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Volumn 42, Issue , 2006, Pages 65-92

Checkpoint and coordinated cellular responses to DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLINE;

EID: 33748350041     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/b136684     Document Type: Article
Times cited : (13)

References (175)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 3
    • 4043133287 scopus 로고    scopus 로고
    • ATR couples FANCD2 monoubiquitination to the DNA-damage response
    • Andreassen PR, D'Andrea AD, Taniguchi T (2004) ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev 18:1958-1963
    • (2004) Genes Dev , vol.18 , pp. 1958-1963
    • Andreassen, P.R.1    D'Andrea, A.D.2    Taniguchi, T.3
  • 4
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 5
    • 3342986735 scopus 로고    scopus 로고
    • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects
    • Bao S, Lu T, Wang X, Zheng H, Wang LE, Wei Q, Hittelman WN, Li L (2004) Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. Oncogene 23:5586-5593
    • (2004) Oncogene , vol.23 , pp. 5586-5593
    • Bao, S.1    Lu, T.2    Wang, X.3    Zheng, H.4    Wang, L.E.5    Wei, Q.6    Hittelman, W.N.7    Li, L.8
  • 8
    • 0029829249 scopus 로고    scopus 로고
    • Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation
    • Beamish H, Williams R, Chen P, Lavin MF (1996) Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J Biol Chem 271:20486-20493
    • (1996) J Biol Chem , vol.271 , pp. 20486-20493
    • Beamish, H.1    Williams, R.2    Chen, P.3    Lavin, M.F.4
  • 10
    • 2342618116 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
    • Block WD, Yu Y, Lees-Miller SP (2004) Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res 32:997-1005
    • (2004) Nucleic Acids Res , vol.32 , pp. 997-1005
    • Block, W.D.1    Yu, Y.2    Lees-Miller, S.P.3
  • 12
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14:397-402
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 13
    • 0037335861 scopus 로고    scopus 로고
    • Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
    • Brown EJ, Baltimore D (2003) Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 17:615-628
    • (2003) Genes Dev , vol.17 , pp. 615-628
    • Brown, E.J.1    Baltimore, D.2
  • 14
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276:42462-42467
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 21
    • 0037178723 scopus 로고    scopus 로고
    • ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    • Cha RS, Kleckner N (2002) ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297:602-606
    • (2002) Science , vol.297 , pp. 602-606
    • Cha, R.S.1    Kleckner, N.2
  • 22
    • 0041689960 scopus 로고    scopus 로고
    • The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint
    • Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N (2003) The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol 23:6564-6573
    • (2003) Mol Cell Biol , vol.23 , pp. 6564-6573
    • Chahwan, C.1    Nakamura, T.M.2    Sivakumar, S.3    Russell, P.4    Rhind, N.5
  • 23
    • 0037716757 scopus 로고    scopus 로고
    • Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    • Chan SW, Blackburn EH (2003) Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell 11:1379-1387
    • (2003) Mol Cell , vol.11 , pp. 1379-1387
    • Chan, S.W.1    Blackburn, E.H.2
  • 24
    • 12844264108 scopus 로고    scopus 로고
    • Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe
    • Chang DY, Lu AL (2005) Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe. J Biol Chem 280:408-417
    • (2005) J Biol Chem , vol.280 , pp. 408-417
    • Chang, D.Y.1    Lu, A.L.2
  • 25
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE (2001) Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 8:1105-1115
    • (2001) Mol Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 26
    • 0043032435 scopus 로고    scopus 로고
    • Human claspin is required for replication checkpoint control
    • Chini CC, Chen J (2003) Human claspin is required for replication checkpoint control. J Biol Chem 278:30057-30062
    • (2003) J Biol Chem , vol.278 , pp. 30057-30062
    • Chini, C.C.1    Chen, J.2
  • 27
    • 0141621266 scopus 로고    scopus 로고
    • Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases
    • Cortez D (2003) Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. J Biol Chem 278:37139-37145
    • (2003) J Biol Chem , vol.278 , pp. 37139-37145
    • Cortez, D.1
  • 28
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • Cortez D, Wang Y, Qin J, Elledge SJ (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286:1162-1166
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 29
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez D, Guntuku S, Qin J, Elledge SJ (2001) ATR and ATRIP: Partners in checkpoint signaling. Science 294:1713-1716
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 30
    • 3042798440 scopus 로고    scopus 로고
    • Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
    • Cortez D, Glick G, Elledge SJ (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci USA 101:10078-10083
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10078-10083
    • Cortez, D.1    Glick, G.2    Elledge, S.J.3
  • 31
  • 32
    • 0035449349 scopus 로고    scopus 로고
    • The yeast Xrs2 complex functions in S phase checkpoint regulation
    • D'Amours D, Jackson SP (2001) The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev 15:2238-2249
    • (2001) Genes Dev , vol.15 , pp. 2238-2249
    • D'Amours, D.1    Jackson, S.P.2
  • 33
    • 1642458364 scopus 로고    scopus 로고
    • Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
    • Davies SL, North PS, Dart A, Lakin ND, Hickson ID (2004) Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol 24:1279-1291
    • (2004) Mol Cell Biol , vol.24 , pp. 1279-1291
    • Davies, S.L.1    North, P.S.2    Dart, A.3    Lakin, N.D.4    Hickson, I.D.5
  • 35
    • 0032530824 scopus 로고    scopus 로고
    • Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
    • Desany BA, Alcasabas AA, Bachant JB, Elledge SJ (1998) Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev 12:2956-2970
    • (1998) Genes Dev , vol.12 , pp. 2956-2970
    • Desany, B.A.1    Alcasabas, A.A.2    Bachant, J.B.3    Elledge, S.J.4
  • 37
    • 0033197541 scopus 로고    scopus 로고
    • The FHA domain is a modular phosphopeptide recognition motif
    • Durocher D, Henckel J, Fersht AR, Jackson SP (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 4:387-394
    • (1999) Mol Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 38
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity 5′ recessed DNA
    • Ellison V, Stillman B (2003) Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity 5′ recessed DNA. PLoS Biol 1:E33
    • (2003) PLoS Biol , vol.1
    • Ellison, V.1    Stillman, B.2
  • 39
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410:842-847
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 43
    • 1542320702 scopus 로고    scopus 로고
    • Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
    • Giannattasio M, Lazzaro F, Longhese MP, Plevani P, Muzi-Falconi M (2004) Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. Embo J 23:429-438
    • (2004) Embo J , vol.23 , pp. 429-438
    • Giannattasio, M.1    Lazzaro, F.2    Longhese, M.P.3    Plevani, P.4    Muzi-Falconi, M.5
  • 44
    • 15444373985 scopus 로고    scopus 로고
    • The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1
    • Giannattasio M, Lazzaro F, Plevani P, Muzi-Falconi M (2005) The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem 280:9879-9886
    • (2005) J Biol Chem , vol.280 , pp. 9879-9886
    • Giannattasio, M.1    Lazzaro, F.2    Plevani, P.3    Muzi-Falconi, M.4
  • 48
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • Hartwell LH, Weinert TA (1989) Checkpoints: Controls that ensure the order of cell cycle events. Science 246:629-634
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 49
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA (2000) Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr Biol 10:1565-1573
    • (2000) Curr Biol , vol.10 , pp. 1565-1573
    • Hekmat-Nejad, M.1    You, Z.2    Yee, M.C.3    Newport, J.W.4    Cimprich, K.A.5
  • 55
    • 0037162506 scopus 로고    scopus 로고
    • Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
    • Jack MT, Woo RA, Hirao A, Cheung A, Mak TW, Lee PW (2002) Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proc Natl Acad Sci USA 99:9825-9829
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9825-9829
    • Jack, M.T.1    Woo, R.A.2    Hirao, A.3    Cheung, A.4    Mak, T.W.5    Lee, P.W.6
  • 57
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan MB, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432:316-323
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 60
    • 0035008609 scopus 로고    scopus 로고
    • Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae
    • Kim HS, Brill SJ (2001) Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol Cell Biol 21:3725-3737
    • (2001) Mol Cell Biol , vol.21 , pp. 3725-3737
    • Kim, H.S.1    Brill, S.J.2
  • 61
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim ST, Xu B, Kastan MB (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 16:560-570
    • (2002) Genes Dev , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 62
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB (2004) Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 18:1423-1438
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 64
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo T, Wakayama T, Naiki T, Matsumoto K, Sugimoto K (2001) Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294:867-870
