Hus1 acts upstream of Chk1 in a mammalian DNA damage response pathway

Current Biology

Volumn 12, Issue 1, 2002, Pages 73-77

  Weiss, Robert S ^a   Matsuoka, Shuhei ^b   Elledge, Stephen J ^b   Leder, Philip ^a,b  

^a Department of Genetics ^*  (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA; UNIDENTIFIED RETROVIRUS;

CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; HUS1 PROTEIN, S POMBE; PROTEIN KINASE; PROTEIN P53; SCHIZOSACCHAROMYCES POMBE PROTEIN;

ANIMAL; ARTICLE; DNA DAMAGE; DNA REPAIR; GENETICS; IONIZING RADIATION; METABOLISM; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN KINASES; RADIATION, IONIZING; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0037039165     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00626-1     Document Type: Article

References (28)

1. The DNA damage response: Putting checkpoints in perspective
2. A conserved role for the Hus1 checkpoint protein in eukaryotic genome maintenance
3. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress
4. Surfing the p53 network
5. Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
6. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
7. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
8. A human homolog of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
9. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
10. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
11. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
12. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
13. -1- mice
14. 2/M DNA damage checkpoint
15. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
16. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
17. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
18. The G2-phase DNA-damage checkpoint
19. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
20. A role for ATR in the DNA damage-induced phosphorylation of p53
21. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
22. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
23. Substrate specificities and identification of putative substrates of ATM kinase family members
24. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
25. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
26. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
27. Protein-PCNA interactions: A DNA-scanning mechanism?