Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Brain Research

Volumn 870, Issue 1-2, 2000, Pages 66-72

  Mu, Xiaojun ^a   Azbill, Robert D ^a   Springer, Joe E ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Excitotoxicity; Glucocorticoids; Glutamate release; Oxidative stress; Spinal cord trauma

Indexed keywords

GLUCOSE; GLUTAMIC ACID; LIPID; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; REACTIVE OXYGEN METABOLITE; RILUZOLE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE TRANSPORT; LIPID PEROXIDATION; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SYNAPTOSOME; TREATMENT OUTCOME;

ANIMALS; FEMALE; GLUTAMIC ACID; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDATIVE STRESS; RATS; RATS, LONG-EVANS; RHODAMINES; RILUZOLE; SPINAL CORD INJURIES; SYNAPTOSOMES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0034617464     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02402-1     Document Type: Article

References (64)

1. Agrawal S.K., Fehlings M.G. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J. Neurosci. 17:1997;1055-1063.
2. Anderson D., Hall E. Pathophysiology of spinal cord trauma. Ann. Emerg. Med. 22:1993;987-992.
3. Azbill R.D., Mu X., Bruce-Keller A.J., Mattson M.P., Springer J.E. Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury. Brain Res. 765:1997;283-290.
4. Barut S., Canbolat A., Bilge T., Aydin Y., Cokneseli B., Kaya U. Lipid peroxidation in experimental spinal cord injury: time-level relationship. Neurosurg. Rev. 16:1993;53-59.
5. Basso D., Beattie M., Breshnahan J. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139:1996;244-256.
6. Behl C., J D., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid protein toxicity. Cell. 77:1994;817-827.
7. Behrmann D.L., Bresnahan J.C., Beattie M.S. Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp. Neurol. 126:1994;61-75.
8. Benoit E., Escande D. Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Pfluger's Arch. 419:1991;603-609.
9. Bensimon G., Lacomblez L., Meininger V., Group A.R.S. A controlled trial of Riluzole in amyotrophic lateral sclerosis. N. Engl. J. Med. 330:1994;585-591.
10. Boening J.A., Kass I.S., Cottrell J.E., Chambers G. The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. Neuroscience. 33:1989;263-268.
11. Bryson H.M., Fulton B., Benfield P. Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs. 52:1996;549-563.
12. Cheramy A., Barbeito L., Godeheu G., Glowinski J. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neurosci. Lett. 147:1992;209-212.
13. Couratier P., Sindou P., Esclaire F., Louvel E., Hugon J. Neuroprotective effects of riluzole in ALS CSF toxicity. NeuroReport. 5:1994;1012-1014.
14. Demediuk P., Daly M.P., Faden A.I. Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord. J. Neurochem. 52:1989;1529-1536.
15. Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 47:1996;S233-241.
16. 3H]aspartate release from cultured cerebellar granule cells. Neurosci. Lett. 140:1992;251-254.
17. Dugan L.L., Sensi S.L., Canzoniero L.M., Handran S.D., Rothman S.M., Lin T.S., Goldberg M.P., Choi D.W. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci. 15:1995;6377-6388.
18. Faden A., Lemke M., Simon R., Noble L. N-methyl-D-aspartate antagonist MK-801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomical, and neurochemical studies. J. Neurotrauma. 5:1988;33-45.
19. Faden A., Simon R. A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann. Neurol. 23:1988;623-626.
20. Faden A.I., Demediuk P., Panter S.S., Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science. 244:1989;798-800.
21. Faden A.I., Ellison J.A., Noble L.J. Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury. Eur. J. Pharmacol. 175:1990;165-174.
22. Farooque M., Hillered L., Holtz A., Olsson Y. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J. Neurotrauma. 13:1996;537-548.
23. Farooque M., Hillered L., Holtz A., Olsson Y. Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord. Exp. Brain Res. 113:1997;1-4.
24. Gentile N., McIntosh T. Antagonists of excitatory amino acids and endogenous opioid peptides in the treatment of experimental central nervous system injury. Ann. Emerg. Med. 22:1993;1028-1034.
25. Goodman Y., Bruce A., Cheng B., Mattson M. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury and amyloid beta-peptide toxicity in hippocampal neurons. J. Neurochem. 66:1996;1836-1844.
26. Goodman Y., Mattson M. Secreted forms of amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide induced oxidative injury. Exp. Neurol. 128:1994;1-12.
27. Goodman Y., Mattson M.P. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity. J. Neurochem. 66:1996;869-872.
28. Hall E.D. Lipid antioxidants in acute central nervous system injury. Ann. Emerg. Med. 22:1993;1022-1027.
29. Hall E.D., Braughler J.M., McCall J.M. Antioxidant effects in brain and spinal cord injury. J. Neurotrauma. 9:(Suppl. 1):1992;S165-172.