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 66
    • 0033634679 scopus 로고    scopus 로고
    • Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • Kumagai A, Dunphy WG (2000) Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 6:839-849
    • (2000) Mol Cell , vol.6 , pp. 839-849
    • Kumagai, A.1    Dunphy, W.G.2
  • 67
    • 0037289840 scopus 로고    scopus 로고
    • Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
    • Kumagai A, Dunphy WG (2003) Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat Cell Biol 5:161-165
    • (2003) Nat Cell Biol , vol.5 , pp. 161-165
    • Kumagai, A.1    Dunphy, W.G.2
  • 68
    • 9644275421 scopus 로고    scopus 로고
    • Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
    • Kumagai A, Kim SM, Dunphy WG (2004) Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem 279:49599-49608
    • (2004) J Biol Chem , vol.279 , pp. 49599-49608
    • Kumagai, A.1    Kim, S.M.2    Dunphy, W.G.3
  • 69
    • 0037291130 scopus 로고    scopus 로고
    • Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
    • Lee J, Kumagai A, Dunphy WG (2003) Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 11:329-340
    • (2003) Mol Cell , vol.11 , pp. 329-340
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 70
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • Lee JH, Paull TT (2004) Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 71
    • 0032493889 scopus 로고    scopus 로고
    • Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
    • Lee SE, Moore JK, Holmes A, Umezu K, Kolodner RD, Haber JE (1998) Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94:399-409
    • (1998) Cell , vol.94 , pp. 399-409
    • Lee, S.E.1    Moore, J.K.2    Holmes, A.3    Umezu, K.4    Kolodner, R.D.5    Haber, J.E.6
  • 72
    • 9444260451 scopus 로고    scopus 로고
    • A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation
    • Lee SJ, Duong JK, Stern DF (2004) A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell 15:5443-5455
    • (2004) Mol Biol Cell , vol.15 , pp. 5443-5455
    • Lee, S.J.1    Duong, J.K.2    Stern, D.F.3
  • 74
    • 2342628449 scopus 로고    scopus 로고
    • Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    • Lin SY, Li K, Stewart GS, Elledge SJ (2004) Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci USA 101:6484-6489
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6484-6489
    • Lin, S.Y.1    Li, K.2    Stewart, G.S.3    Elledge, S.J.4
  • 75
    • 0035949503 scopus 로고    scopus 로고
    • Sancar A Purification and characterization of human DNA damage checkpoint Rad complexes
    • Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001) Purification and characterization of human DNA damage checkpoint Rad complexes. Proc Natl Acad Sci USA 98:11236-1141
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11236-11241
    • Lindsey-Boltz, L.A.1    Bermudez, V.P.2    Hurwitz, J.3
  • 76
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M, Barlow JH, Burgess RC, Rothstein R (2004) Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins. Cell 118:699-713
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 80
    • 0033552943 scopus 로고    scopus 로고
    • Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
    • Lopez-Girona A, Furnari B, Mondesert O, Russell P (1999) Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397:172-175
    • (1999) Nature , vol.397 , pp. 172-175
    • Lopez-Girona, A.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 81
    • 0035182579 scopus 로고    scopus 로고
    • Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast
    • Lopez-Girona A, Kanoh J, Russell P (2001) Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast. Curr Biol 11:50-54
    • (2001) Curr Biol , vol.11 , pp. 50-54
    • Lopez-Girona, A.1    Kanoh, J.2    Russell, P.3
  • 82
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou Z, Minter-Dykhouse K, Wu X, Chen J (2003) MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421:957-961
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 83
    • 1442351990 scopus 로고    scopus 로고
    • Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing
    • Lucca C, Vanoli F, Cotta-Ramusino C, Pellicioli A, Liberi G, Haber J, Foiani M (2004) Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene 23:1206-1213
    • (2004) Oncogene , vol.23 , pp. 1206-1213
    • Lucca, C.1    Vanoli, F.2    Cotta-Ramusino, C.3    Pellicioli, A.4    Liberi, G.5    Haber, J.6    Foiani, M.7
  • 84
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA (2002) A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev 16:2327-2332
    • (2002) Genes Dev , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 85
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
    • Lydall D, Weinert T (1995) Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest. Science 270:1488-1491
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 86
