Glutamate transporters: Animal models to neurologic disease

Neurobiology of Disease

Volumn 15, Issue 3, 2004, Pages 461-473

  Maragakis, Nicholas J ^a   Rothstein, Jeffrey D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Central nervous system; Glutamate; Neurologic diseases

Indexed keywords

AMINO ACID RECEPTOR AFFECTING AGENT; GLUTAMATE TRANSPORTER; GLUTAMIC ACID;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL DAMAGE; CELL DEATH; CENTRAL NERVOUS SYSTEM TUMOR; CYTOPATHOLOGY; DEGENERATIVE DISEASE; EPILEPSY; EXPERIMENTAL MODEL; HUMAN; HUNTINGTON CHOREA; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; STROKE;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS;

EID: 1842524064     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.12.007     Document Type: Review

References (96)

1. Arriza J.L., Eliasof S., Kavanaugh M.P., Amara S.G. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. U. S. A. 94:1997;4155-4160.
2. Arzberger T., Krampfl K., Leimgruber S., Weindl A. Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease - An in situ hybridization study. J. Neuropathol. Exp. Neurol. 56:1997;440-454.
3. Barpeled O., BenHur H., Biegon A., Groner Y., Dewhurst S., Furuta A., Rothstein J.D. Distribution of glutamate transporter subtypes during human brain development. J. Neurochem. 69:1997;2571-2580.
4. Beckstrom H., Julsrud L., Haugeto O., Dewar D., Graham D.I., Lehre K.F., StormMathisen J., Danbolt N.C. Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease. J. Neurosci. Res. 55:1999;218-229.
5. Behrens P.F., Franz P., Woodman B., Lindenberg K.S., Landwehrmeyer G.B. Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain. 125:2002;1908-1922.
6. Bellocchio E.E., Hu H., Pohorille A., Chan J., Pickel V.M., Edwards R.H. The localization of the brain-specific inorganic phosphate transporter suggests a specific presynaptic role in glutamatergic transmission. J. Neurosci. 18:1998;8648-8659.
7. Bruijn L.I., Becher M.W., Lee M.K., Anderson K.L., Jenkins N.A., Copeland N.G., Sisodia S.S., Rothstein J.D., Borchelt D.R., Price D.L., Cleveland D.W. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18:1997;327-338.
8. Chen W., Aoki C., Mahadomrongkul V., Gruber C.E., Wang G.J., Blitzblau R., Irwin N., Rosenberg P.A. Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J. Neurosci. 22:2002;2142-2152.
9. Choi D.W., Mauluccigedde M., Kriegstein A.R. Glutamate neurotoxicity in cortical cell-culture. J. Neurosci. 7:1987;357-368.
10. Crino P.B., Jin H., Shumate M.D., Robinson M.B., Coulter D.A., Brooks-Kayal A.R. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia. 43:2002;211-218.
11. Danbolt N.C., Storm-Mathisen J., Kanner B.I. An [Na++K+]coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience. 51:1992;295-310.
12. Dunlop J., Lou Z., McIlvain H.B. Properties of excitatory amino acid transport in the human U373 astrocytoma cell line. Brain Res. 839:1999;235-242.
13. During M.J., Spencer D.D. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet. 341:1993;1607-1610.
14. Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., Amara S.G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375:1995;599-603.
15. Flowers J.M., Powell J.F., Leigh P.N., Andersen P., Shaw C.E. Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis. Ann. Neurol. 49:2001;643-649.
16. Fukamachi S., Furuta A., Ikeda T., Ikenoue T., Kaneoka T., Rothstein J.D., Iwaki T. Altered expressions of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia. Brain Res. Dev. Brain Res. 132:2001;131-139.
17. Furuta A., Martin L.J., Lin C.L.G., DykesHoberg M., Rothstein J.D. Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience. 81:1997;1031-1042.
18. Furuta A., Rothstein J.D., Martin L.J. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J. Neurosci. 17:1997;8363-8375.
19. Furuta A., Noda M., Suzuki S.O., Goto Y., Kanahori Y., Rothstein J.D., Iwaki T. Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy. Am. J. Pathol. 163:2003;779-787.
20. Ginsberg S.D., Martin L.J., Rothstein J.D. Regional deafferentation down-regulates subtypes of glutamate transporter proteins. J. Neurochem. 65:1995;2800-2803.
21. Guo H., Lai L., Butchbach M.E., Stockinger M.P., Shan X., Bishop G.A., Lin C.L. Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice. Hum. Mol. Genet. 12:2003;2519-2532.
22. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.-X., Chen W., Zhai P., Sufit R.L., Siddique T. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 264:1994;1772-1775.
23. Hamann M., Rossi D.J., Marie H., Attwell D. Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur. J. Neurosci. 15:2002;308-314.
24. Hazell A.S., Itzhak Y., Liu H., Norenberg M.D. 1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J. Neurochem. 68:1997;2216-2219.
25. Hazell A.S., Rao K.V., Danbolt N.C., Pow D.V., Butterworth R.F. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J. Neurochem. 78:2001;560-568.
26. Hazell A.S., Pannunzio P., Rama Rao K.V., Pow D.V., Rambaldi A. Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes. Glia. 43:2003;175-184.
27. Howland D.S., Liu J., She Y., Goad B., Maragakis N.J., Kim B., Erickson J., Kulik J., DeVito L., Psaltis G., DeGennaro L.J., Cleveland D.W., Rothstein J.D. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U. S. A. 99:2002;1604-1609.
28. Ikegaya Y., Matsuura S., Ueno S., Baba A., Yamada M.K., Nishiyama N., Matsuki N. Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy. J. Biol. Chem. 277:2002;32180-32186.
29. Ikematsu K., Tsuda R., Orihara Y., Nakasono I. The expression of excitatory amino acid transporter 2 (EAAT2) in forensic autopsy cases. Forensic Sci. Int. 118:2001;49-55.
30. Inage Y.W., Itoh M., Wada K., Takashima S. Expression of two glutamate transporters, GLAST and EAAT4, in the human cerebellum: their correlation in development and neonatal hypoxic-ischemic damage. J. Neuropathol. Exp. Neurol. 57:1998;554-562.
31. Jackson M., Song W., Liu M.Y., Jin L., Dykes-Hoberg M., Lin C.I., Bowers W.J., Federoff H.J., Sternweis P.C., Rothstein J.D. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410:2001;89-93.
32. Kanai Y., Hediger M.A. Primary structure and functional characterization of a high-affinity glutamate transporter. (see comments) Nature. 360:1992;467-471.
33. Levy L.M., Lehre K.P., Walaas S.I., Storm-Mathisen J., Danbolt N.C. Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain. Eur. J. Neurosci. 7:1995;2036-2041.
34. Li S., Mallory M., Alford M., Tanaka S., Masliah E. Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. J. Neuropathol. Exp. Neurol. 56:1997;901-911.
35. Lievens J.C., Salin P., Had-Aissouni L., Mahy N., Kerkerian-Le Goff L. Differential effects of corticostriatal and thalamostriatal deafferentation on expression of the glutamate transporter GLT1 in the rat striatum. J. Neurochem. 74:2000;909-919.
36. Lievens J.C., Salin P., Nieoullon A., Kerkerian-Le Goff L. Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum. J. Neurochem. 79:2001;893-902.
37. Lievens J.C., Woodman B., Mahal A., Spasic-Boscovic O., Samuel D., Kerkerian-Le Goff L., Bates G.P. Impaired glutamate uptake in the R6 Huntington's disease transgenic mice. Neurobiol. Dis. 8:2001;807-821.
38. Lin C.G., Bristol L.A., Jin L., DykesHoberg M., Crawford T., Clawson L., Rothstein J.D. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2 a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. 20:1998;589-602.
39. Lin C.I., Orlov I., Ruggiero A.M., Dykes-Hoberg M., Lee A., Jackson M., Rothstein J.D. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature. 410:2001;84-88.
40. Marie H., Billups D., Bedford F.K., Dumoulin A., Goyal R.K., Longmore G.D., Moss S.J., Attwell D. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol. Cell. Neurosci. 19:2002;152-164.
41. Martin L.J., Brambrink A.M., Lehmann C., Portera-Cailliau C., Koehler R., Rothstein J., Traystman R.J. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum. Ann. Neurol. 42:1997;335-348.
42. Masliah E., Alford M., DeTeresa R., Mallory M., Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann. Neurol. 40:1996;759-766.
43. Masliah E., Raber J., Alford M., Mallory M., Mattson M.P., Yang D., Wong D., Mucke L. Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis. J. Biol. Chem. 273:1998;12548-12554.
44. Masliah E., Alford M., Mallory M., Rockenstein E., Moechars D., Van Leuven F. Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice. Exp. Neurol. 163:2000;381-387.
45. Mathern G.W., Mendoza D., Lozada A., Pretorius J.K., Dehnes Y., Danbolt N.C., Nelson N., Leite J.P., Chimelli L., Born D.E., Sakamoto A.C., Assirati J.A., Fried I., Peacock W.J., Ojemann G.A., Adelson P.D. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology. 52:1999;453-472.
