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Volumn 87, Issue 1, 2009, Pages 200-207

Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor

Author keywords

Atropine; Caspase 3; CCI; Mecamylamine; XIAP

Indexed keywords

ATROPINE; LEVACECARNINE; MECAMYLAMINE; NICOTINIC RECEPTOR; X LINKED INHIBITOR OF APOPTOSIS;

EID: 63049089317     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21815     Document Type: Article
Times cited : (46)

References (39)
  • 1
    • 16844369051 scopus 로고    scopus 로고
    • Potential energetic implications of emesis in the house musk shrew (Suncus murinus)
    • Andrews PLR, Friedman AI, Liu Y, Smith JE, Sims DW. 2005. Potential energetic implications of emesis in the house musk shrew (Suncus murinus). Physiol Behav, 84:519-524.
    • (2005) Physiol Behav , vol.84 , pp. 519-524
    • Andrews, P.L.R.1    Friedman, A.I.2    Liu, Y.3    Smith, J.E.4    Sims, D.W.5
  • 3
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie YK. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107.
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 4
    • 0037031529 scopus 로고    scopus 로고
    • Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons
    • Bigini P, Larini S, Pasquali C, Muzio V, Mennini T. 2002. Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons. Neurosci Lett 329:334-338.
    • (2002) Neurosci Lett , vol.329 , pp. 334-338
    • Bigini, P.1    Larini, S.2    Pasquali, C.3    Muzio, V.4    Mennini, T.5
  • 5
    • 0025372395 scopus 로고
    • The role of carnitine in intracellular metabolism
    • Bremer J. 1990. The role of carnitine in intracellular metabolism. J Clin Chem Clin Biochem 28:297-301.
    • (1990) J Clin Chem Clin Biochem , vol.28 , pp. 297-301
    • Bremer, J.1
  • 6
    • 0032241067 scopus 로고    scopus 로고
    • Mitochondria in the life and death of neurons
    • Budd SL, Nicholls DG. 1998. Mitochondria in the life and death of neurons. Essays Biochem 33:43-52.
    • (1998) Essays Biochem , vol.33 , pp. 43-52
    • Budd, S.L.1    Nicholls, D.G.2
  • 8
    • 33745033368 scopus 로고    scopus 로고
    • Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells
    • Cervia D, Martini D, Garcia-Gil M, Di Giuseppe G, Guella G, Dini F, Bagnoli P. 2006. Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells. Apoptosis 115:829-843.
    • (2006) Apoptosis , vol.115 , pp. 829-843
    • Cervia, D.1    Martini, D.2    Garcia-Gil, M.3    Di Giuseppe, G.4    Guella, G.5    Dini, F.6    Bagnoli, P.7
  • 10
    • 34548635103 scopus 로고    scopus 로고
    • Anti-apoptotic effects of nicotine in its protection, against salsolinol-induced cytotoxicity
    • Copeland RL Jr, Das JR, Kanaan YM, Taylor RE, Tizabi Y. 2007. Anti-apoptotic effects of nicotine in its protection, against salsolinol-induced cytotoxicity. Neurotox Res 12:61-69.
    • (2007) Neurotox Res , vol.12 , pp. 61-69
    • Copeland Jr, R.L.1    Das, J.R.2    Kanaan, Y.M.3    Taylor, R.E.4    Tizabi, Y.5
  • 11
    • 33646598093 scopus 로고    scopus 로고
    • Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and surviving
    • Dasgupta P, Kinkade R, Joshi B, DeCook C, Haura E, Chellappan S. 2006. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and surviving. Proc Natl Acad Sci U S A 103:6332-6337.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6332-6337
    • Dasgupta, P.1    Kinkade, R.2    Joshi, B.3    DeCook, C.4    Haura, E.5    Chellappan, S.6
  • 15
    • 3042522773 scopus 로고    scopus 로고
    • Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception
    • Galeotti N, Bartolini A, Calvani M, Nicolai R, Ghelardini C. 2004. Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology 472:286-294.
    • (2004) Neuropharmacology , vol.472 , pp. 286-294
    • Galeotti, N.1    Bartolini, A.2    Calvani, M.3    Nicolai, R.4    Ghelardini, C.5
  • 17
    • 0036305545 scopus 로고    scopus 로고