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003) BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302:636-639
    • (2003) Science , vol.302 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 88
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka S, Huang M, Elledge SJ (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282:1893-1897
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 90
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo JA, Cohen J, Toczyski DP (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev 15:2809-28021
    • (2001) Genes Dev , vol.15 , pp. 2809-28021
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 91
    • 2442582392 scopus 로고    scopus 로고
    • Visualization of altered replication dynamics after DNA damage in human cells
    • Merrick CJ, Jackson D, Diffley JF (2004) Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 279:20067-20075
    • (2004) J Biol Chem , vol.279 , pp. 20067-20075
    • Merrick, C.J.1    Jackson, D.2    Diffley, J.F.3
  • 92
    • 0034703330 scopus 로고    scopus 로고
    • Activation of the DNA replication checkpoint through RNA synthesis by primase
    • Michael WM, Ott R, Fanning E, Newport J (2000) Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 289:2133-2137
    • (2000) Science , vol.289 , pp. 2133-2137
    • Michael, W.M.1    Ott, R.2    Fanning, E.3    Newport, J.4
  • 93
    • 0346059615 scopus 로고    scopus 로고
    • 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
    • Mochan TA, Venere M, DiTullio RA, Jr, Halazonetis TD (2003) 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res 63:8586-8591
    • (2003) Cancer Res , vol.63 , pp. 8586-8591
    • Mochan, T.A.1    Venere, M.2    DiTullio Jr., R.A.3    Halazonetis, T.D.4
  • 96
    • 7644232348 scopus 로고    scopus 로고
    • Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
    • Nakada D, Hirano Y, Sugimoto K (2004) Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol Cell Biol 24:10016-10025
    • (2004) Mol Cell Biol , vol.24 , pp. 10016-10025
    • Nakada, D.1    Hirano, Y.2    Sugimoto, K.3
  • 97
    • 0036670615 scopus 로고    scopus 로고
    • Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres
    • Nakamura TM, Moser BA, Russell P (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161:1437-1452
    • (2002) Genetics , vol.161 , pp. 1437-1452
    • Nakamura, T.M.1    Moser, B.A.2    Russell, P.3
  • 98
    • 0033575659 scopus 로고    scopus 로고
    • Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast
    • Neecke H, Lucchini G, Longhese MP (1999) Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast. Embo J 18:4485-4497
    • (1999) Embo J , vol.18 , pp. 4485-4497
    • Neecke, H.1    Lucchini, G.2    Longhese, M.P.3
  • 99
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA (2003) A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 33:497-501
    • (2003) Nat Genet , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 101
    • 0036849432 scopus 로고    scopus 로고
    • Checking on the fork: The DNA-replication stressresponse pathway
    • Osborn AJ, Elledge SJ, Zou L (2002) Checking on the fork: The DNA-replication stressresponse pathway. Trends Cell Biol 12:509-516
    • (2002) Trends Cell Biol , vol.12 , pp. 509-516
    • Osborn, A.J.1    Elledge, S.J.2    Zou, L.3
  • 102
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V, Clerici M, Lucchini G, Longhese MP (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14:2046-2059
    • (2000) Genes Dev , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 104
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull TT, Gellert M (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13:1276-1288
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 106
    • 0035105240 scopus 로고    scopus 로고
    • Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest
    • Pellicioli A, Lee SE, Lucca C, Foiani M, Haber JE (2001) Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol Cell 7:293-300
    • (2001) Mol Cell , vol.7 , pp. 293-300
    • Pellicioli, A.1    Lee, S.E.2    Lucca, C.3    Foiani, M.4    Haber, J.E.5
  • 107
    • 0038391226 scopus 로고    scopus 로고
    • NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage
    • Peng A, Chen PL (2003) NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem 278:8873-8876
    • (2003) J Biol Chem , vol.278 , pp. 8873-8876
    • Peng, A.1    Chen, P.L.2
  • 108
    • 1842576658 scopus 로고    scopus 로고
    • The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways
    • Pichierri P, Rosselli F (2004) The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. Embo J 23:1178-1187
    • (2004) Embo J , vol.23 , pp. 1178-1187
    • Pichierri, P.1    Rosselli, F.2
  • 110
    • 0346101743 scopus 로고    scopus 로고
    • Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains
    • Rodriguez M, Yu X, Chen J, Songyang Z (2003) Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem 278:52914-52918
    • (2003) J Biol Chem , vol.278 , pp. 52914-52918
    • Rodriguez, M.1    Yu, X.2    Chen, J.3    Songyang, Z.4
  • 111
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905-916
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 113
    • 0034329474 scopus 로고    scopus 로고
    • LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
    • Rouse J, Jackson SP (2000) LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. Embo J 19:5801-58012
    • (2000) Embo J , vol.19 , pp. 5801-58012
    • Rouse, J.1    Jackson, S.P.2
  • 114
    • 0036241880 scopus 로고    scopus 로고
    • Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
    • Rouse J, Jackson SP (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9:857-869
    • (2002) Mol Cell , vol.9 , pp. 857-869
    • Rouse, J.1    Jackson, S.P.2
  • 115
    • 8844248619 scopus 로고    scopus 로고
    • Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
    • Sanders SL, Portoso M, Mata J, Bahler J, Allshire RC, Kouzarides T (2004) Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 119:603-614
    • (2004) Cell , vol.119 , pp. 603-614
    • Sanders, S.L.1    Portoso, M.2    Mata, J.3    Bahler, J.4    Allshire, R.C.5    Kouzarides, T.6
  • 116
    • 0032497529 scopus 로고    scopus 로고
    • A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    • Santocanale C, Diffley JF (1998) A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395:615-618
    • (1998) Nature , vol.395 , pp. 615-618
    • Santocanale, C.1    Diffley, J.F.2
  • 118
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz LB, Chehab NH, Malikzay A, Halazonetis TD (2000) p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 151:1381-1390
    • (2000) J Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 119
    • 0030850047 scopus 로고    scopus 로고
    • Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
    • Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM (1997) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90:425-435
    • (1997) Cell , vol.90 , pp. 425-435
    • Scully, R.1    Chen, J.2    Ochs, R.L.3    Keegan, K.4    Hoekstra, M.5    Feunteun, J.6    Livingston, D.M.7
  • 120
  • 122
    • 0033951868 scopus 로고    scopus 로고
    • Characterization of genetic interactions with RFA1: The role of RPA in DNA replication and telomere maintenance
    • Smith J, Zou H, Rothstein R (2000) Characterization of genetic interactions with RFA1: The role of RPA in DNA replication and telomere maintenance. Biochimie 82:71-78
    • (2000) Biochimie , vol.82 , pp. 71-78
    • Smith, J.1    Zou, H.2    Rothstein, R.3
  • 123
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo JM, Lopes M, Foiani M (2002) Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297:599-602
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 124
  • 128
    • 0037009006 scopus 로고    scopus 로고
    • DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
    • Stokes MP, Van Hatten R, Lindsay HD, Michael WM (2002) DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. J Cell Biol 158:863-872
    • (2002) J Cell Biol , vol.158 , pp. 863-872
    • Stokes, M.P.1    Van Hatten, R.2    Lindsay, H.D.3    Michael, W.M.4
  • 130
    • 2442595631 scopus 로고    scopus 로고
    • Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo
    • Takata H, Kanoh Y, Gunge N, Shirahige K, Matsuura A (2004) Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell 14:515-522
    • (2004) Mol Cell , vol.14 , pp. 515-522
    • Takata, H.1    Kanoh, Y.2    Gunge, N.3    Shirahige, K.4    Matsuura, A.5
  • 131
    • 3542999251 scopus 로고    scopus 로고
    • Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1
    • Tanaka K, Russell P (2004) Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J Biol Chem 279:32079-32086
    • (2004) J Biol Chem , vol.279 , pp. 32079-32086
    • Tanaka, K.1    Russell, P.2
  • 132
    • 0032167423 scopus 로고    scopus 로고
    • Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
    • Tanaka T, Nasmyth K (1998) Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. Embo J 17:5182-5191
    • (1998) Embo J , vol.17 , pp. 5182-5191
    • Tanaka, T.1    Nasmyth, K.2
  • 135
    • 0035797444 scopus 로고    scopus 로고
    • Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    • Tercero JA, Diffley JF (2001) Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412:553-557
    • (2001) Nature , vol.412 , pp. 553-557
    • Tercero, J.A.1    Diffley, J.F.2
  • 136
    • 0038730929 scopus 로고    scopus 로고
    • A central role for DNA replication forks in checkpoint activation and response
    • Tercero JA, Longhese MP, Diffley JF (2003) A central role for DNA replication forks in checkpoint activation and response. Mol Cell 11:1323-1336
    • (2003) Mol Cell , vol.11 , pp. 1323-1336
    • Tercero, J.A.1    Longhese, M.P.2    Diffley, J.F.3
  • 138
    • 10644290908 scopus 로고    scopus 로고
    • Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling
    • Tsao CC, Geisen C, Abraham RT (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. Embo J 23:4660-4669
    • (2004) Embo J , vol.23 , pp. 4660-4669
    • Tsao, C.C.1    Geisen, C.2    Abraham, R.T.3
  • 139
    • 0031960691 scopus 로고    scopus 로고
    • Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism
    • Umezu K, Sugawara N, Chen C, Haber JE, Kolodner RD (1998) Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics 148:989-1005
    • (1998) Genetics , vol.148 , pp. 989-1005
    • Umezu, K.1    Sugawara, N.2    Chen, C.3    Haber, J.E.4    Kolodner, R.D.5
  • 140
    • 10944262393 scopus 로고    scopus 로고
    • DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
    • Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, Koshland D (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16:991-1002
    • (2004) Mol Cell , vol.16 , pp. 991-1002
    • Unal, E.1    Arbel-Eden, A.2    Sattler, U.3    Shroff, R.4    Lichten, M.5    Haber, J.E.6    Koshland, D.7
  • 142
    • 10944233962 scopus 로고    scopus 로고
    • Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
    • van Attikum H, Fritsch O, Hohn B, Gasser SM (2004) Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell 119:777-788
    • (2004) Cell , vol.119 , pp. 777-788
    • van Attikum, H.1    Fritsch, O.2    Hohn, B.3    Gasser, S.M.4
  • 143
    • 0030761351 scopus 로고    scopus 로고
    • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
    • Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S (1997) ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. Embo J 16:6018-6033
    • (1997) Embo J , vol.16 , pp. 6018-6033
    • Vaziri, H.1    West, M.D.2    Allsopp, R.C.3    Davison, T.S.4    Wu, Y.S.5    Arrowsmith, C.H.6    Poirier, G.G.7    Benchimol, S.8
  • 144
    • 0034235463 scopus 로고    scopus 로고
    • Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
    • Venclovas C, Thelen MP (2000) Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res 28:2481-2493
    • (2000) Nucleic Acids Res , vol.28 , pp. 2481-2493
    • Venclovas, C.1    Thelen, M.P.2
  • 145
    • 0033534613 scopus 로고    scopus 로고
    • Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex
    • Volkmer E, Karnitz LM (1999) Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. J Biol Chem 274:567-570
    • (1999) J Biol Chem , vol.274 , pp. 567-570
    • Volkmer, E.1    Karnitz, L.M.2
  • 146
    • 0035138557 scopus 로고    scopus 로고
    • Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
    • Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21:755-764
    • (2001) Mol Cell Biol , vol.21 , pp. 755-764
    • Wakayama, T.1    Kondo, T.2    Ando, S.3    Matsumoto, K.4    Sugimoto, K.5
  • 148
    • 19344366752 scopus 로고    scopus 로고
    • Role of saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair
    • Wang X, Haber JE (2004) Role of saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair. PLoS Biol 2:E21
    • (2004) PLoS Biol , vol.2
    • Wang, X.1    Haber, J.E.2
  • 149
    • 0344209296 scopus 로고    scopus 로고
    • Genomic instability and endoreduplication triggered by RAD17 deletion
    • Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L (2003) Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev 17:965-970
    • (2003) Genes Dev , vol.17 , pp. 965-970
    • Wang, X.1    Zou, L.2    Zheng, H.3    Wei, Q.4    Elledge, S.J.5    Li, L.6
  • 150
    • 0347364654 scopus 로고    scopus 로고
    • MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
    • Wang Y, Qin J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci USA 100:15387-15392
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15387-15392
    • Wang, Y.1    Qin, J.2
  • 151
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward IM, Minn K, Jorda G, Chen (2003) Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278:19579-19582
    • (2003) J Biol Chem , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, G.3    Chen4
  • 152
    • 0037039165 scopus 로고    scopus 로고
    • Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway
    • Weiss S, Matsuoka S, Elledge SJ, Leder P (2002) Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol 12:73-77
    • (2002) Curr Biol , vol.12 , pp. 73-77
    • Weiss, S.1    Matsuoka, S.2    Elledge, S.J.3    Leder, P.4
  • 154
    • 0037424296 scopus 로고    scopus 로고
    • NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
    • Xu X, Stern DF (2003) NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J Biol Chem 278:8795-8803
    • (2003) J Biol Chem , vol.278 , pp. 8795-8803
    • Xu, X.1    Stern, D.F.2
  • 155
    • 0038746602 scopus 로고    scopus 로고
    • Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint
    • Yamane K, Chen J, Kinsella TJ (2003) Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res 63:3049-3053
