Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia

Journal of Neuroscience

Volumn 21, Issue 8, 2001, Pages 2580-2588

  Tikka, Tiina ^a   Fiebich, Bernd L ^c   Goldsteins, Gundars ^a   Keinänen, Riitta ^a   Koistinaho, Jari ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Alzheimer's disease; Cell culture; Glutamate; Inflammation; Ischemia; MAPK; Mitogen activated protein kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLUTAMIC ACID; INTERLEUKIN 1BETA; KAINIC ACID; LACTATE DEHYDROGENASE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TETRACYCLINE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; MICROGLIA; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

EID: 0035871840     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-08-02580.2001     Document Type: Article

References (56)

1. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia
2. A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
3. Inflammatory mediators and stroke: New opportunities for novel therapeutics
4. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs
5. Aging, energy, and oxidative stress in neurodegenerative diseases
6. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures
7. Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia
8. Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes
9. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
10. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
11. Excitotoxic cell death
12. Key issues in Alzheimer's disease inflammation
13. Why do neuroprotective drugs work in animals but not humans?
14. Pathobiology of ischaemic stroke: An integrated view
15. Excitotoxicity, free radicals, and cell membrane changes
16. Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells
17. Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: Involvement of p38 mitogen-activated protein kinase and nuclear factor-kappa B
18. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro
19. Suppression of human neutrophil functions by tetracyclines
20. Microglial secretion products and their impact on the nervous system
21. Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system
22. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
23. Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia
24. Extracellular-signal-regulated kinase signalling in neurons
25. Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia
26. Increased vulnerability to focal brain ischemia in APP751 transgenic mice
27. Microglia: A sensor for pathological events in the CNS
28. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
29. The changing landscape of ischaemic brain injury mechanisms
30. Brain inflammation in Alzheimer disease and the therapeutic implications
31. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia
32. Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death
33. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system
34. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neuronas in a cell-culture model of seizure activity
35. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia
36. A novel mechanism of action of chemically modified tetracyclines: Inhibition of COX-2-mediated prostaglandin E2 production
37. Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: Correlation with the progression of cell death
38. Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus
39. Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
40. Interleukin-1 receptor antagonist attenuates regional neuronal cell death and cognitive dysfunction after experimental brain injury
41. Role of astrocytes in glutamate homeostasis. Implications for excitotoxicity
42. Autoimmune encephalomyelitis ameliorated by AMPA antagonists
43. Reactive microgliosis
44. Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
45. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells
46. Potential mechanisms of interleukin-1 involvement in cerebral ischaemia
47. Neuronal cell death and tPA
48. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
49. Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons
50. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals
51. Activation of p38MAPK in microglia after ischemia
52. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
53. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
54. Mitogen-activated protein kinase p38 is activated in focal brain ischemia
55. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
56. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window