-
1
-
-
0036139856
-
The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology
-
Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 2001 ;52:159-64.
-
(2001)
IUBMB Life
, vol.52
, pp. 159-164
-
-
Lenaz, G.1
-
3
-
-
0030897739
-
Genetic and functional changes in mitochondria associated with aging
-
Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol Rev 1997;77:425-64.
-
(1997)
Physiol Rev
, vol.77
, pp. 425-464
-
-
Ozawa, T.1
-
4
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
5
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 1972;20:145-7.
-
(1972)
J Am Geriatr Soc
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
6
-
-
0020516814
-
Free radical theory of aging: Consequences of mitochondrial aging
-
Harman D. Free radical theory of aging: Consequences of mitochondrial aging. Age 1983;6:86-94.
-
(1983)
Age
, vol.6
, pp. 86-94
-
-
Harman, D.1
-
7
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;i:642-5.
-
(1989)
Lancet
, vol.1
, pp. 642-645
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
Tanaka, M.4
-
8
-
-
0026746336
-
Mitochondrial DNA alterations as ageing-associated molecular events
-
Wei YH. Mitochondrial DNA alterations as ageing-associated molecular events. Mutat Res 1992;275:145-55.
-
(1992)
Mutat Res
, vol.275
, pp. 145-155
-
-
Wei, Y.H.1
-
9
-
-
0029116061
-
Oxidative damage to mitochondrial DNA and its relationship to ageing
-
Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 1995;27:647-53.
-
(1995)
Int J Biochem Cell Biol
, vol.27
, pp. 647-653
-
-
Richter, C.1
-
10
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998;78:547-81.
-
(1998)
Physiol Rev
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
11
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605.
-
(1979)
Physiol Rev
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
12
-
-
0029147191
-
Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies
-
Sohal RS, Sohal BH, Orr WC. Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Radic BiolMed 1995;19:499-504.
-
(1995)
Free Radic BiolMed
, vol.19
, pp. 499-504
-
-
Sohal, R.S.1
Sohal, B.H.2
Orr, W.C.3
-
13
-
-
0036420161
-
Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
-
Lee HC, Yin PH, Chi CW, Wei YH. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J Biomed Sci 2002;9:517-26.
-
(2002)
J Biomed Sci
, vol.9
, pp. 517-526
-
-
Lee, H.C.1
Yin, P.H.2
Chi, C.W.3
Wei, Y.H.4
-
14
-
-
0019891031
-
Ubisemiquinone radicals from the cytochrome b-c1 complex of the mitochondrial electron transport chain - demonstration of QP-S radical formation
-
Wei YH, Scholes CP, King TE. Ubisemiquinone radicals from the cytochrome b-c1 complex of the mitochondrial electron transport chain - demonstration of QP-S radical formation. Biochem Biophys Res Commun 1981 ;99: 1411-9.
-
(1981)
Biochem Biophys Res Commun
, vol.99
, pp. 1411-1419
-
-
Wei, Y.H.1
Scholes, C.P.2
King, T.E.3
-
15
-
-
0028342438
-
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
-
Sohal RS, Ku HH, Agarwal S, Forster MJ, Lai H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 1994;74:121- 33.
-
(1994)
Mech Ageing Dev
, vol.74
, pp. 121-133
-
-
Sohal, R.S.1
Ku, H.H.2
Agarwal, S.3
Forster, M.J.4
Lai, H.5
-
16
-
-
2542446099
-
Aging in vertebrates, and the effect of caloric restriction: A mitochondrial free radical production - DNA damage mechanism?
-
Barja G. Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production - DNA damage mechanism? Biol Rev Camb Philos Soc 2004;79:235-51.
-
(2004)
Biol Rev Camb Philos Soc
, vol.79
, pp. 235-251
-
-
Barja, G.1
-
17
-
-
0023811053
-
Normal oxidative damage to mitochondrial and nuclear DNA is extensive
-
Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6465-7.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6465-6467
-
-
Richter, C.1
Park, J.W.2
Ames, B.N.3
-
19
-
-
0027171266
-
Oxidants, antioxidants, and the degenerative diseases of aging
-
Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-22.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7915-7922
-
-
Ames, B.N.1
Shigenaga, M.K.2
Hagen, T.M.3
-
20
-
-
0031032817
-
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
-
Yakes FM, van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514-9.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 514-519
-
-
Yakes, F.M.1
van Houten, B.2
-
21
-
-
0242321023
-
Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation
-
Lin PH, Lee SH, Su CP, Wei YH. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic Biol Med 2003;35:1310-8.
-
(2003)
Free Radic Biol Med
, vol.35
, pp. 1310-1318
-
-
Lin, P.H.1
Lee, S.H.2
Su, C.P.3
Wei, Y.H.4
-
22
-
-
0026784592
-
Lipid peroxidation and mtDNA degeneration. A hypothesis
-
Hruszkewycz AM. Lipid peroxidation and mtDNA degeneration. A hypothesis. Mutat Res 1992;275:243-8.
-
(1992)
Mutat Res
, vol.275
, pp. 243-248
-
-
Hruszkewycz, A.M.1
-
23
-
-
0029594475
-
Differential oxidative damage to mitochondrial proteins during aging
-
Agarwal S, Sohal RS. Differential oxidative damage to mitochondrial proteins during aging. Mech Ageing Dev 1995;85:55-63.
-
(1995)
Mech Ageing Dev
, vol.85
, pp. 55-63
-
-
Agarwal, S.1
Sohal, R.S.2
-
24
-
-
0000350066
-
Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA
-
de la Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo FV, Sastre J, Vina J. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J 1996;10:333-8.
-
(1996)
FASEB J
, vol.10
, pp. 333-338
-
-
de la Asuncion, J.G.1
Millan, A.2
Pla, R.3
Bruseghini, L.4
Esteras, A.5
Pallardo, F.V.6
Sastre, J.7
Vina, J.8
-
25
-
-
0034214103
-
Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
-
Lee HC, Yin PH, Lu CY, Chi CW, Wei YH. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 2000;348: 425-32.
-
(2000)
Biochem J
, vol.348
, pp. 425-432
-
-
Lee, H.C.1
Yin, P.H.2
Lu, C.Y.3
Chi, C.W.4
Wei, Y.H.5
-
26
-
-
0035854649
-
Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects
-
Lezza AM, Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Cantatore P, Gadaleta MN. Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. FEBS Lett 2001;501:74-8.
-
(2001)
FEBS Lett
, vol.501
, pp. 74-78
-
-
Lezza, A.M.1
Pesce, V.2
Cormio, A.3
Fracasso, F.4
Vecchiet, J.5
Felzani, G.6
Cantatore, P.7
Gadaleta, M.N.8
-
27
-
-
33745137507
-
Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress
-
Lee CF, Chen YC, Liu CY, Wei YH. Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. Free Radic Biol Med 2006;40:2136-46.
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 2136-2146
-
-
Lee, C.F.1
Chen, Y.C.2
Liu, C.Y.3
Wei, Y.H.4
-
29
-
-
0002026429
-
Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin
-
Lu CY, Lee HC, Fahn HJ, Wei YH. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res 1999;423:11-21.
-
(1999)
Mutat Res
, vol.423
, pp. 11-21
-
-
Lu, C.Y.1
Lee, H.C.2
Fahn, H.J.3
Wei, Y.H.4
-
30
-
-
0036790385
-
Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
-
Wei YH, Lee HC. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med 2002;227:671-82.
-
(2002)
Exp Biol Med
, vol.227
, pp. 671-682
-
-
Wei, Y.H.1
Lee, H.C.2
-
31
-
-
0035685590
-
Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging
-
Lee HC, Wei YH. Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2001;2:231-44.
-
(2001)
Biogerontology
, vol.2
, pp. 231-244
-
-
Lee, H.C.1
Wei, Y.H.2
-
32
-
-
42649129672
-
MtDNA mutations, functional decline and turnover of mitochondria in aging
-
Pang CY, Ma YS, Wei YH. MtDNA mutations, functional decline and turnover of mitochondria in aging. Front Biosci2008;13:3661-75.
-
Front Biosci2008;13
, pp. 3661-3675
-
-
Pang, C.Y.1
Ma, Y.S.2
Wei, Y.H.3
-
33
-
-
0024547664
-
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
-
Phillips JP, Campbell SD, Michaud D, Charbonneau M, Hilliker AJ. Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 1989;86: 2761-5.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 2761-2765
-
-
Phillips, J.P.1
Campbell, S.D.2
Michaud, D.3
Charbonneau, M.4
Hilliker, A.J.5
-
34
-
-
0027284743
-
Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster
-
Griswold CM, Matthews AL, Bewley KE, Mahaffey JW. Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster. Genetics 1993;134:781-8.
-
(1993)
Genetics
, vol.134
, pp. 781-788
-
-
Griswold, C.M.1
Matthews, A.L.2
Bewley, K.E.3
Mahaffey, J.W.4
-
35
-
-
0028827252
-
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
-
Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995;11:376-81.
-
(1995)
Nat Genet
, vol.11
, pp. 376-381
-
-
Li, Y.1
Huang, T.T.2
Carlson, E.J.3
Melov, S.4
Ursell, P.C.5
Olson, J.L.6
Noble, L.J.7
Yoshimura, M.P.8
Berger, C.9
Chan, P.H.10
Wallace, D.C.11
Epstein, C.J.12
-
36
-
-
13044285432
-
Mitochondrial disease in superoxide dismutase 2 mutant mice
-
Melov S, Coskun P, Patel M, Tuinstra R, Cottrell B, Jun AS, Zastawny TH, Dizdaroglu M, Goodman SI, Huang TT, Miziorko H, Epstein CJ, Wallace DC. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc Natl Acad Sci USA 1999;96:846-51.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 846-851
-
-
Melov, S.1
Coskun, P.2
Patel, M.3
Tuinstra, R.4
Cottrell, B.5
Jun, A.S.6
Zastawny, T.H.7
Dizdaroglu, M.8
Goodman, S.I.9
Huang, T.T.10
Miziorko, H.11
Epstein, C.J.12
Wallace, D.C.13
-
37
-
-
15844393658
-
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
-
Reaume AG, Elliott JL, Hoffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH Jr, Scott RW, Snider WD. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet 1996;13:43-7.
-
(1996)
Nat Genet
, vol.13
, pp. 43-47
-
-
Reaume, A.G.1
Elliott, J.L.2
Hoffman, E.K.3
Kowall, N.W.4
Ferrante, R.J.5
Siwek, D.F.6
Wilcox, H.M.7
Flood, D.G.8
Beal, M.F.9
Brown Jr, R.H.10
Scott, R.W.11
Snider, W.D.12
-
38
-
-
0032561328
-
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice
-
Williams MD, van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J BiolChem 1998;273:28510-5.
-
(1998)
J BiolChem
, vol.273
, pp. 28510-28515
-
-
Williams, M.D.1
van Remmen, H.2
Conrad, C.C.3
Huang, T.T.4
Epstein, C.J.5
Richardson, A.6
-
39
-
-
32244448364
-
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
-
Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, van Remmen H. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev 2006; 127:298-306.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 298-306
-
-
Mansouri, A.1
Muller, F.L.2
Liu, Y.3
Ng, R.4
Faulkner, J.5
Hamilton, M.6
Richardson, A.7
Huang, T.T.8
Epstein, C.J.9
van Remmen, H.10
-
41
-
-
0028220114
-
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 1994;263:1128-30.
