Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord

Brain Research

Volumn 865, Issue 2, 2000, Pages 283-285

  McAdoo, David J ^a   Xu, Guo Ying ^a   Robak, Gregory ^a   Hughes, Michael G ^a   Price, Edna M ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Amino acid transport reversal; Dihydrokainic acid; Disorders of the nervous system; Excitatory amino acids; Microdialysis; Spinal cord injury; Trauma

Indexed keywords

DIHYDROKAINIC ACID; EXCITATORY AMINO ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; RAT; SHORT SURVEY; SPINAL CORD INJURY;

EID: 0034717084     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02296-4     Document Type: Article

References (14)

1. Faden A.I., Simon R.P. Potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann. Neurol. 23:1988;623-626.
2. Koch H.P., Chamberlin A.R., Bridges R.J. Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult. Mol. Pharmacol. 55:1999;1044-1048.
3. Lazarewicz J.W., Salinska E. Role of calcium in glutamate-mediated toxicity: mechanisms of calcium fluxes in rabbit hippocampus in vivo investigated with microdialysis. Acta Neurobiol. Exp. 53:1993;3-13.
4. Liu D. An experimental model combining microdialysis with electrophysiology, histology, and neurochemistry for studying excitotoxicity in spinal cord injury. Mol. Chem. Neuropathol. 23:1994;77-92.
5. Liu D., Thangnipon W., McAdoo D.J. Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res. 547:1991;344-348.
6. Liu D., Xu G.-Y., Pan E., McAdoo D.J. Neurotoxicity of glutamate at the concentrations released upon spinal cord injury. Neuroscience. 93:1999;1383-1389.
7. Robinson M.B., Djali S., Buchhalter J.R. Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures. J. Neurochem. 61:1993;2099-2103.
8. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., Kuncl R.W. Localization of neuronal and glial glutamate transporters. Neuron. 13:1994;713-725.
9. Seki Y., Feustel P.J., Keller R.W. Jr., Trammer B.I., Kimelberg H.K. Inhibition of ischemia induced glutamate release in rat striatum by dihydrokainate and an anion channel blocker. Stroke. 30:1999;433-440.
10. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17:1994;359-365.
11. Waldmeier P.C., Wicki P., Feldtrauer J.-J. Release of endogenous glutamate from rat cortical slices in presence of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;478-485.
12. Wrathall J.R., Choiniere D., Teng Y.D. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J. Neurosci. 14:1994;6598-6607.
13. Xu G.-Y., Hughes M.G., Liu D., McAdoo D.J. The effect of the glutamate uptake inhibitor dihydrokainic acid on glutamate release following experimental spinal cord injury. J. Neurotrauma. 12:1995;148.
14. Xu G.-Y., McAdoo D.J., Hughes M.G., Robak G., De Castro R. Jr. Considerations in the determination by microdialysis of resting extracellular amino acid concentrations and release upon spinal cord injury. Neuroscience. 86:1998;1011-1021.