메뉴 건너뛰기




Volumn 32, Issue 2, 2009, Pages 113-132

Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging

Author keywords

Aging; Altered gene expression; Metabolic shift; Mitochondria; mTDNA mutation; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; DNA DIRECTED DNA POLYMERASE GAMMA; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 64949161526     PISSN: 20720939     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (102)

References (140)
  • 1
    • 0036139856 scopus 로고    scopus 로고
    • The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology
    • Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 2001 ;52:159-64.
    • (2001) IUBMB Life , vol.52 , pp. 159-164
    • Lenaz, G.1
  • 3
    • 0030897739 scopus 로고    scopus 로고
    • Genetic and functional changes in mitochondria associated with aging
    • Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol Rev 1997;77:425-64.
    • (1997) Physiol Rev , vol.77 , pp. 425-464
    • Ozawa, T.1
  • 4
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 5
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972;20:145-7.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 6
    • 0020516814 scopus 로고
    • Free radical theory of aging: Consequences of mitochondrial aging
    • Harman D. Free radical theory of aging: Consequences of mitochondrial aging. Age 1983;6:86-94.
    • (1983) Age , vol.6 , pp. 86-94
    • Harman, D.1
  • 7
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;i:642-5.
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 8
    • 0026746336 scopus 로고
    • Mitochondrial DNA alterations as ageing-associated molecular events
    • Wei YH. Mitochondrial DNA alterations as ageing-associated molecular events. Mutat Res 1992;275:145-55.
    • (1992) Mutat Res , vol.275 , pp. 145-155
    • Wei, Y.H.1
  • 9
    • 0029116061 scopus 로고
    • Oxidative damage to mitochondrial DNA and its relationship to ageing
    • Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 1995;27:647-53.
    • (1995) Int J Biochem Cell Biol , vol.27 , pp. 647-653
    • Richter, C.1
  • 10
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998;78:547-81.
    • (1998) Physiol Rev , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 11
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 12
    • 0029147191 scopus 로고
    • Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies
    • Sohal RS, Sohal BH, Orr WC. Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Radic BiolMed 1995;19:499-504.
    • (1995) Free Radic BiolMed , vol.19 , pp. 499-504
    • Sohal, R.S.1    Sohal, B.H.2    Orr, W.C.3
  • 13
    • 0036420161 scopus 로고    scopus 로고
    • Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
    • Lee HC, Yin PH, Chi CW, Wei YH. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J Biomed Sci 2002;9:517-26.
    • (2002) J Biomed Sci , vol.9 , pp. 517-526
    • Lee, H.C.1    Yin, P.H.2    Chi, C.W.3    Wei, Y.H.4
  • 14
    • 0019891031 scopus 로고
    • Ubisemiquinone radicals from the cytochrome b-c1 complex of the mitochondrial electron transport chain - demonstration of QP-S radical formation
    • Wei YH, Scholes CP, King TE. Ubisemiquinone radicals from the cytochrome b-c1 complex of the mitochondrial electron transport chain - demonstration of QP-S radical formation. Biochem Biophys Res Commun 1981 ;99: 1411-9.
    • (1981) Biochem Biophys Res Commun , vol.99 , pp. 1411-1419
    • Wei, Y.H.1    Scholes, C.P.2    King, T.E.3
  • 15
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • Sohal RS, Ku HH, Agarwal S, Forster MJ, Lai H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 1994;74:121- 33.
    • (1994) Mech Ageing Dev , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lai, H.5
  • 16
    • 2542446099 scopus 로고    scopus 로고
    • Aging in vertebrates, and the effect of caloric restriction: A mitochondrial free radical production - DNA damage mechanism?
    • Barja G. Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production - DNA damage mechanism? Biol Rev Camb Philos Soc 2004;79:235-51.
