Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat-Effects on BBB breakdown and MMP expression in the acute and subacute phase

Brain Research

Volumn 1188, Issue 1, 2008, Pages 198-206

  Nagel, Simon ^a   Su, Ying ^a,d   Horstmann, Solveig ^a   Heiland, Sabine ^a   Gardner, Humphrey ^b   Koziol, Jim ^c   Martinez Torres, Francisco J ^a   Wagner, Simone ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

BBB breakdown; Focal cerebral ischemia; Hypothermia; MCAO R; Metalloproteinase; Minocycline; MRI

Indexed keywords

GELATINASE A; GELATINASE B; MINOCYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; ENZYME INHIBITION; INDUCED HYPOTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SERUM; ZYMOGRAPHY;

ACUTE DISEASE; ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HYPOTHERMIA, INDUCED; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACRANIAL HEMORRHAGES; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METALLOPROTEASES; MINOCYCLINE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; REPERFUSION INJURY; TIME FACTORS;

RATTUS; RATTUS NORVEGICUS;

EID: 37349030729     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.10.052     Document Type: Article

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