    • (2003) Cancer Res , vol.63 , pp. 3049-3053
    • Yamane, K.1    Chen, J.2    Kinsella, T.J.3
  • 156
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC (2002) BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 30:285-289
    • (2002) Nat Genet , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 157
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 16:571-582
    • (2002) Genes Dev , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 158
    • 2542459341 scopus 로고    scopus 로고
    • Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
    • Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG (2004a) Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117:575-588
    • (2004) Cell , vol.117 , pp. 575-588
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 159
    • 11144227916 scopus 로고    scopus 로고
    • Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
    • Yoo HY, Shevchenko A, Shevchenko A, DunphyWG (2004b) Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem 279:53353-53364
    • (2004) J Biol Chem , vol.279 , pp. 53353-53364
    • Yoo, H.Y.1    Shevchenko, A.2    Shevchenko, A.3    Dunphy, W.G.4
  • 160
    • 0037178814 scopus 로고    scopus 로고
    • The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint
    • You Z, Kong L, Newport J (2002) The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J Biol Chem 277:27088-27093
    • (2002) J Biol Chem , vol.277 , pp. 27088-27093
    • You, Z.1    Kong, L.2    Newport, J.3
  • 161
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • Yu X, Chen J (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24:9478-9486
    • (2004) Mol Cell Biol , vol.24 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 162
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • Yu X, Chini CC, He M, Mer G, Chen J (2003) The BRCT domain is a phospho-protein binding domain. Science 302:639-642
    • (2003) Science , vol.302 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 163
    • 0037415735 scopus 로고    scopus 로고
    • Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
    • Zachos G, Rainey MD, Gillespie DA (2003) Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. Embo J 22:713-723
    • (2003) Embo J , vol.22 , pp. 713-723
    • Zachos, G.1    Rainey, M.D.2    Gillespie, D.A.3
  • 165
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao H, Piwnica-Worms H (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21:4129-4139
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 166
    • 0037069326 scopus 로고    scopus 로고
    • Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
    • Zhao H, Watkins JL, Piwnica-Worms H (2002) Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci USA 99:14795-14800
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14795-14800
    • Zhao, H.1    Watkins, J.L.2    Piwnica-Worms, H.3
  • 168
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao X, Muller EG, Rothstein R (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 2:329-340
    • (1998) Mol Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3
  • 169
    • 0037099520 scopus 로고    scopus 로고
    • Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
    • Zhong Q, Boyer TG, Chen PL, Lee WH (2002a) Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res 62:3966-3970
    • (2002) Cancer Res , vol.62 , pp. 3966-3970
    • Zhong, Q.1    Boyer, T.G.2    Chen, P.L.3    Lee, W.H.4
  • 170
    • 0037047387 scopus 로고    scopus 로고
    • BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks
    • Zhong Q, Chen CF, Chen PL, Lee WH (2002b) BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem 277:28641-28647
    • (2002) J Biol Chem , vol.277 , pp. 28641-28647
    • Zhong, Q.1    Chen, C.F.2    Chen, P.L.3    Lee, W.H.4
  • 171
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ (2000) The DNA damage response: Putting checkpoints in perspective. Nature 408:433-439
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 172
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu XD, Kuster B, Mann M, Petrini JH, de Lange T (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet 25:347-352
    • (2000) Nat Genet , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    de Lange, T.5
  • 173
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300:1542-1548
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 174
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou L, Cortez D, Elledge SJ (2002) Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 16:198-208
    • (2002) Genes Dev , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3
  • 175
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou L, Liu D, Elledge SJ (2003) Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci USA 100:13827-13832
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3


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