Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres

Genetics

Volumn 161, Issue 4, 2002, Pages 1437-1452

  Nakamura, Toru M ^a   Moser, Bettina A ^a   Russell, Paul ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHECKPOINT KINASE RAD3; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; KU ANTIGEN; MUTANT PROTEIN; PROTEIN CRB2; PROTEIN HUS1; PROTEIN RAD1; PROTEIN RAD17; PROTEIN RAD26; PROTEIN RAD32; PROTEIN RAD9; PROTEIN TEL1; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CHROMOSOME; CONTROLLED STUDY; DNA REPAIR; EPISTASIS; GENE DELETION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SCHIZOSACCHAROMYCES POMBE; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE; YEAST;

CELL CYCLE PROTEINS; DNA LIGASES; ENDONUCLEASES; EPISTASIS, GENETIC; FUNGAL PROTEINS; GENES, CDC; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERE;

SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0036670615     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (86)

1. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
2. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
3. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
4. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe
5. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
6. Protection of telomeres by the Ku protein in fission yeast
7. Pot1, the putative telomere end-binding protein in fission yeast and humans
8. The Schizosaccharomyces pombe rad3 checkpoint gene
9. Switching and signaling at the telomere
10. Replication checkpoint enforced by kinases Cdsl and Chk1
11. Components of the Ku-dependent non-homologous endjoining pathway are involved in telomeric length maintenance and telomeric silencing
12. Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
13. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins
14. DNA structure checkpoint pathways in Schizosaccharomyces pombe
15. Characterization of Schizosaccharomyces pombe Hus1: A PCNA-related protein that associates with Rad1 and Rad9
16. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
17. Regulation of telomere length and function by a Myb-domain protein in fission yeast
18. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions
19. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae
20. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
21. The yeast Xrs2 complex functions in S phase checkpoint regulation
22. Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe
23. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
24. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
25. The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions
26. ATM-dependent phosphorylation of nibrin in response to radiation exposure
27. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
28. Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination
29. Yeast Ku as a regulator of chromosomal DNA end structure
30. Structures of the human rad17-replication factor C and checkpoint rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy
31. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
32. Genetic engineering of Schizosaccharomyces pombe: A system for gene disruption and replacement using the ura4 gene as a selectable marker
33. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe
34. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
35. Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
36. Ku is associated with the telomere in mammals
37. Ku acts in a unique way at the mammalian telomere to prevent end joining
38. Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures
39. spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast
40. Structure-function analysis of fission yeast hus1-rad1-rad9 checkpoint complex
41. DNA double-strand breaks: Signaling, repair and the cancer connection
42. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
43. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
44. Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints
45. High-efficiency gene targeting in Schizosaccharomyces pombe using a modular, PCR-based approach with long tracts of flanking homology
46. Molecular cloning and analysis of Schizosaccharomyces pombe rad9, a gene involved in DNA repair and mutagenesis
47. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
48. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres
49. Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast
50. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
51. Genetic control of telomere integrity in Schizosaccharomyces pombe: Rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+)
52. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
53. Mechanism of caffeine-induced checkpoint override in fission yeast
54. Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe
55. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
56. Telomerase catalytic subunit homologs from fission yeast and human
57. Two modes of survival of fission yeast without telomerase
58. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
59. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein
60. Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde crosslinked chromatin
61. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
62. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
63. Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells
64. Mitotic DNA damage and replication checkpoints in yeast
65. A generic protein purification method for protein complex characterization and proteome exploration
66. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
67. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
68. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
69. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
70. Interaction of human Ku70 with TRF2
71. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
72. Cloning and analysis of a gene involved in DNA repair and recombination, the rad1 gene of Schizosaccharomyces pombe
73. Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of double strand breaks and recombination
74. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
75. A DNA damage response pathway controlled by Tel1 and the Mre11 complex
76. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
77. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
78. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
79. Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase
80. Schizosaccharomyces pombe rad32 protein: A phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks
81. The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance
82. Fission yeast rad26 is a regulatory subunit of the rad3 checkpoint kinase
83. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
84. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres