalva I., Guízar-Sahagún G., Madrazo I., Franco-Bourland R., Salgado-Ceballos H., Ibarra A., Espitia L. Neuroprotection by methylprednisolone for mechanic-enzimatic manipulation of contused spinal cord areas in rats. Neurodegeneration. 3:1994;159-162.
7. Guízar-Sahagún G., Grijalva I., Madrazo I., Franco-Bourland R., Salgado H., Ibarra A., Oliva E., Zepeda A. Development of post-traumatic cysts in the spinal cord contusion. Surg. Neurol. 41:1994;149-241.
8. Guízar-Sahagún G., Garcia-López P., Espitia A.L., Grijalva I., Franco-Bourland R., Madrazo I. Transitory expression of NADPH diaphorase (NOS) in axonal swellings after spinal cord injury. NeuroReport. 9:1998;2899-2902.
9. Hall D.E., Braughler J.M. Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radical Biol. Med. 6:1989;303-307.
10. Hall D.E. The role of oxygen radicals in traumatic injury: clinical implications. J. Emerg. Med. 11:1993;31-36.
11. Halliwell B., Gutteridge J.M.C. Oxigen radicals and the nervous system. Trends Neurosci. 8:1985;22-26.
12. Ibarra A., Reyes J., Martinez S., Correa D., Guizar-Sahagún G., Grijalva I., Castañeda-Hernández G., Flores-Murrieta F.J., Franco-Bourland R., Madrazo I. Use of cyclosporin-A in experimental spinal cord injury: design of a dosing strategy to maintain therapeutic levels. J. Neurotrauma. 13:1996;569-572.
13. Paker M.A., Murphy M.P. Peroxinitrite causes calcium efflux from mitocondria which is prevented by Cyclosporin A. FEBS Lett. 345:1994;237-240.
14. Palladini, G., Caronti, B., Pozzessere, G., Teichner, A., Buttarelli, F.R., Morselli, E., Valle, E., Venturini, G., Fortuna, A. and Pontieri, F.L., Treatment with cyclosporin-A promotes axonal regeneration in rats submitted to transverse section of the spinal cord. II. Recovery of function, J. Brain Res., 37 (1996) 145-153.
15. Popovich P.G., Wei P., Stokes B.T. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J. Comp. Neurol. 377:1997;443-464.
16. Santamaria A., Ríos C. MK an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci. Lett. 159:1993;51-54.
17. Stellato C., De Pauli A., Ciccarelli A., Cirillo R., Patella V., Casolaro V., Marone G. Anti-inflammatory effect of cyclosporin-A on human skin mast cells. J. Invest. Dermatol. 98:1992;800-804.
18. Stokes B.T., Reier P.J. Fetal grafts alter chronic behavioural outcome after contusion damage to the adult rat spinal cord. Exp. Neurol. 116:1992;1-12.
19. Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol. Med. 8:1990;583-599.
20. Suzuki S., Toledo-Pereyra L.H., Rodriguez F.J., Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and Cyclosporine. Transplantation. 55:1993;1265-1272.