    • (2004) Biol Rev Camb Philos Soc , vol.79 , pp. 235-251
    • Barja, G.1
  • 17
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6465-7.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 18
    • 0027055332 scopus 로고
    • Ageassociated oxygen damage and mutations in mitochondrial DNA in human hearts
    • Hayakawa M, Hattori K, Sugiyama S, Ozawa T. Ageassociated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem Biophys Res Commun 1992;189:979-85.
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 979-985
    • Hayakawa, M.1    Hattori, K.2    Sugiyama, S.3    Ozawa, T.4
  • 19
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-22.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 20
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM, van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    van Houten, B.2
  • 21
    • 0242321023 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation
    • Lin PH, Lee SH, Su CP, Wei YH. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic Biol Med 2003;35:1310-8.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1310-1318
    • Lin, P.H.1    Lee, S.H.2    Su, C.P.3    Wei, Y.H.4
  • 22
    • 0026784592 scopus 로고
    • Lipid peroxidation and mtDNA degeneration. A hypothesis
    • Hruszkewycz AM. Lipid peroxidation and mtDNA degeneration. A hypothesis. Mutat Res 1992;275:243-8.
    • (1992) Mutat Res , vol.275 , pp. 243-248
    • Hruszkewycz, A.M.1
  • 23
    • 0029594475 scopus 로고
    • Differential oxidative damage to mitochondrial proteins during aging
    • Agarwal S, Sohal RS. Differential oxidative damage to mitochondrial proteins during aging. Mech Ageing Dev 1995;85:55-63.
    • (1995) Mech Ageing Dev , vol.85 , pp. 55-63
    • Agarwal, S.1    Sohal, R.S.2
  • 25
    • 0034214103 scopus 로고    scopus 로고
    • Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
    • Lee HC, Yin PH, Lu CY, Chi CW, Wei YH. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 2000;348: 425-32.
    • (2000) Biochem J , vol.348 , pp. 425-432
    • Lee, H.C.1    Yin, P.H.2    Lu, C.Y.3    Chi, C.W.4    Wei, Y.H.5
  • 26
    • 0035854649 scopus 로고    scopus 로고
    • Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects
    • Lezza AM, Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Cantatore P, Gadaleta MN. Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. FEBS Lett 2001;501:74-8.
    • (2001) FEBS Lett , vol.501 , pp. 74-78
    • Lezza, A.M.1    Pesce, V.2    Cormio, A.3    Fracasso, F.4    Vecchiet, J.5    Felzani, G.6    Cantatore, P.7    Gadaleta, M.N.8
  • 27
    • 33745137507 scopus 로고    scopus 로고
    • Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress
    • Lee CF, Chen YC, Liu CY, Wei YH. Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. Free Radic Biol Med 2006;40:2136-46.
    • (2006) Free Radic Biol Med , vol.40 , pp. 2136-2146
    • Lee, C.F.1    Chen, Y.C.2    Liu, C.Y.3    Wei, Y.H.4
  • 29
    • 0002026429 scopus 로고    scopus 로고
    • Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin
    • Lu CY, Lee HC, Fahn HJ, Wei YH. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res 1999;423:11-21.
    • (1999) Mutat Res , vol.423 , pp. 11-21
    • Lu, C.Y.1    Lee, H.C.2    Fahn, H.J.3    Wei, Y.H.4
  • 30
    • 0036790385 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
    • Wei YH, Lee HC. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med 2002;227:671-82.
    • (2002) Exp Biol Med , vol.227 , pp. 671-682
    • Wei, Y.H.1    Lee, H.C.2
  • 31
    • 0035685590 scopus 로고    scopus 로고
    • Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging
    • Lee HC, Wei YH. Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2001;2:231-44.
    • (2001) Biogerontology , vol.2 , pp. 231-244
    • Lee, H.C.1    Wei, Y.H.2
  • 32
    • 42649129672 scopus 로고    scopus 로고
    • MtDNA mutations, functional decline and turnover of mitochondria in aging
    • Pang CY, Ma YS, Wei YH. MtDNA mutations, functional decline and turnover of mitochondria in aging. Front Biosci2008;13:3661-75.
