Defending genome integrity during S-phase: Putative roles for RecQ helicases and topoisomerase III

DNA Repair

Volumn 1, Issue 3, 2002, Pages 175-207

  Oakley, Thomas J ^a   Hickson, Ian D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cell cycle checkpoints; Genome stability; Homologous recombination; RecQ helicases; Replication fork repair; Topoisomerase III

Indexed keywords

DNA TOPOISOMERASE; HELICASE; ISOENZYME; ADENOSINE TRIPHOSPHATASE; DNA TOPOISOMERASE III; RECQ HELICASE; RECQL PROTEIN, HUMAN;

CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; DNA TEMPLATE; ENZYME ANALYSIS; EUKARYOTIC CELL; GENE DELETION; GENETIC ANALYSIS; GENETIC STABILITY; GENOME; HOMOLOGOUS RECOMBINATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; DNA REPAIR; PHYSIOLOGY; REVIEW;

ADENOSINETRIPHOSPHATASE; ANIMAL; DNA HELICASES; DNA REPAIR; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; GENOME; HUMAN; S PHASE; SUPPORT, NON-U.S. GOV'T; ADENOSINE TRIPHOSPHATASES; ANIMALS; HUMANS; RECQ HELICASES;

EUKARYOTA;

EID: 0037187198     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00002-2     Document Type: Short Survey

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267. Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity
268. Ku complex interacts with and stimulates the Werner protein
269. Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex
270. A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase
271. Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase
272. The essential role of yeast topoisomerase III in meiosis depends on recombination
273. Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: Studies of fusion proteins
274. Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe
275. The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity
276. A new human topoisomerase III that interacts with SGS1 protein
277. Human TOP3: A single-copy gene encoding DNA topoisomerase III
278. Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis
279. Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan
280. Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype
281. Purification and characterisation of human DNA topoisomerase IIIalpha
282. The Bloom's syndrome gene product interacts with topoisomerase III
283. Association of the Bloom syndrome protein with topoisomerase III alpha in somatic and meiotic cells
284. Evidence for BLM and topoisomerase IIIalpha interaction in genomic stability
285. Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha
286. Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death
287. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta
288. Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases
289. n trinucleotide repeat sequence
290. Oligomeric ring structure of the Bloom's syndrome helicase