Recombinant human erythropoietin: Possible role as an antioxidant in premature rabbits

Pediatric Research

Volumn 40, Issue 3, 1996, Pages 381-387

  Bany Mohammed, Payez M ^a   Slivka, Stefan ^a   Hallman, Mikko ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Med Surge 1   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; IRON; MALONALDEHYDE; OXYGEN; PHOSPHOLIPID; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROPOIESIS; HYPEROXIA; IRON BINDING CAPACITY; IRON BLOOD LEVEL; LIPID PEROXIDATION; LUNG INJURY; LUNG LAVAGE; NEWBORN; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RABBIT; RETICULOCYTE; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSFERRIN BLOOD LEVEL;

EID: 9444291812     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199609000-00003     Document Type: Article

References (54)

1. Frank L 1985 Effects of oxygen on the newborn. Fed Proc 7:2328-2334
2. Phelps DL 1982 Neonatal oxygen toxicity: is it preventable? Pediatr Clin North Am 29:1233-1240
3. Saugstad OD 1990 Oxygen toxicity in the neonatal period. Acta Paediatr Scand 79:881-892
4. Sullivan JL 1988 Iron, plasma antioxidants, and the "oxygen radical disease of prematurity." Am J Dis Child 142:1341-1344
5. Wispe JR, Roberts RJ 1987 Molecular basis of pulmonary oxygen toxicity. Clin Perinatol 14:651-566
6. Halliwell B, Gutteridge JM, Cross CE 1992 Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 119:598-620
7. Aruoma OI, Kaur H, Halliwell B 1991 Oxygen free radicals and human diseases. J R Soc Health 111:172-177
8. Gutteridge JM, Halliwell B 1993 The measurement and mechanism of lipid peroxidation in biological absorption. Prog Clin Biol Res 380:203-219
9. Valenzuela A 1991 The biological significance of malondialdenyde determination in the assessment of tissue oxidative stress. Life Sci 48:301-309
10. Janero DR 1990 Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 9:515-540
11. Halliwell B, Gutteridge JM 1984 Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219:1-14
12. Halliwell B, Gutteridge JM 1992 Biologically relevant metal ion-dependent hydroxyl radical generation: an update. FEBS Lett 307:108-112
13. Pearson HA 1967 Life-span of the fetal red blood cell. J Pediatr 70:166-171
14. Gairdner D, Marks J, Roscoe JD 1955 Blood formation in infancy. Part IV. The early anemia of prematurity. Arch Dis Child 30:203-226
15. Stockman JA 3rd, Graeber JE, Clark DA, McClellan K, Garcia JF, Kavey RE 1984 Anemia of prematurity: determinants of the erythropoietin response. J Pediatr 105:B56-B124
16. Strauss RG 1995 Red blood cell transfusion practices in the neonate. Clin Perinatol 22:641-655
17. Galet S, Schulman HM, Bard H 1976 The postnatal hypotransferrinemia of early preterm newborn infants. Pediatr Res 10:118-120
18. Saarinen UM, Siimes MA 1977 Developmental changes in serum iron, total ironbinding capacity, and transferrin saturation in infancy. J Pediatr 91:875-877
19. Scott PH, Berger HM, Kenward C, Scott P, Wharton BA 1975 Effect of gestational age and intrauterine nutrition on plasma transferrin and iron in the newborn. Arch Dis Child 50:796-798
20. Gutteridge JM 1989 Iron and oxygen: a biologically damaging mixture. Acta Paediatr Scand Suppl 361:78-85
21. Evans PJ, Evans R, Kovar IZ, Holton AF, Halliwell B 1992 Bleomycin-detectable iron in the plasma of premature and full-term neonates. FEBS Lett 303:210-212
22. Lindeman JH, Houdkamp E, Lentjes EG, Poorthuis BJ, Berger HM 1992 Limited protection against iron-induced lipid peroxidation by cord blood. Free Radic Res Commun 16:285-292
23. Lazarus JM, Hakim RM, Newell J 1990 Recombinant human erythropoietin and phlebotomy in the treatment of iron overload in chronic hemodialysis patients. Am J Kidney Dis 16:101-108
24. Nomura S, Osawa G, Karai M 1990 Treatment of a patient with end-stage renal disease, severe iron overload and ascites by weekly phlebotomy combined with recombinant human erythropoietin. Nephron 55:210-213
25. Onoyama K, Nakamura S, Yamamoto M, Kawadoko T, Nanishi F, Komoda T, Murai K, Fujishima M 1990 Correction of serious iron overload in a chronic hemodialysis patient by recombinant human erythropoietin and removal of red blood cells: confirmation by follow-up liver biopsy. Nephron 56:325-328
26. Shannon KM, Keith JF III, Mentzer W, Ehrenkranz RA, Brown MS, Widness JA, Gleason CA, Bifano EM, Millard DD, Davis CB, Stevenson DK, Alverson DC, Simmons CF, Brim M, Abels RI, Phibbs RH 1995 Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants. Pediatrics 95:1-8
27. Maier RF, Obladen M, Scigalla P, Linderkamp O, Duc, Hieronimi G, Halliday HL, Versmold HT, Moriette G, Jorch G, Verallen G, Semmekrot B, Grauel EL, Holland B, Wardrop CAJ 1994 The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants. N Engl J Med 330:1173-1178
28. Meyer MP, Meyer JH, Commerford A, Hann FM, Sive AA, Moller G, Jacobs P, Malan AF 1994 Recombinant human erythropoietin in the treatment of the anemia of prematurity: results of a double-blind, placebo-controlled study. Pediatrics 93:918-923
29. Günther T, Höllriegl V, Vormann J 1993 Perinatal development of iron and antioxidant defense systems. J Trace Elem Electrolytes Health Dis 7:47-52
30. Brown BA 1988 Hematology: Principles and Procedures. Lee & Febiger, Philadelphia, pp 109-113
31. Doeg KA, Zeigler DM 1992 Simplified methods for the estimation of iron in the mitochondria and submitochondrial fractions. Arch Biochem Biophys 97:37-40
32. Persijn JP, Van Der Slik W, Riethorst W 1971 Determination of serum iron and latent iron binding capacity (LIBC). Clin Chim Acta 35:91-98
33. Pacht PR, Davis WP 1988 Role of transferrin and ceruloplasminin antioxidant activity of lung epithelial lining fluid. J Appl Physiol 64:2092-2099
34. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC 1985 Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85
35. Hallman M, Merritt TA, Pohjavuori M, Gluck L 1986 Effect of surfactant substitution on lung effluent phospholipids in respiratory distress syndrome: evaluation of surfactant phospholipid turnover, pool size, and the relationship to severity of respiratory failure. Pediatr Res 20:1228-1235
36. Frank L, Sosenko IR 1991 Failure of premature rabbits to increase antioxidant enzymes during nyperoxic exposure: increased susceptibility to pulmonary oxygen toxicity compared with term rabbits. Pediatr Res 29:292-296
37. Fuchs A, Eder H 1992 Dose-dependent effects of recombinant human erythropoietin on the reticulocyte population of rabbits. Arzneimittelforschung 42:1266-1268
38. Dormandy TL 1988 In praise of peroxidation. Lancet 2:1126-1128
39. Hochstein P, Jain SK 1981 Association of lipid peroxidation and polymerization of membrane proteins with erythrocyte aging. Fed Proc 40:183-188
40. Frankel EN 1980 Lipid oxidation. Prog Lipid Res 19:1-22
41. Wispe JR, Knight M, Roberts RJ 1986 Lipid peroxidation in newborn rabbits: effects of oxygen, lipid emulsion, and vitamin E. Pediatr Res 20:505-510
42. Grigg J, Barber A, Silverman M 1993 Bronchoalveolar lavage fluid glutathione in intubated premature infants. Arch Dis Child 69:49-51
43. Smith CV, Hansen TN, Martin NE, McMicken HW, Elliott SJ 1993 Oxidant stress responses in premature infants during exposure to hyperoxia. Pediatr Res 34:360-365
44. Patt A, Horesh IR, Berger EM, Harken AH, Repine JE 1990 Iron depletion or chelation reduces ischemia/reperfusion-induced edema in gerbil brains. J Pediatr Surg 25:224-227
45. Andrews FJ, Morris CJ, Lewis EJ, Blake DR 1987 Effect of nutritional iron deficiency on acute and chronic inflammation. Ann Rheum Dis 46:859-865
46. Chandler DB, Barton JC, Briggs 3d DD, Butler TW, Kennedy JI, Grizzle WE, Fulmer JD 1988 Effect of iron deficiency on bleomycin-induced lung fibrosis in the hamster. Am Rev Respir Dis 137:85-89
47. Shah M, Hallman M, Slivka S and Bry K 1993 Colloid infusion to premature rabbits: transferrin protects against hyperoxic lung injury. Pediatr Res 33:344A(abstr)
48. Halliwell B 1989 Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radic Biol Med 7:645-651
49. Blanco LN, Frank L 1993 The formation of alveoli in rat lung during the third and fourth postnatal weeks: effect of hyperoxia, dexamethasone, and deferoxamine. Pediatr Res 34:334-340
50. Frank L 1991 Hyperoxic inhibition of newborn rat lung development: protection by deferoxamine. Free Radiv Biol Med 11:341-348
51. Holm BA, Notter RH, Siegle J, Matalon S 1985 Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia. J Appl Physiol 59:1402-1409
52. Novotny WE, Hudak BB, Matalon S, Holm BA 1995 Hyperoxic lung injury reduces exogenous surfactant clearance in vivo. Am J Respir Crit Care Med 151:1843-1847
53. Ohls RK, Osbome KA, Christensen RD 1995 Efficacy and cost analysis of treating very low birth weight infants with erythropoietin during their first two weeks of life: a randomized, placebo-controlled trial. J Pediatr 126:421-426
54. Carnielli V, Montini G, Da Riol R, Dall'Amico R, Cantarutti F 1992 Effect of high doses of human recombinant erythropoietin on the need for blood transfusions in preterm infants. J Pediatr 121:98-102