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Volumn 2, Issue 3, 1998, Pages 329-340

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DEOXYRIBONUCLEOTIDE; ENZYME INHIBITOR; FUNGAL PROTEIN; MEC1 PROTEIN, S CEREVISIAE; PRIMER DNA; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAD53 PROTEIN, S CEREVISIAE; RIBONUCLEOTIDE REDUCTASE; SACCHAROMYCES CEREVISIAE PROTEIN; SML1 PROTEIN, S CEREVISIAE;

EID: 0032161269     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80277-4     Document Type: Article
Times cited : (627)

References (48)
  • 2
    • 0027968012 scopus 로고
    • The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
    • Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C., and Elledge, S.J. (1994). The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8, 2401-2415.
    • (1994) Genes Dev. , vol.8 , pp. 2401-2415
    • Allen, J.B.1    Zhou, Z.2    Siede, W.3    Friedberg, E.C.4    Elledge, S.J.5
  • 6
    • 0021668558 scopus 로고
    • A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
    • Boeke, J.D., LaCroute, F., and Fink, G.R. (1984). A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197, 342-346.
    • (1984) Mol. Gen. Genet. , vol.197 , pp. 342-346
    • Boeke, J.D.1    LaCroute, F.2    Fink, G.R.3
  • 8
    • 0027265346 scopus 로고
    • A simplified HPLC method for simultaneously quantitating ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues
    • Cross, D.R., Miller, B.J., and James, S.J. (1993). A simplified HPLC method for simultaneously quantitating ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues. Cell Prolif. 26, 327-336.
    • (1993) Cell Prolif. , vol.26 , pp. 327-336
    • Cross, D.R.1    Miller, B.J.2    James, S.J.3
  • 9
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 10
    • 0023395932 scopus 로고
    • Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability
    • Elledge, S.J., and Davis, R.W. (1987). Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol. Cell. Biol. 7, 2783-2793.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2783-2793
    • Elledge, S.J.1    Davis, R.W.2
  • 11
    • 0024376690 scopus 로고
    • DNA damage induction of ribonucleotide reductase
    • Elledge, S.J., and Davis, R.W. (1989). DNA damage induction of ribonucleotide reductase. Mol. Cell. Biol. 9, 4932-4940.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4932-4940
    • Elledge, S.J.1    Davis, R.W.2
  • 12
    • 0026582672 scopus 로고
    • Ribonucleotide reductase: Regulation, regulation, regulation
    • Elledge, S.J., Zhou, Z., and Allen, J.B. (1992). Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem. Sci. 17, 119-123.
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 119-123
    • Elledge, S.J.1    Zhou, Z.2    Allen, J.B.3
  • 13
    • 0027605113 scopus 로고
    • DNA damage and cell cycle regulation of ribonucleotide reductase
    • Elledge, S.J., Zhou, Z., Allen, J.B., and Navas, T.A. (1993). DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 15, 333-339.
    • (1993) Bioessays , vol.15 , pp. 333-339
    • Elledge, S.J.1    Zhou, Z.2    Allen, J.B.3    Navas, T.A.4
  • 15
    • 0031059414 scopus 로고    scopus 로고
    • Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions
    • Fay, D.S., Sun, Z., and Stern, D.F. (1997). Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions. Curr. Genet. 31, 97-105.
    • (1997) Curr. Genet. , vol.31 , pp. 97-105
    • Fay, D.S.1    Sun, Z.2    Stern, D.F.3
  • 17
    • 0003448569 scopus 로고
    • Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Harlow, E., and Lane, D. (1988). Antibodies, a Laboratory Manual (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
    • (1988) Antibodies, a Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 18
    • 0030813561 scopus 로고    scopus 로고
    • Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae
    • Huang, M., and Elledge, S.J. (1997). Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol. Cell. Biol. 17, 6105-6113.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6105-6113
    • Huang, M.1    Elledge, S.J.2
  • 19
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James, P., Halladay, J., and Craig, E.A. (1996). Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144, 1425-1436.
    • (1996) Genetics , vol.144 , pp. 1425-1436
    • James, P.1    Halladay, J.2    Craig, E.A.3
  • 20
    • 0027971222 scopus 로고
    • An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
    • Kato, R., and Ogawa, H. (1994). An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 22, 3104-3112.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3104-3112
    • Kato, R.1    Ogawa, H.2
  • 22
    • 0027501142 scopus 로고
    • A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase
    • Koch, C., Moll, T., Neuberg, M., Ahorn, H., and Nasmyth, K. (1993). A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science 261, 1551-1557.
