-
1
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou, B. B., and Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature (Lond.). 408: 433-439, 2000.
-
(2000)
Nature (Lond.)
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
2
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl, G. M., and Carr, A. M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell. Biol., 3: E277-E286, 2001.
-
(2001)
Nat. Cell. Biol.
, vol.3
-
-
Wahl, G.M.1
Carr, A.M.2
-
3
-
-
0037365789
-
ATM related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer, 3: 155-168, 2003.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
4
-
-
0031574247
-
A DNA-topoisomerase II-binding protein with eight repeating regions similar to DNA-repeir enzymes and to a cell-cycle regulator
-
Yamane, K., Kawabata, M., and Tsumo, T. A DNA-topoisomerase II-binding protein with eight repeating regions similar to DNA-repeir enzymes and to a cell-cycle regulator. Eur. J. Biochem., 250: 794-799, 1997.
-
(1997)
Eur. J. Biochem.
, vol.250
, pp. 794-799
-
-
Yamane, K.1
Kawabata, M.2
Tsumo, T.3
-
5
-
-
0036134979
-
A DNA damage-regulated BRCT-containing protein. TopBP1, is required for cell survival
-
Yamane, K., Wu, X., and Chen, J. A DNA damage-regulated BRCT-containing protein. TopBP1, is required for cell survival. Mol. Cell. Biol., 22: 555-566. 2002.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 555-566
-
-
Yamane, K.1
Wu, X.2
Chen, J.3
-
6
-
-
0028148225
-
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control
-
Saka, Y., Fantes, P., Sutani, T., McInemy, C., Creanor, J. and Yanagida, M. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J., 13: 5319-5329, 1994.
-
(1994)
EMBO J.
, vol.13
, pp. 5319-5329
-
-
Saka, Y.1
Fantes, P.2
Sutani, T.3
McInemy, C.4
Creanor, J.5
Yanagida, M.6
-
7
-
-
0037188475
-
A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway
-
Marchetti, M. A., Kumar, S., Hartsuiker, E. Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C., and Huberman, J. A. A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc. Natl. Acad. Sci. USA, 99: 7472-7477, 2002.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7472-7477
-
-
Marchetti, M.A.1
Kumar, S.2
Hartsuiker, E.3
Maftahi, M.4
Carr, A.M.5
Freyer, G.A.6
Burhans, W.C.7
Huberman, J.A.8
-
8
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hyssey, C., Trail, T. McClure, M. Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo. K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayanath, P., Ward, J., Tonin, P., Nard, S. Bristow, P., Norris, F., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Wash. DC), 266: 66-71, 1994.
-
(1994)
Science (Wash. DC)
, vol.266
, pp. 66-71
-
-
Miki, Y.1
Swensen, J.2
Shattuck-Eidens, D.3
Futreal, P.A.4
Harshman, K.5
Tavtigian, S.6
Liu, Q.7
Cochran, C.8
Bennett, L.M.9
Ding, W.10
Bell, R.11
Rosenthal, J.12
Hyssey, C.13
Trail, T.14
McClure, M.15
Frye, C.16
Hattier, T.17
Phelps, R.18
Haugen-Strano, A.19
Katcher, H.20
Yakumo, K.21
Gholami, Z.22
Shaffer, D.23
Stone, S.24
Bayer, S.25
Wray, C.26
Bogden, R.27
Dayanath, P.28
Ward, J.29
Tonin, P.30
Nard, S.31
Bristow, P.32
Norris, F.33
Helvering, L.34
Morrison, P.35
Rosteck, P.36
Lai, M.37
Barrett, J.C.38
Lewis, C.39
Neuhausen, S.40
Cannon-Albright, L.41
Goldgar, D.42
Wiseman, R.43
Kamb, A.44
Skolnick, M.45
more..
-
9
-
-
0031031787
-
From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
-
Callebaut, I. and Momon, J. P. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett., 400:25-30, 1997.
-
(1997)
FEBS Lett.
, vol.400
, pp. 25-30
-
-
Callebaut, I.1
Momon, J.P.2
-
10
-
-
0031046294
-
A superfamily of conserved domains in DNA damage-responsive cell cycle check-point proteins
-
Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., and Koonin, E. V. A superfamily of conserved domains in DNA damage-responsive cell cycle check-point proteins. FASEB J., 11: 68-76, 1997.
-
(1997)
FASEB J.
, vol.11
, pp. 68-76
-
-
Bork, P.1
Hofmann, K.2
Bucher, P.3
Neuwald, A.F.4
Altschul, S.F.5
Koonin, E.V.6
-
11
-
-
0242456024
-
BRCT domain-containing protein TopBPI functions in DNA replication and damage response
-
Makiniemi, M., Hillukkala, T., Tuusa, J., Reini, K., Vaara, M., Huang, D., Pospiech. H., Majuri, I., Westerling, T., Makela, T. P., and Syvaoja, J. E. BRCT domain-containing protein TopBPI functions in DNA replication and damage response, J. Biol. Chem., 276:30399-303406, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30399-303406
-
-
Makiniemi, M.1
Hillukkala, T.2
Tuusa, J.3
Reini, K.4
Vaara, M.5
Huang, D.6
Pospiech, H.7
Majuri, I.8
Westerling, T.9
Makela, T.P.10
Syvaoja, J.E.11
-
12
-
-
0033527717
-
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double strand breaks
-
Cortez, D., Wang, Y., Qin, J., and Elledge, S. J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double strand breaks. Science (Wash. DC). 286: 1162-1166, 1999.
