The FHA domain is a modular phosphopeptide recognition motif

Molecular Cell

Volumn 4, Issue 3, 1999, Pages 387-394

  Durocher, Daniel ^a   Henckel, Julia ^b   Fersht, Alan R ^b   Jackson, Stephen P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPEPTIDE; PROTEIN KINASE;

ARTICLE; BINDING KINETICS; DNA DAMAGE; NONHUMAN; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EUKARYOTA; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0033197541     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80340-8     Document Type: Article

References (35)

1. Blasina, A., Van de Weyer, I., Laus, M.C., Luyten, W.H.M.L., Parker, A.E., and McGowan, C.H. (1999). A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9, 1-10.
2. Brown, A.L., Lee, C.H., Schwarz, J.K., Mitiku, N., Piwinica-Worms, H., and Chung, J.H. (1999). A human Cds1 related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl. Acad. Sci. USA 96, 3745-3750.
3. Emili, A. (1998). Mec1-dependent phosphorylation of Rad9p in response to DNA damage. Mol. Cell 2, 183-189.
4. Fay, D.S., Sun, Z.X., and Stern, D.F. (1997). Mutations in SPK1/ RAD53 that specifically abolish checkpoint - But not growth-related functions. Curr. Genet. 31, 97-105.
5. Featherstone, C., and Jackson, S.P. (1998). DNA repair: The Nijmegen breakage syndrome protein. Curr. Biol. 8, R622-R625.
6. Feldman, R.M.R., Correll, C.C., Kaplan, K.B., and Deshaies, R.J. (1997). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230.
7. Hofmann, K., and Bucher, P. (1995). The FHA domain: A putative nuclear signaling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20, 347-349.
8. Jackson, S.P. (1996). DNA damage detection by DNA-dependent protein kinase and related enzymes. Cancer Surv. 28, 261-279.
9. Kavanaugh, W.M., and Williams, L.T. (1994). An alternative to SH2 domains for binding tyrosine phosphorylated proteins. Science 266, 1862-1865.
10. Kuriyan, J., and Cowburn, D. (1997). Modular peptide-recognition domains in eukaryotic signaling. Annu. Rev. Biophys. Biomol. Struct. 26, 259-288.
11. Kwok, R.P.S., Lundblad, J.R., Chrivia, J.C., Richards, J.P., BachinGer, H.P., Brennan, R.G., Roberts, S.G.E., Green, M.R., and GoodMan, R.H. (1994). Nuclear protein Cbp is a coactivator for the transcription factor Creb. Nature 370, 223-226.
12. Ladbury, J.E., Lemmon, M.A., Zhou, M., Green, J., Botfield, M.C., and Schlessinger, J. (1995). Measurement of the binding of tyrosyl phosphopeptides to Sh2 domains a reappraisal. Proc. Natl. Acad. Sci. USA 92, 3199-3203.
13. Lakin, N.D., and Jackson, S.P. (1999). Regulation of p53 by DNA damage. Oncogene, in press.
14. Li, S.C., Zhou, S.Y., Vincent, S.J.F., Zwahlen, C., Wiley, S., Cantley, L., Kay, L.E., FormanKay, J., and Pawson, T. (1997). High affinity binding of the Drosophila Numb phosphotyrosine binding domain to peptides containing a Gly Pro (p)Tyr motif. Proc. Natl. Acad. Sci. USA 94, 7204-7209.
15. Li, J., Smith, G.P., and Walker, J.C. (1999). Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96, 7821-7826.
16. Lu, P.J., Zhou, X.Z., Shen, M.H., and Lu, K.P. (1999). Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-1328.
17. Maser, R.S., Monsen, K.J., Nelms, B.E., and Petrini, J.H.J. (1997). hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol. 17, 6087-6096.
18. Matsumoto, A., Hong, S.K., Ishizuka, H., Horinouchi, S., and Beppu, T. (1994). Phosphorylation of the Afsr protein involved in secondary metabolism in Saccharomyces species by a eukaryotic type protein kinase. Gene 146, 47-56.
19. Matsuoka, S., Huang, M.X., and Elledge, S.J. (1998). Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897.
20. Murakami, H., and Okayama, H. (1995). A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374, 817-819.
21. Muslin, A.J., Tanner, J.W., Allen, P.M., and Shaw, A.S. (1996). Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84, 889-897.
22. Oishi, I., Sugiyama, S., Otani, H., Yamamura, H., Nishida, Y., and Minami, Y. (1998). A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. Mech. Dev. 71, 49-63.
23. Pawson, T., and Gish, G.D. (1992). SH2 and SH3 domains: From structure to function. Cell 71, 359-362.
24. Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., and Bonner, W.M. (1998). DNA double stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868.
25. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q.H., Wang, B., and Elledge, S.J. (1996). Regulation of Rad53 by the Atm-like kinases Mec1 and Tel1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
26. Siede, W., Friedberg, A.S., and Friedberg, E.C. (1993). Rad9-dependent G(1) arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90, 7985-7989.
27. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J., and Harper, J.W. (1997). F box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin ligase complex. Cell 91, 209-219.
28. Stone, J.M., Collinge, M.A., Smith, R.D., Horn, M.A., and Walker, J.C. (1994). Interaction of a protein phosphatase with an arabidopsis serine-threonine receptor kinase. Science 266, 793-795.
29. Sun, Z.X., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F. (1996). Spk1/rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10, 395-406.
30. Sun, Z.X., Hsiao, J., Fay, D.S., and Stern, D.F. (1998). Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281, 272-274.
31. Vialard, J.E., Gilbert, C.S., Green, C.M., and Lowndes, N.F. (1998). The budding yeast Rad9 checkpoint protein is subjected to Mec1/ Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 17, 5679-5688.
32. Weinert, T. (1998). DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair. Cell 94, 555-558.
33. Wiseman, T., Williston, S., Brandts, J.F., and Lin, L.N. (1989). Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Anal. Biochem. 179, 131-137.
34. Yaffe, M.B., Schutkowski, M., Shen, M.H., Zhou, X.Z., Stukenberg, P.T., Rahfeld, J.U., Xu, J., Kuang, J., Kirschner, M.W., Fischer, G., et al. (1997). Sequence specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism. SciEnce 278, 1957-1960.
35. Zakian, V.A. (1995). Atm-related genes: What do they tell us about functions of the human gene. Cell 82, 685-687.