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Volumn 44, Issue 5, 1999, Pages 1027-1040

Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury

Author keywords

Excitotoxicity; Ischemia; Methylprednisolone; Neural regeneration; Secondary injury; Spinal cord injury

Indexed keywords

ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; GANGLIOSIDE; GLUTAMATE RECEPTOR ANTAGONIST; METHYLPREDNISOLONE; OPIATE ANTAGONIST;

EID: 0032905498     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199905000-00052     Document Type: Review
Times cited : (347)

References (107)
  • 1
    • 0023180846 scopus 로고
    • High-resolution CT scanning in the evaluation of cervical spine fractures: Comparison with plain film examinations
    • Acheson MB, Livingston RR, Richardson ML, Stimac GK: High-resolution CT scanning in the evaluation of cervical spine fractures: Comparison with plain film examinations. AJR Am J Roentgenol 148:1179-1185, 1987.
    • (1987) AJR Am J Roentgenol , vol.148 , pp. 1179-1185
    • Acheson, M.B.1    Livingston, R.R.2    Richardson, M.L.3    Stimac, G.K.4
  • 2
    • 0031020308 scopus 로고    scopus 로고
    • Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
    • Agrawal SK, Fehlings MG: Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 17:1055-1063, 1997.
    • (1997) J Neurosci , vol.17 , pp. 1055-1063
    • Agrawal, S.K.1    Fehlings, M.G.2
  • 3
    • 0032911902 scopus 로고    scopus 로고
    • Surgical controversies in the management of spinal cord injury
    • Amar AP, Levy ML: Surgical controversies in the management of spinal cord injury. J Am Coll Surg 188:546-561, 1999.
    • (1999) J Am Coll Surg , vol.188 , pp. 546-561
    • Amar, A.P.1    Levy, M.L.2
  • 4
    • 0023737151 scopus 로고
    • Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury
    • Anderson DK, Braughler JM, Hall ED, Waters TR, McCall JM, Means ED: Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury. J Neurosurg 69:562-567, 1988.
    • (1988) J Neurosurg , vol.69 , pp. 562-567
    • Anderson, D.K.1    Braughler, J.M.2    Hall, E.D.3    Waters, T.R.4    McCall, J.M.5    Means, E.D.6
  • 5
    • 0019962854 scopus 로고
    • Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment
    • Anderson DK, Means ED, Waters TR, Green ES: Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment. J Neurosurg 56:106-113, 1982.
    • (1982) J Neurosurg , vol.56 , pp. 106-113
    • Anderson, D.K.1    Means, E.D.2    Waters, T.R.3    Green, E.S.4
  • 6
    • 0029840675 scopus 로고    scopus 로고
    • Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma
    • Anthes DL, Theriault E, Tator CH: Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma. Neurosurgery 39:804-814, 1996.
    • (1996) Neurosurgery , vol.39 , pp. 804-814
    • Anthes, D.L.1    Theriault, E.2    Tator, C.H.3
  • 7
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256, 1996.
    • (1996) Exp Neurol , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 8
    • 0024418456 scopus 로고
    • Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
    • Blight AR: Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury. Brain Res Bull 22:47-52, 1989.
    • (1989) Brain Res Bull , vol.22 , pp. 47-52
    • Blight, A.R.1
  • 9
    • 0024322029 scopus 로고
    • Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells
    • Blight AR, Young W: Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells. J Neurol Sci 91:15-34, 1989.
    • (1989) J Neurol Sci , vol.91 , pp. 15-34
    • Blight, A.R.1    Young, W.2
  • 10
    • 0021988737 scopus 로고
    • The results of treatment of acute injuries of the upper thoracic spine with paralysis
    • Bohlman HH, Freehafer A, Dejak J: The results of treatment of acute injuries of the upper thoracic spine with paralysis. J Bone Joint Surg Am 67A:360-369, 1985.
    • (1985) J Bone Joint Surg Am , vol.67 A , pp. 360-369
    • Bohlman, H.H.1    Freehafer, A.2    Dejak, J.3
  • 11
    • 0026346427 scopus 로고
    • A prospective analysis of a two-year experience using computed tomography as an adjunct for cervical spine clearance
    • Borock EC, Gabram SGA, Jacobs LM, Murphy MA: A prospective analysis of a two-year experience using computed tomography as an adjunct for cervical spine clearance. J Trauma 31: 1001-1006, 1991.