-
(1999)
Science (Wash. DC)
, vol.286
, pp. 1162-1166
-
-
Cortez, D.1
Wang, Y.2
Qin, J.3
Elledge, S.J.4
-
13
-
-
0030850047
-
Dynamic changes of BRCA 1 subnuclear location and phosphorylation state are initiated by DNA damage
-
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D. M. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 90: 425-435, 1997.
-
(1997)
Cell
, vol.90
, pp. 425-435
-
-
Scully, R.1
Chen, J.2
Ochs, R.L.3
Keegan, K.4
Hoekstra, M.5
Feunteun, J.6
Livingston, D.M.7
-
14
-
-
0032146256
-
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
-
Tomlinson, G. E., Chen, T. T., Stastny, V. A., Virmani, A. K., Spillman, M. A., Tonk, V., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., Minna, J. D., and Gazdar, A. F. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res., 58: 3237-3242, 1999.
-
(1999)
Cancer Res.
, vol.58
, pp. 3237-3242
-
-
Tomlinson, G.E.1
Chen, T.T.2
Stastny, V.A.3
Virmani, A.K.4
Spillman, M.A.5
Tonk, V.6
Blum, J.L.7
Schneider, N.R.8
Wistuba, I.I.9
Shay, J.W.10
Minna, J.D.11
Gazdar, A.F.12
-
15
-
-
0033400828
-
Genetic analysis of BRCA 1 function in a defined tumor cell line
-
Scully, R,. Ganesan, S., Vlasakova, K., Chert. J., Socolovsky. M., and Livingston, D. M. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol. Cell. 4: 1093-1099, 1999.
-
(1999)
Mol. Cell.
, vol.4
, pp. 1093-1099
-
-
Scully, R.1
Ganesan, S.2
Vlasakova, K.3
Chert, J.4
Socolovsky, M.5
Livingston, D.M.6
-
16
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation, and early embryonic lethality
-
Brown, E. J., and Baltimore, D. ATR disruption leads to chromosomal fragmentation, and early embryonic lethality. Genes Dev., 14: 397-402, 2000.
-
(2000)
Genes Dev.
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
17
-
-
0034177408
-
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein, A., Muijtjens, M., van Os, R., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., and Hoeijmakers, J. H. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol., 10: 479-482, 2000.
-
(2000)
Curr. Biol.
, vol.10
, pp. 479-482
-
-
De Klein, A.1
Muijtjens, M.2
Van Os, R.3
Verhoeven, Y.4
Smit, B.5
Carr, A.M.6
Lehmann, A.R.7
Hoeijmakers, J.H.8
-
18
-
-
17644432403
-
2/M DNA damage checkpoint
-
2/M DNA damage checkpoint. Genes Dev., 14: 1448-1459, 2000.
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
Donehower, L.A.11
Elledge, S.J.12
-
19
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T. Ikeda, K., Nakayama, K., and Nakanishi, M. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes, Dev., 14: 1439-1447, 2000.
-
(2000)
Genes Dev.
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
Minamishima, Y.A.4
Nagahama, H.5
Tsukiyama, T.6
Ikeda, K.7
Nakayama, K.8
Nakanishi, M.9
-
20
-
-
0035032649
-
2-phase checkpoints after ionizing irradiation
-
2-phase checkpoints after ionizing irradiation. Mol. Cell. Biol., 21: 3445-3450, 2001.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3445-3450
-
-
Xu, B.1
Kim, S.2
Kastan, M.B.3
-
21
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao, H., and Piwnica-Worms, H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol., 21: 4129-4139, 2001.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
22
-
-
0034306332
-
Threonine 68 is required for radiation-induced phosphorylation and activation of cds1
-
Melchionna, R., Chen, X. B., Blasina, A., and McGowan, C. H. Threonine 68 is required for radiation-induced phosphorylation and activation of cds1. Nat. Cell. Biol., 2: 762-765, 2000.
-
(2000)
Nat. Cell. Biol.
, vol.2
, pp. 762-765
-
-
Melchionna, R.1
Chen, X.B.2
Blasina, A.3
McGowan, C.H.4
-
23
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn, J. Y. Schwarz, J. K., Piwnica-Worms, H., and Canman, C. E. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res., 60: 5934-5936, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
24
-
-
0031438163
-
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
-
Saka, Y., Esashi, F., Matsusaka, T., Mochida, S., and Yanagida, M. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev., 11: 3387-3400, 1997.
-
(1997)
Genes Dev.