-
(1994)
Science
, vol.263
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
42
-
-
0029039854
-
Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster
-
Sohal RS, Agarwal A, Agarwal S, Orr WC. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J Biol Chem 1995;270:15671-4.
-
(1995)
J Biol Chem
, vol.270
, pp. 15671-15674
-
-
Sohal, R.S.1
Agarwal, A.2
Agarwal, S.3
Orr, W.C.4
-
43
-
-
0027293919
-
Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster
-
Orr WC, Sohal RS. Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys 1993;301:34-40.
-
(1993)
Arch Biochem Biophys
, vol.301
, pp. 34-40
-
-
Orr, W.C.1
Sohal, R.S.2
-
44
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, van Remmen H, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005;308:1909-11.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
45
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study
-
Müller-Höcker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol 1989;134:1167-73.
-
(1989)
Am J Pathol
, vol.134
, pp. 1167-1173
-
-
Müller-Höcker, J.1
-
46
-
-
0025673968
-
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
-
Müller-Höcker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci 1990;100:14-21.
-
(1990)
J Neurol Sci
, vol.100
, pp. 14-21
-
-
Müller-Höcker, J.1
-
47
-
-
0027525966
-
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
-
Müller-Höcker J, Seibel P, Schneiderbanger K, Kadenbach B. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch A Pathol Anat Histopathol 1993;422:7-15.
-
(1993)
Virchows Arch A Pathol Anat Histopathol
, vol.422
, pp. 7-15
-
-
Müller-Höcker, J.1
Seibel, P.2
Schneiderbanger, K.3
Kadenbach, B.4
-
48
-
-
0024980878
-
Liver mitochondrial respiratory functions decline with age
-
Yen TC, Chen YS, King KL, Yeh SH, Wei YH. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 1989;165:944-1003.
-
(1989)
Biochem Biophys Res Commun
, vol.165
, pp. 944-1003
-
-
Yen, T.C.1
Chen, Y.S.2
King, K.L.3
Yeh, S.H.4
Wei, Y.H.5
-
49
-
-
0024580556
-
-
Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;i:637-9.
-
Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;i:637-9.
-
-
-
-
50
-
-
0026469073
-
Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing
-
Cooper JM, Mann VM, Schapira AH. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. JNeurol Sci 1992;113:91-8.
-
(1992)
JNeurol Sci
, vol.113
, pp. 91-98
-
-
Cooper, J.M.1
Mann, V.M.2
Schapira, A.H.3
-
51
-
-
0028235259
-
Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria
-
Hsieh RH, Hou JH, Hsu HS, Wei YH. Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem Mol Biol Int 1994;32:1009-22.
-
(1994)
Biochem Mol Biol Int
, vol.32
, pp. 1009-1022
-
-
Hsieh, R.H.1
Hou, J.H.2
Hsu, H.S.3
Wei, Y.H.4
-
52
-
-
0027182560
-
Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
-
Sugiyama S, Takasawa M, Hayakawa M, Ozawa T. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem Mol Biol Int 1993;30:937-44.
-
(1993)
Biochem Mol Biol Int
, vol.30
, pp. 937-944
-
-
Sugiyama, S.1
Takasawa, M.2
Hayakawa, M.3
Ozawa, T.4
-
53
-
-
0026438658
-
Agerelated decrease in respiratory muscle mitochondrial function in rats
-
Torii K, Sugiyama S, Takagi K, Satake T, Ozawa T. Agerelated decrease in respiratory muscle mitochondrial function in rats. Am J Respir Cell Mol Biol 1992;6:88-92.
-
(1992)
Am J Respir Cell Mol Biol
, vol.6
, pp. 88-92
-
-
Torii, K.1
Sugiyama, S.2
Takagi, K.3
Satake, T.4
Ozawa, T.5
-
54
-
-
0027309116
-
Age-associated damage in mitochondrial function in rat hearts
-
Takasawa M, Hayakawa M, Sugiyama S, Hattori K, Ito T, Ozawa T. Age-associated damage in mitochondrial function in rat hearts. Exp Gerontol 1993;28:269-80.
-
(1993)
Exp Gerontol
, vol.28
, pp. 269-280
-
-
Takasawa, M.1
Hayakawa, M.2
Sugiyama, S.3
Hattori, K.4
Ito, T.5
Ozawa, T.6
-
55
-
-
0031032817
-
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
-
Yakes FM, van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 1997;94:514-9.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 514-519
-
-
Yakes, F.M.1
van Houten, B.2
-
56
-
-
0028788763
-
Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factorkappa B: Studies with isolated mitochondria and rat hepatocytes
-
Garcia-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernandez-Checa JC. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factorkappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 1995;48:825-34.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 825-834
-
-
Garcia-Ruiz, C.1
Colell, A.2
Morales, A.3
Kaplowitz, N.4
Fernandez-Checa, J.C.5
-
57
-
-
28244454785
-
Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
-
Yarian CS, Toroser D, Sohal RS. Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice. Mech Ageing Dev 2006;127:79- 84.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 79-84
-
-
Yarian, C.S.1
Toroser, D.2
Sohal, R.S.3
-
58
-
-
0037082142
-
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age
-
Atamna H, Walter PB, Ames BN. The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys 2002;397:345-53.
