DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts

Biochemical Journal

Volumn 349, Issue 1, 2000, Pages 1-12

  Murakami, Hiroshi ^a   Nurse, Paul ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cdc2 CDK; Cell cycle; Checkpoint; Meiosis; Yeasts

Indexed keywords

FUNGAL DNA; PROTEIN KINASE; UBIQUITIN PROTEIN LIGASE;

CELL CYCLE; DNA DAMAGE; DNA REPLICATION; MEIOSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW; SCHIZOSACCHAROMYCES POMBE; YEAST;

ANIMALS; CELL CYCLE; DNA DAMAGE; DNA REPLICATION; MEIOSIS; MODELS, BIOLOGICAL; RECOMBINATION, GENETIC; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES; TELOMERE; XENOPUS;

EUKARYOTA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0034235529     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490001     Document Type: Review

References (204)

1. 1 Murray, A. and Hunt, T. (1993) The Cell Cycle, An Introduction. Oxford University Press Inc., New York
2. 2 Roberts, J. M. (1999) Evolving ideas about cyclins. Cell 98, 129-132
3. 3 Sherr, C. J. and Roberts, J. M. (1999) CDK inhibitors: positive and negative regulator of G1-phase progression. Genes Dev. 13, 1501-1512
4. 4 Osmani, S. A. and Ye, X. S. (1996) Cell cycle regulation in Aspergillus by two protein kinases. Biochem. J. 317, 633-641
5. 5 Swanton, C., Card, G. L., Mann, D., McDonald, N. and Jones, N. (1999) Overcoming inhibitions: subversion of CKI function by viral cyclins. Trends Biochem. Sci. 24, 116-120
6. 6 Okayama, H., Nagata, A., Jinno, S., Murakami, H., Tanaka, K. and Nakashima, N. (1996) Cell cycle control in lission yeast and mammals: identification of new regulatory mechanisms. Adv. Cancer Res. 69, 17-62
7. 7 Sagata, N. (1997) What does Mos do in oocytes and somatic cells? Bioessays 19, 13-21
8. 8 Kishimoto, T. (1999) Activation of MPF at meiosis reinitiation in starfish oocytes. Dev. Biol. 214, 1-8
9. 9 Nurse, P. (1990) Universal control mechanism regulating onset of M-phase. Nature (London) 344, 503-508
10. 10 Nurse, P. and Bissett, Y. (1981) Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature (London) 292, 558-560
11. 11 Nurse, P. and Thuriaux, P. (1980) Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics 96, 627-637
12. 12 MacNeill, S. A. and Nurse, P (1997) In Cell Cycle Control in Fission Yeast, Schizosaccharomyces pombe (Pringle, J. R., Broach, J. R. and Jones, E. W., eds.), pp. 697-763, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
13. 13 Lew, D. J., Weinert, T. and Pringle, J. R. (1997) In Cell cycle control in Saccharomyces cerevisiae (Pringle, J. R., Broach, J. R. and Jones, E. W., eds.), pp. 607-695, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
14. 14 Mendenhall, M. D. and Hodge, A. E. (1998) Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62, 1191-1243
15. 15 Martin-Castellanos, C., Labib, K. and Moreno, S. (1996) B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor. EMBO J. 15, 839-849
16. 16 Hayles, J. and Nurse, P. (1995) A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation. EMBO J. 14, 2760-2771
17. 17 Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M. and Beach, D. (1991) mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64, 1111-1122
18. 18 Millar, J. B. and Russell, P. (1992) The cdc25 M-phase inducer: an unconventional protein phosphatase. Cell 68, 407-410
19. 19 Millar, J. B., Lenaers, G. and Russell, P. (1992) Pyp3 PTPase acts as a mitotic inducer in fission yeast. EMBO J. 11, 4933-4941
20. 20 Borgne, A. and Meijer, L. (1996) Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition. J. Biol. Chem. 271, 27847-27854
21. 21 Moreno, S., Hayles, J. and Nurse, P. (1989) Regulation of p34cdc2 protein kinase during mitosis. Cell 58, 361-372
22. 22 Fisher, D. L. and Nurse, P. (1996) A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J. 15, 850-860