    • (1991) J Trauma , vol.31 , pp. 1001-1006
    • Borock, E.C.1    Gabram, S.G.A.2    Jacobs, L.M.3    Murphy, M.A.4
  • 12
    • 0022572610 scopus 로고
    • Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cordtransected rats
    • Bose B, Osterholm JL, Kalia M: Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cordtransected rats. Neurosci Lett 63:165-169, 1986.
    • (1986) Neurosci Lett , vol.63 , pp. 165-169
    • Bose, B.1    Osterholm, J.L.2    Kalia, M.3
  • 13
    • 0027377378 scopus 로고
    • Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2
    • Bracken MB, Holford TR: Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosurg 79:500-507, 1993.
    • (1993) J Neurosurg , vol.79 , pp. 500-507
    • Bracken, M.B.1    Holford, T.R.2
  • 19
    • 0027487867 scopus 로고
    • Expanding roles for the Schwann cell: Ensheathment, myelination, trophism and regeneration
    • Bunge RP: Expanding roles for the Schwann cell: Ensheathment, myelination, trophism and regeneration. Curr Opin Neurobiol 3:805-809, 1993.
    • (1993) Curr Opin Neurobiol , vol.3 , pp. 805-809
    • Bunge, R.P.1
  • 20
    • 0027944232 scopus 로고
    • Thoracolumbar spine fractures with neurologic deficit
    • Chapman JR, Anderson PA: Thoracolumbar spine fractures with neurologic deficit. Orthop Clin N Am 25:595-612, 1994.
    • (1994) Orthop Clin N Am , vol.25 , pp. 595-612
    • Chapman, J.R.1    Anderson, P.A.2
  • 21
    • 0029840835 scopus 로고    scopus 로고
    • Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
    • Cheng H, Cao Y, Olson L: Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function. Science 273:510-513, 1996.
    • (1996) Science , vol.273 , pp. 510-513
    • Cheng, H.1    Cao, Y.2    Olson, L.3
  • 22
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi DW: Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379, 1987.
    • (1987) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 23
    • 0023753142 scopus 로고
    • Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
    • Choi DW: Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 11:465-469, 1988.
    • (1988) Trends Neurosci , vol.11 , pp. 465-469
    • Choi, D.W.1
  • 24
    • 0025265926 scopus 로고
    • The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
    • Choi DW, Rothman SM: The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13:171-182, 1990.
    • (1990) Annu Rev Neurosci , vol.13 , pp. 171-182
    • Choi, D.W.1    Rothman, S.M.2
  • 25
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
    • Choi DW, Koh J, Peters S: Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J Neurosci 8:185-196, 1988.
    • (1988) J Neurosci , vol.8 , pp. 185-196
    • Choi, D.W.1    Koh, J.2    Peters, S.3
  • 27
    • 0022639713 scopus 로고
    • Role of free radical scavenger in protection of spinal cord during ischemia
    • Coles JC, Ahmed SN, Mehta HU, Kaufmann JCE: Role of free radical scavenger in protection of spinal cord during ischemia. Ann Thorac Surg 41:551-556, 1986.
    • (1986) Ann Thorac Surg , vol.41 , pp. 551-556
    • Coles, J.C.1    Ahmed, S.N.2    Mehta, H.U.3    Kaufmann, J.C.E.4
  • 28
    • 0027954265 scopus 로고
    • The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats
    • Constantini S, Young W: The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 80:97-111, 1994.
    • (1994) J Neurosurg , vol.80 , pp. 97-111
    • Constantini, S.1    Young, W.2
  • 29
    • 0019955945 scopus 로고
    • The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord
    • Dolan EJ, Tator CH: The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord. J Neurosurg 56:350-358, 1982.
    • (1982) J Neurosurg , vol.56 , pp. 350-358
    • Dolan, E.J.1    Tator, C.H.2
  • 30
    • 0019135776 scopus 로고
    • The value of decompression for acute experimental spinal cord compression injury
    • Dolan EJ, Tator CH, Endrenyi L: The value of decompression for acute experimental spinal cord compression injury. J Neurosurg 53:749-755, 1980.
    • (1980) J Neurosurg , vol.53 , pp. 749-755
    • Dolan, E.J.1    Tator, C.H.2    Endrenyi, L.3
  • 32
    • 0016738442 scopus 로고
    • Immediate consequences of spinal cord injury: Possible role of potassium in axonal conduction block
    • Eidelberg E, Sullivan J, Brigham A: Immediate consequences of spinal cord injury: Possible role of potassium in axonal conduction block. Surg Neurol 3:317-321, 1975.
