Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases

EMBO Journal

Volumn 17, Issue 17, 1998, Pages 5182-5191

  Tanaka, Tomoyuki ^a   Nasmyth, Kim ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

CDK; DNA primase; Mcm; Rad53; RPA

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; DNA BINDING PROTEIN; DNA PRIMASE; HYDROXYUREA; PROTEIN KINASE;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMOSOME REPLICATION; CONTROLLED STUDY; DNA REPLICATION ORIGIN; IMMUNOPRECIPITATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATASES; CELL CYCLE PROTEINS; CHROMOSOMES, FUNGAL; CYCLIN-DEPENDENT KINASES; DNA HELICASES; DNA REPLICATION; DNA-BINDING PROTEINS; FUNGAL PROTEINS; HYDROXYUREA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REPLICATION ORIGIN; REPLICATION PROTEIN A; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EUKARYOTA; FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0032167423     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.17.5182     Document Type: Article

References (47)

1. Adachi, Y. and Laemmli, U.K. (1994) Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts. EMBO J., 13, 4153-4164.
2. Adachi, Y., Usukura, J. and Yanagida, M. (1997) A globular complex formation by Nda1 and other five members of the MCM protein family in fission yeast. Genes Cell, 2, 467-479.
3. Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C. and Elledge, S.J. (1994) The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev., 8, 2401-2415.
4. Aparicio, O.M., Weinstein, D.M. and Bell, S.P. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell, 91, 59-69.
5. Bousset, K. and Diffley, J.F.X. (1998) The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev., 12, 480-490.
6. Campbell, J.L. and Newlon, C.S. (1991) Chromosomal DNA replication. In Broach, J.R. (ed.), The Molecular and Cellular Biology of the Yeast Saccharomyces. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, Vol. I, pp. 41-146.
7. Chapman, J.W. and Johnston, L.H. (1989) The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated. Exp. Cell Res., 180, 419-428.
8. Coleman, T.R., Carpenter, P.B. and Dunphy, W.G. (1996) The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell, 87, 53-63.
9. Dahmann, C., Diffley, J.F. and Nasmyth, K.A. (1995) S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol., 5, 1257-1269.
10. Diffley, J.F. (1996) Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev., 10, 2819-2830.
11. Diffley, J.F., Cocker, J.H., Dowell, S.J. and Rowley, A. (1994) Two steps in the assembly of complexes at yeast replication origins in vivo. Cell. 78, 303-316.
12. Donovan, S., Harwood, J., Drury, L.S. and Diffley, J.F. (1997) Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl Acad. Sci. USA, 94, 5611-5616.
13. Ferguson, B.M., Brewer, B.J., Reynolds, A.E. and Fangman, W.L. (1991) A yeast origin of replication is activated late in S phase. Cell, 65, 507-515.
14. Foiani, M., Lucchini, G. and Plevani, P. (1997) The DNA polymerase α-primase complex couples DNA replication, cell-cycle progression and DNA-damage response. Trends Biochem. Sci., 22, 424-427.
15. Gilbert, D.M. (1998) Replication origins in yeast versus metazoa: separation of the haves and the have nots. Curr. Opin. Genet. Dev., 8, 194-199.
16. Hennessy, K.M., Clark, C.D. and Botstein, D. (1990) Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev., 4, 2252-2263.
17. Herendeen, D. and Kelly, T.J. (1996) SV40 DNA replication. In Blow, J.J. (ed.), Eukaryotic DNA Replication. Oxford University Press, Oxford, UK, pp. 29-65.
18. Heyer, W.D., Rao, M.R., Erdile, L.F., Kelly, T.J. and Kolodner, R.D. (1990) An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A. EMBO J., 9, 2321-2329.
19. Hua, X.H., Yan, H. and Newport, J. (1997) A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle. J. Cell Biol., 137, 183-192.
20. Ishimi, Y. (1997) A DNA helicase activity is associated with an MCM4, -6 and -7 protein complex. J. Biol Chem., 272, 24508-24513.
