DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

Molecular and Cellular Biology

Volumn 24, Issue 21, 2004, Pages 9478-9486

  Yu, Xiaochun ^a   Chen, Junjie ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CTBP INTERACTING PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; BRCA1 PROTEIN; CARRIER PROTEINS; CELL CYCLE; CELL DIVISION; CELL LINE; DNA DAMAGE; ENZYME ACTIVATION; G2 PHASE; HUMANS; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE;

EID: 6344264992     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.21.9478-9486.2004     Document Type: Article

References (40)

1. Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
2. Botuyan, M. V., Y. Nomine, X. Yu, N. Juranic, S. Macura, J. Chen, and G. Mer. 2004. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12:1137-1146.
3. Brown, E. J., and D. Baltimore. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:615-628.
4. Cantor, S. B., D. W. Bell, S. Ganesan, E. M. Kass, R. Drapkin, S. Grossman, D. C. Wahrer, D. C. Sgroi, W. S. Lane, D. A. Haber, and D. M. Livingston. 2001. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105:149-160.
5. Chen, J. 2000. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 60:5037-5039.
6. Clapperton, J. A., I. A. Manke, D. M. Lowery, T. Ho, L. F. Haire, M. B. Yaffe, and S. J. Smerdon. 2004. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat. Struct. Mol. Biol. 11:512-518.
7. Cortez, D., S. Guntuku, J. Qin, and S. J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science 294:1713-1716.
8. Cortez, D., Y. Wang, J. Qin, and S. J. Elledge. 1999. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286:1162-1166.
9. Deming, P. B., C. A. Cistulli, H. Zhao, P. R. Graves, H. Piwnica-Worms, R. S. Paules, C. S. Downes, and W. K. Kaufmann. 2001. The human decatenation checkpoint. Proc. Natl. Acad. Sci. USA 98:12044-12049.
10. Deng, C. X., and S. G. Brodie. 2000. Roles of BRCA1 and its interacting proteins. Bioessays 22:728-737.
11. Foray, N., D. Marot, A. Gabriel, V. Randrianarison, A. M. Carr, M. Perricaudet, A. Ashworth, and P. Jeggo. 2003. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J. 22:2860-2871.
12. Ganesan, S., D. P. Silver, R. A. Greenberg, D. Avni, R. Drapkin, A. Miron, S. C. Mok, V. Randrianarison, S. Brodie, J. Salstrom, T. P. Rasmussen, A. Klimke, C. Marrese, Y. Marahrens, C. X. Deng, J. Feunteun, and D. M. Livingston. 2002. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell 111:393-405.
13. 2/M checkpoint: a new order of regulation. Cell Cycle 1:178-180.
14. Li, S., P. L. Chen, T. Subramanian, G. Chinnadurai, G. Tomlinson, C. K. Osborne, Z. D. Sharp, and W. H. Lee. 1999. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J. Biol. Chem. 274:11334-11338.
15. Li, S., N. S. Ting, L. Zheng, P. L. Chen, Y. Ziv, Y. Shiloh, E. Y. Lee, and W. H. Lee. 2000. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406:210-215.
16. 2/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
17. Ludwig, T., P. Fisher, S. Ganesan, and A. Efstratiadis. 2001. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev. 15:1188-1193.
18. Manke, I. A., D. M. Lowery, A. Nguyen, and M. B. Yaffe. 2003. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302:635-639.
19. Rodriguez, M., X. Yu, J. Chen, and Z. Songyang. 2003. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J. Biol. Chem. 278:52914-52918.
20. Rouse, J., and S. P. Jackson. 2002. Interfaces between the detection, signaling, and repair of DNA damage. Science 297:547-551.
21. Schaeper, U., T. Subramanian, L. Lim, J. M. Boyd, and G. Chinnadurai. 1998. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J. Biol. Chem. 273:8549-8552.
22. Scully, R., and D. M. Livingston. 2000. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408:429-432.
23. Shiozaki, E. N., L. Gu, N. Yan, and Y. Shi. 2004. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol. Cell 14:405-412.
24. -/-) mice. Genes Dev. 14:1439-1447.
25. Tibbetts, R. S., D. Cortez, K. M. Brumbaugh, R. Scully, D. Livingston, S. J. Elledge, and R. T. Abraham. 2000. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14:2989-3002.
26. Venkitaraman, A. R. 2002. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108:171-182.
27. Vilkki, S., V. Launonen, A. Karhu, P. Sistonen, I. Vastrik, and L. A. Aaltonen. 2002. Screening for microsatellite instability target genes in colorectal cancers. J. Med. Genet. 39:785-789.
28. Walworth, N. C. 2001. DNA damage: Chk1 and Cdc25, more than meets the eye. Curr. Opin. Genet. Dev. 11:78-82.
29. Welcsh, P. L., and M. C. King. 2001. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum. Mol. Genet. 10:705-713.
30. Williams, R. S., M. S. Lee, D. D. Hau, and J. N. Glover. 2004. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat. Struct. Mol. Biol. 11:519-525.
31. Wong, A. K., P. A. Ormonde, R. Pero, Y. Chen, L. Lian, G. Salada, S. Berry, Q. Lawrence, P. Dayananth, P. Ha, S. V. Tavtigian, D. H. Teng, and P. L. Bartel. 1998. Characterization of a carboxy-terminal BRCA1 interacting protein. Oncogene 17:2279-2285.
32. Wu-Baer, F., and R. Baer. 2001. Effect of DNA damage on a BRCA1 complex. Nature 414:36.
33. 2-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21:3445-3450.
34. 2/M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22:1049-1059.
35. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3:389-395.
36. 2/M. checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30:285-289.
37. Yu, X., and R. Baer. 2000. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 275:18541-18549.
38. Yu, X., C. C. Chini, M. He, G. Mer, and J. Chen. 2003. The BRCT domain is a phospho-protein binding domain. Science 302:639-642.
39. Yu, X., L. C. Wu, A. M. Bowcock, A. Aronheim, and R. Baer. 1998. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J. Biol. Chem. 273:25388-25392.
40. 2 checkpoints. Proc. Natl. Acad. Sci. USA 99:14795-14800.