    • (1975) Surg Neurol , vol.3 , pp. 317-321
    • Eidelberg, E.1    Sullivan, J.2    Brigham, A.3
  • 33
    • 0021741995 scopus 로고
    • Cervical sagittal spinal canal size in spine injury
    • Eismont FJ, Clifford S, Goldberg M, Green B: Cervical sagittal spinal canal size in spine injury. Spine 9:663-666, 1984.
    • (1984) Spine , vol.9 , pp. 663-666
    • Eismont, F.J.1    Clifford, S.2    Goldberg, M.3    Green, B.4
  • 34
    • 0022639257 scopus 로고
    • Neuropeptides and central nervous system injury: Clinical implications
    • Faden AI: Neuropeptides and central nervous system injury: Clinical implications. Arch Neurol 43:501-504, 1986.
    • (1986) Arch Neurol , vol.43 , pp. 501-504
    • Faden, A.I.1
  • 35
    • 0023235709 scopus 로고
    • Pharmacotherapy in spinal cord injury: A critical review of recent developments
    • Faden AI: Pharmacotherapy in spinal cord injury: A critical review of recent developments. Clin Neuropharmacol 10:193-204, 1987.
    • (1987) Clin Neuropharmacol , vol.10 , pp. 193-204
    • Faden, A.I.1
  • 36
    • 0026540898 scopus 로고
    • Pharmacological strategies in CNS trauma
    • Faden AI, Salzman S: Pharmacological strategies in CNS trauma. Trends Pharmacol Sci 13:29-35, 1992.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 29-35
    • Faden, A.I.1    Salzman, S.2
  • 37
    • 0024365739 scopus 로고
    • The role of excitatory amino acids and NMDA receptors in traumatic brain injury
    • Faden AI, Demediuk P, Panter SS, Vink R: The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798-800, 1989.
    • (1989) Science , vol.244 , pp. 798-800
    • Faden, A.I.1    Demediuk, P.2    Panter, S.S.3    Vink, R.4
  • 38
    • 0019491552 scopus 로고
    • Opiate antagonist improves neurologic recovery after spinal injury
    • Faden AI, Jacobs TP, Holaday JW: Opiate antagonist improves neurologic recovery after spinal injury. Science 211:493-494, 1981.
    • (1981) Science , vol.211 , pp. 493-494
    • Faden, A.I.1    Jacobs, T.P.2    Holaday, J.W.3
  • 39
    • 0019510328 scopus 로고
    • Endorphins in experimental spinal injury: Therapeutic effect of naloxone
    • Faden AI, Jacobs TP, Mougey E, Holaday JW: Endorphins in experimental spinal injury: Therapeutic effect of naloxone. Ann Neurol 10:326-332, 1981.
    • (1981) Ann Neurol , vol.10 , pp. 326-332
    • Faden, A.I.1    Jacobs, T.P.2    Mougey, E.3    Holaday, J.W.4
  • 40
    • 0021352717 scopus 로고
    • Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia
    • Faden AI, Jacobs TP, Smith MT: Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia. J Neurosurg 60:796-799, 1984.
    • (1984) J Neurosurg , vol.60 , pp. 796-799
    • Faden, A.I.1    Jacobs, T.P.2    Smith, M.T.3
  • 41
    • 0020537888 scopus 로고
    • Comparisons of thyrotropin-releasing hormone (TRH), naloxone, and dexamethasone treatments in experimental spinal injury
    • Faden AI, Jacobs TP, Smith MT, Holaday JW: Comparisons of thyrotropin-releasing hormone (TRH), naloxone, and dexamethasone treatments in experimental spinal injury. Neurology 33: 673-678, 1983.
    • (1983) Neurology , vol.33 , pp. 673-678
    • Faden, A.I.1    Jacobs, T.P.2    Smith, M.T.3    Holaday, J.W.4
  • 42
    • 0021143690 scopus 로고
    • Naloxone in experimental spinal cord ischemia: Dose-response studies
    • Faden AI, Jacobs TP, Smith MT, Zivin JA: Naloxone in experimental spinal cord ischemia: Dose-response studies. Eur J Pharmacol 103:115-120, 1984.
    • (1984) Eur J Pharmacol , vol.103 , pp. 115-120
    • Faden, A.I.1    Jacobs, T.P.2    Smith, M.T.3    Zivin, J.A.4
  • 43
    • 0029012783 scopus 로고
    • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
    • Fehlings MG, Tator CH: The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp Neurol 132:220-228, 1995.
    • (1995) Exp Neurol , vol.132 , pp. 220-228
    • Fehlings, M.G.1    Tator, C.H.2
  • 44
    • 0024326071 scopus 로고
    • The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury
    • Fehlings MG, Tator CH, Linden RD: The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg 71:403-416, 1989.
    • (1989) J Neurosurg , vol.71 , pp. 403-416
    • Fehlings, M.G.1    Tator, C.H.2    Linden, R.D.3
  • 45
    • 0027367088 scopus 로고
    • Spinal cord transection in adult rats: Effects of local infusion of nerve growth factor on the corticospinal tract axons
    • Fernandez E, Pallini R, Lauretti L, Mercanti D, Serra A, Calissano P: Spinal cord transection in adult rats: Effects of local infusion of nerve growth factor on the corticospinal tract axons. Neurosurgery 33:889-893, 1993.
    • (1993) Neurosurgery , vol.33 , pp. 889-893
    • Fernandez, E.1    Pallini, R.2    Lauretti, L.3    Mercanti, D.4    Serra, A.5    Calissano, P.6
  • 46
    • 0000695642 scopus 로고    scopus 로고
    • Management of thoracic fractures
    • Menezes AH, Sonntag VKH (eds). New York, McGraw-Hill
    • Fessler RG, Masson RL: Management of thoracic fractures, in Menezes AH, Sonntag VKH (eds): Principles of Spinal Surgery. New York, McGraw-Hill, 1996, pp 899-918.
    • (1996) Principles of Spinal Surgery , pp. 899-918
    • Fessler, R.G.1    Masson, R.L.2
  • 48
    • 0028807384 scopus 로고
    • Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
    • Frisen J, Johansson CB, Torok C, Risling M, Lendahl U: Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. J Cell Biol 131:453-464, 1995.
    • (1995) J Cell Biol , vol.131 , pp. 453-464
    • Frisen, J.1    Johansson, C.B.2    Torok, C.3    Risling, M.4    Lendahl, U.5
  • 49
    • 0019424064 scopus 로고
    • The clinical application of hyperbaric oxygen therapy in spinal cord injury: A preliminary report
    • Gamache FW, Myers RA, Ducker TB, Cowley RA: The clinical application of hyperbaric oxygen therapy in spinal cord injury: A preliminary report. Surg Neurol 15:85-87, 1981.
    • (1981) Surg Neurol , vol.15 , pp. 85-87
    • Gamache, F.W.1    Myers, R.A.2    Ducker, T.B.3    Cowley, R.A.4
  • 50
    • 0027525882 scopus 로고
    • GM-1 ganglioside and motor recovery following human spinal cord injury
    • Geisler FH: GM-1 ganglioside and motor recovery following human spinal cord injury. J Emerg Med 11:49-55, 1993.
    • (1993) J Emerg Med , vol.11 , pp. 49-55
    • Geisler, F.H.1
  • 51
    • 0001471320 scopus 로고    scopus 로고
    • Neuroprotection and regeneration of the spinal cord
    • Menezes AH, Sonntag VKH (eds). New York, McGraw-Hill
    • Geisler FH: Neuroprotection and regeneration of the spinal cord, in Menezes AH, Sonntag VKH (eds): Principles of Spinal Surgery. New York, McGraw-Hill, 1996, pp 769-784.
    • (1996) Principles of Spinal Surgery , pp. 769-784
    • Geisler, F.H.1
  • 52
    • 0026432654 scopus 로고
    • Recovery of motor function after spinal-cord injury: A randomized placebo-controlled trial with GM-1 ganglioside
    • Geisler FH, Dorsey FC, Coleman WP: Recovery of motor function after spinal-cord injury: A randomized placebo-controlled trial with GM-1 ganglioside. N Engl J Med 324:1829-1838, 1991.
    • (1991) N Engl J Med , vol.324 , pp. 1829-1838
    • Geisler, F.H.1    Dorsey, F.C.2    Coleman, W.P.3
  • 53
    • 0026694626 scopus 로고
    • Scoliosis Research Society Multicenter Spine Fracture study
    • Gertzbein SD: Scoliosis Research Society Multicenter Spine Fracture study. Spine 17:528-540, 1992.
    • (1992) Spine , vol.17 , pp. 528-540
    • Gertzbein, S.D.1
  • 54
    • 0028535113 scopus 로고
    • Anatomy and physiology of glutamate in the CNS
    • Greenamyre JT, Porter RH: Anatomy and physiology of glutamate in the CNS. Neurology 44[Suppl 8]:S7-S13, 1994.
    • (1994) Neurology , vol.44 , Issue.8 SUPPL.
