Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation

Cell Death and Differentiation

Volumn 8, Issue 12, 2001, Pages 1136-1142

  Van Loo, G ^a   Schotte, P ^a   Van Gurp, M ^a   Demol, H ^a   Hoorelbeke, B ^a   Gevaert, K ^a   Rodriguez, I ^b   Ruiz Carrillo, A ^c   Vandekerckhove, J ^a   Declercq, W ^a   Beyaert, R ^a   Vandenabeele, P ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b ROCKEFELLER UNIVERSITY   (United States)

^c DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

Apoptosis; Caspase; Endonuclease G; Mitochondria; tBid

Indexed keywords

CASPASE; CASPASE 3; CELL NUCLEUS DNA; DEOXYRIBONUCLEASE; DNA FRAGMENT; ENDONUCLEASE; FAS ANTIBODY; MITOCHONDRIAL DNA; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVITY; ENZYME RELEASE; IN VIVO STUDY; LIVER MITOCHONDRION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASES; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENDODEOXYRIBONUCLEASES; GENES, BCL-2; MICE; MITOCHONDRIAL PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0035674047     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400944     Document Type: Article

References (23)

1. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
2. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
3. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
4. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45
5. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes
6. Molecular characterization of mitochondrial apoptosis-inducing factor
7. Two Distinct Pathways Leading to Nuclear Apoptosis
8. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
9. Review: Nuclear events in apoptosis
10. Functional characterization of DNase X, a novel endonuclease expressed in muscle cells
11. Primers for mitochondrial DNA replication generated by endonuclease G
12. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection
13. A peptide concentration and purification method for protein characterization in the subpicomole range using matrix assisted laser desorption/ionization-post-source decay (MALDI-PSD) sequencing
14. Mitochondrial endonuclease G is important for apoptosis in C. elegans
15. Endonuclease G is an apoptotic DNase when released from mitochondria
16. Structure and promoter analysis of murine CAD and ICAD genes
17. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
18. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
19. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax
20. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route
21. Apoptosis without caspases: An inefficient molecular guillotine?
22. Molecular cloning and identification of murine caspase-8
23. Cathepsin B-mediated activation of the proinflammatory caspase-11