21. Jackson, A.L., Pahl, P.M.B., Harrison, K., Rosamond, J. and Sclafani, R.A. (1993) Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol., 13, 2899-2908.
22. Krek, W. (1998) Proteolysis and the G1-S transition: the SCF connection. Curr. Opin. Genet. Dev., 8, 36-42.
23. Liang, C. and Stillman, B. (1997) Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev., 11, 3375-3386.
24. Lucchini, G., Francesconi, S., Foiani, M., Badaracco, G. and Plevani, P. (1987) Yeast DNA polymerase-DNA primase complex; cloning of PRI 1, a single essential gene related to DNA primase activity. EMBO J., 6, 737-742.
25. Lucchini, G., Falconi, M.M., Pizzagalli, A., Aguilera, A., Klein, H.L. and Plevani, P. (1990) Nucleotide sequence and characterization of temperature-sensitive poll mutants of Saccharomyces cerevisiae. Gene, 90, 99-104.
26. Marahrens, Y. and Stillman, B. (1994) Replicator dominance in a eukaryotic chromosome. EMBO J., 13, 3395-3400.
27. Nasmyth, K. (1996) Control of S phase. In DePamphilis, M.L. (ed.), DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 331-386.
28. Pasero, P. and Gasser, S.M. (1998) New systems for replicating DNA in vitro. Curr. Opin. Cell Biol., 10, 304-310.
29. Paulovich, A.G. and Hartwell, L.H. (1995) A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell, 82, 841-847.
30. Piatti, S., Bohm, T., Cocker, J.H., Diffley, J.F. and Nasmyth, K. (1996) Activation of S-phase-promoting CDKs in late G1 defines a 'point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev., 10, 1516-1531.
31. Rivin, C.J. and Fangman, W.L. (1980) Replication fork rate and origin activation during the S phase of Saccharomyces cerevisiae. J. Cell Biol. 85, 108-115.
32. Romanowski, P., Madine, M.A., Rowles, A., Blow, J.J. and Laskey, R.A. (1996) The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol., 6, 1416-1425.
33. Rowles, A., Chong, J.P., Brown, L., Howell, M., Evan, G.I. and Blow, J.J. (1996) Interaction between the origin recognition complex and replication licensing system in Xenopus. Cell, 87, 287-296.
34. Sanchez, Y. Desany, B.A., Jones, W.J., Liu, Q., Wang, B. and Elledge, S.J. (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science, 271, 357-360.
35. Santocanale, C. and Diffley, J.F.X. (1998) A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature, in press.
36. Santocanale, C., Neecke, H., Longhese, M.P., Lucchini, G. and Plevani, P. (1995) Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression. J. Mol. Biol., 254, 595-607.
37. Schwob, E., Bohm, T., Mendenhall, M.D. and Nasmyth, K. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S.cerevisiae. Cell, 79, 233-244.
38. Stillman, B. (1994) Smart machines at the DNA replication fork. Cell, 78, 725-728.
39. Stillman, B. (1996) Cell cycle control of DNA replication. Science, 274, 1659-1664.
40. Stueland, C.S., Lew, D.J., Cismowski, M.J. and Reed, S.I. (1993) Full activation of p34Cdc28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol., 13, 3744-3755.
41. Tanaka, S., Tanaka, Y. and Isono, K. (1996) Systematic mapping of autonomously replicating sequences on chromosome V of Saccharomyces cerevisiae using a novel strategy. Yeast, 12, 101-113.
42. Tanaka, T. Knapp, D. and Nasmyth, K. (1997) Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell, 90, 649-660.
43. Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G. and Deshaies, R.J. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science, 278, 455-460.
44. Weinert, T. (1998) DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev., 8, 185-193.
45. Weinert, T.A., Kiser, G.L. and Hartwell, L.H. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev., 8, 652-665.
46. Wold, M.S. (1997) Replication protein A: a heterotrimeric, single-stranded DNA-hinding protein required for cukaryotic DNA metabolism. Annu. Rev. Binchem., 66, 61-92.
47. Zou, L. and Stillman, B. (1998) Formation of preinitiation complex by S-phase cyclin CDK-depending loading of Cdc45p onto chromatin. Science, 280, 593-586.