Minocycline Treatment Reduces Delayed Oligodendrocyte Death, Attenuates Axonal Dieback, and Improves Functional Outcome after Spinal Cord Injury

Journal of Neuroscience

Volumn 24, Issue 9, 2004, Pages 2182-2190

  Stirling, David P ^a   Khodarahmi, Kourosh ^a   Liu, Jie ^a   McPhail, Lowell T ^a   McBride, Christopher B ^a   Steeves, John D ^a   Ramer, Matt S ^a   Tetzlaff, Wolfram ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Intl Collaborat On Repair Discov   (Canada)

Author keywords

Apoptosis; Axonal dieback; Caspase 3; Footprint analysis; Macrophages; Microglia; Minocycline; Neuroprotection; Oligodendrocyte; Spinal cord injury

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; MINOCYCLINE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MICROGLIA; NERVE FIBER; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; AXONS; CASPASE 3; CASPASES; DISEASE MODELS, ANIMAL; MICROGLIA; MINOCYCLINE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OLIGODENDROGLIA; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 1542376941     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5275-03.2004     Document Type: Article

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