ATR couples FANCD2 monoubiquitination to the DNA-damage responsey

Genes and Development

Volumn 18, Issue 16, 2004, Pages 1958-1963

  Andreassen, Paul R ^a   D'Andrea, Alan D ^a   Taniguchi, Toshiyasu ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer susceptibility; Checkpoint; FANCD2; Fanconi anemia; Replication stress

Indexed keywords

ATR PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; GENE PRODUCT; MITOMYCIN C; PHOSPHOTRANSFERASE; PROTEIN RPA1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CANCER SUSCEPTIBILITY; CELL LINE; CHROMOSOME; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; ENZYME ACTIVITY; FANCONI ANEMIA; HELA CELL; HUMAN; HUMAN CELL; MONOUBIQUITINATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; SECKEL SYNDROME; STRESS; UBIQUITINATION;

BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FLOW CYTOMETRY; HUMANS; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; UBIQUITIN;

EID: 4043133287     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1196104     Document Type: Article

References (29)

1. Abraham, R.T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes & Dev. 15: 2177-2196.
2. Andreassen, P.R., Lohez, O.D., Lacroix, F.B., and Margolis, R.L. 2001. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol. Biol. Cell 12: 1315-1328.
3. Bruun, D., Folias, A., Akkari, Y., Cox, Y., Olson, S., and Moses, R. 2003. siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells. DNA Repair (Amst) 2: 1007-1013.
4. Casper, A.M., Nghiem, P., Arlt, M.F., and Glover, T.W. 2002. ATR regulates fragile site stability. Cell 111: 779-789.
5. Chanan-Khan, A., Holkova, B., Perle, M.A., Reich, E., Wu, C.D., Inghirami, G., and Takeshita, K. 2003. T-cell clonality and myelodysplasia without chromosomal fragility in a patient with features of Seckel syndrome. Haematologica 88: ECR14.
6. D'Andrea, A.D. and Grompe, M. 2003. The Fanconi anaemia/BRCA pathway. Nat. Rev. Cancer 3: 23-34.
7. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M.S., Timmers, C., Hejna, J., Grompe, M., and D'Andrea, A.D. 2001. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7: 249-262.
8. Kupfer, G., Naf, D., Garcia-Higuera, I., Wasik, J., Cheng, A., Yamashita, T., Tipping, A., Morgan, N., Mathew, C.G., and D'Andrea, A.D. 1999. A patient-derived mutant form of the Fanconi anemia protein, FANCA, is defective in nuclear accumulation. Exp. Hematol. 27: 587-593.
9. Liu, Q., Guntuku, S., Cui, X.S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes & Dev. 14: 1448-1459.
10. Lomonosov, M., Anand, S., Sangrithi, M., Davies, R., and Venkitaraman, A.R. 2003. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes & Dev. 17: 3017-3022.
11. Lupardus, P.J., Byun, T., Yee, M.C., Hekmat-Nejad, M., and Cimprich, K.A. 2002. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes & Dev. 16: 2327-2332.
12. Meetei, A.R., De Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., Van De Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., et al. 2003a. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet. 35: 165-170.
13. Meetei, A.R., Sechi, S., Wallisch, M., Yang, D., Young, M.K., Joenje, H., Hoatlin, M.E., and Wang, W. 2003b. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol. Cell. Biol. 23: 3417-3426.
14. Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H.V., Moreau, L.A., Stotsky, M., Mathew, C.G., Kastan, M.B., Weaver, D.T., and D'Andrea, A.D. 2002. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat. Cell Biol. 4: 913-920.
15. O'Driscoll, M., Ruiz-Perez, V.L., Woods, C.G., Jeggo, P.A., and Goodship, J.A. 2003. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33: 497-501.
16. Osborn, A.J., Elledge, S.J., and Zou, L. 2002. Checking on the fork: The DNA-replication stress-response pathway. Trends Cell Biol. 12: 509-516.
17. Pichierri, P. and Rosselli, F. 2004. The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 23: 1178-1187.
18. Qiao, F., Moss, A., and Kupfer, G.M. 2001. Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. J. Biol. Chem. 276: 23391-23396.
19. Rothfuss, A. and Grompe, M. 2004. Repair kinetics of genomic interstrand DNA cross-links: Evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 24: 123-134.
20. Taniguchi, T., Garcia-Higuera, I., Andreassen, P.R., Gregory, R.C., Grompe, M., and D'Andrea, A.D. 2002a. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100: 2414-2420.
21. Taniguchi, T., Garcia-Higuera, I., Xu, B., Andreassen, P.R., Gregory, R.C., Kim, S.T., Lane, W.S., Kastan, M.B., and D'Andrea, A.D. 2002b. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109: 459-472.
22. Tercero, J.A., Longhese, M.P., and Diffley, J.F. 2003. A central role for DNA replication forks in checkpoint activation and response. Mol. Cell 11: 1323-1336.
23. Tibbetts, R.S., Cortez, D., Brumbaugh, K.M., Scully, R., Livingston, D., Elledge, S.J., and Abraham, R.T. 2000. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes & Dev. 14: 2989-3002.
24. Walter, J. and Newport, J. 2000. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase α. Mol. Cell 5: 617-627.
25. Wang, X.Z., Andreassen, P.R., and D'Andrea, A.D. 2004. Functional Interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol. Cell. Biol. 24: 5850-5862.
26. Wu, G., Lee, W.H., and Chen, P.L. 2000. NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J. Biol. Chem. 275: 30618-30622.
27. Yazlovitskaya, E.M. and Persons, D.L. 2003. Inhibition of cisplatin-induced ATR activity and enhanced sensitivity to cisplatin. Anticancer Res. 23: 2275-2279.
28. Zhao, H. and Piwnica-Worms, H. 2001. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chkl. Mol. Cell. Biol. 21: 4129-4139.
29. Zou, L. and Elledge, S.J. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.