46. Mathews G.C., Diamond J.S. Neuronal glutamate uptake contributes to GABA synthesis and inhibitory synaptic strength. J. Neurosci. 23:2003;2040-2048.
47. McAdoo D.J., Xu G., Robak G., Hughes M.G., Price E.M. Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord. Brain Res. 865:2000;283-285.
48. Meldrum B.S. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44:1994;S14-S23.
49. Meyer T., Fromm A., Munch C., Schwalenstocker B., Fray A.E., Ince P.G., Stamm S., Gron G., Ludolph A.C., Shaw P.J. The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals. J. Neurol. Sci. 170:1999;45-50.
50. Miller H.P., Levey A.I., Rothstein J.D., Tzingounis A.V., Conn P.J. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J. Neurochem. 68:1997;1564-1570.
51. Munch C., Penndorf A., Schwalenstocker B., Troost D., Ludolph A.C., Ince P., Meyer T. Impaired RNA splicing of 5′-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma. J. Neurol. Neurosurg. Psychiatry. 71:2001;675-678.
52. Nagai M., Abe K., Okamoto K., Itoyama Y. Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients. Neurosci. Lett. 244:1998;165-168.
53. Nagai M., Aoki M., Miyoshi I., Kato M., Pasinelli P., Kasai N., Brown R.H. Jr., Itoyama Y. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J. Neurosci. 21:2001;9246-9254.
54. Namura S., Maeno H., Takami S., Jiang X.F., Kamichi S., Wada K., Nagata I. Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice. Neurosci. Lett. 324:2002;117-120.
55. Noda M., Nakanishi H., Akaike N. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience. 92:1999;1465-1474.
56. Pappas T.C., Alagarsamy S., Pollard R.B., Nokta M. HIV decreases glutamate transport in SK-N-MC neuroblastoma cells. J. Neurovirology. 4:1998;69-79.
57. Peghini P., Janzen J., Stoffel W. Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 16:1997;3822-3832.
58. Pow D.V., Barnett N.L. Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina. Neurosci. Lett. 280:2000;21-24.
59. Proper E.A., Hoogland G., Kappen S.M., Jansen G.H., Rensen M.G., Schrama L.H., van Veelen C.W., van Rijen P.C., van Nieuwenhuizen O., Gispen W.H., de Graan P.N. Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain. 125:2002;32-43.
60. Raghavendra R.V., Bowen K.K., Dempsey R.J. Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain. Neurochem. Res. 26:2001;497-502.
61. Rao V.L., Baskaya M.K., Dogan A., Rothstein J.D., Dempsey R.J. Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain. J. Neurochem. 70:1998;2020-2027.
62. Rao V.L., Bowen K.K., Dempsey R.J. Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain. Neurochem. Res. 26:2001;497-502.
63. Rao V.L., Dogan A., Todd K.G., Bowen K.K., Kim B.T., Rothstein J.D., Dempsey R.J. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. J. Neurosci. 21:2001;1876-1883.
64. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.-X., Rahmani Z., Krizus A., McKenna-Yasek D., Cayabyab A., Gaston S.M., Berger R., Tanzi R.E., Halperin J.J., Herzfeldt B., Van den Bergh R., Hung W.-Y., Bird T., Deng G., Mulder D.W., Smyth C., Laing N.G., Soriano E., Pericak-Vance M.A., Haines J., Rouleau G.A., Gusella J.S., Horvitz H.R., Brown R.H. Jr. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:1993;59-62.
65. Rossi D.J., Oshima T., Attwell D. Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature. 403:2000;316-321.
66. Rothstein J.D., Tsai G., Kuncl R.W., Clawson L., Cornblath D.R., Drachman D.B., Pestronk A., Stauch B.L., Coyle J.T. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. (see comments) Ann. Neurol. 28:1990;18-25.
67. Rothstein J.D., Martin L.J., Kuncl R.W. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 326:1992;1464-1468.
68. Rothstein J.D., Van Kammen M., Levey A.I., Martin L.J., Kuncl R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38:1995;73-84.
69. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J., Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
70. Schmitt A., Asan E., Lesch K.P., Kugler P. A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Neuroscience. 109:2002;45-61.
71. Scholz, R.E., Sutherland, M.L. (2003). The role of enhanced glutamate transport in two mouse models of ALS. Society for Neuroscience Annual Meeting, New Orleans, La. 96.8. 11-8-2003. Ref Type: Abstract.
72. Schreiber R., Freund W.D. Glutamate transport is downregulated in the cerebral cortex of alcohol-preferring rats. Med. Sci. Monit. 6:2000;649-652.
