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Volumn 10, Issue 2, 2000, Pages 144-150

DNA double strand break repair in mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DOUBLE STRANDED DNA;

EID: 0034031137     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00069-1     Document Type: Review
Times cited : (392)

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    • -/- mouse cells is seen in chicken cells in which MRE11 is conditionally inactivated. The absence of Mre11 causes proliferative arrest and an increase in spontaneous and radiation-induced chromosome aberrations. The effects are more apparent when combined with a Ku defect, indicating that the NHEJ and SSA HR pathways process DSBs independently.
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