23. 23 Stern, B. and Nurse, P. (1996) A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12, 345-350
24. 24 Booher, R. N., Deshaies, R. J. and Kirschner, M. W. (1993) Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 12, 3417-3426
25. 25 Russell, P., Moreno, S. and Reed, S. I. (1989) Conservation of mitotic controls in fission and budding yeasts. Cell 57, 295-303
26. 26 Lew, D. J. and Reed, S. I. (1995) A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J. Cell Biol. 129, 739-749
27. 27 Sia, R. A., Herald, H. A. and Lew, D. J. (1996) Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol. Biol. Cell 7, 1657-1666
28. 28 McMillan, J. N., Sia, R. A., Bardes, E. S. and Lew, D. J. (1999) Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint. Mol. Cell. Biol. 19, 5981-5990
29. 29 Dutta, A. and Bell, S. P. (1997) Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13, 293-332
30. 30 Donaldson, A. D. and Blow, J. J. (1999) The regulation of replication origin activation. Curr. Opin. Genet. Dev. 9, 62-68
31. 31 Newlon, C. S. (1997) Putting it all together: building a prereplicative complex. Cell 91, 717-720
32. 32 Bell, S. P. and Stillman, B. (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (London) 357, 128-134
33. 33 Rowles, A., Chong, J. P., Brown, L., Howell, M., Evan, G. I. and Blow, J. J. (1996) Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87, 287-296
34. 34 Romanowski, P., Madine, M. A., Rowles, A., Blow, J. J. and Laskey, R. A. (1996) The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6, 1416-1425
35. 35 Coleman, T. R., Carpenter, P. B. and Dunphy, W. G. (1996) The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-63
36. 36 Donovan, S., Harwood, J., Drury, L. S. and Diffley, J. F. (1997) Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. U.S.A. 94, 5611-5616
37. 37 Tanaka, T., Knapp, D. and Nasmyth, K. (1997) Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660
38. 38 Aparicio, O. M., Weinstein, D. M. and Bell, S. P. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91, 59-69
39. 39 Zou, L. and Stillman, B. (1998) Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280, 593-596
40. 40 Hua, X. H. and Newport, J. (1998) Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J. Cell. Biol. 140, 271-281
41. 41 Bousset, K. and Diffley, J. F. (1998) The Cdc7 protein kinase is required for origin tiring during S phase. Genes Dev. 12, 480-490
42. 42 Donaldson, A. D., Fangman, W. L. and Brewer, B. J. (1998) Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev. 12, 491-501
43. 43 D'Urso, G., Grallert, B. and Nurse, P. (1995) DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci. 108, 3109-3118
44. 44 Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A. and Nurse, P. (1993) The fission yeast cdc18+ gene product couples S phase to START and mitosis. Cell 74, 371-382
45. 45 Hofmann, J. F. and Beach, D. (1994) cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J. 13, 425-434
46. 46 Saka, Y. and Yanagida, M. (1993) Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+ . Cell 74, 383-393
47. 47 Leatherwood, J., Lopez-Girona, A. and Russell, P. (1996) Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature (London) 379, 360-363
48. 48 Grallert, B. and Nurse, P. (1996) The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10, 2644-2654
49. 49 Lygerou, Z. and Nurse, P. (1999) The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle. J. Cell Sci. 112, 3703-3712
50. 50 Muzi-Falconi, M. and Kelly, T. J. (1995) Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc. Natl. Acad. Sci. U.S.A. 92, 12475-12479
51. 51 Maiorano, D., Van Assendelft, G. B. and Kearsey, S. E. (1996) Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle. EMBO J. 15, 861-872
52. 52 Masai, H., Miyake, T. and Arai, K. (1995) hsk1 +, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J. 14, 3094-3104