73. Scott H.L., Pow D.V., Tannenberg A.E., Dodd P.R. Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease. J. Neurosci. 22:2002;RC206.
74. Sepkuty J.P., Cohen A.S., Eccles C., Rafiq A., Behar K., Ganel R., Coulter D.A., Rothstein J.D. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J. Neurosci. 22:2002;6372-6379.
75. Shashidharan P., Plaitakis A. Cloning and characterization of a glutamate transporter cDNA from human cerebellum. Biochim. Biophys. Acta. 1216:1993;161-164.
76. Shashidharan P., Wittenberg I., Plaitakis A. Molecular cloning of human brain glutamate/aspartate transporter II. Biochim. Biophys. Acta. 1191:1994;393-396.
77. Siddique T., Figlewicz D.A., Pericak-Vance M.A., Haines J.L., Rouleau G., Jeffers A.J., Sapp P., Hung W.-Y., Bebout J., McKenna-Yasek D., Deng G., Horvitz H.B., Gusella J.F., Brown R.H. Jr., Roses A.D., Roos R.P., Williams D.B., Mulder D.W., Watkins P.C., Noore R., Nicholson G., Reed R., Brooks B.R., Festoff B., Antel J.P., Tandan R., Munsat T.L., Laing N.G., Halperin J.J., Norris F.H., Van den Bergh R., Swerts L., Tanzi R.E., Jubelt B., Mathews K.D., Bosch E.P. Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. N. Engl. J. Med. 324:1991;1381-1384.
78. Simantov R., Crispino M., Hoc W., Broutman G., Tocco G., Rothstein J.D., Baudry M. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity. Mol. Brain Res. 65:1999;112-123.
79. Spreux-Varoquaux O., Bensimon G., Lacomblez L., Salachas F., Pradat P.F., Le Forestier N., Marouan A., Dib M., Meininger V. Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. J. Neurol. Sci. 193:2002;73-78.
80. Storck T., Schulte S., Hofmann K., Stoffel W. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. U. S. A. 89:1992;10955-10959.
81. Su Z.Z., Leszczyniecka M., Kang D.C., Sarkar D., Chao W., Volsky D.J., Fisher P.B. Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). Proc. Natl. Acad. Sci. U. S. A. 100:2003;1955-1960.
82. Takamori S., Rhee J.S., Rosenmund C., Jahn R. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature. 407:2000;189-194.
83. Takamori S., Malherbe P., Broger C., Jahn R. Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Rep. 3:2002;798-803.
84. Takano T., Lin J.H., Arcuino G., Gao Q., Yang J., Nedergaard M. Glutamate release promotes growth of malignant gliomas. Nat. Med. 7:2001;1010-1015.
85. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Hori S., Takimoto M., Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 276:1997;1699-1702.
86. Tao F., Lu S.D., Zhang L.M., Huang Y.L., Sun F.Y. Role of excitatory amino acid transporter 1 in neonatal rat neuronal damage induced by hypoxia-ischemia. Neuroscience. 102:2001;503-513.
87. Tessler S., Danbolt N.C., Faull R.L.M., StormMathisen J., Emson P.C. Expression of the glutamate transporters in human temporal lobe epilepsy. Neuroscience. 88:1999;1083-1091.
88. Thai D.R. Excitatory amino acid transporter EAAT-2 in tangle-bearing neurons in Alzheimer's disease. Brain Pathol. 12:2002;405-411.
89. Trotti D., Rolfs A., Danbolt N.C., Brown R.H. Jr., Hediger M.A. SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter. (in process citation) Nat. Neurosci. 2:1999;427-433.
90. Ueda Y., Doi T., Tsuru N., Tokumaru J., Mitsuyama Y. Expression of glutamate transporters and ionotropic glutamate receptors in GLAST knockout mice. Brain Res. Mol. Brain Res. 104:2002;120-126.
91. Utsunomiya-Tate N., Endou H., Kanai Y. Tissue specific variants of glutamate transporter GLT-1. FEBS Lett. 416:1997;312-316.
92. Vallat-Decouvelaere A.V., Chretien F., Gras G., Le Pavec G., Dormont D., Gray F. Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia? J. Neuropathol. Exp. Neurol. 62:2003;475-485.
93. Wang Z., Pekarskaya O., Bencheikh M., Chao W., Gelbard H.A., Ghorpade A., Rothstein J.D., Volsky D.J. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology. 312:2003;60-73.
94. Watanabe T., Morimoto K., Hirao T., Suwaki H., Watase K., Tanaka K. Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice. Brain Res. 845:1999;92-96.
95. Watase K., Hashimoto K., Kano M., Yamada K., Watanabe M., Inoue Y., Okuyama S., Sakagawa T., Ogawa S., Kawashima N., Hori S., Takimoto M., Wada K., Tanaka K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10:1998;976-988.
96. Ye Z.C., Rothstein J.D., Sontheimer H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J. Neurosci. 19:1999;10767-10777.