    • Front Biosci2008;13 , pp. 3661-3675
    • Pang, C.Y.1    Ma, Y.S.2    Wei, Y.H.3
  • 33
    • 0024547664 scopus 로고
    • Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
    • Phillips JP, Campbell SD, Michaud D, Charbonneau M, Hilliker AJ. Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 1989;86: 2761-5.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2761-2765
    • Phillips, J.P.1    Campbell, S.D.2    Michaud, D.3    Charbonneau, M.4    Hilliker, A.J.5
  • 34
    • 0027284743 scopus 로고
    • Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster
    • Griswold CM, Matthews AL, Bewley KE, Mahaffey JW. Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster. Genetics 1993;134:781-8.
    • (1993) Genetics , vol.134 , pp. 781-788
    • Griswold, C.M.1    Matthews, A.L.2    Bewley, K.E.3    Mahaffey, J.W.4
  • 38
    • 0032561328 scopus 로고    scopus 로고
    • Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice
    • Williams MD, van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J BiolChem 1998;273:28510-5.
    • (1998) J BiolChem , vol.273 , pp. 28510-28515
    • Williams, M.D.1    van Remmen, H.2    Conrad, C.C.3    Huang, T.T.4    Epstein, C.J.5    Richardson, A.6
  • 40
    • 0035956929 scopus 로고    scopus 로고
    • +/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis
    • +/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci USA 2001;98:2278-83.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2278-2283
    • Kokoszka, J.E.1    Coskun, P.2    Esposito, L.A.3    Wallace, D.C.4
  • 41
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
    • Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 1994;263:1128-30.
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 42
    • 0029039854 scopus 로고
    • Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster
    • Sohal RS, Agarwal A, Agarwal S, Orr WC. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J Biol Chem 1995;270:15671-4.
    • (1995) J Biol Chem , vol.270 , pp. 15671-15674
    • Sohal, R.S.1    Agarwal, A.2    Agarwal, S.3    Orr, W.C.4
  • 43
    • 0027293919 scopus 로고
    • Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster
    • Orr WC, Sohal RS. Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys 1993;301:34-40.
    • (1993) Arch Biochem Biophys , vol.301 , pp. 34-40
    • Orr, W.C.1    Sohal, R.S.2
  • 45
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study
    • Müller-Höcker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol 1989;134:1167-73.
    • (1989) Am J Pathol , vol.134 , pp. 1167-1173
    • Müller-Höcker, J.1
  • 46
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
    • Müller-Höcker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci 1990;100:14-21.
    • (1990) J Neurol Sci , vol.100 , pp. 14-21
    • Müller-Höcker, J.1
  • 47
    • 0027525966 scopus 로고
    • Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
    • Müller-Höcker J, Seibel P, Schneiderbanger K, Kadenbach B. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch A Pathol Anat Histopathol 1993;422:7-15.
    • (1993) Virchows Arch A Pathol Anat Histopathol , vol.422 , pp. 7-15
    • Müller-Höcker, J.1    Seibel, P.2    Schneiderbanger, K.3    Kadenbach, B.4
  • 49
    • 0024580556 scopus 로고    scopus 로고
    • Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;i:637-9.
    • Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;i:637-9.
  • 50
    • 0026469073 scopus 로고
    • Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing
    • Cooper JM, Mann VM, Schapira AH. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. JNeurol Sci 1992;113:91-8.
    • (1992) JNeurol Sci , vol.113 , pp. 91-98
    • Cooper, J.M.1    Mann, V.M.2    Schapira, A.H.3
  • 51
    • 0028235259 scopus 로고
    • Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria
    • Hsieh RH, Hou JH, Hsu HS, Wei YH. Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem Mol Biol Int 1994;32:1009-22.
    • (1994) Biochem Mol Biol Int , vol.32 , pp. 1009-1022
    • Hsieh, R.H.1    Hou, J.H.2    Hsu, H.S.3    Wei, Y.H.4
  • 52
    • 0027182560 scopus 로고
    • Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
    • Sugiyama S, Takasawa M, Hayakawa M, Ozawa T. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem Mol Biol Int 1993;30:937-44.