53. 53 Takeda, T., Ogino, K., Matsui, E., Cho, M. K., Kumagai, H., Miyake, T., Arai, K. and Masai, H. (1999) A fission yeast gene, him1(+) /dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol. Cell. Biol. 19, 5535-5547
54. 54 Brown, G. W. and Kelly, T. J. (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proc. Natl. Acad. Sci. U.S.A. 96, 8443-8448
55. 55 Reynolds, N., Fantes, P. A. and MacNeill, S. A. (1999) A key role for replication factor C in DNA replication checkpoint function in fission yeast. Nucleic Acids Res. 27, 462-469
56. 56 Shimada, M., Okuzaki, D., Tanaka, S., Tougan, T., Tamai, K. K., Shimoda, C. and Nojima, H. (1999) Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints. Mol. Biol. Cell 10, 3991-4003
57. 57 Nishitani, H., Lygerou, Z., Nishimoto, T. and Nurse, P. (2000) The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (London) 404, 625-628
58. 58 D'Urso, G. and Nurse, P. (1997) Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint. Proc. Natl. Acad Sci. U.S.A 94, 12491-12496
59. 59 Francesconi, S., De Recondo, A. M. and Baldacci, G. (1995) DNA polymerase delta is required for the replication feedback control of cell cycle progression in Schizosaccharomyces pombe. Mol. Gen. Genet. 246, 561-569
60. 60 MacNeill, S. A., Moreno, S., Reynolds. N., Nurse, P. and Fantes, P. A. (1996) The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27. EMBO J. 15, 4613-4628
61. 61 Waseem, N. H., Labib, K., Nurse, P. and Lane, D. P. (1992) Isolation and analysis of the fission yeast gene encoding polymerase delta accessory protein PCNA. EMBO J. 11, 5111-5120
62. 62 Gould, K. L., Burns, C. G., Feoktistova, A., Hu, C. P., Pasion, S. G. and Forsburg, S. L. (1998) Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity. Genetics 149, 1221-1233
63. 63 Tanaka, H., Tanaka, K., Murakami, H. and Okayama, H. (1999) Fission yeast cdc24 is a replication factor C-and proliferating cell nuclear antigen-interacting factor essential for S-phase completion. Mol. Cell. Biol. 19, 1038-1048
64. 64 al-Khodairy, F. and Carr, A. M. (1992) DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11, 1343-1350
65. 65 al-Khodairy, F., Fotou, E., Sheldrick, K. S., Griffiths, D. J., Lehmann, A. R. and Carr, A. M. (1994) Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5, 147-160
66. 66 Rowley, R., Subramani, S. and Young, P. G. (1992) Checkpoint controls in Schizosaccharomyces pombe: rad1. EMBO J. 11, 1335-1342
67. 67 Enoch, T., Carr, A. and Nurse, P. (1992) Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev. 6, 2035-2046
68. + gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad Sci. U.S A 89, 4952-4956
69. 69 Weinert, T. (1998) DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev. 8, 185-193
70. 70 Long, K. E., Sunnerhagen, P. and Subramani, S. (1994) The Schizosaccharomyces pombe rad1 gene consists of three exons and the cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA. Gene 148, 155-159
71. 71 Parker, A. E., Van de Weyer, I., Laus, M. C., Oostveen, I., Yon, J., Verhasselt, P. and Luyten, W. H. (1998) A human homologue of the Schizosaccharomyces pombe rad1 + checkpoint gene encodes an exonuclease. J. Biol. Chem. 273, 18332-18339
72. 72 Thelen, M. P., Venclovas, C. and Fidelis, K. (1999) A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell 96, 769-770
73. 73 Griffiths, D. J., Barbet, N. C., McCready, S., Lehmann, A. R. and Carr, A. M. (1995) Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 14, 5812-5823
74. 74 Kostrub, C. F., Knudsen, K., Subramani, S. and Enoch, T. (1998) Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J. 17, 2055-2066
75. 75 Paciotti, V., Lucchini, G., Plevani, P. and Longhese, M. P. (1998) Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J. 17, 4199-4209
76. 76 Kondo, T., Matsumoto, K. and Sugimoto, K. (1999) Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol. Cell. Biol. 19, 1136-1143