    • Greenamyre, J.T.1    Porter, R.H.2
  • 55
    • 0023387596 scopus 로고
    • Decompression of the spinal cord improves recovery after experimental spinal cord compression injury
    • Guha A, Tator CH, Endrenyi L, Piper I: Decompression of the spinal cord improves recovery after experimental spinal cord compression injury. Paraplegia 25:324-339, 1987.
    • (1987) Paraplegia , vol.25 , pp. 324-339
    • Guha, A.1    Tator, C.H.2    Endrenyi, L.3    Piper, I.4
  • 56
    • 0023129205 scopus 로고
    • Effect of a calcium channel blocker on posttraumatic spinal cord blood flow
    • Guha A, Tator CH, Piper I: Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J Neurosurg 66:423-430, 1987.
    • (1987) J Neurosurg , vol.66 , pp. 423-430
    • Guha, A.1    Tator, C.H.2    Piper, I.3
  • 57
    • 0023873759 scopus 로고
    • Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats
    • Hall ED: Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats. J Neurosurg 68:462-465, 1988.
    • (1988) J Neurosurg , vol.68 , pp. 462-465
    • Hall, E.D.1
  • 58
    • 0026500593 scopus 로고
    • The neuroprotective pharmacology of methylprednisolone
    • Hall ED: The neuroprotective pharmacology of methylprednisolone. J Neurosurg 76:13-22, 1992.
    • (1992) J Neurosurg , vol.76 , pp. 13-22
    • Hall, E.D.1
  • 59
    • 0027389031 scopus 로고
    • The role of oxygen radicals in traumatic injury: Clinical implications
    • Hall ED: The role of oxygen radicals in traumatic injury: Clinical implications. J Emerg Med 11:31-36, 1993.
    • (1993) J Emerg Med , vol.11 , pp. 31-36
    • Hall, E.D.1
  • 60
    • 0020048289 scopus 로고
    • +)-ATPase activity: Dose-response analysis during 1st hour after contusion injury in the cat
    • +)-ATPase activity: Dose-response analysis during 1st hour after contusion injury in the cat. J Neurosurg 57:247-253, 1982.
    • (1982) J Neurosurg , vol.57 , pp. 247-253
    • Hall, E.D.1    Braughler, J.M.2
  • 61
    • 0022527394 scopus 로고
    • A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia
    • Hall ED, Wolf DL: A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia. J Neurosurg 64:951-961, 1986.
    • (1986) J Neurosurg , vol.64 , pp. 951-961
    • Hall, E.D.1    Wolf, D.L.2
  • 64
    • 0017608536 scopus 로고
    • The use of hyperbaric oxygenation in the treatment of spinal cord lesions
    • Holbach KH, Wassmann H, Linke D: The use of hyperbaric oxygenation in the treatment of spinal cord lesions. Eur Neurol 16:213-221, 1977.
    • (1977) Eur Neurol , vol.16 , pp. 213-221
    • Holbach, K.H.1    Wassmann, H.2    Linke, D.3
  • 65
    • 0021849126 scopus 로고
    • Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury
    • Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot PL: Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. Neurology 35:1003-1009, 1985.
    • (1985) Neurology , vol.35 , pp. 1003-1009
    • Hsu, C.Y.1    Halushka, P.V.2    Hogan, E.L.3    Banik, N.L.4    Lee, W.A.5    Perot, P.L.6
  • 66
    • 0021724328 scopus 로고
    • Regeneration in the human spinal cord: A review of the response to injury of the various constituents of the human spinal cord
    • Hughes TJ: Regeneration in the human spinal cord: A review of the response to injury of the various constituents of the human spinal cord. Paraplegia 22:131-137, 1984.
    • (1984) Paraplegia , vol.22 , pp. 131-137
    • Hughes, T.J.1
  • 67
    • 0024529769 scopus 로고
    • Pathogenesis of spinal cord injury and newer treatments: A review
    • Janssen L, Hansebout RR: Pathogenesis of spinal cord injury and newer treatments: A review. Spine 14:23-32, 1989.
    • (1989) Spine , vol.14 , pp. 23-32
    • Janssen, L.1    Hansebout, R.R.2
  • 69
    • 0016683741 scopus 로고
    • The neuronal theory of experimental traumatic spinal cord dysfunction
    • Kobrine AI: The neuronal theory of experimental traumatic spinal cord dysfunction. Surg Neurol 3:261-264, 1975.
    • (1975) Surg Neurol , vol.3 , pp. 261-264
    • Kobrine, A.I.1
  • 70
    • 0023836750 scopus 로고
    • Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia
    • Kochhar A, Zivin JA, Lyden PD, Mazzarella V: Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia. Arch Neurol 45:148-153, 1988.
