Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity

EMBO Journal

Volumn 19, Issue 18, 2000, Pages 5027-5038

  Liberi, G ^a   Chiolo, I ^a   Pellicioli, A ^a   Lopes, M ^a   Plevani, P ^a   Muzi Falconi, M ^a   Foiani, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Checkpoint; DNA recombination; DNA repair; DNA replication; Srs2

Indexed keywords

CYCLIN DEPENDENT KINASE; HELICASE;

ARTICLE; DNA DAMAGE; DNA DETERMINATION; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; FUNGAL GENETICS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0034665462     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.18.5027     Document Type: Article

References (65)

1. RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene
2. Regulation of p34(CDC28) tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae
3. DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints
4. The ATM homolog MEC1 is required for phosphorylation of replication protein A in yeast
5. The cellular response to DNA damage
6. Defending genome integrity during replication: A proposed role for RecQ family helicases
7. Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase
8. Cell cycle regulation of DNA replication initiator factor Dbf4p
9. - phenotype by expression of a bacterial Holliday junction resolvase
10. RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae
11. Cell cycle checkpoints: Preventing an identity crisis
12. Radiosensitive and mitotic recombination phenotypes of the Saccharomyces cerevisiae dun1 mutant defective in DNA damage-inducible gene expression
13. Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase α-primase B subunit
14. The DNA polymerase α-primase complex couples DNA replication, cell cycle progression and DNA-damage response
15. Saccharomyces cerevisiae as a model system to study DNA replication
16. DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae
17. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
18. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
19. 2/M checkpoint pathways in budding yeast
20. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six base-pair restriction sites
21. + gene, encodes a subunit of the Cdc28 protein kinase complex
22. Cell cycle controls and cancer
23. Regulation of the Saccharomyces cerevisiae Srs2 helicase during the mitotic cell cycle, meiosis and after irradiation
24. A model for replication repair in mammalian cells
25. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases
26. Cell cycle control of DNA synthesis in budding yeast
27. Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
28. The complexity of the interaction between RAD52 and SRS2
29. DNA polymerase ε catalytic domains are dispensable for DNA replication, DNA repair and cell viability
30. Stable DNA replication: Interplay between DNA replication, homologous recombination and transcription
31. 2/M arrest after DNA damage
32. Requirement of yeast SGS1 and SRS2 genes for replication and transcription
33. Sensing and responding to DNA damage
34. 2/M checkpoint - Genes of Saccharomyces cerevisiae: Further evidence for roles in DNA replication and/or repair
35. Double-strand break repair in the absence of RAD51 in yeast: A possible role for break-induced DNA replication
36. A role for DNA primase in coupling DNA replication to DNA damage response
37. Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51
38. DNA polymerase ε links the DNA replication machinery to the S-phase checkpoint
39. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
40. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
41. A checkpoint regulates the rate of progression through S-phase in S. cerevisiae in response to DNA damage
42. When checkpoints fail
43. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage
44. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
45. Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
46. The hypergene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
47. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
48. Control of the DNA damage checkpont by Chk1 and Rad53 protein kinases through distinct mechanisms
49. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
50. The SRS2 suppressor of rad6 mutations of Saccharomycs cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway
51. Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating type heterozygosity
52. Ruv AB acts at the arrested replication forks
53. S-phase feedback control in budding yeast is independent of tyrosine phosphorylation of p34(CDC28)
54. Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway
55. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and DNA damage checkpoint pathway
56. Rad53 FHA domain is associated with phosphorylated Rad9 in the DNA damage checkpoint
57. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
58. New heterologous modules for classical or PCR-based gene disruption in Saccharomyces cerevisiae
59. Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae
60. Yeast checkpoints controls and relevance to cancer
61. DNA damage checkpoints update: Getting molecular
62. Replication protein A: A heterotrimeric, single-stranded DNA-binding potein required for eukaryotic DNA metabolism
63. DUN1 encodes a protein kinase that controls the DNA damage response in yeast
64. Holliday junctions accumulate in replication mutants via RecA homolog-independent mechanism