77. 77 Parker, A. E., Van de Weyer, I., Laus, M. C., Verhasselt, P. and Luyten, W. H. (1998) Identification of a human homologue of the Schizosaccharomyces pombe rad17 + checkpoint gene. J. Biol. Chem. 273, 18340-18346
78. 78 Shimomura, T., Ando, S., Matsumoto, K. and Sugimoto, K. (1998) Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Mol. Cell Biol. 18, 5485-5491
79. 79 Edwards, R. J., Bentley, N. J. and Carr, A. M. (1999) A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1, 393-398
80. 80 Naito, T., Matsuura, A. and Ishikawa, F. (1998) Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat. Genet. 20, 203-206
81. 81 Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A., Ford, J. C., Hoekstra, M. and Carr, A. M. (1996) The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15, 6641-6651
82. 82 Walworth, N., Davey, S. and Beach, D. (1993) Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (London) 363, 368-371
83. 83 Murakami, H. and Okayama, H. (1995) A kinase from fission yeast responsible for blocking mitosis in S phase Nature (London) 374, 817-819
84. 84 Murakami, H. and Okayama, H. (1997) Cell cycle checkpoint control. Exp. Mol. Med. 29, 1-11
85. 85 Boddy, M. N., Furnari, B., Mondesert, O. and Russell, P. (1998) Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280, 909-912
86. 86 Lindsay, H. D., Griffiths, D. J., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N. and Carr, A. M. (1998) S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev. 12, 382-395
87. 87 Zeng, Y., Forbes, K. C., Wu, Z., Moreno, S., Piwnica-Worms, H. and Enoch, T. (1998) Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature (London) 395, 507-510
88. 88 Hofmann, K. and Bucher, P. (1995) The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20, 347-349
89. 89 Sun, Z., Hsiao, J., Fay, D. S. and Stern, D. F. (1998) Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281, 272-274
90. 90 Fay, D. S., Sun, Z. and Stern, D. F. (1997) Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions. Curr. Genet. 31, 97-105
91. 91 Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F. and Koonin, E. V. (1997) A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. Faseb. J. 11, 68-76
92. 92 Saka, Y., Esashi, F., Matsusaka, T., Mochida, S. and Yanagida, M. (1997) Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev. 11, 3387-3400
93. 93 Willson, J., Wilson, S., Warr, N. and Watts, F. Z. (1997) Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint. Nucleic Acids Res. 25, 2138-2146
94. 94 Esashi, F. and Yanagida, M. (1999) Cdc2 phosphorylation of Crb2 is required for re-establishing cell cycle progression after the damage checkpoint. Mol. Cell 4, 167-174
95. 95 Furnari, B., Rhind, N. and Russell, P. (1997) Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science 277, 1495-1497
96. 96 O'Connell, M. J., Raleigh, J. M., Verkade, H. M. and Nurse, P. (1997) Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 16, 545-554
97. 97 Nurse, P. (1997) Checkpoint pathways come of age. Cell 91, 865-867
98. 98 Furnari, B., Blasina, A., Boddy, M. N., McGowan, C. H. and Russell, P. (1999) Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. Mol. Biol. Cell 10, 833-845
99. 99 Zeng, Y. and Piwnica-Worms, H. (1999) DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol. Cell. Biol. 19, 7410-7419
100. 100 Lopez-Girona, A., Furnari, B., Mondesert, O. and Russell, P. (1999) Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature (London) 397, 172-175
101. 101 Ford, J. C., al-Khodairy, F., Fotou, E., Sheldrick, K. S., Griffiths, D. J. and Carr, A. M. (1994) 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science 265, 533-535
102. 102 Enoch, T. and Nurse, P. (1990) Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60, 665-673