    • (1993) Biochem Mol Biol Int , vol.30 , pp. 937-944
    • Sugiyama, S.1    Takasawa, M.2    Hayakawa, M.3    Ozawa, T.4
  • 55
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM, van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    van Houten, B.2
  • 56
    • 0028788763 scopus 로고
    • Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factorkappa B: Studies with isolated mitochondria and rat hepatocytes
    • Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernandez-Checa JC. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factorkappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 1995;48:825-34.
    • (1995) Mol Pharmacol , vol.48 , pp. 825-834
    • Garcia-Ruiz, C.1    Colell, A.2    Morales, A.3    Kaplowitz, N.4    Fernandez-Checa, J.C.5
  • 57
    • 28244454785 scopus 로고    scopus 로고
    • Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
    • Yarian CS, Toroser D, Sohal RS. Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice. Mech Ageing Dev 2006;127:79- 84.
    • (2006) Mech Ageing Dev , vol.127 , pp. 79-84
    • Yarian, C.S.1    Toroser, D.2    Sohal, R.S.3
  • 58
    • 0037082142 scopus 로고    scopus 로고
    • The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age
    • Atamna H, Walter PB, Ames BN. The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys 2002;397:345-53.
    • (2002) Arch Biochem Biophys , vol.397 , pp. 345-353
    • Atamna, H.1    Walter, P.B.2    Ames, B.N.3
  • 59
    • 0030881686 scopus 로고    scopus 로고
    • Oxidative damage during aging targets mitochondrial aconitase
    • Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci USA 1997;94:11168-72.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11168-11172
    • Yan, L.J.1    Levine, R.L.2    Sohal, R.S.3
  • 60
    • 0032573066 scopus 로고    scopus 로고
    • Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
    • Yan LJ, Sohal RS. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci USA 1998;95:12896-901.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12896-12901
    • Yan, L.J.1    Sohal, R.S.2
  • 61
    • 0028075773 scopus 로고
    • Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs
    • Gardner PR, Nguyen DD, White CW. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA 1994;91:12248-52.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12248-12252
    • Gardner, P.R.1    Nguyen, D.D.2    White, C.W.3
  • 63
    • 0032436502 scopus 로고    scopus 로고
    • Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function
    • Wei YH, Lu CY, Lee HC, Pang CY, Ma YS. Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function. Ann NY Acad Sci 1998;854:155-70.
    • (1998) Ann NY Acad Sci , vol.854 , pp. 155-170
    • Wei, Y.H.1    Lu, C.Y.2    Lee, H.C.3    Pang, C.Y.4    Ma, Y.S.5
  • 64
    • 0027244097 scopus 로고
    • Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced
    • Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 1993;268:18891-7.
    • (1993) J Biol Chem , vol.268 , pp. 18891-18897
    • Calleja, M.1    Pena, P.2    Ugalde, C.3    Ferreiro, C.4    Marco, R.5    Garesse, R.6
  • 65
    • 0025115244 scopus 로고
    • Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L- carnitine
    • Gadaleta MN, Petruzzella V, Renis M, Fracasso F, Cantatore P. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L- carnitine. Eur J Biochem 1990;187:501-6.
    • (1990) Eur J Biochem , vol.187 , pp. 501-506
    • Gadaleta, M.N.1    Petruzzella, V.2    Renis, M.3    Fracasso, F.4    Cantatore, P.5
  • 69
    • 0030059079 scopus 로고    scopus 로고
    • Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
    • Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 1996;271:15891-7.
    • (1996) J Biol Chem , vol.271 , pp. 15891-15897
    • Laderman, K.A.1    Penny, J.R.2    Mazzucchelli, F.3    Bresolin, N.4    Scarlato, G.5    Attardi, G.6
  • 70
    • 0141483496 scopus 로고    scopus 로고
    • Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
    • Greco M, Villani G, Mazzucchelli F, Bresolin N, Papa S, Attardi G. Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts. FASEB J2003;17:1706-8.