-
(2002)
Arch Biochem Biophys
, vol.397
, pp. 345-353
-
-
Atamna, H.1
Walter, P.B.2
Ames, B.N.3
-
59
-
-
0030881686
-
Oxidative damage during aging targets mitochondrial aconitase
-
Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci USA 1997;94:11168-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11168-11172
-
-
Yan, L.J.1
Levine, R.L.2
Sohal, R.S.3
-
60
-
-
0032573066
-
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
-
Yan LJ, Sohal RS. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci USA 1998;95:12896-901.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12896-12901
-
-
Yan, L.J.1
Sohal, R.S.2
-
61
-
-
0028075773
-
Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs
-
Gardner PR, Nguyen DD, White CW. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA 1994;91:12248-52.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12248-12252
-
-
Gardner, P.R.1
Nguyen, D.D.2
White, C.W.3
-
62
-
-
0033609069
-
Mitochondrial disease in mouse results in increased oxidative stress
-
Esposito LA, Melov S, Panov A, Cottrell BA, Wallace DC. Mitochondrial disease in mouse results in increased oxidative stress. Proc Natl Acad Sci USA 1999;96:4820- 5.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4820-4825
-
-
Esposito, L.A.1
Melov, S.2
Panov, A.3
Cottrell, B.A.4
Wallace, D.C.5
-
63
-
-
0032436502
-
Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function
-
Wei YH, Lu CY, Lee HC, Pang CY, Ma YS. Oxidative damage and mutation to mitochondrial DNA and agedependent decline of mitochondrial respiratory function. Ann NY Acad Sci 1998;854:155-70.
-
(1998)
Ann NY Acad Sci
, vol.854
, pp. 155-170
-
-
Wei, Y.H.1
Lu, C.Y.2
Lee, H.C.3
Pang, C.Y.4
Ma, Y.S.5
-
64
-
-
0027244097
-
Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced
-
Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 1993;268:18891-7.
-
(1993)
J Biol Chem
, vol.268
, pp. 18891-18897
-
-
Calleja, M.1
Pena, P.2
Ugalde, C.3
Ferreiro, C.4
Marco, R.5
Garesse, R.6
-
65
-
-
0025115244
-
Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L- carnitine
-
Gadaleta MN, Petruzzella V, Renis M, Fracasso F, Cantatore P. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L- carnitine. Eur J Biochem 1990;187:501-6.
-
(1990)
Eur J Biochem
, vol.187
, pp. 501-506
-
-
Gadaleta, M.N.1
Petruzzella, V.2
Renis, M.3
Fracasso, F.4
Cantatore, P.5
-
66
-
-
0025777672
-
Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain
-
Fernandez-Silva P, Petruzzella V, Fracasso F, Gadaleta MN, Cantatore P. Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain. Biochem Biophys Res Commun 1991;176:645-53.
-
(1991)
Biochem Biophys Res Commun
, vol.176
, pp. 645-653
-
-
Fernandez-Silva, P.1
Petruzzella, V.2
Fracasso, F.3
Gadaleta, M.N.4
Cantatore, P.5
-
67
-
-
0031430744
-
Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process
-
Barrientos A, Casademont J, Cardellach F, Ardite E, Estivill X, Urbano-Marquez A, Fernandez-Checa JC, Nunes V. Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process. Biochem Mol Med 1997;62:165-71.
-
(1997)
Biochem Mol Med
, vol.62
, pp. 165-171
-
-
Barrientos, A.1
Casademont, J.2
Cardellach, F.3
Ardite, E.4
Estivill, X.5
Urbano-Marquez, A.6
Fernandez-Checa, J.C.7
Nunes, V.8
-
68
-
-
0031574362
-
Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging
-
Barrientos A, Casademont J, Cardellach F, Estivill X, Urbano-Marquez A, Nunes V. Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging. Brain Res Mol Brain Res 1997;52:284-9.
-
(1997)
Brain Res Mol Brain Res
, vol.52
, pp. 284-289
-
-
Barrientos, A.1
Casademont, J.2
Cardellach, F.3
Estivill, X.4
Urbano-Marquez, A.5
Nunes, V.6
-
69
-
-
0030059079
-
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
-
Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 1996;271:15891-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 15891-15897
-
-
Laderman, K.A.1
Penny, J.R.2
Mazzucchelli, F.3
Bresolin, N.4
Scarlato, G.5
Attardi, G.6
-
70
-
-
0141483496
-
Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
-
Greco M, Villani G, Mazzucchelli F, Bresolin N, Papa S, Attardi G. Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts. FASEB J2003;17:1706-8.
-
FASEB
, vol.J2003
, Issue.17
, pp. 1706-1708
-
-
Greco, M.1
Villani, G.2
Mazzucchelli, F.3
Bresolin, N.4
Papa, S.5
Attardi, G.6
-
71
-
-
0021348372
-
Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age
-
Bailey PJ, Webster GC. Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age. Mech Ageing Dev 1984;24:233-41.
-
(1984)
Mech Ageing Dev
, vol.24
, pp. 233-241
-
-
Bailey, P.J.1
Webster, G.C.2
-
72
-
-
0020353123
-
Age-related decline in the biosynthesis of mitochondrial inner membrane proteins
-
Marcus DL, Ibrahim NG, Freedman ML. Age-related decline in the biosynthesis of mitochondrial inner membrane proteins. Exp Gerontol 1982; 17:333-41.
-
(1982)
Exp Gerontol
, vol.17
, pp. 333-341
-
-
Marcus, D.L.1
Ibrahim, N.G.2
Freedman, M.L.3
-
73
-
-
0030451773
-
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
-
Rooyackers OE, Adey DB, Ades PA, Nair KS. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 1996;93:15364-9.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 15364-15369
-
-
Rooyackers, O.E.1
Adey, D.B.2
Ades, P.A.3
Nair, K.S.4
-
74
-
-
17244363631
-
-
Short KR, Bigelow ML, Kahl J, Singh R, Coenen- Schimke J, Raghavakaimal S, Nair KS. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005;102:5618-23.