103. 103 Rhind, N., Furnari, B. and Russell, P. (1997) Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11, 504-511
104. 104 Rhind, N. and Russell, P. (1998) Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Mol. Cell. Biol. 18, 3782-3787
105. 105 Rowley, R., Hudson, J. and Young, P. G. (1992) The wee1 protein kinase is required for radiation-induced mitotic delay. Nature (London) 356, 353-355
106. 106 Enoch, T., Gould, K. L. and Nurse, P. (1991) Mitotic checkpoint control in fission yeast. Cold Spring Harbor Symp. Quant. Biol. 56, 409-416
107. cdc2 kinase activity is maintained upon activation of the replication checkpoint in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. U.S.A 93, 8278-8283
108. 108 Amon, A., Surana, U., Muroff, I. and Nasmyth, K. (1992) Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae Nature (London) 355, 368-371
109. 109 Sorger, P. K. and Murray, A. W. (1992) S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature (London) 355, 365-368
110. 110 Stueland, C. S., Lew, D. J., Cismowski, M. J. and Reed, S. I. (1993) Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 3744-3755
111. 111 Li, X. and Cai, M. (1997) Inactivalion of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly ot mitotic spindles in Saccharomyces cerevisiae. Mol. Cell. Biol. 17, 2723-2734
112. 112 Yamamoto, A., Guacci, V. and Koshland, D. (1996) Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell. Biol. 133, 99-110
113. 113 Cohen-Fix, O. and Koshland, D. (1997) The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc. Natl. Acad. Sci. U.S.A. 94, 14361-14366
114. 114 Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M. and Elledge, S. J. (1999) Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286, 1166-1171
115. 115 Glover, D. M., Hagan, I. M. and Tavares, A. A. (1998) Polo-like kinases: a team that plays throughout mitosis. Genes Dev. 12, 3777-3787
116. 116 Nigg, E. A. (1998) Polo-like kinases: positive regulators of cell division from start to finish. Curr. Opin. Cell Biol. 10, 776-783
117. 117 Cheng, L., Hunke, L. and Hardy, C. F. J. (1998) Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p. Mol. Cell Biol. 18, 7360-7370
118. 118 Esposito, R. E. and Klapholz, S. (1981) Meiosis and Ascospore Development (Strathern, J. N., Jones, E. W. and Broach, J. R., eds.), pp. 211-287, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
119. 119 Fox, M. E. and Smith, G. R. (1998) Control of meiotic recombination in Schizosaccharomyces pombe. Prog. Nucleic Acid Res Mol. Biol. 61, 345-378
120. 120 Yamamoto, M., Imai, Y. and Watanabe, Y. (1997) Mating and Sporulation in Scizosaccharomyces pombe (Pringle, J. R., Broach, J. R. and Jones, E. W., eds.) 1035-1106, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
121. 121 Roeder, G. S. (1997) Meiotic chromosomes: it takes two to tango. Genes Dev. 11, 2600-2621
122. 122 Kleckner, N. (1996) Meiosis: how could it work? Proc. Natl. Acad. Sci. U.S.A. 93, 8167-8174
123. 123 Williamson, D. H., Johnston, L. H., Fennell, D. J. and Simchen, G. (1983) The timing of the S phase and other nuclear events in yeast meiosis. Exp. Cell Res. 145, 209-217
124. 124 Callan, H. G. (1974) DNA replication in the chromosomes of eukaryotes. Cold Spring Harb. Symp. Quant. Biol. 38, 195-203
125. 125 Stern, B. and Nurse, P. (1997) Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase. EMBO J. 16, 534-544
126. 126 Stern, B. and Nurse, P. (1998) Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast. Mol. Biol. Cell 9, 1309-1321
127. 127 Yamaguchi, S., Murakami, H. and Okayama, H. (1997) A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol. Biol. Cell 8, 2475-2486
128. 128 Kitamura, K., Maekawa, H. and Shimoda, C. (1998) Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase. Mol. Biol. Cell 9, 1065-1080
129. 129 Morgan, D. O. (1999) Regulation of the APC and the exit from mitosis. Nat. Cell Biol. 1, E47-E53
130. 130 Aves, S. J., Durkacz, B. W., Carr, A. and Nurse, P. (1985) Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene. EMBO J 4, 457-463
131. 131 Tanaka, K., Okazaki, K., Okazaki, N., Ueda, T., Sugiyama, A., Nojima, H. and Okayama, H. (1992) A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SW14 gene products. EMBO J. 11, 4923-4932
132. 132 Caligiuri, M. and Beach, D. (1993) Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell 72, 607-619
133. 133 Miyamoto, M., Tanaka, K. and Okayama, H. (1994) res2 + , a new member of the cdc10 + /SW14 family, controls the 'start' of mitotic and meiotic cycles in fission yeast. EMBO J. 13, 1873-1880
134. 134 Nakashima, N., Tanaka, K., Sturm, S. and Okayama, H. (1995) Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. EMBO J. 14, 4794-4802
135. 135 Zhu, Y., Takeda, T., Nasmyth, K. and Jones, N. (1994) pct1 +, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe. Genes Dev. 8, 885-898
136. 136 Sugiyama, A., Tanaka, K., Okazaki, K., Nojima, H. and Okayama, H. (1994) A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade. EMBO J. 13, 1881-1887
137. 137 Ding, R. and Smith. G. R. (1998) Global control of meiotic recombination genes by Schizosaccharomyces pombe red16 (rep1). Mol. Gen. Genet. 258, 663-670
138. 138 Li, Y. F. and Smith, G. R. (1997) The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events. Genetics 146, 57-67
139. 139 Dirick, L., Goetsch, L., Ammerer, G. and Byers, B. (1998) Regulation of meiotic S phase by Ime2 and a Clb5,6-associated kinase in Saccharomyces cerevisiae. Science 281, 1854-1857
140. 140 Leem, S. H., Chung, C. N., Sunwoo, Y. and Araki, H. (1998) Meiotic role of SW16 in Saccharomyces cerevisiae. Nucleic Acids Res. 26, 3154-3158
141. 141 Nurse, P., Thuriaux, P. and Nasmyth, K. (1976) Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol.. Gen. Genet. 146, 167-178
142. 142 Iino, Y., Hiramine, Y. and Yamamoto, M. (1995) The role of cdc2 and other genes in meiosis in Schizosaccharomyces pombe. Genetics 140, 1235-1245
143. 143 Beach, D., Rodgers, L. and Gould, J. (1985) ran1 + controls the transition from mitotic division to meiosis in fission yeast. Curr. Genet. 10, 297-311
144. 144 Grallert, B. and Sipiczki, M. (1989) Initiation of the second meiotic division in Schizosaccharomyces pombe shares common functions with that of mitosis. Curr. Genet. 15, 231-233
145. 145 Grallert, B. and Sipiczki, M. (1991) Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe. Curr. Genet. 20, 199-204
146. 146 Grallert, B. and Sipiczki, M. (1990) Dissociation of meiotic and mitotic roles of the fission yeast cdc2 gene. Mol. Gen. Genet. 222, 473-475
147. 147 Nakaseko, Y., Niwa, O. and Yanagida, M. (1984) A meiotic mutant of the fission yeast Schizosaccharomyces pombe that produces mature asci containing two diploid spores. J. Bacteriol. 157, 334-336
148. 148 Murakami, H. and Nurse, P. (1999) Meiotic DNA replication checkpoint control in fission yeast. Genes Dev. 13, 2581-2593
149. cdc2 during meiosis in Schizosaccharomyces pombe. Biochem. Cell. Biol. 70, 1088-1096
150. 150 Yamamoto, M. (1996) The molecular control mechanisms of meiosis in fission yeast. Trends Biochem. Sci. 21, 18-22
151. 151 Watanabe, Y., Shinozaki-Yabana, S., Chikashige, Y., Hiraoka, Y. and Yamamoto, M. (1997) Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature (London) 386, 187-190
152. + encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which co-operates with a novel RNA species meiRNA. Cell 78, 487-498
153. 153 Shuster, E. O. and Byers, B. (1989) Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae. Genetics 123, 29-43
154. 154 Stuart, D. and Wittenberg, C. (1998) CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint. Genes Dev. 12, 2698-2710