    • (1988) Arch Neurol , vol.45 , pp. 148-153
    • Kochhar, A.1    Zivin, J.A.2    Lyden, P.D.3    Mazzarella, V.4
  • 71
    • 0027250516 scopus 로고
    • Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part 2: Acute spinal cord injury
    • Koyanagi I, Tator CH, Lea PJ: Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part 2: Acute spinal cord injury. Neurosurgery 33:285-291, 1993.
    • (1993) Neurosurgery , vol.33 , pp. 285-291
    • Koyanagi, I.1    Tator, C.H.2    Lea, P.J.3
  • 72
    • 0026700707 scopus 로고
    • Management of thoracolumbar fractures with accompanying neurologic injury
    • Lemons VB, Wagner FC, Montesano PX: Management of thoracolumbar fractures with accompanying neurologic injury. Neurosurgery 30:667-671, 1992.
    • (1992) Neurosurgery , vol.30 , pp. 667-671
    • Lemons, V.B.1    Wagner, F.C.2    Montesano, P.X.3
  • 73
    • 0029951720 scopus 로고    scopus 로고
    • Use of methylprednisolone as an adjunct in the management of patients with penetrating spinal cord injury: Outcome analysis
    • Levy ML, Gans W, Wijesinghe HS, SooHoo WE, Adkins RH, Stillerman CB: Use of methylprednisolone as an adjunct in the management of patients with penetrating spinal cord injury: Outcome analysis. Neurosurgery 39:1141-1149, 1996.
    • (1996) Neurosurgery , vol.39 , pp. 1141-1149
    • Levy, M.L.1    Gans, W.2    Wijesinghe, H.S.3    SooHoo, W.E.4    Adkins, R.H.5    Stillerman, C.B.6
  • 74
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA: Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330: 613-622, 1994.
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 75
    • 0019445085 scopus 로고
    • Effect of methylprednisolone in compression trauma to the feline spinal cord
    • Means ED, Anderson DK, Waters TR, Kalaf L: Effect of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg 55:200-208, 1981.
    • (1981) J Neurosurg , vol.55 , pp. 200-208
    • Means, E.D.1    Anderson, D.K.2    Waters, T.R.3    Kalaf, L.4
  • 76
    • 0025148608 scopus 로고
    • Cervical fractures and spinal cord injury: Outcome of surgical and nonsurgical management
    • Murphy KP, Opitz JL, Cabanela ME, Ebersold MJ: Cervical fractures and spinal cord injury: Outcome of surgical and nonsurgical management. Mayo Clin Proc 65:949-959, 1990.
    • (1990) Mayo Clin Proc , vol.65 , pp. 949-959
    • Murphy, K.P.1    Opitz, J.L.2    Cabanela, M.E.3    Ebersold, M.J.4
  • 77
    • 0025162091 scopus 로고
    • Alteration in extracellular amino acids after traumatic spinal cord injury
    • Panter SS, Yum SW, Faden AI: Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27:96-99, 1990.
    • (1990) Ann Neurol , vol.27 , pp. 96-99
    • Panter, S.S.1    Yum, S.W.2    Faden, A.I.3
  • 78
    • 0031028248 scopus 로고    scopus 로고
    • Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase 1 trial)
    • Penn RD, Kroin JS, York MM, Cedarbaum JM: Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase 1 trial). Neurosurgery 40:94-100, 1997.
    • (1997) Neurosurgery , vol.40 , pp. 94-100
    • Penn, R.D.1    Kroin, J.S.2    York, M.M.3    Cedarbaum, J.M.4
  • 80
    • 0018908523 scopus 로고
    • Axons from CNS neurones regenerate into PNS grafts
    • Richardson PM, McGuinness UM, Aguayo AJ: Axons from CNS neurones regenerate into PNS grafts. Nature 284:264-265, 1980.
    • (1980) Nature , vol.284 , pp. 264-265
    • Richardson, P.M.1    McGuinness, U.M.2    Aguayo, A.J.3
  • 81
    • 0017650830 scopus 로고
    • Objective clinical assessment of motor function after experimental spinal cord injury in the rat
    • Rivlin AS, Tator CH: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47:577-581, 1977.
    • (1977) J Neurosurg , vol.47 , pp. 577-581
    • Rivlin, A.S.1    Tator, C.H.2
  • 82
    • 0027374595 scopus 로고
    • Effect of nimodipine or methylprednisolone on recovery from acute experimental spinal cord injury in rats
    • Ross IB, Tator CH, Theriault E: Effect of nimodipine or methylprednisolone on recovery from acute experimental spinal cord injury in rats. Surg Neurol 40:461-470, 1993.