    • FASEB , vol.J2003 , Issue.17 , pp. 1706-1708
    • Greco, M.1    Villani, G.2    Mazzucchelli, F.3    Bresolin, N.4    Papa, S.5    Attardi, G.6
  • 71
    • 0021348372 scopus 로고
    • Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age
    • Bailey PJ, Webster GC. Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age. Mech Ageing Dev 1984;24:233-41.
    • (1984) Mech Ageing Dev , vol.24 , pp. 233-241
    • Bailey, P.J.1    Webster, G.C.2
  • 72
    • 0020353123 scopus 로고
    • Age-related decline in the biosynthesis of mitochondrial inner membrane proteins
    • Marcus DL, Ibrahim NG, Freedman ML. Age-related decline in the biosynthesis of mitochondrial inner membrane proteins. Exp Gerontol 1982; 17:333-41.
    • (1982) Exp Gerontol , vol.17 , pp. 333-341
    • Marcus, D.L.1    Ibrahim, N.G.2    Freedman, M.L.3
  • 73
    • 0030451773 scopus 로고    scopus 로고
    • Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
    • Rooyackers OE, Adey DB, Ades PA, Nair KS. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 1996;93:15364-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15364-15369
    • Rooyackers, O.E.1    Adey, D.B.2    Ades, P.A.3    Nair, K.S.4
  • 74
    • 17244363631 scopus 로고    scopus 로고
    • Short KR, Bigelow ML, Kahl J, Singh R, Coenen- Schimke J, Raghavakaimal S, Nair KS. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005;102:5618-23.
    • Short KR, Bigelow ML, Kahl J, Singh R, Coenen- Schimke J, Raghavakaimal S, Nair KS. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005;102:5618-23.
  • 75
    • 51649126499 scopus 로고    scopus 로고
    • Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice
    • Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi- Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice. J Neurosci 2008;28:8624-34.
    • (2008) J Neurosci , vol.28 , pp. 8624-8634
    • Hayashi, Y.1    Yoshida, M.2    Yamato, M.3    Ide, T.4    Wu, Z.5    Ochi- Shindou, M.6    Kanki, T.7    Kang, D.8    Sunagawa, K.9    Tsutsui, H.10    Nakanishi, H.11
  • 76
    • 0025741445 scopus 로고
    • Ageing-associated 5 kb deletion in human liver mitochondrial DNA
    • Yen TC, Su JH, King KL,Wei YH. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem Biophys Res Commun 1991;178:124-31.
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 124-131
    • Yen, T.C.1    Su, J.H.2    King, K.L.3    Wei, Y.H.4
  • 78
    • 0028349234 scopus 로고
    • Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
    • Lee HC, Pang CY, Hsu HS, Wei YH. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1994;1226:37-43.
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 37-43
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 79
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999;286:774-9.
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 83
    • 0027198359 scopus 로고
    • Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans
    • Zhang C, Linnane AW, Nagley P. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun 1993;195:1104-10.
    • (1993) Biochem Biophys Res Commun , vol.195 , pp. 1104-1110
    • Zhang, C.1    Linnane, A.W.2    Nagley, P.3
  • 84
    • 0027476395 scopus 로고
    • The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages
    • Munscher C, Rieger T, Muller-Hocker J, Kadenbach B. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 1993;317:27-30.
    • (1993) FEBS Lett , vol.317 , pp. 27-30
    • Munscher, C.1    Rieger, T.2    Muller-Hocker, J.3    Kadenbach, B.4
  • 85
    • 0026532722 scopus 로고
    • Multiple mitochondrial DNA deletions in an elderly human individual
    • Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 1992;297:34-8.
    • (1992) FEBS Lett , vol.297 , pp. 34-38
    • Zhang, C.1    Baumer, A.2    Maxwell, R.J.3    Linnane, A.W.4    Nagley, P.5
  • 86
    • 0028061412 scopus 로고
    • Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle
    • Lee HC, Pang CY, Hsu HS, Wei YH. Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle. FEBS Lett 1994;354:79-83.