30. Harr S.D., Simonian N.A., Hyman B.T. Functional alterations in Alzheimer's disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone. J. Neuropathol. Exp. Neurol. 54:1995;38-41.
31. Hebert T., Drapeau P., Pradier L., Dunn R.J. Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole. Mol. Pharmacol. 45:1994;1055-1060.
32. Henderson L., Chappell J. Dihydrorhodamine 123: a fluorescence probe for superoxide generation? Eur. J. Biochem. 217:1993;273-280.
33. Huang C.S., Song J.H., Nagata K., Yeh J.Z., Narahashi T. Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 282:1997;1280-1290.
34. Hubert J.P., Delumeau J.C., Glowinski J., Premont J., Doble A. Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. Br. J. Pharmacol. 113:1994;261-267.
35. +2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment. Neurosurg. Rev. 18:1995;35-44.
36. Kooy N., Royall J., Ischoropoulos H., Beckman J. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med. 16:1994;149-156.
37. Liu S., Ruenes G.L., Yezierski R.P. NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord. Brain Res. 756:1997;160-167.
38. Malgouris C., Bardot F., Daniel M., Pellis F., Rataud J., Uzan A., Blanchard J.C., Laduron P.M. Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J. Neurosci. 9:1989;3720-3727.
39. Malgouris C., Daniel M., Doble A. Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices. Neurosci. Lett. 177:1994;95-99.
40. Martin D., Thompson M.A., Nadler J.V. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur. J. Pharmacol. 250:1993;473-476.
41. Page B., Page M., Noel C. A new fluorometric assay for cytotoxic measurements in vitro. Int. J. Oncol. 3:1993;473-476.
42. Panter S.S., Yum S.W., Faden A.I. Alteration in extracellular amino acids after traumatic spinal cord injury. Ann. Neurol. 27:1990;96-99.
43. Pratt J., Rataud J., Bardot F., Roux M., Blanchard J.C., Laduron P.M., Stutzmann J.M. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. Neurosci. Lett. 140:1992;225-230.
44. Prenen G.H., Go K.G., Postema F., Zuiderveen F., Korf J. Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp. Neurol. 99:1988;118-132.
45. Romettino S., Lazdunski M., Gottesmann C. Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy. Eur. J. Pharmacol. 199:1991;371-373.
46. Shahan T.A., Siegel P.D., Sorenson W.G., Kuschner W.G., Lewis D.M. A sensitive new bioassay for tumor necrosis factor. J. Immunol. Methods. 175:1994;181-187.
47. Simpson I., Vannucci S., Maher F. Glucose transporters in mammalian brain. Biochem. Soc. Trans. 22:1994;671-675.
48. Simpson I.A., Davies P. Reduced glucose transporter concentrations in brains of patients with Alzheimer's disease. Ann. Neurol. 36:1994;800-801.
49. Song J.H., Huang C.S., Nagata K., Yeh J.Z., Narahashi T. Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J. Pharmacol. Exp. Ther. 282:1997;707-714.
50. Springer J.E., Azbill R.D., Carlson S.L. A rapid and sensitive assay for measuring mitochondrial metabolic activity in isolated neural tissue. Brain Res. Protocols. 2:1998;259-263.
51. Springer J.E., Azbill R.D., Kennedy S.E., George J., Geddes J.W. Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. J. Neurochem. 69:1997;1592-1600.
52. Springer J.E., Azbill R.D., Mark R.J., Begley J.G., Waeg G., Mattson M.P. 4-Hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake. J. Neurochem. 68:1997;2469-2476.
53. Stutzmann J.M., Pratt J., Boraud T., Gross C. The effect of riluzole on post-traumatic spinal cord injury in the rat. NeuroReport. 7:1996;387-392.
54. Tator C., Fehlings M. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75:1991;15-26.
55. Volterra A., Trotti D., Floridi S., Racagni G. Reactive oxygen species inhibit high-affinity glutamate uptake: molecular mechanism and neuropathological implications. Ann. NY Acad. Sci. 738:1994;153-162.
56. Volterra A., Trotti D., Tromba C., Floridi S., Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14:1994;2924-2932.
57. Wahl F., Renou E., Stutzmann J.-M. Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury. Brain Res. 756:1997;247-253.
58. Watanabe M., Fujimura Y., Nakamura M., Yato Y., Ohta K., Okai H., Ogawa Y. Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury. J. Neurotrauma. 15:1998;285-293.
59. Wokke J. Riluzole. Lancet. 348:1996;795-799.
60. Wrathall J.R., Choiniere D., Teng Y.D. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J. Neurosci. 14:1994;6598-6607.
61. Wrathall J.R., Teng Y.D., Choiniere D. Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-N-methyl-D-aspartate receptors. Exp. Neurol. 137:1996;119-126.
62. Wrathall J.R., Teng Y.D., Choiniere D., Mundt D.J. Evidence that local non-NMDA receptors contribute to functional deficits in contusive spinal cord injury. Brain Res. 586:1992;140-143.
63. Wrathall J.R., Teng Y.D., Marriott R. Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma. Exp. Neurol. 145:1997;565-573.
64. Young W. Secondary injury mechanisms in acute spinal cord injury. J. Emerg. Med. 11:(Suppl. 1):1993;13-22.