Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Cell

Volumn 90, Issue 3, 1997, Pages 425-435

  Scully, Ralph ^a   Chen, Junjie ^a   Ochs, Robert L ^b   Keegan, Kathleen ^c   Hoekstra, Merl ^c   Feunteun, Jean ^d   Livingston, David M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHROMOSOME 17Q; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA SYNTHESIS INHIBITION; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

EID: 0030850047     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80503-6     Document Type: Article

References (55)

1. Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C., and Elledge, S.J. (1994). The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8, 2401-2415.
2. Ashley, T., Plug, A.W., Xu, J., Solari, A.J., Reddy, G., et al. (1995). Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates. Chromosoma 104, 19-28.
3. Baumann, P., Benson, F.E., and West, S.C. (1996). Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87, 757-766.
4. Bentley, N.J., Holtzman, D.A., Keegan, K.S., Flaggs, G., DeMaggio, A.J., et al. (1996). The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15, 6641-6651.
5. Bhatia, P.K., Wang, Z., and Friedberg, E.C. (1996). DNA repair and transcription. Curr. Opin. Genet. Dev. 6, 146-150.
6. Bishop, D.K. (1994). RecA homologues Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis. Cell 79, 1081-1092.
7. Bork, P., Hofmann, K., Bucher, P., Neuwald, A.F., Altschul, S.F., and Koonin, E.V. (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76.
8. Bravo, R. (1986). Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. Exp. Cell. Res. 763, 287-293.
9. Bravo, R., and Macdonald-Bravo, H. (1987). Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell. Biol. 105, 1549-1554.
10. Callebaut, I., and Mornon, J.P. (1997). From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30.
11. Carr, A.M. (1995). DNA structure checkpoints in fission yeast. Semin. Cell Biol. 6, 65-72.
12. Chapman, M.S., and Verma, I.M. (1996). Transcriptional activation by BRCA1. Nature 382, 678-679.
13. Chen, Y.M., Farmer, A.A., Chen, C.F., Jones, D.C., Chen, P.L., and Lee, W.H. (1996). BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172.
14. Cimprich, K.A., Shin, T.B., Keith, C.T., and Schreiber, S.L. (1996). cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl. Acad. Sci. USA 7, 2850-2855.
15. Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672.
16. Feunteun, J., and Lenoir, G.M. (1996). BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer. Biochim. Biophys. Acta 1242, 177-180.
17. Fornace, A.J., Jr. (1983). Recombiation of parent and daughter strand DNA after UV-irradiation in mammalian cells. Nature 304, 552-554.
18. Fried berg, E.C., Walker, G.C., and Siede, W. (1995). DNA Repair and Mutagenesis. (Washington: ASM Press).
19. Futreal, P.A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshmann, K., et al. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122.
20. Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K., and Koller, B.H. (1996). BRCA1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12, 191-194.
21. Hakem, R., de la Pomba, J.L., Sirard, C., Mo, R., Woo, M., et al. (1996). The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023.
22. Hall, J.M., Lee, M.K., and Newmann, B. (1990). Linkage of early-onset breast cancer to chromosome 17q21. Science 250, 1684-1689.
23. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B., and Hawley, R.S. (1995). The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82, 815-821.
24. Hartley, K.O., Gell, D., Smith, G.C., Zhang, H., Divecha, N., et al. (1995). DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
25. Humphrey, J.S., Salim, A., Erdos, M.R., Collins, F.S., Brody, L.C., and Klausner, R.D. (1997). Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing. Proc. Natl. Acad. Sci. USA 94, 5820-5825.
26. Keegan, K.S., Holtzman, D.A., Plug, A.W., Christenson, E.R., Brainerd, E.E., et al. (1996). The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10, 2423-2437.
27. Keith, C.T., and Schreiber, S.L. (1995). PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270, 50-51.
28. Kleckner, N. (1996). Meiosis: How could it work? Proc. Natl. Acad. Sci. USA 93, 8167-8174.
29. Ko, L.J., and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
30. Koonin, V.F., Altschul, S.F., and Bork, P. (1996). BRCA1 protein products: functional motifs. Nature Genet. 13, 266-267.
31. Lane, T.F., Deng, C., Elson, A., Lyu, M.S., Kozak, C.A., and Leder, P. (1995). Expression of BRCA1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 9, 2712-2722.
32. Lees-Miller, S.P., Godbout, R., Chan, D.W., Weinfeld, M., Day, R.S.I., et al. (1995). Absense of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267, 1183-1185.
33. Li, R., Hannon, G.J., Beach, D., and Stillman, B. (1996). Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr. Biol. 6, 189-199.
34. Lieber, M.R., Grawunder, U., Wu, X., and Yaneva, M. (1997). Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev. 7, 99-104.
35. Liu, C.Y., Flesken-Nikitin, A., Li, S., Zeng, Y., and Lee, W.-H. (1996). Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843.
36. Marquis, ST., Rajan, J.V., Wynshaw-Boris, A., Xu, J., and Yin, G.-Y. (1995). The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues. Nature Genet. 11, 17-26.
37. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P.A., Harshman, K., et al. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71.
38. Monteiro, A.N.A., August, A., and Hanafusa, H. (1996). Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA 93, 13595-13599.
39. Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S., and Hieter, P. (1995).TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
40. Nakamura, H., Morita, T., and Sato, C. (1986). Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp. Cell Res. 165, 291-297.
41. Neuhausen, S.L., and Marshall, C.J. (1994). Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res. 54, 6069-6072.
42. Painter, R.B., and Young, B.R. (1980). Radiosensitivity in ataxia telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77, 7315-7317.
43. Paulovich, A.G., and Hartwell, L.H. (1995). A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82, 841-847.
44. Ruffner, H., and Verma, I. (1997). BRCA1 is a cell cycle-regulated nuclear phosphoprotein. Proc. Natl. Acad. Sci. USA 94, 7138-7143.
45. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. (1996). Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 277, 357-360.
46. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., et al. (1995). A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753.
47. Scully, R., Ganesan, S., Brown, M., De Caprio, J.A., Cannistra, S.A., et al. (1996). Location of BRCA1 in human breast and ovarian cell lines. Science 272, 123-125.
48. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., et al. (1997a). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275.
49. Scully, R., Anderson, S.F., Chao, D.M., Wei, W., Ye, L., et al. (1997b). BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 94, 5605-5610.
50. Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.-S., Regel, E., et al. (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking BRCA2. Nature 386, 804-810.
51. Shinohara, A., Ogawa, H., and Ogawa, T. (1992). Rad51 protein involved in repair and recombination in Saccharomyces cerevisiae is a RecA-like protein. Cell 69, 457-470.
52. Smith, S.A., Easton, D.F., Evans, D.G.R., and Ponder, B.A.J. (1992). Allele losses in the region 17q12-q21 in familial breast and ovarian cancer non-randomly involve the wild-type chromosome. Nature Genet. 2, 128-131.
53. Sun, Z., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F.(1996). Spk1/ Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10, 395-406.
54. Terasawa, M., Shinohara, A., Hotta, Y., Ogawa, H., and Ogawa, T. (1995). Localization of RecA-like recombination proteins on chromosomes of lily at various meiotic stages. Genes Dev. 9, 925-934.
55. Wu, L.C., Wang, Z.W., Tsan, J.T., Spillman, M.A., Phung, A., et al. (1996). Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nature Genet. 14, 430-440.