    • (1994) FEBS Lett , vol.354 , pp. 79-83
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 87
    • 0029741620 scopus 로고    scopus 로고
    • Wei YH, Pang CY, You BJ, Lee HC. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann NY Acad Sci 12996;786:82-101.
    • Wei YH, Pang CY, You BJ, Lee HC. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann NY Acad Sci 12996;786:82-101.
  • 88
    • 0032401024 scopus 로고    scopus 로고
    • Ageing and mammalian mitochondrial genetics
    • Nagley P, Wei YH. Ageing and mammalian mitochondrial genetics. Trends Genet 1998;14:513-7.
    • (1998) Trends Genet , vol.14 , pp. 513-517
    • Nagley, P.1    Wei, Y.H.2
  • 89
    • 0030877134 scopus 로고    scopus 로고
    • Multiorgan characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age
    • Melov S, Hinerfeld D, Esposito L, Wallace DC. Multiorgan characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res 1997;25:974-82.
    • (1997) Nucleic Acids Res , vol.25 , pp. 974-982
    • Melov, S.1    Hinerfeld, D.2    Esposito, L.3    Wallace, D.C.4
  • 93
    • 0035349906 scopus 로고    scopus 로고
    • The genetics and pathology of oxidative phosphorylation
    • Smeitink J, van den Heuvel L, DiMauro S. The genetics and pathology of oxidative phosphorylation. Nat Rev Genet 2001;2:342-52.
    • (2001) Nat Rev Genet , vol.2 , pp. 342-352
    • Smeitink, J.1    van den Heuvel, L.2    DiMauro, S.3
  • 95
    • 0032511842 scopus 로고    scopus 로고
    • An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle
    • Kopsidas G, Kovalenko SA, Kelso JM, Linnane AW. An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle. Mutat Res 1998;421:27-36.
    • (1998) Mutat Res , vol.421 , pp. 27-36
    • Kopsidas, G.1    Kovalenko, S.A.2    Kelso, J.M.3    Linnane, A.W.4
  • 96
    • 0035504933 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
    • Cao Z, Wanagat J, McKiernan SH, Aiken JM. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res 2001 ;29:4502-8.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4502-4508
    • Cao, Z.1    Wanagat, J.2    McKiernan, S.H.3    Aiken, J.M.4
  • 98
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 2006;38:518- 20.
    • (2006) Nat Genet , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 100
    • 0027941299 scopus 로고
    • Human skin mitochondrial DNA deletions associated with light exposure
    • Pang CY, Lee HC, Yang JH, Wei YH. Human skin mitochondrial DNA deletions associated with light exposure. Arch Biochem Biophys 1994;312:534-8.
    • (1994) Arch Biochem Biophys , vol.312 , pp. 534-538
    • Pang, C.Y.1    Lee, H.C.2    Yang, J.H.3    Wei, Y.H.4
  • 101
    • 0029121602 scopus 로고
    • Photoageing-associated mitochondrial DNA length mutations in human skin
    • Yang JH, Lee HC, Wei YH. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res 1995;287:641-8.
    • (1995) Arch Dermatol Res , vol.287 , pp. 641-648
    • Yang, J.H.1    Lee, H.C.2    Wei, Y.H.3
  • 102
    • 0033016467 scopus 로고    scopus 로고
    • Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion
    • Berneburg M, Grether-Beck S, Kurten V, Ruzicka T, Briviba K, Sies H, Krutmann J. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem 1999;274:15345-9.
    • (1999) J Biol Chem , vol.274 , pp. 15345-15349
    • Berneburg, M.1    Grether-Beck, S.2    Kurten, V.3    Ruzicka, T.4    Briviba, K.5    Sies, H.6    Krutmann, J.7
  • 104
    • 0033557111 scopus 로고    scopus 로고
    • Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging-smoking enhances oxidative stress on the aged tissues
    • Lee HC, Lim ML, Lu CY, Liu VW, Fahn HJ, Zhang C, Nagley P, Wei YH. Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging-smoking enhances oxidative stress on the aged tissues. Arch Biochem Biophys 1999;362:309-16.
