Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

Molecular and Cellular Biochemistry

Volumn 174, Issue 1-2, 1997, Pages 167-172

  Halestrap, A R ^a   Connern, C R ^a   Griffiths, E J ^a   Kerr, P M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Calcium; Cyclophilin; Cyclosporin A; Mitochondrial permeability transition; Oxidative stress; Reperfusion injury

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CYCLOPHILIN; CYCLOSPORIN A;

ARTICLE; CELL MEMBRANE POTENTIAL; CELL PH; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; HUMAN; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; REPERFUSION INJURY;

ANIMALS; CALCIUM; CYCLOSPORINE; HUMANS; INTRACELLULAR MEMBRANES; MITOCHONDRIA, HEART; MITOCHONDRIAL SWELLING; MYOCARDIAL REPERFUSION INJURY; PEPTIDYLPROLYL ISOMERASE; PERMEABILITY; PROTEIN BINDING; RATS;

EID: 0030826778     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006879618176     Document Type: Article

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