155. 155 Colomina, N., Gari, E., Gallego, C., Herrero, E. and Aldea, M. (1999) G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast. EMBO J. 18, 320-329
156. 156 Kupiec, M., Byers, B., Esposito, R. E. and Mitchell, A. P. (1997) Meiosis and Sporulation in Saccharomyces cerevisiae (Pringle, J. R., Broach, J. R. and Jones, E. W., eds.), pp. 889-1036, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
157. 157 Schneider, B. L., Yang, Q. H. and Futcher, A. B. (1996) Linkage of replication to start by the Cdk inhibitor Sic1. Science 272, 560-562
158. 158 Yoshida, M., Kawaguchi, H., Sakata, Y., Kominami, K., Hirano, M., Shima, H., Akada, R. and Yamashita, I. (1990) Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologue. Mol. Gen. Genet. 221, 176-186
159. 159 Foiani, M., Nadjar-Boger, E., Capone, R., Sagee, S., Hashimshoni, T. and Kassir, Y. (1996) A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosis. Mol. Gen Genet. 253, 278-288
160. 160 Kominami, K., Sakata, Y., Sakai, M. and Yamashita, I. (1993) Protein kinase activity associated with the IME2 gene product, a meiotic inducer in the yeast Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 57, 1731-1735
161. 161 Chu, S. and Herskowitz, I. (1998) Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol. Cell 1, 685-696
162. 162 Grandin, N. and Reed, S. I. (1993) Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis. Mol. Cell. Biol. 13, 2113-2125
163. 163 Fogarty, P., Campbell, S. D., Abu-Shumays, R., Phalle, B. S., Yu, K. R., Uy, G. L., Goldberg, M. L. and Sullivan, W. (1997) The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Curr. Biol. 7, 418-426
164. 164 Su, T. T., Walker, J. and Stumpff, J. (2000) Activating the DNA damage checkpoint in a developmental context. Curr. Biol. 10, 119-126
165. cdc2, inhibit NIMA and prevent premature mitosis. EMBO J. 15, 3599-3610
166. 166 Kumagai, A. and Dunphy, W. G. (1995) Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. Mol. Biol. Cell 6, 199-213
167. 167 Kumagai, A., Guo, Z., Emami, K. H., Wang, S. X. and Dunphy, W. G. (1998) The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J. Cell Biol. 142, 1559-1569
168. 168 Blasina, A., Paegle, E. S. and McGowan, C. H. (1997) The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells. Mol. Biol. Cell 8, 1013-1023
169. 169 Jin, P., Gu, Y. and Morgan, D. O. (1996) Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J. Cell Biol. 134, 963-970
170. 170 Toyoshima, F., Moriguchi, T., Wada, A., Fukuda, M. and Nishida, E. (1998) Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 17, 2728-2735
171. 171 Jin, P., Hardy, S. and Morgan, D. O. (1998) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141, 875-885
172. 172 Bishop, D. K., Park, D., Xu, L. and Kleckner, N. (1992) DMC1 : a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69, 439-456
173. 173 Xu, L., Weiner, B. M. and Kleckner, N. (1997) Meiotic cells monitor the status of the interhomolog recombination complex. Genes Dev. 11, 106-118
174. 174 Lydall, D., Nikolsky, Y., Bishop, D. K. and Weinert, T. (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature (London) 383, 840-843
175. 175 Leu, J-Y. and Boeder, G. S. (1999) The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28. Mol. Cell 4, 805-814
176. 176 San-Segundo, P. A. and Boeder, G. S. (1999) Pch2 links chromatin silencing to meiotic checkpoint control. Cell 97, 313-324
177. 177 Smith, A. V. and Roeder, G. S. (1997) The yeast Red1 protein localizes to the cores of meiotic chromosomes. J. Cell Biol. 136, 957-967
178. 178 Bailis, J. M. and Roeder, G. S. (1998) Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein. Genes Dev. 12, 3551-3563
179. 179 Weber, L. and Byers, B. (1992) A RAD9-dependent checkpoint blocks meiosis of cdc13 yeast cells. Genetics 131, 55-63
180. 180 Nasmyth, K. (1999) Separating sister chromatids. Trends Biochem. Sci. 24, 98-104
