ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Journal of Biological Chemistry

Volumn 276, Issue 45, 2001, Pages 42462-42467

  Burma, Sandeep ^c   Chen, Benjamin P ^c   Murphy, Michael ^c   Kurimasa, Akihiro ^a   Chen, David J ^b  

^a TOTTORI UNIVERSITY   (Japan)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; ENZYMES;

PHOSPHORYLATION;

BIOCHEMISTRY;

ATM PROTEIN; ATR PROTEIN; DNA; DNA DEPENDENT PROTEIN KINASE; HISTONE H2A; HISTONE H2AX; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; ELF4 PROTEIN, MOUSE; HISTONE; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL CULTURE; METABOLISM; NON-PROGRAMMATIC; PHOSPHORYLATION; PHYSIOLOGY; RADIATION EXPOSURE;

ANIMALIA; MAMMALIA;

NON-PROGRAMMATIC;

ANDROSTADIENES; ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; DNA; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HISTONES; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035834693     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100466200     Document Type: Article

References (28)

1. Khanna, K. K., and Jackson, S. P. (2001) Nat. Genet. 27, 247-254
2. Modesti, M., and Kanaar, R. (2001) Curr. Biol. 11, R229-R232
3. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., and Bonner, W. M. (1998) J. Biol. Chem. 273, 5858-5868
4. Rogakou, E. P., Boon, C., Redon, C., and Bonner, W. M. (1999) J. Cell Biol. 146, 905-915
5. Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., and Bonner, W. M. (2000) Curr. Biol. 10, 886-895
6. Chen, H. T., Bhandoola, A., Difilippantonio, M. J., Zhu, J., Brown, M. J., Tai, X., Rogakou, E. P., Brotz, T. M., Bonner, W. M., Ried, T., and Nussenzweig, A. (2000) Science (Wash. D. C.) 290, 1962-1964
7. Mahadevaiah, S. K., Turner, J. M. A., Baudat, F., Rogakou, E. P., de Boer, P., Blanco-Rodriguez, J., Jasin, M., Keeney, S., Bonner, W. M., and Burgoyne, P. S. (2001) Nat. Genet. 27, 271-276
8. Downs, J. A., Lowndes, N. F., and Jackson, S. P. (2000) Nature 408, 1001-1004
9. Rappold, I., Iwabuchi, K., Date, T., and Chen, J. (2001) J. Cell Biol. 153, 613-620
10. Durocher, D., and Jackson, S. P. (2001) Curr. Opin. Cell Biol. 13, 225-231
11. van Gent, D. C., Hoeijmakers, J. H., and Kanaar, R. (2001) Nat. Rev. Genet. 2, 196-206
12. Kurimasa, A., Ouyang, H., Dong, L. J., Wang, S., Li, X., Cordon-Cardo, C., Chen, D. J., and Li, G. C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1403-1408
13. Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., and Baltimore, D. (1996) Genes Dev. 10, 2411-2422
14. D'Anna, J. A., Valdez, J. G., Habbersett, R. C., and Crissman, H. A. (1997) Radiat. Res. 148, 260-271
15. Andegeko, Y., Moyal, L., Mitelman, L., Tsarfaty, I., Shiloh, Y., and Rotman, G. (2001) J. Biol. Chem. 276, 38224-38230
16. Zhang, N., Chen, P., Khanna, K. K., Scott, S., Gatei, M., Kozlov, S., Watters, D., Spring, K., Yen, T., and Lavin, M. F. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8021-8026
17. Ziv, Y., Banin, S., Lim, D. S., Canman, C. E., Kastan, M. B., Shiloh, Y., Chan, D. W., Gately, D. P., Urban, S., Galloway, A. M., Lees-Miller, S. P., Yen, T., and Allalunis-Turner, J. (2000) Methods Mol. Biol. 99, 99-108
18. Saintigny, Y., Delacote, F., Vares, G., Petitot, F., Lambert, S., Averbeck, D., and Lopez, B. S. (2001) EMBO J. 20, 3861-3870
19. Skog, S., Heiden, T., Eriksson, S., Wallström, B., and Tribukait, B. (1992) Anticancer Drugs 3, 379-386
20. Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., and Abraham, R. T. (1998) Cancer Res. 58, 4375-4382
21. Burma, S., Kurimasa, A., Xie, G., Taya, Y., Araki, R., Abe, M., Crissman, H. A., Ouyang, H., Li, G. C., and Chen, D. J. (1999) J. Biol. Chem. 274, 17139-17143
22. Kastan, M. B., and Lim, D. S. (2000) Nat. Rev. Mol. Cell. Biol. 1, 179-186
23. Smith, G. C., and Jackson, S. P. (1999) Genes Dev. 13, 916-934
24. Hoppe, B. S., Jensen, R. B., and Kirchgessner, C. U. (2000) Radiat. Res. 153, 125-130
25. Gately, D. P., Hittle, J. C., Chan, G. K., and Yen, T. J. (1998) Mol. Biol. Cell 9, 2361-2374
26. Chan, D. W., Gately, D. P., Urban, S., Galloway, A. M., Lees-Miller, S. P., Yen, T., and Allalunis-Turner, J. (1998) Int. J. Radiat. Biol. 74, 217-224
27. Rotman, G., and Shiloh, Y. (1999) Oncogene 18, 6135-6144
28. Guo, C. Y., Wang, Y., Brautigan, D. L., and Larner, J. M. (1999) J. Biol. Chem. 274, 18715-18720