-
Short KR, Bigelow ML, Kahl J, Singh R, Coenen- Schimke J, Raghavakaimal S, Nair KS. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005;102:5618-23.
-
-
-
-
75
-
-
51649126499
-
Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice
-
Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi- Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice. J Neurosci 2008;28:8624-34.
-
(2008)
J Neurosci
, vol.28
, pp. 8624-8634
-
-
Hayashi, Y.1
Yoshida, M.2
Yamato, M.3
Ide, T.4
Wu, Z.5
Ochi- Shindou, M.6
Kanki, T.7
Kang, D.8
Sunagawa, K.9
Tsutsui, H.10
Nakanishi, H.11
-
77
-
-
0026860988
-
Aging-associated deletions of human diaphragmatic mitochondrial DNA
-
Torii K, Sugiyama S, Tanaka M, Takagi K, Hanaki Y, Iida K, Matsuyama M, Hirabayashi N, Uno Y, Ozawa T. Aging-associated deletions of human diaphragmatic mitochondrial DNA. Am J Respir Cell Mol Biol 1992;6:543-9.
-
(1992)
Am J Respir Cell Mol Biol
, vol.6
, pp. 543-549
-
-
Torii, K.1
Sugiyama, S.2
Tanaka, M.3
Takagi, K.4
Hanaki, Y.5
Iida, K.6
Matsuyama, M.7
Hirabayashi, N.8
Uno, Y.9
Ozawa, T.10
-
78
-
-
0028349234
-
Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
-
Lee HC, Pang CY, Hsu HS, Wei YH. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1994;1226:37-43.
-
(1994)
Biochim Biophys Acta
, vol.1226
, pp. 37-43
-
-
Lee, H.C.1
Pang, C.Y.2
Hsu, H.S.3
Wei, Y.H.4
-
79
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999;286:774-9.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
80
-
-
0029113657
-
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys
-
Schwarze SR, Lee CM, Chung SS, Roecker EB, Weindruch R, Aiken JM. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev 1995;83:91-101.
-
(1995)
Mech Ageing Dev
, vol.83
, pp. 91-101
-
-
Schwarze, S.R.1
Lee, C.M.2
Chung, S.S.3
Roecker, E.B.4
Weindruch, R.5
Aiken, J.M.6
-
81
-
-
0037448025
-
Accumulation of point mutations in mitochondrial DNA of aging mice
-
Khaidakov M, Heflich RH, Manjanatha MG, Myers MB, Aidoo A. Accumulation of point mutations in mitochondrial DNA of aging mice. Mutat Res 2003;526:1-7.
-
(2003)
Mutat Res
, vol.526
, pp. 1-7
-
-
Khaidakov, M.1
Heflich, R.H.2
Manjanatha, M.G.3
Myers, M.B.4
Aidoo, A.5
-
82
-
-
0035957323
-
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
-
Wang Y, Michikawa Y, Mallidis C, Bai Y, Woodhouse L, Yarasheski KE, Miller CA, Askanas V, Engel WK, Bhasin S, Attardi G. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 2001;98:4022-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4022-4027
-
-
Wang, Y.1
Michikawa, Y.2
Mallidis, C.3
Bai, Y.4
Woodhouse, L.5
Yarasheski, K.E.6
Miller, C.A.7
Askanas, V.8
Engel, W.K.9
Bhasin, S.10
Attardi, G.11
-
83
-
-
0027198359
-
Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans
-
Zhang C, Linnane AW, Nagley P. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun 1993;195:1104-10.
-
(1993)
Biochem Biophys Res Commun
, vol.195
, pp. 1104-1110
-
-
Zhang, C.1
Linnane, A.W.2
Nagley, P.3
-
84
-
-
0027476395
-
The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages
-
Munscher C, Rieger T, Muller-Hocker J, Kadenbach B. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 1993;317:27-30.
-
(1993)
FEBS Lett
, vol.317
, pp. 27-30
-
-
Munscher, C.1
Rieger, T.2
Muller-Hocker, J.3
Kadenbach, B.4
-
85
-
-
0026532722
-
Multiple mitochondrial DNA deletions in an elderly human individual
-
Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 1992;297:34-8.
-
(1992)
FEBS Lett
, vol.297
, pp. 34-38
-
-
Zhang, C.1
Baumer, A.2
Maxwell, R.J.3
Linnane, A.W.4
Nagley, P.5
-
86
-
-
0028061412
-
Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle
-
Lee HC, Pang CY, Hsu HS, Wei YH. Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle. FEBS Lett 1994;354:79-83.
-
(1994)
FEBS Lett
, vol.354
, pp. 79-83
-
-
Lee, H.C.1
Pang, C.Y.2
Hsu, H.S.3
Wei, Y.H.4
-
87
-
-
0029741620
-
-
Wei YH, Pang CY, You BJ, Lee HC. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann NY Acad Sci 12996;786:82-101.
-
Wei YH, Pang CY, You BJ, Lee HC. Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann NY Acad Sci 12996;786:82-101.
-
-
-
-
88
-
-
0032401024
-
Ageing and mammalian mitochondrial genetics
-
Nagley P, Wei YH. Ageing and mammalian mitochondrial genetics. Trends Genet 1998;14:513-7.
-
(1998)
Trends Genet
, vol.14
, pp. 513-517
-
-
Nagley, P.1
Wei, Y.H.2
-
89
-
-
0030877134
-
Multiorgan characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age
-
Melov S, Hinerfeld D, Esposito L, Wallace DC. Multiorgan characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res 1997;25:974-82.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 974-982
-
-
Melov, S.1
Hinerfeld, D.2
Esposito, L.3
Wallace, D.C.4
-
90
-
-
0033457963
-
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA
-
Melov S, Schneider JA, Coskun PE, Bennett DA, Wallace DC. Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol Aging 1999;20:565-71.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 565-571
-
-
Melov, S.1
Schneider, J.A.2
Coskun, P.E.3
Bennett, D.A.4
Wallace, D.C.5
-
91
-
-
0035371185
-
Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle
-
Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Lezza AM, Cantatore P, Gadaleta MN. Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle. Free Radic Biol Med 2001;30:1223-33.