    • (1993) Science , vol.261 , pp. 1551-1557
    • Koch, C.1    Moll, T.2    Neuberg, M.3    Ahorn, H.4    Nasmyth, K.5
  • 23
    • 0021906691 scopus 로고
    • Genetic analysis of the mitotic transmission of minichromosomes
    • Koshland, D., Kent, J.C., and Hartwell, L.H. (1985). Genetic analysis of the mitotic transmission of minichromosomes. Cell 40, 393-403.
    • (1985) Cell , vol.40 , pp. 393-403
    • Koshland, D.1    Kent, J.C.2    Hartwell, L.H.3
  • 24
    • 0028884961 scopus 로고
    • Overexpression of the RNR1 gene rescues Saccharomyces cerevisiae mutants in the mitochondrial DNA polymerase-encoding MIP1 gene
    • Lecrenier, N., and Foury, F. (1995). Overexpression of the RNR1 gene rescues Saccharomyces cerevisiae mutants in the mitochondrial DNA polymerase-encoding MIP1 gene. Mol. Gen. Genet. 249, 1-7.
    • (1995) Mol. Gen. Genet. , vol.249 , pp. 1-7
    • Lecrenier, N.1    Foury, F.2
  • 25
    • 0023615620 scopus 로고
    • Plasmid construction by homologous recombination in yeast
    • Ma, H., Kunes, S., Schatz, P.J., and Botstein, D. (1987). Plasmid construction by homologous recombination in yeast. Gene 58, 201-216.
    • (1987) Gene , vol.58 , pp. 201-216
    • Ma, H.1    Kunes, S.2    Schatz, P.J.3    Botstein, D.4
  • 26
    • 0027182508 scopus 로고
    • Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast
    • Mitchell, D.A., Marshall, T.K., and Deschenes, R.J. (1993). Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast. Yeast 9, 715-722.
    • (1993) Yeast , vol.9 , pp. 715-722
    • Mitchell, D.A.1    Marshall, T.K.2    Deschenes, R.J.3
  • 27
    • 0029150855 scopus 로고
    • TEL 1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
    • Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S., and Hieter, P. (1995). TEL 1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
    • (1995) Cell , vol.82 , pp. 831-840
    • Morrow, D.M.1    Tagle, D.A.2    Shiloh, Y.3    Collins, F.S.4    Hieter, P.5
  • 28
    • 0028003648 scopus 로고
    • Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis
    • Muller, E.G. (1994). Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis. J. Biol. Chem. 269, 24466-24471.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24466-24471
    • Muller, E.G.1
  • 29
    • 0028017443 scopus 로고
    • YBR1012, an essential gene from S. cerevisiae: Construction of an RNA antisense conditional allele and isolation of a multicopy suppressor
    • Nasr, F., Becam, A.M., Slonimski, P.P., and Herbert, C.J. (1994). YBR1012, an essential gene from S. cerevisiae: construction of an RNA antisense conditional allele and isolation of a multicopy suppressor. Compt. Rend. Acad. Sci. III 317, 607-613.
    • (1994) Compt. Rend. Acad. Sci. III , vol.317 , pp. 607-613
    • Nasr, F.1    Becam, A.M.2    Slonimski, P.P.3    Herbert, C.J.4
  • 30
    • 0031036995 scopus 로고    scopus 로고
    • RAD9, RAD17, and RAD24 are required for s phase regulation in Saccharomyces cerevisiae in response to DNA damage
    • Paulovich, A.G., Margulies, R.U., Garvik, B.M., and Hartwell, L.H. (1997). RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics 145, 45-62.
    • (1997) Genetics , vol.145 , pp. 45-62
    • Paulovich, A.G.1    Margulies, R.U.2    Garvik, B.M.3    Hartwell, L.H.4
  • 31
    • 0023925454 scopus 로고
    • Interactions between deoxyribonucleotide and DNA synthesis
    • Reichard, P. (1988). Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57, 379-374.
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 379-1374
    • Reichard, P.1
  • 32
    • 77049310288 scopus 로고
    • Studies of gene mutation in Saccharomyces
    • Roman, H. (1956). Studies of gene mutation in Saccharomyces. Cold Spring Harb. Symp. Quant. Biol. 21, 175-185.