, vol.11
, pp. 3387-3400
-
-
Saka, Y.1
Esashi, F.2
Matsusaka, T.3
Mochida, S.4
Yanagida, M.5
-
25
-
-
0034312277
-
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV damaged DNA in Xenopos egg extracts
-
Guo, Z., Kumagai, A., Wang, S. X., and Dunphy, W. G. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV damaged DNA in Xenopos egg extracts. Genes Dev., 14: 2745-2756. 2000.
-
(2000)
Genes Dev.
, vol.14
, pp. 2745-2756
-
-
Guo, Z.1
Kumagai, A.2
Wang, S.X.3
Dunphy, W.G.4
-
26
-
-
0033106326
-
2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
-
2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell., 3: 389-395, 1999.
-
(1999)
Mol. Cell.
, vol.3
, pp. 389-395
-
-
Xu, X.1
Weaver, Z.2
Linke, S.P.3
Li, C.4
Gotay, J.5
Wang, X.W.6
Harris, C.C.7
Ried, T.8
Deng, C.X.9
-
29
-
-
0032159062
-
Stable interation between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
-
Chen, J., Silver, D. P., Walpita, D. Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T. Livingston, D. M., and Scully, R. Stable interation between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell., 2: 317-328, 1998.
-
(1998)
Mol. Cell.
, vol.2
, pp. 317-328
-
-
Chen, J.1
Silver, D.P.2
Walpita, D.3
Cantor, S.B.4
Gazdar, A.F.5
Tomlinson, G.6
Couch, F.J.7
Weber, B.L.8
Ashley, T.9
Livingston, D.M.10
Scully, R.11
-
30
-
-
0035941021
-
ATR ATRIP: Partners in checkpoint signaling
-
Cortez, D., Guntuku, S., Qin, J., and Elledge, S. J. ATR and ATRIP: partners in checkpoint signaling. Science (Wash. DC), 294: 1713-1716, 2001.
-
(2001)
Science (Wash. DC)
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
31
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defect, in cell cycle checkpoints
-
Cliby, W. A., Roberts, C. J., Cimprich, K. A. Stringer, C. M., Lamb, J. R., Schreiber, S. L., and Friend, S. H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defect, in cell cycle checkpoints. EMBO J., 17: 159-169, 1998.
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
Roberts, C.J.2
Cimprich, K.A.3
Stringer, C.M.4
Lamb, J.R.5
Schreiber, S.L.6
Friend, S.H.7
-
32
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A. Kong, Y. Y., Matsuoka, S., Wakeham, A., Ruled, J., Yoshida, H., Liu, D., Elledge, S. J., and Mak, T. W. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (Wash. DC), 287: 1824-1827, 2000.
-
(2000)
Science (Wash. DC)
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruled, J.5
Yoshida, H.6
Liu, D.7
Elledge, S.J.8
Mak, T.W.9
-
34
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H., Naka, K., Okada. Y., Watanabe, M., Harada, N., Saito, S., Anderson, C. W., Appella, E., Nakanishi, M., Suzuki, H., Nagashima, K., Sawa, H., Ikeda, K., and Motoyama, N. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J., 21; 5195-5205, 2002.
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
Watanabe, M.4
Harada, N.5
Saito, S.6
Anderson, C.W.7
Appella, E.8
Nakanishi, M.9
Suzuki, H.10
Nagashima, K.11
Sawa, H.12
Ikeda, K.13
Motoyama, N.14
-
35
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull. T. T., Rogakou, E. P. Yamazaki, V., Kirchgessner, C. U. Gellert, M., and Bonner, W. M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage, Curr. Biol., 10: 886-895, 2000.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
36
-
-
0032562595
-
In situ visualization of DNA double-strand break repair in human fibroblasts
-
Nelms, B. E., Maser, R. S., MacKay, J. F., Lagally, M. G., and Petrini, J. H. In situ visualization of DNA double-strand break repair in human fibroblasts, Science (Wash. DC). 280: 590-592, 1999.
-
(1999)
Science (Wash. DC).
, vol.280
, pp. 590-592
-
-
Nelms, B.E.1
Maser, R.S.2
MacKay, J.F.3
Lagally, M.G.4
Petrini, J.H.5
-
37
-
-
0033575865
-
Conserved BRCT regions of TopBPI and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA
-
Yamane, K., and Tsumo, T. Conserved BRCT regions of TopBPI and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene, 18: 5194-5203, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 5194-5203
-
-
Yamane, K.1
Tsumo, T.2
-
38
-
-
0034694841
-
The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature
-
Yamane, K., Katayama, E., and Tsumo, T. The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature. Biochem. Biophys. Res. Commun., 279: 678-684, 2000.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.279
, pp. 678-684
-
-
Yamane, K.1
Katayama, E.2
Tsumo, T.3
-
39
-
-
0029592020
-
Dpbl 1, which interacts with DNA polymerase llε in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
-
Araki, H., Leem, S. H., Phongdara, A., and Sugino, A. Dpbl 1, which interacts with DNA polymerase llε in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc. Natl. Acad. Sci. USA, 92: 11791-11795, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11791-11795
-
-
Araki, H.1
Leem, S.H.2
Phongdara, A.3
Sugino, A.4
|