-
(2001)
Free Radic Biol Med
, vol.30
, pp. 1223-1233
-
-
Pesce, V.1
Cormio, A.2
Fracasso, F.3
Vecchiet, J.4
Felzani, G.5
Lezza, A.M.6
Cantatore, P.7
Gadaleta, M.N.8
-
92
-
-
0030582373
-
Age-related extensive fragmentation of mitochondrial DNA into minicircles
-
Hayakawa M, Katsumata K, Yoneda M, Tanaka M, Sugiyama S, Ozawa T. Age-related extensive fragmentation of mitochondrial DNA into minicircles. Biochem Biophys Res Commun 1996;226:369-77.
-
(1996)
Biochem Biophys Res Commun
, vol.226
, pp. 369-377
-
-
Hayakawa, M.1
Katsumata, K.2
Yoneda, M.3
Tanaka, M.4
Sugiyama, S.5
Ozawa, T.6
-
95
-
-
0032511842
-
An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle
-
Kopsidas G, Kovalenko SA, Kelso JM, Linnane AW. An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle. Mutat Res 1998;421:27-36.
-
(1998)
Mutat Res
, vol.421
, pp. 27-36
-
-
Kopsidas, G.1
Kovalenko, S.A.2
Kelso, J.M.3
Linnane, A.W.4
-
96
-
-
0035504933
-
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
-
Cao Z, Wanagat J, McKiernan SH, Aiken JM. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res 2001 ;29:4502-8.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 4502-4508
-
-
Cao, Z.1
Wanagat, J.2
McKiernan, S.H.3
Aiken, J.M.4
-
97
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006;38:515-7.
-
(2006)
Nat Genet
, vol.38
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
Taylor, G.A.4
Reeve, A.K.5
Perry, R.H.6
Jaros, E.7
Hersheson, J.S.8
Betts, J.9
Klopstock, T.10
Taylor, R.W.11
Turnbull, D.M.12
-
98
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 2006;38:518- 20.
-
(2006)
Nat Genet
, vol.38
, pp. 518-520
-
-
Kraytsberg, Y.1
Kudryavtseva, E.2
McKee, A.C.3
Geula, C.4
Kowall, N.W.5
Khrapko, K.6
-
99
-
-
0033963144
-
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
-
Dumont P, Burton M, Chen QM, Gonos ES, Frippiat C, Mazarati JB, Eliaers F, Remacle J, Toussaint O. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 2000;28:361-73.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 361-373
-
-
Dumont, P.1
Burton, M.2
Chen, Q.M.3
Gonos, E.S.4
Frippiat, C.5
Mazarati, J.B.6
Eliaers, F.7
Remacle, J.8
Toussaint, O.9
-
100
-
-
0027941299
-
Human skin mitochondrial DNA deletions associated with light exposure
-
Pang CY, Lee HC, Yang JH, Wei YH. Human skin mitochondrial DNA deletions associated with light exposure. Arch Biochem Biophys 1994;312:534-8.
-
(1994)
Arch Biochem Biophys
, vol.312
, pp. 534-538
-
-
Pang, C.Y.1
Lee, H.C.2
Yang, J.H.3
Wei, Y.H.4
-
101
-
-
0029121602
-
Photoageing-associated mitochondrial DNA length mutations in human skin
-
Yang JH, Lee HC, Wei YH. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res 1995;287:641-8.
-
(1995)
Arch Dermatol Res
, vol.287
, pp. 641-648
-
-
Yang, J.H.1
Lee, H.C.2
Wei, Y.H.3
-
102
-
-
0033016467
-
Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion
-
Berneburg M, Grether-Beck S, Kurten V, Ruzicka T, Briviba K, Sies H, Krutmann J. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem 1999;274:15345-9.
-
(1999)
J Biol Chem
, vol.274
, pp. 15345-15349
-
-
Berneburg, M.1
Grether-Beck, S.2
Kurten, V.3
Ruzicka, T.4
Briviba, K.5
Sies, H.6
Krutmann, J.7
-
103
-
-
0032247061
-
Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues
-
Fahn HJ, Wang LS, Kao SH, Chang SC, Huang MH, Wei YH. Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues. Am J Respir Cell Mol Biol 1998;19:901-9.
-
(1998)
Am J Respir Cell Mol Biol
, vol.19
, pp. 901-909
-
-
Fahn, H.J.1
Wang, L.S.2
Kao, S.H.3
Chang, S.C.4
Huang, M.H.5
Wei, Y.H.6
-
104
-
-
0033557111
-
Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging-smoking enhances oxidative stress on the aged tissues
-
Lee HC, Lim ML, Lu CY, Liu VW, Fahn HJ, Zhang C, Nagley P, Wei YH. Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging-smoking enhances oxidative stress on the aged tissues. Arch Biochem Biophys 1999;362:309-16.
-
(1999)
Arch Biochem Biophys
, vol.362
, pp. 309-316
-
-
Lee, H.C.1
Lim, M.L.2
Lu, C.Y.3
Liu, V.W.4
Fahn, H.J.5
Zhang, C.6
Nagley, P.7
Wei, Y.H.8
-
105
-
-
0035958278
-
Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer
-
Lee HC, Yin PH, Yu TN, Chang YD, Hsu WC, Kao SY, Chi CW, Liu TY, Wei YH. Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer. Mutat Res 2001;493:67- 74.