    • (1999) Arch Biochem Biophys , vol.362 , pp. 309-316
    • Lee, H.C.1    Lim, M.L.2    Lu, C.Y.3    Liu, V.W.4    Fahn, H.J.5    Zhang, C.6    Nagley, P.7    Wei, Y.H.8
  • 105
    • 0035958278 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer
    • Lee HC, Yin PH, Yu TN, Chang YD, Hsu WC, Kao SY, Chi CW, Liu TY, Wei YH. Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer. Mutat Res 2001;493:67- 74.
    • (2001) Mutat Res , vol.493 , pp. 67-74
    • Lee, H.C.1    Yin, P.H.2    Yu, T.N.3    Chang, Y.D.4    Hsu, W.C.5    Kao, S.Y.6    Chi, C.W.7    Liu, T.Y.8    Wei, Y.H.9
  • 106
    • 17344372911 scopus 로고    scopus 로고
    • Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans
    • Srivastava S, Moraes CT. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum Mol Genet 2005;14:893-902.
    • (2005) Hum Mol Genet , vol.14 , pp. 893-902
    • Srivastava, S.1    Moraes, C.T.2
  • 109
    • 2342525090 scopus 로고    scopus 로고
    • Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis
    • Liu CY, Lee CF, Hong CH, Wei YH. Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis. Ann NY Acad Sci 2004;1011:133-45.
    • (2004) Ann NY Acad Sci , vol.1011 , pp. 133-145
    • Liu, C.Y.1    Lee, C.F.2    Hong, C.H.3    Wei, Y.H.4
  • 113
    • 30044434360 scopus 로고    scopus 로고
    • The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
    • Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc Natl Acad Sci USA 2005;102:18769-70.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18769-18770
    • Loeb, L.A.1    Wallace, D.C.2    Martin, G.M.3
  • 114
    • 0034610286 scopus 로고    scopus 로고
    • Genomewide study of aging and oxidative stress response in Drosophila melanogaster
    • Zou S, Meadows S, Sharp L, Jan LY, Jan YN. Genomewide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci USA 2000;97:13726-31.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13726-13731
    • Zou, S.1    Meadows, S.2    Sharp, L.3    Jan, L.Y.4    Jan, Y.N.5
  • 115
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 1999;285:1390-3.
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 116
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 2000;25:294- 7.
    • (2000) Nat Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 117
    • 0035852759 scopus 로고    scopus 로고
    • The effects of aging on gene expression in the hypothalamus and cortex of mice
    • Jiang CH, Tsien JZ, Schultz PG, Hu Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci USA 2001 ;98:1930-4.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1930-1934
    • Jiang, C.H.1    Tsien, J.Z.2    Schultz, P.G.3    Hu, Y.4
  • 119
    • 0037069375 scopus 로고    scopus 로고
    • Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
    • Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA 2002;99:14988-93.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14988-14993
    • Lee, C.K.1    Allison, D.B.2    Brand, J.3    Weindruch, R.4    Prolla, T.A.5
  • 121
  • 122
    • 0035845492 scopus 로고    scopus 로고
    • Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice
    • Cao SX, Dhahbi JM, Mote PL, Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 2001;98:10630-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10630-10635
    • Cao, S.X.1    Dhahbi, J.M.2    Mote, P.L.3    Spindler, S.R.4
  • 123
    • 0035122576 scopus 로고    scopus 로고
    • Gene expression profile of the aging process in rat liver: Normalizing effects of growth hormone replacement
    • Tollet-Egnell P, Flores-Morales A, Stahlberg N, Malek RL, Lee N, Norstedt G. Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrinol 2001;15:308-18.
