Deficient nonhomologous end-joining activity in cell-free extracts from BRCA1-null fibroblasts

Cancer Research

Volumn 62, Issue 14, 2002, Pages 3966-3970

  Zhong, Qing ^a   Boyer, Thomas G ^a   Chen, Phang Lang ^a   Lee, Wen Hwa ^a  

^a Univ of Texas Health Science Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CELL PROTEIN; DNA; DNA LIGASE 4; KU ANTIGEN; MAGNESIUM ION; MANGANESE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN KU80; PROTEIN NHEJ; PROTEIN XRCC4; RAD50 PROTEIN; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CATALYSIS; CELL ACTIVITY; CELL FREE SYSTEM; CELL KINETICS; COMPLEMENT ACTIVATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO CELL; ENZYME BINDING; FIBROBLAST CULTURE; GENETIC STABILITY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHOMOLOGOUS END JOINING ACTIVITY; NONHUMAN; NULL ALLELE; ONCOGENE; PRIORITY JOURNAL; PROTEIN PURIFICATION; REACTION ANALYSIS;

ANIMALS; BRCA1 PROTEIN; CELL EXTRACTS; CELL LINE; CELL-FREE SYSTEM; DNA REPAIR; FIBROBLASTS; HELA CELLS; HUMANS; LYMPHOCYTES; MICE;

EID: 0037099520     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Emerging roles of BRCA1 in transcriptional regulation and DNA repair
2. Insights into the functions of BRCA1 and BRCA2
3. Lessons learned from BRCA1 and BRCA2
4. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
5. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
6. BRCA1 required for transcription-coupled repair of oxidative DNA damage
7. Growth retardation, DNA repair defects and lack of spermatogenesis in BRCA1-deficient mice
8. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
9. Genetic analysis of BRCA 1 function in a defined tumor cell line
10. Brca1 controls homology-directed DNA repair
11. The many interfaces of Mre11
12. Double-strand break repair mediated by DNA end-joining
13. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
14. A mechanistic basis for Mre11-directed DNA joining at microhomologies
15. Promotion of Dn14-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
16. DNA end-joining catalyzed by human cell-free extracts
17. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein
18. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
19. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing
20. Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
21. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
22. Human Rad50/Mre11 is a flexible complex that can tether DNA ends
23. From the cover: Direct DNA binding by Brca1
24. The rejoining of double-strand breaks in DNA by human cell extracts
25. The identification and characterization of mammalian proteins involved in the rejoining of DNA double-strand breaks in vitro
26. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: Implications for Ku serving as an alignment factor in non-homologous DNA end joining
27. DNA-PK-independent rejoining of DNA double-strand breaks in human cell extracts in vitro
28. Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts
29. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
30. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
31. BRCA1 facilitates microhomology mediated end-joining of DNA double-strand breaks
32. A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining