Role of BRCA2 in control of the RAD51 recombination and DNA repair protein

Molecular Cell

Volumn 7, Issue 2, 2001, Pages 273-282

  Davies, Adelina A ^a   Masson, Jean Yves ^a   McIlwraith, Michael J ^a   Stasiak, Alicja Z ^b   Stasiak, Andrzej ^b   Venkitaraman, Ashok R ^c   West, Stephen C ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; RAD51 PROTEIN;

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CARCINOGENESIS; DNA REPAIR; ESCHERICHIA COLI; GENE MUTATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; NONHUMAN; OVARY CANCER; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ESCHERICHIA COLI;

EID: 0035105999     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00175-7     Document Type: Article

References (62)

1. Identification of a novel human RAD51 homolog, RAD51B
2. The human Rad51 protein: Polarity of strand transfer and stimulation by hRP-A
3. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
4. Purification of human Rad51 protein by selective spermidine precipitation
5. Purification and characterisation of the human Rad51 protein, an analogue of E. coli RecA
6. Synergistic actions of Rad51 and Rad52 in genetic recombination and DNA repair
7. The BRC repeats are conserved in mammalian BRCA2 proteins
8. Internal repeats in the BRCA2 protein sequence
9. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family
10. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
11. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
12. The BRC repeats in Brca2 are critical for Rad51 binding and resistance to methyl methanesulfonate treatment
13. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
14. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATP and c-Abl
15. Tumorigenesis and a DNA-repair defect in mice with a truncating BRCA2 mutation
16. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells
17. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes
18. In vitro reconstitution of the late steps of genetic recombination in E. coli
19. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
20. Activities of human recombination protein Rad51
21. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon skipped transcript in meiosis
22. hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma
23. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
24. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: Evidence for functional conservation
25. The complete genome sequence of the hyperthermophilic, sulfate-reducing archaeon Archaeoglobus fulgidus
26. A mutation in mouse RAD51 results in an early embryonic lethal that is suppressed by a mutation in p53
27. Xrcc2 and Xrcc3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
28. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of BRCA1, BRCA2, BRCA1/BRCA2, BRCA1/p53, and BRCA2/p53 null zygous embryos
29. The BRCA2 gene product functionally interacts with p53 and Rad51
30. The meiosis-specific recombinase Dmc1 forms rings structures and interacts with hRad51
31. Mutations in the RAD54 recombination gene in primary cancers
32. Reconstitution of the strand invasion step of double-strand break repair using human Rad51, Rad52 and RPA proteins
33. Rab22 and Rab163/mouse Brca2: Proteins that specifically interact with the Rad51 protein
34. Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to γ-radiation and premature senescence
35. BRCA2 is required for homology-directed repair of chromosomal breaks
36. Involvement of Brca2 in DNA repair
37. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
38. Identification, characterization, and genetic mapping of RAD51D, a new mouse and human RAD51/recA-related gene
39. Frequent chromosomal translocations induced by DNA double-strand breaks
40. Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas
41. In search of the tumour-suppressor functions of BRCA1 and BRCA2
42. Activation of RuvC Holliday junction resolvase in vitro
43. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking BRCA2
44. (-/-) background
45. Negative staining of proteins and filaments
46. Rad51 deficient vertebrate cells accumulate chromosomal breaks prior to cell death
47. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
48. Brca2 is required for embryonic cellular proliferation in the mouse
49. The RAD51 paralog RAD51B promotes homologous recombinational repair
50. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation
51. A surfeit of RAD51-like genes?
52. Targeted disruption of the RAD51 gene leads to lethality in embryonic mice
53. Breast cancer genes and DNA repair
54. The breast cancer susceptibility gene, BRCA2: At the crossroads between DNA replication and recombination
55. Rad51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene BRCA2
56. Identification of the breast cancer susceptibility gene BRCA2
57. The mouse recA-like gene DMC1 is required for homologous chromosome synapsis during meiosis
58. Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas
59. Gross chromosomal rearrangements and genetic exchange between non-homologous chromosomes following BRCA2 inactivation
60. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
61. Regulation of Rad51 function by c-Abl in response to DNA damage
62. Brca1, Brca2, and DNA-damage response: Collision or collusion