    • (1993) Surg Neurol , vol.40 , pp. 461-470
    • Ross, I.B.1    Tator, C.H.2    Theriault, E.3
  • 83
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman SM, Olney JW: Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:105-111, 1986.
    • (1986) Ann Neurol , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 84
    • 0017200396 scopus 로고
    • Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates
    • Sandler AN, Tator CH: Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. J Neurosurg 45:660-676, 1976.
    • (1976) J Neurosurg , vol.45 , pp. 660-676
    • Sandler, A.N.1    Tator, C.H.2
  • 85
    • 0017199445 scopus 로고
    • Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord
    • Sandler AN, Tator CH: Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J Neurosurg 45:638-646, 1976.
    • (1976) J Neurosurg , vol.45 , pp. 638-646
    • Sandler, A.N.1    Tator, C.H.2
  • 86
    • 0028115777 scopus 로고
    • Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
    • Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME: Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367:170-173, 1994.
    • (1994) Nature , vol.367 , pp. 170-173
    • Schnell, L.1    Schneider, R.2    Kolbeck, R.3    Barde, Y.A.4    Schwab, M.E.5
  • 87
    • 0029900303 scopus 로고    scopus 로고
    • Degeneration and regeneration of axons in the lesioned spinal cord
    • Schwab ME, Bartholdi D: Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev 76:319-370, 1996.
    • (1996) Physiol Rev , vol.76 , pp. 319-370
    • Schwab, M.E.1    Bartholdi, D.2
  • 88
    • 0023740854 scopus 로고
    • Historical overview: Calcium, ischemia, and death of brain cells
    • Siesjö BK: Historical overview: Calcium, ischemia, and death of brain cells. Ann N Y Acad Sci 522:638-661, 1988.
    • (1988) Ann N Y Acad Sci , vol.522 , pp. 638-661
    • Siesjö, B.K.1
  • 89
    • 0026482160 scopus 로고
    • Prediction of neurologic outcome in acute spinal cord injury: The role of CT and MR
    • Silberstein M, Tress BM, Hennessy O: Prediction of neurologic outcome in acute spinal cord injury: The role of CT and MR. AJNR Am J Neuroradiol 13:1597-1608, 1992.
    • (1992) AJNR Am J Neuroradiol , vol.13 , pp. 1597-1608
    • Silberstein, M.1    Tress, B.M.2    Hennessy, O.3
  • 90
    • 0014340364 scopus 로고
    • Morphology of the regenerated spinal cord in the lizard, Anolis carolinensis
    • Simpson SB: Morphology of the regenerated spinal cord in the lizard, Anolis carolinensis. J Comp Neurol 134:193-210, 1968.
    • (1968) J Comp Neurol , vol.134 , pp. 193-210
    • Simpson, S.B.1
  • 91
    • 0041431460 scopus 로고    scopus 로고
    • History of spinal disorders
    • Menezes AH, Sonntag VKH (eds). New York, McGraw-Hill
    • Sonntag VKH: History of spinal disorders, in Menezes AH, Sonntag VKH (eds): Principles of Spinal Surgery. New York, McGraw-Hill, 1996, pp 3-23.
    • (1996) Principles of Spinal Surgery , pp. 3-23
    • Sonntag, V.K.H.1
  • 92
    • 0021229886 scopus 로고
    • Neurological recovery following injuries to the cervical spinal cord and nerve roots
    • Stauffer ES: Neurological recovery following injuries to the cervical spinal cord and nerve roots. Spine 9:532-534, 1984.
    • (1984) Spine , vol.9 , pp. 532-534
    • Stauffer, E.S.1
  • 93
    • 0021011489 scopus 로고
    • Spine-spinal cord relationships in spinal cord trauma
    • Tator CH: Spine-spinal cord relationships in spinal cord trauma. Clin Neurosurg 30:479-494, 1983.
    • (1983) Clin Neurosurg , vol.30 , pp. 479-494
    • Tator, C.H.1
  • 94
    • 0002311048 scopus 로고    scopus 로고
    • Spinal cord syndromes with physiological and anatomical correlations
    • Menezes AH, Sonntag VKH (eds). New York, McGraw-Hill
    • Tator CH: Spinal cord syndromes with physiological and anatomical correlations, in Menezes AH, Sonntag VKH (eds): Principles of Spinal Surgery. New York, McGraw-Hill, 1996, pp 785-799.
    • (1996) Principles of Spinal Surgery , pp. 785-799
    • Tator, C.H.1
  • 95
    • 0031970232 scopus 로고    scopus 로고
    • Biology of neurological recovery and functional restoration after spinal cord injury
    • Tator CH: Biology of neurological recovery and functional restoration after spinal cord injury. Neurosurgery 42:696-708, 1998.
    • (1998) Neurosurgery , vol.42 , pp. 696-708
    • Tator, C.H.1
  • 96
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator CH, Fehlings MG: Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15-26, 1991.
    • (1991) J Neurosurg , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 97
    • 0031017950 scopus 로고    scopus 로고
    • Vascular mechanisms in the pathophysiology of human spinal cord injury
    • Tator CH, Koyanagi I: Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 86:483-492, 1997.
    • (1997) J Neurosurg , vol.86 , pp. 483-492
    • Tator, C.H.1    Koyanagi, I.2
  • 98
    • 0030015166 scopus 로고    scopus 로고
    • Normal and abnormal calcium homeostasis in neurons: A basis for the pathophysiology of traumatic and ischemic central nervous system injury
    • Tymianski M, Tator CH: Normal and abnormal calcium homeostasis in neurons: A basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery 38:1176-1195, 1996.
    • (1996) Neurosurgery , vol.38 , pp. 1176-1195
    • Tymianski, M.1    Tator, C.H.2
  • 99
    • 0023127634 scopus 로고
    • Chronic regenerative changes in the spinal cord after cord compression injury in rats
    • Wallace MC, Tator CH, Lewis AJ: Chronic regenerative changes in the spinal cord after cord compression injury in rats. Surg Neurol 27:209-219, 1987.
    • (1987) Surg Neurol , vol.27 , pp. 209-219
    • Wallace, M.C.1    Tator, C.H.2    Lewis, A.J.3
  • 100
    • 0029860591 scopus 로고    scopus 로고
    • Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis
    • Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, Reynolds BA: Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 16: 7599-7609, 1996.
    • (1996) J Neurosci , vol.16 , pp. 7599-7609
    • Weiss, S.1    Dunne, C.2    Hewson, J.3    Wohl, C.4    Wheatley, M.5    Peterson, A.C.6    Reynolds, B.A.7
  • 101
    • 0022344980 scopus 로고
    • Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist
    • Wieloch T: Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science 230:681-683, 1985.
    • (1985) Science , vol.230 , pp. 681-683
    • Wieloch, T.1
  • 102
    • 0345064290 scopus 로고
    • The Edwin Smith surgical papyrus
    • Chicago, American Association of Neurological Surgeons
    • Wilkins RH (ed): The Edwin Smith surgical papyrus, in Neurosurgical Classics. Chicago, American Association of Neurological Surgeons, 1992, pp 1-5.
    • (1992) Neurosurgical Classics , pp. 1-5
    • Wilkins, R.H.1
  • 103
    • 0030054133 scopus 로고    scopus 로고
    • Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors
    • Wrathall JR, Teng YD, Choiniere D: Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors. Exp Neurol 137:119-126, 1996.
    • (1996) Exp Neurol , vol.137 , pp. 119-126
    • Wrathall, J.R.1    Teng, Y.D.2    Choiniere, D.3
  • 104
    • 0028870347 scopus 로고
    • Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord
    • Xu XM, Guenard V, Kleitman N, Bunge MB: Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord. J Comp Neurol 351:145-160, 1995.
    • (1995) J Comp Neurol , vol.351 , pp. 145-160
    • Xu, X.M.1    Guenard, V.2    Kleitman, N.3    Bunge, M.B.4
  • 105
    • 0027475987 scopus 로고
    • Secondary injury mechanisms in acute spinal cord injury
    • Young W: Secondary injury mechanisms in acute spinal cord injury. J Emerg Med 11:13-22, 1993.
    • (1993) J Emerg Med , vol.11 , pp. 13-22
    • Young, W.1
  • 106
    • 0023782824 scopus 로고
    • Pharmacological therapy of acute spinal cord injury: Studies of high dose methylprednisolone and naloxone
    • Young W, DeCrescito V, Flamm ES, Blight AR, Gruner JA: Pharmacological therapy of acute spinal cord injury: Studies of high dose methylprednisolone and naloxone. Clin Neurosurg 36:675-697, 1988.
    • (1988) Clin Neurosurg , vol.36 , pp. 675-697
    • Young, W.1    DeCrescito, V.2    Flamm, E.S.3    Blight, A.R.4    Gruner, J.A.5


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