    • Systemic acetyl-L-carnitine eliminates sensory neuronal loss after pezipheral axotomy: A new clinical approach in the management of peripheral nerve trauma
    • Hart AM, Wiberg M, Youle M, Terenghi G. 2002. Systemic acetyl-L-carnitine eliminates sensory neuronal loss after pezipheral axotomy: a new clinical approach in the management of peripheral nerve trauma. Exp Brain-Res 145:182-189.
    • (2002) Exp Brain-Res , vol.145 , pp. 182-189
    • Hart, A.M.1    Wiberg, M.2    Youle, M.3    Terenghi, G.4
  • 18
    • 0024971871 scopus 로고
    • Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats
    • Imperato A, Ramacci MT, Angelucci L. 1989. Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 107:251-255.
    • (1989) Neurosci Lett , vol.107 , pp. 251-255
    • Imperato, A.1    Ramacci, M.T.2    Angelucci, L.3
  • 20
    • 34548674477 scopus 로고    scopus 로고
    • A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: synthesis, analgesic efficacy and tolerability profile in animal models
    • Ji J, Bunnelle WH, Anderson DJ, Faltynek C, Dyhring T, Ahring PK, Rueter LE, Curzon P, Buckley MJ, Marsh KC, Kempf-Grote A, Meyer MD. 2007. A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: synthesis, analgesic efficacy and tolerability profile in animal models. Biochem Pharmacol 74:1253-1262.
    • (2007) Biochem Pharmacol , vol.74 , pp. 1253-1262
    • Ji, J.1    Bunnelle, W.H.2    Anderson, D.J.3    Faltynek, C.4    Dyhring, T.5    Ahring, P.K.6    Rueter, L.E.7    Curzon, P.8    Buckley, M.J.9    Marsh, K.C.10    Kempf-Grote, A.11    Meyer, M.D.12
  • 21
    • 10844229048 scopus 로고    scopus 로고
    • Caspase signaling in neuropathic and inflammatory pain in the rat
    • Joseph EK, Levine JD. 2004. Caspase signaling in neuropathic and inflammatory pain in the rat. Eur J Neurosci 20:2896-2902.
    • (2004) Eur J Neurosci , vol.20 , pp. 2896-2902
    • Joseph, E.K.1    Levine, J.D.2
  • 22
    • 0035957946 scopus 로고    scopus 로고
    • Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
    • Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. 2001. Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541-13546.
    • (2001) J Biol Chem , vol.276 , pp. 13541-13546
    • Kihara, T.1    Shimohama, S.2    Sawada, H.3    Honda, K.4    Nakamizo, T.5    Shibasaki, H.6    Kume, T.7    Akaike, A.8
  • 24
    • 0023850632 scopus 로고    scopus 로고
    • Leighton GE, Rodriguez RE, Hill RG, Hughes J. 1988. k-Opioid-agonist produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. Br J Pharmacol 93:553-560.
    • Leighton GE, Rodriguez RE, Hill RG, Hughes J. 1988. k-Opioid-agonist produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. Br J Pharmacol 93:553-560.
  • 25
    • 1842453822 scopus 로고    scopus 로고
    • Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures
    • Liu Q, Zhao B. 2004. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol 141:746-754.
    • (2004) Br J Pharmacol , vol.141 , pp. 746-754
    • Liu, Q.1    Zhao, B.2
  • 26
    • 0026700009 scopus 로고
    • Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl-L-carnitine and NGF
    • Manfridi A, Forloni GL, Arrigoni-Martelli E, Mancia M. 1992. Culture of dorsal root ganglion neurons from aged rats: effects of acetyl-L-carnitine and NGF. Int J Dev Neurosci 10:321-329.
    • (1992) Int J Dev Neurosci , vol.10 , pp. 321-329
    • Manfridi, A.1    Forloni, G.L.2    Arrigoni-Martelli, E.3    Mancia, M.4
  • 27
    • 33746363249 scopus 로고    scopus 로고
    • Protective role of carnitine ester against radiation-induced oxidative stress in rats
    • Mansour HH. 2006. Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res 54:165-171.
    • (2006) Pharmacol Res , vol.54 , pp. 165-171
    • Mansour, H.H.1
  • 28
    • 0037121596 scopus 로고    scopus 로고
    • Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment
    • McKay-Hart A, Wiberg M, Terenghi G. 2002. Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment. Neurosci Lett 334:181-185.