181. 181 Guacci, V., Koshland, D. and Strunnikov, A. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91, 47-57
182. 182 Michaelis, C., Ciosk, R. and Nasmyth, K. (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91, 35-45
183. 183 Toth, A., Ciosk, B., Uhlmann, F., Galova, M., Schleiffer, A. and Nasmyth, K. (1999) Yeast cohesin complex requires a conserved protein, Eco1 p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev. 13, 320-333
184. 184 Yanagida, M. (2000) Cell cycle mechanisms of sister chromatid separation; Roles of Cut1/separin and Cut2/securin. Genes Cells 5, 1-8
185. 185 Hirano, T. (1999) SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev. 13. 11-19
186. 186 Uhlmann, F., Lottspeich, F. and Nasmyth, K. (1999) Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature (London) 400, 37-42
187. 187 Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M. and Nasmyth, K. (1998) An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93, 1067-1076
188. 188 Cohen-Fix, O., Peters, J. M., Kirschner, M. W. and Koshland, D. (1996) Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10, 3081-3093
189. 189 Visintin, R., Prinz, S. and Amon, A. (1997) CDC20 and CDH1 : a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460-463
190. 190 Bickel, S. E. and Orr-Weaver, T. L. (1996) Holding chromatids together to ensure they go their separate ways. Bioessays 18, 293-300
191. 191 Molnar, M., Bahler, J., Sipiczki, M. and Kohli, J. (1995) The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis. Genetics 141, 61-73
192. 192 Watanabe, Y. and Nurse, P. (1999) Cohesin Rec8 is required for reductional chromosome segregation at meiosis. Nature (London) 400, 461-464
193. 193 Parisi, S., McKay, M. J., Molnar, M., Thompson, M. A., van der Spek, P. J., van Drunen-Schoenmaker, E., Kanaar, R., Lehmann, E., Hoeijmakers, J. H. and Kohli, J. (1999) Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. Mol. Cell. Biol. 19, 3515-3528
194. 194 Klein, F., Mahr, P., Galova, M., Buonomo, S. B., Michaelis, C., Nairz, K. and Nasmyth, K. (1999) A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell 98, 91-103
195. 195 Cooper, J. P., Nimmo, E. R., Allshire, R. C. and Cech, T. R. (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature (London) 385, 744-747
196. 196 Nimmo, E. R., Pidoux, A. L., Perry, P. E. and Allshire, R. C. (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature (London) 392, 825-828
197. 197 Cooper, J. P., Watanabe, Y. and Nurse, P. (1998) Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature (London) 392, 828-831
198. 198 Hiraoka, Y. (1998) Meiotic telomeres: a matchmaker for homologous chromosomes. Genes Cells 3, 405-413
199. 199 Chikashige, Y., Ding, D. Q., Funabiki, H., Haraguchi, T., Mashiko, S., Yanagida, M. and Hiraoka, Y. (1994) Telomere-led premeiotic chromosome movement in fission yeast. Science 264, 270-273
200. 200 Chikashige, Y, Ding, D. Q., Imai, Y., Yamamoto, M., Haraguchi, T. and Hiraoka, Y. (1997) Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO J 16, 193-202
201. 201 Furuno, N., Nishizawa, M., Okazaki, K., Tanaka, H., Iwashita, J., Nakajo, N., Ogawa, Y. and Sagata, N. (1994) Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes. EMBO J 13, 2399-2410
202. 202 Picard, A., Galas, S., Peaucellier, G. and Doree, M. (1996) Newly assembled cyclin B-cdc2 kinase is required to suppress DNA replication between meiosis I and meiosis II in starfish oocytes. EMBO J. 15, 3590-3598
203. 203 Ohsumi, K., Sawada, W. and Kishimoto, T. (1994) Meiosis-specilic cell cycle regulation in maturing Xenopus oocytes. J. Cell Sci. 107, 3005-3013
204. 204 Nakajo, N., Yoshitome, S., Iwashita, J., Iida, M., Uto, K., Ueno, S., Okamoto, K. and Sagata, N. (2000) Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes. Genes Dev. 14, 328-338