-
(2001)
Mutat Res
, vol.493
, pp. 67-74
-
-
Lee, H.C.1
Yin, P.H.2
Yu, T.N.3
Chang, Y.D.4
Hsu, W.C.5
Kao, S.Y.6
Chi, C.W.7
Liu, T.Y.8
Wei, Y.H.9
-
106
-
-
17344372911
-
Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans
-
Srivastava S, Moraes CT. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum Mol Genet 2005;14:893-902.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 893-902
-
-
Srivastava, S.1
Moraes, C.T.2
-
107
-
-
41349087783
-
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
-
Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 2008;40:392-4.
-
(2008)
Nat Genet
, vol.40
, pp. 392-394
-
-
Vermulst, M.1
Wanagat, J.2
Kujoth, G.C.3
Bielas, J.H.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
108
-
-
0035957398
-
Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
-
Wang J, Silva JP, Gustafsson CM, Rustin P, Larsson NG. Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci USA 2001;98:4038-43.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4038-4043
-
-
Wang, J.1
Silva, J.P.2
Gustafsson, C.M.3
Rustin, P.4
Larsson, N.G.5
-
109
-
-
2342525090
-
Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis
-
Liu CY, Lee CF, Hong CH, Wei YH. Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis. Ann NY Acad Sci 2004;1011:133-45.
-
(2004)
Ann NY Acad Sci
, vol.1011
, pp. 133-145
-
-
Liu, C.Y.1
Lee, C.F.2
Hong, C.H.3
Wei, Y.H.4
-
110
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417-23.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
111
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481-4.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
112
-
-
29144458899
-
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
-
Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 2005;102:17993-8.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17993-17998
-
-
Trifunovic, A.1
Hansson, A.2
Wredenberg, A.3
Rovio, A.T.4
Dufour, E.5
Khvorostov, I.6
Spelbrink, J.N.7
Wibom, R.8
Jacobs, H.T.9
Larsson, N.G.10
-
113
-
-
30044434360
-
The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
-
Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc Natl Acad Sci USA 2005;102:18769-70.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18769-18770
-
-
Loeb, L.A.1
Wallace, D.C.2
Martin, G.M.3
-
114
-
-
0034610286
-
Genomewide study of aging and oxidative stress response in Drosophila melanogaster
-
Zou S, Meadows S, Sharp L, Jan LY, Jan YN. Genomewide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci USA 2000;97:13726-31.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13726-13731
-
-
Zou, S.1
Meadows, S.2
Sharp, L.3
Jan, L.Y.4
Jan, Y.N.5
-
115
-
-
0033610079
-
Gene expression profile of aging and its retardation by caloric restriction
-
Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 1999;285:1390-3.
-
(1999)
Science
, vol.285
, pp. 1390-1393
-
-
Lee, C.K.1
Klopp, R.G.2
Weindruch, R.3
Prolla, T.A.4
-
116
-
-
0000847978
-
Gene-expression profile of the ageing brain in mice
-
Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 2000;25:294- 7.
-
(2000)
Nat Genet
, vol.25
, pp. 294-297
-
-
Lee, C.K.1
Weindruch, R.2
Prolla, T.A.3
-
117
-
-
0035852759
-
The effects of aging on gene expression in the hypothalamus and cortex of mice
-
Jiang CH, Tsien JZ, Schultz PG, Hu Y. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci USA 2001 ;98:1930-4.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1930-1934
-
-
Jiang, C.H.1
Tsien, J.Z.2
Schultz, P.G.3
Hu, Y.4
-
119
-
-
0037069375
-
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
-
Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA 2002;99:14988-93.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14988-14993
-
-
Lee, C.K.1
Allison, D.B.2
Brand, J.3
Weindruch, R.4
Prolla, T.A.5
-
120
-
-
0036713499
-
Gene expression profiling of the aging mouse cardiac myocytes
-
Bodyak N, Kang PM, Hiromura M, Sulijoadikusumo I, Horikoshi N, Khrapko K, Usheva A. Gene expression profiling of the aging mouse cardiac myocytes. Nucleic Acids Res 2002;30:3788-94.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3788-3794
-
-
Bodyak, N.1
Kang, P.M.2
Hiromura, M.3
Sulijoadikusumo, I.4
Horikoshi, N.5
Khrapko, K.6
Usheva, A.7
-
121
-
-
0038519707
-
Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart
-
Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiol Genomics 2003;13:119-27.
-
(2003)
Physiol Genomics
, vol.13
, pp. 119-127
-
-
Edwards, M.G.1
Sarkar, D.2
Klopp, R.3
Morrow, J.D.4
Weindruch, R.5
Prolla, T.A.6
-
122
-
-
0035845492
-
Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice
-
Cao SX, Dhahbi JM, Mote PL, Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 2001;98:10630-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10630-10635
-
-
Cao, S.X.1
Dhahbi, J.M.2
Mote, P.L.3
Spindler, S.R.4
-
123
-
-
0035122576
-
Gene expression profile of the aging process in rat liver: Normalizing effects of growth hormone replacement
-
Tollet-Egnell P, Flores-Morales A, Stahlberg N, Malek RL, Lee N, Norstedt G. Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrinol 2001;15:308-18.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 308-318
-
-
Tollet-Egnell, P.1
Flores-Morales, A.2
Stahlberg, N.3
Malek, R.L.4
Lee, N.5
Norstedt, G.6
-
124
-
-
35449004149
-
Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle
-
O'Connell K, Gannon J, Doran P, Ohlendieck K. Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. Int J Mol Med 2007;20:145-53.