    • (2002) Neurosci Lett , vol.334 , pp. 181-185
    • McKay-Hart, A.1    Wiberg, M.2    Terenghi, G.3
  • 29
    • 0037019887 scopus 로고    scopus 로고
    • Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats
    • Ori C, Freo U, Pizzolato, G, Dam M. 2002. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. Brain Res 951:330-335.
    • (2002) Brain Res , vol.951 , pp. 330-335
    • Ori, C.1    Freo, U.2    Pizzolato, G.3    Dam, M.4
  • 30
    • 33644783056 scopus 로고    scopus 로고
    • AcetyL-L-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: An open label study
    • Osio M, Muscia F, Zampini L, Nascimbene C, Mailland E, Cargnel A, Mariani C. 2006. AcetyL-L-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study. J Peripher Nerv Syst 11:72-76.
    • (2006) J Peripher Nerv Syst , vol.11 , pp. 72-76
    • Osio, M.1    Muscia, F.2    Zampini, L.3    Nascimbene, C.4    Mailland, E.5    Cargnel, A.6    Mariani, C.7
  • 31
    • 0033653231 scopus 로고    scopus 로고
    • Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: Relevance for its mode of action in Alzheimer's disease and geriatric depression
    • Pettegrew JW, Levine J, McClure RJ. 2000. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol Psychiatry 5:616-632.
    • (2000) Mol Psychiatry , vol.5 , pp. 616-632
    • Pettegrew, J.W.1    Levine, J.2    McClure, R.J.3
  • 33
    • 0032723242 scopus 로고    scopus 로고
    • In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling
    • Rapoport SI. 1999. In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling. Neurochem Res 24:1403-1415.
    • (1999) Neurochem Res , vol.24 , pp. 1403-1415
    • Rapoport, S.I.1
  • 34
    • 33845932804 scopus 로고    scopus 로고
    • Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: Involvement of the alpha7 nAChR subtype
    • Rosa AO, Egea J, Gandia L, Lopez MG, Garcia AG. 2006. Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype. J Mol Neurosci 30:61-62.
    • (2006) J Mol Neurosci , vol.30 , pp. 61-62
    • Rosa, A.O.1    Egea, J.2    Gandia, L.3    Lopez, M.G.4    Garcia, A.G.5
  • 35
    • 0030221060 scopus 로고    scopus 로고
    • Behavioral and electrophysiological assessment of hyperalgesia and changes in dorsal-horn responses following partial sciatic nerve ligatioii in rats
    • Takaishi K, Eisele JH Jr, Carstens E. 1996. Behavioral and electrophysiological assessment of hyperalgesia and changes in dorsal-horn responses following partial sciatic nerve ligatioii in rats. Pain 66:297-306.
    • (1996) Pain , vol.66 , pp. 297-306
    • Takaishi, K.1    Eisele Jr, J.H.2    Carstens, E.3
  • 36
    • 0021911491 scopus 로고
    • Stereospecific effects of acetyl-carnitine on the spontaneous activity of brainstem neurcones and their responses to acetylcholine and serotonin
    • Tempesta E, Janiri L, Pirrongelli C. 1985. Stereospecific effects of acetyl-carnitine on the spontaneous activity of brainstem neurcones and their responses to acetylcholine and serotonin. Neuropharmacology 24:43-50.
    • (1985) Neuropharmacology , vol.24 , pp. 43-50
    • Tempesta, E.1    Janiri, L.2    Pirrongelli, C.3
  • 37
    • 0026576909 scopus 로고
    • Protection from oxygen radio: Damage in human diploid fibroblasts by acetyl-L-carnitine
    • Tesco G, Latorraca S, Piersanti P, Piacentini S, Amaducci L, Sorbi S. 1992. Protection from oxygen radio: damage in human diploid fibroblasts by acetyl-L-carnitine. Dementia 3:58-64.
    • (1992) Dementia , vol.3 , pp. 58-64
    • Tesco, G.1    Latorraca, S.2    Piersanti, P.3    Piacentini, S.4    Amaducci, L.5    Sorbi, S.6
  • 39
    • 0025284835 scopus 로고
    • Acetyl-L-carnitine as precursor of acerylcholine
    • White HL, Scates PW. 1990. Acetyl-L-carnitine as precursor of acerylcholine. Neurochem Res 15:597-601.
    • (1990) Neurochem Res , vol.15 , pp. 597-601
    • White, H.L.1    Scates, P.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.