    • (1956) Cold Spring Harb. Symp. Quant. Biol. , vol.21 , pp. 175-185
    • Roman, H.1
  • 33
    • 0020645054 scopus 로고
    • One-step gene disruption in yeast
    • Rothstein, R. (1983). One-step gene disruption in yeast. Methods Enzymol. 101, 202-211.
    • (1983) Methods Enzymol. , vol.101 , pp. 202-211
    • Rothstein, R.1
  • 34
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. (1996). Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 35
    • 0028841139 scopus 로고
    • Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae
    • Schneider, B.L., Seufert, W., Steiner, B., Yang, Q.H., and Futcher, A.B. (1995). Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae. Yeast 11, 1265-1274.
    • (1995) Yeast , vol.11 , pp. 1265-1274
    • Schneider, B.L.1    Seufert, W.2    Steiner, B.3    Yang, Q.H.4    Futcher, A.B.5
  • 36
    • 0031466618 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
    • Shiloh, Y. (1997). Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31, 635-662.
    • (1997) Annu. Rev. Genet. , vol.31 , pp. 635-662
    • Shiloh, Y.1
  • 37
    • 0018449422 scopus 로고
    • High-frequency transformation of yeast: Autonomous replication of hybrid DNA molecules
    • Struhl, K., Stinchcomb, D.T., Scherer, S., and Davis, R.W. (1979). High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc. Natl. Acad. Sci. USA 76, 1035-1039.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 1035-1039
    • Struhl, K.1    Stinchcomb, D.T.2    Scherer, S.3    Davis, R.W.4
  • 38
    • 0029928222 scopus 로고    scopus 로고
    • Spk1/ Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    • Sun, Z., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F. (1996). Spk1/ Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10, 395-406.
    • (1996) Genes Dev. , vol.10 , pp. 395-406
    • Sun, Z.1    Fay, D.S.2    Marini, F.3    Foiani, M.4    Stern, D.F.5
  • 39
    • 0024977417 scopus 로고
    • Elevated recombination rates in transcriptionally active DNA
    • Thomas, B.J., and Rothstein, R. (1989). Elevated recombination rates in transcriptionally active DNA. Cell 56, 619-630.
    • (1989) Cell , vol.56 , pp. 619-630
    • Thomas, B.J.1    Rothstein, R.2
  • 41
    • 0031474756 scopus 로고    scopus 로고
    • Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
    • Wang, Y.A., Elson, A., and Leder, P. (1997b). Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA 94, 14590-14595.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14590-14595
    • Wang, Y.A.1    Elson, A.2    Leder, P.3
  • 42
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T.A., Kiser, G.L., and Hartwell, L.H. (1994). Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
    • (1994) Genes Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 43
    • 0030941281 scopus 로고    scopus 로고
    • Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints
    • Westphal, C.H., Schmaltz, C., Rowan, S., Elson, A., Fisher, D.E., and Leder, P. (1997). Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. Cancer Res. 57, 1664-1667.
    • (1997) Cancer Res. , vol.57 , pp. 1664-1667
    • Westphal, C.H.1    Schmaltz, C.2    Rowan, S.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 44
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu, Y., and Baltimore, D. (1996). Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410.
    • (1996) Genes Dev. , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 45
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S., and Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422.
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 46
    • 0029127643 scopus 로고
    • ATM-related genes: What do they tell us about functions of the human gene?
    • Zakian, V.A. (1995). ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687.
    • (1995) Cell , vol.82 , pp. 685-687
    • Zakian, V.A.1
  • 47
    • 0027290933 scopus 로고
    • SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase
    • Zheng, P., Fay, D.S., Burton, J., Xiao, H., Pinkham, J.L., and Stern, D.F. (1993). SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. Mol. Cell. Biol. 13, 5829-5842.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5829-5842
    • Zheng, P.1    Fay, D.S.2    Burton, J.3    Xiao, H.4    Pinkham, J.L.5    Stern, D.F.6
  • 48
    • 0027145127 scopus 로고
    • DUN1 encodes a protein kinase that controls the DNA damage response in yeast
    • Zhou, Z., and Elledge, S.J. (1993). DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75, 1119-1127.
    • (1993) Cell , vol.75 , pp. 1119-1127
    • Zhou, Z.1    Elledge, S.J.2


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