-
(2007)
Int J Mol Med
, vol.20
, pp. 145-153
-
-
O'Connell, K.1
Gannon, J.2
Doran, P.3
Ohlendieck, K.4
-
125
-
-
0035942222
-
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
-
Kayo T, Allison DB, Weindruch R, Prolla TA. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 2001;98:5093-8.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5093-5098
-
-
Kayo, T.1
Allison, D.B.2
Weindruch, R.3
Prolla, T.A.4
-
126
-
-
33846576691
-
Proteomic analysis of the aging-related proteins in human normal colon epithelial tissue
-
Li M, Xiao ZQ, Chen ZC, Li JL, Li C, Zhang PF, Li MY. Proteomic analysis of the aging-related proteins in human normal colon epithelial tissue. J Biochem Mol Biol2007;40:72-81.
-
J Biochem Mol Biol2007;40
, pp. 72-81
-
-
Li, M.1
Xiao, Z.Q.2
Chen, Z.C.3
Li, J.L.4
Li, C.5
Zhang, P.F.6
Li, M.Y.7
-
127
-
-
33744990402
-
The human muscle proteome in aging
-
Gelfi C, Vigano A, Ripamonti M, Pontoglio A, Begum S, Pellegrino MA, Grassi B, Bottinelli R, Wait R, Cerretelli P. The human muscle proteome in aging. J Proteome Res 2006;5:1344-53.
-
(2006)
J Proteome Res
, vol.5
, pp. 1344-1353
-
-
Gelfi, C.1
Vigano, A.2
Ripamonti, M.3
Pontoglio, A.4
Begum, S.5
Pellegrino, M.A.6
Grassi, B.7
Bottinelli, R.8
Wait, R.9
Cerretelli, P.10
-
128
-
-
34248556312
-
Effect of aging and caloric restriction on the mitochondrial proteome
-
Chang J, Cornell JE, Van Remmen H, Hakala K, Ward WF, Richardson A. Effect of aging and caloric restriction on the mitochondrial proteome. J Gerontol A Biol Sci Med Sci 2007;62:223-34.
-
(2007)
J Gerontol A Biol Sci Med Sci
, vol.62
, pp. 223-234
-
-
Chang, J.1
Cornell, J.E.2
Van Remmen, H.3
Hakala, K.4
Ward, W.F.5
Richardson, A.6
-
129
-
-
1342265400
-
Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women
-
Welle S, Brooks AI, Delehanty JM, Needier N, Bhatt K, Shah B, Thornton CA. Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women. Exp Gerontol 2004;39:369-77.
-
(2004)
Exp Gerontol
, vol.39
, pp. 369-377
-
-
Welle, S.1
Brooks, A.I.2
Delehanty, J.M.3
Needier, N.4
Bhatt, K.5
Shah, B.6
Thornton, C.A.7
-
130
-
-
51549096735
-
Transcriptome-wide assessment of human brain and lymphocyte senescence
-
Hong MG, Myers AJ, Magnusson PK, Prince JA. Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS One 2008;3:3024-36.
-
(2008)
PLoS One
, vol.3
, pp. 3024-3036
-
-
Hong, M.G.1
Myers, A.J.2
Magnusson, P.K.3
Prince, J.A.4
-
132
-
-
64949165302
-
Mitochondria and oxidative stress during aging tal muscle
-
Yau-Huei Wei, et al Mitochondria and oxidative stress during aging tal muscle. Int J Mol Med 2008;22:33-42.
-
(2008)
Int J Mol Med
, vol.22
, pp. 33-42
-
-
Wei, Y.-H.1
-
133
-
-
0021673561
-
Increased glycolysis in ageing cultured human diploid fibroblasts
-
Bittles AH, Harper N. Increased glycolysis in ageing cultured human diploid fibroblasts. Biosci Rep 1984;4:751- 6.
-
(1984)
Biosci Rep
, vol.4
, pp. 751-756
-
-
Bittles, A.H.1
Harper, N.2
-
134
-
-
0346256784
-
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
-
Zwerschke W, Mazurek S, Stockl P, Hutter E, Eigenbrodt E, Jansen-Durr P. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 2003;376:403-11.
-
(2003)
Biochem J
, vol.376
, pp. 403-411
-
-
Zwerschke, W.1
Mazurek, S.2
Stockl, P.3
Hutter, E.4
Eigenbrodt, E.5
Jansen-Durr, P.6
-
135
-
-
42049114034
-
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
-
Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008;88:611-38.
-
(2008)
Physiol Rev
, vol.88
, pp. 611-638
-
-
Scarpulla, R.C.1
-
136
-
-
0029894544
-
Crosstalk between nuclear and mitochondrial genomes
-
Poyton RO, McEwen JE. Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 1996; 65:563-607.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 563-607
-
-
Poyton, R.O.1
McEwen, J.E.2
-
137
-
-
13444271923
-
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
-
Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol 2005;37:822-34.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 822-834
-
-
Lee, H.C.1
Wei, Y.H.2
-
138
-
-
0022650598
-
Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle
-
Williams RS, Salmons S, Newsholme EA, Kaufman RE, Mellor J. Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J Biol Chem 1986;261:376-80.
-
(1986)
J Biol Chem
, vol.261
, pp. 376-380
-
-
Williams, R.S.1
Salmons, S.2
Newsholme, E.A.3
Kaufman, R.E.4
Mellor, J.5
-
139
-
-
0030881873
-
Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation
-
Xia Y, Buja LM, Scarpulla RC, McMillin JB. Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation. Proc Natl Acad Sci USA 1997;94:11399-404.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11399-11404
-
-
Xia, Y.1
Buja, L.M.2
Scarpulla, R.C.3
McMillin, J.B.4
-
140
-
-
34247623639
-
Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging
-
Lee HC, Wei YH. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med 2007;232:592-606.
-
(2007)
Exp Biol Med
, vol.232
, pp. 592-606
-
-
Lee, H.C.1
Wei, Y.H.2
|