    • (2001) Mol Endocrinol , vol.15 , pp. 308-318
    • Tollet-Egnell, P.1    Flores-Morales, A.2    Stahlberg, N.3    Malek, R.L.4    Lee, N.5    Norstedt, G.6
  • 124
    • 35449004149 scopus 로고    scopus 로고
    • Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle
    • O'Connell K, Gannon J, Doran P, Ohlendieck K. Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. Int J Mol Med 2007;20:145-53.
    • (2007) Int J Mol Med , vol.20 , pp. 145-153
    • O'Connell, K.1    Gannon, J.2    Doran, P.3    Ohlendieck, K.4
  • 125
    • 0035942222 scopus 로고    scopus 로고
    • Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
    • Kayo T, Allison DB, Weindruch R, Prolla TA. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 2001;98:5093-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5093-5098
    • Kayo, T.1    Allison, D.B.2    Weindruch, R.3    Prolla, T.A.4
  • 130
    • 51549096735 scopus 로고    scopus 로고
    • Transcriptome-wide assessment of human brain and lymphocyte senescence
    • Hong MG, Myers AJ, Magnusson PK, Prince JA. Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS One 2008;3:3024-36.
    • (2008) PLoS One , vol.3 , pp. 3024-3036
    • Hong, M.G.1    Myers, A.J.2    Magnusson, P.K.3    Prince, J.A.4
  • 132
    • 64949165302 scopus 로고    scopus 로고
    • Mitochondria and oxidative stress during aging tal muscle
    • Yau-Huei Wei, et al Mitochondria and oxidative stress during aging tal muscle. Int J Mol Med 2008;22:33-42.
    • (2008) Int J Mol Med , vol.22 , pp. 33-42
    • Wei, Y.-H.1
  • 133
    • 0021673561 scopus 로고
    • Increased glycolysis in ageing cultured human diploid fibroblasts
    • Bittles AH, Harper N. Increased glycolysis in ageing cultured human diploid fibroblasts. Biosci Rep 1984;4:751- 6.
    • (1984) Biosci Rep , vol.4 , pp. 751-756
    • Bittles, A.H.1    Harper, N.2
  • 134
    • 0346256784 scopus 로고    scopus 로고
    • Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
    • Zwerschke W, Mazurek S, Stockl P, Hutter E, Eigenbrodt E, Jansen-Durr P. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 2003;376:403-11.
    • (2003) Biochem J , vol.376 , pp. 403-411
    • Zwerschke, W.1    Mazurek, S.2    Stockl, P.3    Hutter, E.4    Eigenbrodt, E.5    Jansen-Durr, P.6
  • 135
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008;88:611-38.
    • (2008) Physiol Rev , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 136
    • 0029894544 scopus 로고    scopus 로고
    • Crosstalk between nuclear and mitochondrial genomes
    • Poyton RO, McEwen JE. Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 1996; 65:563-607.
    • (1996) Annu Rev Biochem , vol.65 , pp. 563-607
    • Poyton, R.O.1    McEwen, J.E.2
  • 137
    • 13444271923 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
    • Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol 2005;37:822-34.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 822-834
    • Lee, H.C.1    Wei, Y.H.2
  • 138
    • 0022650598 scopus 로고
    • Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle
    • Williams RS, Salmons S, Newsholme EA, Kaufman RE, Mellor J. Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J Biol Chem 1986;261:376-80.
    • (1986) J Biol Chem , vol.261 , pp. 376-380
    • Williams, R.S.1    Salmons, S.2    Newsholme, E.A.3    Kaufman, R.E.4    Mellor, J.5
  • 139
    • 0030881873 scopus 로고    scopus 로고
    • Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation
    • Xia Y, Buja LM, Scarpulla RC, McMillin JB. Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation. Proc Natl Acad Sci USA 1997;94:11399-404.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11399-11404
    • Xia, Y.1    Buja, L.M.2    Scarpulla, R.C.3    McMillin, J.B.4
  • 140
    • 34247623639 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging
    • Lee HC, Wei YH. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med 2007;232:592-606.
    • (2007) Exp Biol Med , vol.232 , pp. 592-606
    • Lee, H.C.1    Wei, Y.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.