The BRCT Domain Is a Phospho-Protein Binding Domain

Science

Volumn 302, Issue 5645, 2003, Pages 639-642

  Yu, Xiaochun ^a   Chini, Claudia Christiano Silva ^a   He, Miao ^a   Mer, Georges ^a   Chen, Junjie ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENES; TUMORS;

BINDING DOMAINS;

PROTEINS;

BRCA1 ASSOCIATED CARBOXYL TERMINAL HELICASE 1; BRCA1 PROTEIN; BRCT PROTEIN; PHOSPHOPROTEIN; PROTEIN; UNCLASSIFIED DRUG;

CANCER; GENE; PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EUKARYOTE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROKARYOTE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

AMINO ACID MOTIFS; BRCA1 PROTEIN; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; G2 PHASE; HUMANS; MITOSIS; MUTATION; PEPTIDE LIBRARY; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA HELICASES; RNA POLYMERASE II; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EUKARYOTA; PROKARYOTA;

EID: 0142147272     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088753     Document Type: Article

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17. We thank D. Livingston, S. Cantor, and R. Drapkin for valuable reagents and sharing unpublished observations. We thank L. Karnitz, S. Kaufmann, and members of the Chen and Karnitz laboratories for helpful discussion, and the Mayo Clinic Protein core facility for peptide synthesis. We also thank J. Parvin for suggestions; C. Merkle, K. Minter-Dykhouse, and M. Petcherskaia for proofreading this manuscript; and E. Goetzman for technical support. X.Y. is grateful to E. Mekada for previous mentoring. This work is supported in part by grants from the National Institute of Health (CA89239 and CA92312), the Prospect Creek Foundation, and the Breast Cancer Research Foundation. J.C. is a recipient of the U.S. Department of Defense Breast Cancer Career Development Award (DAHD17-02-1-0472).